Search Results - "LESSARD, Christopher J"

Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica by Agasing, Agnieshka M., Wu, Qi, Khatri, Bhuwan, Borisow, Nadja, Ruprecht, Klemens, Brandt, Alexander Ulrich, Gawde, Saurabh, Kumar, Gaurav, Quinn, James L., Ko, Rose M., Mao-Draayer, Yang, Lessard, Christopher J., Paul, Friedemann, Axtell, Robert C.

“…Type I interferon (IFN-I) and T helper 17 (TH17) drive pathology in neuromyelitis optica spectrum disorder (NMOSD) and in TH17-induced experimental autoimmune…”
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Ancestral origins are associated with SARS-CoV-2 susceptibility and protection in a Florida patient population by Shen, Yiran, Khatri, Bhuwan, Rananaware, Santosh, Li, Danmeng, Ostrov, David A, Jain, Piyush K, Lessard, Christopher J, Nguyen, Cuong Q

“…COVID-19 is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The severity of COVID-19 is highly variable and related to known (e.g.,…”
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Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjögren's syndrome by Nocturne, Gaetane, Boudaoud, Saida, Miceli-Richard, Corinne, Viengchareun, Say, Lazure, Thierry, Nititham, Joanne, Taylor, Kimberly E., Ma, Averil, Busato, Florence, Melki, Judith, Lessard, Christopher J., Sivils, Kathy L., Dubost, Jean-Jacques, Hachulla, Eric, Gottenberg, Jacques Eric, Lombès, Marc, Tost, Jorg, Criswell, Lindsey A., Mariette, Xavier

“…Several autoimmune diseases, including primary Sjögren's syndrome (pSS), are associated with an increased risk for lymphoma. Polymorphisms of TNFAIP3, which…”
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Sjögren Syndrome without Focal Lymphocytic Infiltration of the Salivary Glands by Sharma, Rohan, Chaudhari, Kaustubh S, Kurien, Biji T, Grundahl, Kiely, Radfar, Lida, Lewis, David M, Lessard, Christopher J, Li, He, Rasmussen, Astrid, Sivils, Kathy L, Scofield, R Hal

“…Primary Sjögren syndrome (SS) is characterized by a focal lymphocytic infiltrate in exocrine glands. We describe patients who lacked this key feature. We…”
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Genetics in Sjögren Syndrome by Reksten, Tove Ragna, PhD, Lessard, Christopher J., PhD, Sivils, Kathy L., PhD

“…The genes associated with Sjögren syndrome (SS) can be assigned to the NF-kB pathway, the IFN signaling pathway, lymphocyte signaling, and antigen…”
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Defective Efferocytosis in a Murine Model of Sjögren's Syndrome Is Mediated by Dysfunctional Mer Tyrosine Kinase Receptor by Witas, Richard, Rasmussen, Astrid, Scofield, Robert H, Radfar, Lida, Stone, Donald U, Grundahl, Kiely, Lewis, David, Sivils, Kathy L, Lessard, Christopher J, Farris, A Darise, Nguyen, Cuong Q

“…Sjögren's syndrome (SjS) is a chronic autoimmune disease primarily involving the exocrine glands in which the involvement of the innate immune system is…”
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Germline variation of TNFAIP3 in primary Sjögren's syndrome-associated lymphoma by Nocturne, Gaetane, Tarn, Jessica, Boudaoud, Saida, Locke, James, Miceli-Richard, Corinne, Hachulla, Eric, Dubost, Jean-Jacques, Bowman, Simon, Gottenberg, Jacques-Eric, Criswell, Lindsey A, Lessard, Christopher J, Sivils, Kathy L, Carapito, Raphael, Bahram, Siamak, Seror, Raphaèle, Ng, Wan-Fai, Mariette, Xavier

“…A germline and coding polymorphism (rs2230926) of TNFAIP3 (A20), a central gatekeeper of nuclear factor-kappa B (NF-kB) activation, was recently found…”
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Transcriptomic and Network Analysis of Minor Salivary Glands of Patients With Primary Sjögren's Syndrome by Oyelakin, Akinsola, Horeth, Erich, Song, Eun-Ah Christine, Min, Sangwon, Che, Monika, Marzullo, Brandon, Lessard, Christopher J, Rasmussen, Astrid, Radfar, Lida, Scofield, R Hal, Lewis, David M, Stone, Donald U, Grundahl, Kiely, De Rossi, Scott S, Kurago, Zoya, Farris, A Darise, Sivils, Kathy L, Sinha, Satrajit, Kramer, Jill M, Romano, Rose-Anne

“…Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterized primarily by immune-mediated destruction of exocrine tissues, such as those of…”
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Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility by Adrianto, Indra, Lin, Chee Paul, Hale, Jessica J, Levin, Albert M, Datta, Indrani, Parker, Ryan, Adler, Adam, Kelly, Jennifer A, Kaufman, Kenneth M, Lessard, Christopher J, Moser, Kathy L, Kimberly, Robert P, Harley, John B, Iannuzzi, Michael C, Rybicki, Benjamin A, Montgomery, Courtney G

“…Sarcoidosis is a systemic inflammatory disease characterized by the formation of granulomas in affected organs. Genome-wide association studies (GWASs) of this…”
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Effect of Tobacco Smoking on The Clinical, Histopathological, and Serological Manifestations of Sjögren's Syndrome by Stone, Donald U, Fife, Dustin, Brown, Michael, Earley, Keith E, Radfar, Lida, Kaufman, C Erick, Lewis, David M, Rhodus, Nelson L, Segal, Barbara M, Wallace, Daniel J, Weisman, Michael H, Venuturupalli, Swamy, Brennan, Michael T, Lessard, Christopher J, Montgomery, Courtney G, Scofield, R Hal, Sivils, Kathy L, Rasmussen, Astrid

“…To assess the association of smoking habits with the clinical, serological, and histopathological manifestations of Sjögren's syndrome (SS) and non-Sjögren's…”
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Detrimental effects of duplicate reads and low complexity regions on RNA- and ChIP-seq data by Dozmorov, Mikhail G, Adrianto, Indra, Giles, Cory B, Glass, Edmund, Glenn, Stuart B, Montgomery, Courtney, Sivils, Kathy L, Olson, Lorin E, Iwayama, Tomoaki, Freeman, Willard M, Lessard, Christopher J, Wren, Jonathan D

“…Adapter trimming and removal of duplicate reads are common practices in next-generation sequencing pipelines. Sequencing reads ambiguously mapped to repetitive…”
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The genomics of autoimmune disease in the era of genome-wide association studies and beyond by Lessard, Christopher J, Ice, John A, Adrianto, Indra, Wiley, Graham B, Kelly, Jennifer A, Gaffney, Patrick M, Montgomery, Courtney G, Moser, Kathy L

“…Abstract Recent advances in the field of genetics have dramatically changed our understanding of autoimmune disease. Candidate gene and, more recently,…”
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Fatty infiltration of the minor salivary glands is a selective feature of aging but not Sjögren's syndrome by Leehan, Kerry M., Pezant, Nathan P., Rasmussen, Astrid, Grundahl, Kiely, Moore, Jacen S., Radfar, Lida, Lewis, David M., Stone, Donald U., Lessard, Christopher J., Rhodus, Nelson L., Segal, Barbara M., Kaufman, C. Erick, Scofield, R. Hal, Sivils, Kathy L., Montgomery, Courtney, Farris, A. Darise

“…Objective: Determine the presence and assess the extent of fatty infiltration of the minor salivary glands (SG) of primary SS patients (pSS) as compared to…”
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Genes and Sjögren's Syndrome by Cobb, Beth L., MBA, Lessard, Christopher J., BS, Harley, John B., MD, PhD, Moser, Kathy L., PhD

“…The evidence for a strong genetic component conferring susceptibility to primary Sjögren's syndrome (SS) is mounting. Several associations with SS have been…”
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Interferons in Sjögren's Syndrome: Genes, Mechanisms, and Effects by Li, He, Ice, John A, Lessard, Christopher J, Sivils, Kathy L

“…Sjögren's syndrome (SS) is a common, progressive autoimmune exocrinopathy distinguished by dry eyes and mouth and affects ∼0.7% of the European population…”
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A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases by Zhao, Jian, Ma, Jianyang, Deng, Yun, Kelly, Jennifer A, Kim, Kwangwoo, Bang, So-Young, Lee, Hye-Soon, Li, Quan-Zhen, Wakeland, Edward K, Qiu, Rong, Liu, Mengru, Guo, Jianping, Li, Zhanguo, Tan, Wenfeng, Rasmussen, Astrid, Lessard, Christopher J, Sivils, Kathy L, Hahn, Bevra H, Grossman, Jennifer M, Kamen, Diane L, Gilkeson, Gary S, Bae, Sang-Cheol, Gaffney, Patrick M, Shen, Nan, Tsao, Betty P

“…Betty Tsao, Jian Zhao, Nan Shen and colleagues show that a common missense variant in NCF1 confers susceptibility to multiple autoimmune diseases. This…”
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Gene expression profiling of epithelium-associated FcRL4+ B cells in primary Sjögren's syndrome reveals a pathogenic signature by Verstappen, Gwenny M., Ice, John A., Bootsma, Hendrika, Pringle, Sarah, Haacke, Erlin A., de Lange, Kim, van der Vries, Gerben B., Hickey, Peter, Vissink, Arjan, Spijkervet, Frederik K.L., Lessard, Christopher J., Kroese, Frans G.M.

“…In primary Sjögren's syndrome (pSS), FcRL4+ B cells are present in inflamed salivary gland tissue, within or in close proximity to ductal epithelium. FcRL4 is…”
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TScan-II: A genome-scale platform for the de novo identification of CD4 + T cell epitopes by Dezfulian, Mohammad H, Kula, Tomasz, Pranzatelli, Thomas, Kamitaki, Nolan, Meng, Qingda, Khatri, Bhuwan, Perez, Paola, Xu, Qikai, Chang, Aiquan, Kohlgruber, Ayano C, Leng, Yumei, Jupudi, Ananth Aditya, Joachims, Michelle L, Chiorini, John A, Lessard, Christopher J, Darise Farris, A, Muthuswamy, Senthil K, Warner, Blake M, Elledge, Stephen J

“…CD4 T cells play fundamental roles in orchestrating immune responses and tissue homeostasis. However, our inability to associate peptide human leukocyte…”
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Autoantibodies identify primary Sjögren's syndrome in patients lacking serum IgG specific for Ro/SS-A and La/SS-B by Longobardi, Sherri, Lopez-Davis, Charmaine, Khatri, Bhuwan, Georgescu, Constantin, Pritchett-Frazee, Cherilyn, Lawrence, Christina, Rasmussen, Astrid, Radfar, Lida, Scofield, Robert Hal, Baer, Alan N, Robinson, Susan A, Darrah, Erika, Axtell, Robert C, Pardo, Gabriel, Wren, Jonathan D, Koelsch, Kristi A, Guthridge, Joel M, James, Judith A, Lessard, Christopher J, Farris, Amy Darise

“…Identify autoantibodies in anti-Ro/SS-A negative primary Sjögren's syndrome (SS). This is a proof-of-concept, case-control study of SS, healthy (HC) and other…”
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Anti-vimentin antibodies are associated with higher severity of Sjögren's disease by Bagavant, Harini, Araszkiewicz, Antonina M., Rasmussen, Astrid, Pezant, Nathan, Montgomery, Courtney, Scofield, Robert Hal, Farris, Darise, Lessard, Christopher J., Deshmukh, Umesh S.

“…Vimentin is a ubiquitously present Type III intermediate filament protein, often targeted by autoimmune responses in multiple rheumatic disorders. Although…”
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