Search Results - "LESMA, Giordano"

Cellulose nanofibrils as reinforcing agents for PLA-based nanocomposites: An in situ approach by Gazzotti, Stefano, Rampazzo, Riccardo, Hakkarainen, Minna, Bussini, Daniele, Ortenzi, Marco Aldo, Farina, Hermes, Lesma, Giordano, Silvani, Alessandra

“…One-pot in situ polymerization approach was explored for the preparation of polylactide (PLA)-cellulose nanofibril (CNF) bio-nanocomposites. CNF were first…”
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One step access to oxindole-based β-lactams through Ugi four-center three-component reaction by Rainoldi, Giulia, Lesma, Giordano, Picozzi, Claudia, Lo Presti, Leonardo, Silvani, Alessandra

“…A multicomponent Ugi reaction involving isatin, isocyanide and β-amino acid components has been developed. The reactions proceeded smoothly to give…”
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Chlorine Dioxide Degradation Issues on Metal and Plastic Water Pipes Tested in Parallel in a Semi-Closed System by Vertova, Alberto, Miani, Alessandro, Lesma, Giordano, Rondinini, Sandra, Minguzzi, Alessandro, Falciola, Luigi, Ortenzi, Marco Aldo

“…Chlorine dioxide (ClO ) has been widely used as a disinfectant in drinking water in the past but its effects on water pipes have not been investigated deeply,…”
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Disrupting the PCSK9/LDLR protein-protein interaction by an imidazole-based minimalist peptidomimetic by Stucchi, Mattia, Grazioso, Giovanni, Lammi, Carmen, Manara, Silvia, Zanoni, Chiara, Arnoldi, Anna, Lesma, Giordano, Silvani, Alessandra

“…Herein we report on the multicomponent synthesis of a novel imidazole-based compound, able to act efficiently as a minimalist β-strand mimic. Biological…”
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Organocatalytic Access to Enantioenriched Spirooxindole-Based 4-Methyleneazetidines by Rainoldi, Giulia, Faltracco, Matteo, Spatti, Claudia, Silvani, Alessandra, Lesma, Giordano

“…This work describes the synthesis of enantioenriched spiro compounds, incorporating the azetidine and the oxindole motifs. The preparation relies on a formal…”
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Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives by Lesma, Giordano, Meneghetti, Fiorella, Sacchetti, Alessandro, Stucchi, Mattia, Silvani, Alessandra

“…An efficient Ugi three-component reaction of a preformed chiral ketimine derived from isatin with various isonitrile and acid components has been developed…”
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Olefin Metathesis Based Approach to Diversely Functionalized Pyrrolizidines and Indolizidines; Total Synthesis of (+)-Monomorine by Lesma, Giordano, Colombo, Alessia, Sacchetti, Alessandro, Silvani, Alessandra

“…New scaffolds for the stereoselective synthesis of diversely functionalized chiral enantiopure indolizidines and pyrrolizidines were synthesized from the cross…”
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Addition of TMSCN to chiral ketimines derived from isatin. Synthesis of an oxindole-based peptidomimetic and a bioactive spirohydantoin by Sacchetti, Alessandro, Silvani, Alessandra, Gatti, Francesco G, Lesma, Giordano, Pilati, Tullio, Trucchi, Beatrice

“…We investigated the Strecker-type reaction of isatin derived chiral ketimines with TMSCN in the presence of a Lewis acid. The desired α-amino nitriles have…”
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The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure by Airaghi, Francesco, Fiorati, Andrea, Lesma, Giordano, Musolino, Manuele, Sacchetti, Alessandro, Silvani, Alessandra

“…Aiming at restricting the conformational freedom of tryptophan-containing peptide ligands, we designed a THBC (tetrahydro-β-carboline)-DKP…”
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Thiocolchicine−Podophyllotoxin Conjugates:  Dynamic Libraries Based on Disulfide Exchange Reaction by Danieli, Bruno, Giardini, Alessandra, Lesma, Giordano, Passarella, Daniele, Peretto, Bruno, Sacchetti, Alessandro, Silvani, Alessandra, Pratesi, Graziella, Zunino, Franco

“…A dynamic combinatorial library of thiocolchicine−podophyllotoxin derivatives based on the disulfide bond exchange reaction is described. The influence of a…”
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Remote Stereocenter Discrimination in the Enzymatic Resolution of Piperidine-2-ethanol. Short Enantioselective Synthesis of Sedamine and Allosedamine by Angoli, Marco, Barilli, Alessio, Lesma, Giordano, Passarella, Daniele, Riva, Sergio, Silvani, Alessandra, Danieli, Bruno

“…Kinetic resolution of N-Boc-piperidine-2-ethanol (2), a case of remote stereocenter discrimination, was accomplished by sequential transesterification mediated…”
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Concise asymmetric synthesis of (−)-halosaline and (2 R,9a R)-(+)-2-hydroxy-quinolizidine by ruthenium-catalyzed ring-rearrangement metathesis by Lesma, Giordano, Crippa, Sergio, Danieli, Bruno, Passarella, Daniele, Sacchetti, Alessandro, Silvani, Alessandra, Virdis, Andrea

“…A ruthenium-catalyzed ring opening–ring closing metathesis reaction serves as the key step in the stereoselective synthesis of a new enantiopure…”
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Enzyme assisted enantioselective synthesis of the alkaloid (+)-aloperine by Barilli, Alessio, Belinghieri, Francesca, Passarella, Daniele, Lesma, Giordano, Riva, Sergio, Silvani, Alessandra, Danieli, Bruno

“…[Display omitted] The enantioselective synthesis of the lupinine alkaloid (+)-aloperine is described. The synthetic scheme presents three steps that are…”
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New solution free and polymer anchored chiral bispidine-based amino alcohols. Synthesis and screening for the enantioselective addition of diethylzinc to benzaldehyde by Lesma, Giordano, Danieli, Bruno, Passarella, Daniele, Sacchetti, Alessandro, Silvani, Alessandra

“…A new approach has been evaluated for the preparation of solution free and polymer supported chiral bicyclic amino alcohols. This strategy involves the use of…”
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Split-Ugi Reaction with Chiral Compounds: Synthesis of Piperazine- and Bispidine-Based Peptidomimetics by Stucchi, Mattia, Lesma, Giordano

“…A simple, one‐step, stereoconservative synthesis of diamine‐based peptidomimetics is described, by split‐Ugi multicomponent reaction, involving chiral…”
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Computationally Driven Structure Optimization, Synthesis, and Biological Evaluation of Imidazole-Based Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Inhibitors by Lammi, Carmen, Sgrignani, Jacopo, Arnoldi, Anna, Lesma, Giordano, Spatti, Claudia, Silvani, Alessandra, Grazioso, Giovanni

“…Proprotein convertase subtilisin/kexin 9 (PCSK9) is responsible for the degradation of the hepatic low-density lipoprotein receptor (LDLR), which in turn…”
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Organocatalytic Asymmetric Biginelli-like Reaction Involving Isatin by Stucchi, Mattia, Lesma, Giordano, Meneghetti, Fiorella, Rainoldi, Giulia, Sacchetti, Alessandro, Silvani, Alessandra

“…The first asymmetric, Brønsted acid catalyzed Biginelli-like reaction of a ketone has been developed, employing N-substituted isatins as carbonyl substrates,…”
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Polylactide/cellulose nanocrystals: The in situ polymerization approach to improved nanocomposites by Gazzotti, Stefano, Farina, Hermes, Lesma, Giordano, Rampazzo, Riccardo, Piergiovanni, Luciano, Ortenzi, Marco Aldo, Silvani, Alessandra

“…[Display omitted] •A novel approach for the preparation of PLA-CNC nanocomposites is proposed.•This approach is based on an in situ polymerization…”
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trans-6-Aminocyclohept-3-enols, a New Designed Polyfunctionalized Chiral Building Block for the Asymmetric Synthesis of 2-Substituted-4-hydroxypiperidines by Celestini, Paolo, Danieli, Bruno, Lesma, Giordano, Sacchetti, Alessandro, Silvani, Alessandra, Passarella, Daniele, Virdis, Andrea

“…trans-6-Aminocyclohept-3-enols 18 and ent-18 are new designed polyfunctionalized chiral building blocks for piperidine alkaloids synthesis and are prepared in…”
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Grignard Addition to Imines Derived from Isatine: A Method for the Asymmetric Synthesis of Quaternary 3-Aminooxindoles by Lesma, Giordano, Landoni, Nicola, Pilati, Tullio, Sacchetti, Alessandro, Silvani, Alessandra

“…Addition of Grignard reagents to chiral imines derived from isatine afforded chiral, optically enriched 3-substituted 3-aminooxindoles in satisfactory yields…”
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