Search Results - "LESLIE, R. David"

Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment by Leslie, R. David, Palmer, Jerry, Schloot, Nanette C., Lernmark, Ake

“…Diabetes is not a single homogeneous disease but composed of many diseases with hyperglycaemia as a common feature. Four factors have, historically, been used…”
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Adult-Onset Type 1 Diabetes: Current Understanding and Challenges by Leslie, R David, Evans-Molina, Carmella, Freund-Brown, Jacquelyn, Buzzetti, Raffaella, Dabelea, Dana, Gillespie, Kathleen M, Goland, Robin, Jones, Angus G, Kacher, Mark, Phillips, Lawrence S, Rolandsson, Olov, Wardian, Jana L, Dunne, Jessica L

“…Recent epidemiological data have shown that more than half of all new cases of type 1 diabetes occur in adults. Key genetic, immune, and metabolic differences…”
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Allostasis and the origins of adult-onset diabetes by Leslie, R. David, Vartak, Tanwi

“…Physiological plasticity enables homeostasis to be maintained in biological systems, but when such allostasis fails, then disease can develop. In a new…”
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Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains by Rakyan, Vardhman K, Down, Thomas A, Maslau, Siarhei, Andrew, Toby, Yang, Tsun-Po, Beyan, Huriya, Whittaker, Pamela, McCann, Owen T, Finer, Sarah, Valdes, Ana M, Leslie, R David, Deloukas, Panogiotis, Spector, Timothy D

“…There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here, we report the first genome-scale study of…”
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C-peptide persistence in type 1 diabetes: 'not drowning, but waving'? by Leslie, R David, Vartak, Tanwi

“…Keywords: Type 1 diabetes, Stratification, Gene risk scores, Proinsulin, C-peptide, Insulin secretion…”
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Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies by Lowe, Robert, Gemma, Carolina, Beyan, Huriya, Hawa, Mohammed I., Bazeos, Alexandra, Leslie, R. David, Montpetit, Alexandre, Rakyan, Vardhman K., Ramagopalan, Sreeram V.

“…There is increasing evidence that interindividual epigenetic variation is an etiological factor in common human diseases. Such epigenetic variation could be…”
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Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis by Rakyan, Vardhman K, Beyan, Huriya, Down, Thomas A, Hawa, Mohammed I, Maslau, Siarhei, Aden, Deeqo, Daunay, Antoine, Busato, Florence, Mein, Charles A, Manfras, Burkhard, Dias, Kerith-Rae M, Bell, Christopher G, Tost, Jörg, Boehm, Bernhard O, Beck, Stephan, Leslie, R David

“…Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is ∼50%, implicating roles for genetic and non-genetic factors in the…”
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The A1C and ABCD of glycaemia management in type 2 diabetes: a physician's personalized approach by Pozzilli, Paolo, David Leslie, R., Chan, Juliana, De Fronzo, Ralph, Monnier, Louis, Raz, Itamar, Del Prato, Stefano

“…Recent intervention trials (Veterans Affairs Diabetes Trial, Action to Control Cardiovascular Risk in Diabetes, Action in Diabetes and Vascular Disease) have…”
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The Dynamic Origins of Type 1 Diabetes by Leslie, R David, Grant, Struan F A

“…This article talks about the dynamic origins of type 1 diabetes (T1D). Over a century ago, there was diabetes and only diabetes. Subsequently, diabetes came to…”
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Variation and the spice of life by Leslie, R David, Jerram, Samuel

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Improving clinical utility of GAD65 autoantibodies by electrochemiluminescence assay and clinical phenotype when identifying autoimmune adult-onset diabetes by Gu, Yong, Jia, Xiaofan, Vartak, Tanwi, Miao, Dongmei, Dong, Fran, Jerram, Samuel T., Rewers, Marian, Ferrara, Assiamira, Lawrence, Jean M., Yu, Liping, Leslie, R. David

“…Aims/hypothesis It is important to differentiate the two major phenotypes of adult-onset diabetes, autoimmune type 1 diabetes and non-autoimmune type 2…”
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Teasing Diabetes Apart, One Locus at a Time by Leslie, R David, Grant, Struan F A

“…Although most organ-specific autoimmune diseases show middle-age onset and a range of severity, type 1 diabetes appears to be relatively atypical given its…”
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Type 1 diabetes in Africa: an immunogenetic study in the Amhara of North-West Ethiopia by Balcha, Shitaye A., Demisse, Abayneh G., Mishra, Rajashree, Vartak, Tanwi, Cousminer, Diana L., Hodge, Kenyaita M., Voight, Benjamin F., Lorenz, Kim, Schwartz, Stanley, Jerram, Samuel T., Gamper, Arla, Holmes, Alice, Wilson, Hannah F., Williams, Alistair J. K., Grant, Struan F. A., Leslie, R. David, Phillips, David I. W., Trimble, Elisabeth R.

“…Aims/hypothesis We aimed to characterise the immunogenic background of insulin-dependent diabetes in a resource-poor rural African community. The study was…”
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Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture by Allen, Jennifer S, Pang, Karl, Skowera, Ania, Ellis, Richard, Rackham, Chloe, Lozanoska-Ochser, Biliana, Tree, Timothy, Leslie, R David G, Tremble, Jennifer M, Dayan, Colin M, Peakman, Mark

“…Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune…”
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CLINICAL REVIEW: Type 1 Diabetes and Latent Autoimmune Diabetes in Adults: One End of the Rainbow by Leslie, R David G, Williams, Rhys, Pozzilli, Paolo

“…CONTEXT:The aim of this review was to explore the pathogenic and clinical spectrum of type 1 diabetes, which includes a form of adult onset autoimmune diabetes…”
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Heterogeneity of Altered Cytokine Levels Across the Clinical Spectrum of Diabetes in China by Xiang, Yufei, Zhou, Pengcheng, Li, Xiaojue, Huang, Gan, Liu, Zhenqi, Xu, Aimin, Leslie, R. David, Zhou, Zhiguang

“…OBJECTIVE: To determine the relationship between selected cytokines and diabetes in Chinese subjects. RESEARCH DESIGN AND METHODS: Adult patients with…”
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Evidence for Independent Heritability of the Glycation Gap (Glycosylation Gap) Fraction of HbA₁c in Nondiabetic Twins by Cohen, Robert M, Snieder, Harold, Lindsell, Christopher J, Beyan, Huriya, Hawa, Mohammed I, Blinko, Stuart, Edwards, Raymond, Spector, Timothy D, Leslie, R. David G

“…OBJECTIVE:--HbA₁c (A1C) is substantially determined by genetic factors not shared in common with glucose. Fractions of the variance in A1C, the glycation gap…”
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Towards secondary prevention of Type 1 diabetes by David Leslie, R.

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Heritability of thyroid peroxidase autoantibody levels in type 1 diabetes: evidence from discordant twin pairs by Wang, Bin, Hawa, Mohammed I., Rijsdijk, Frühling V., Fain, Pamela R., Paschou, Stavroula A., Boehm, Bernhard O., Steck, Andrea K., Snieder, Harold, Leslie, R. David G.

“…Aims/hypothesis The discordance status of (autoimmune) type 1 diabetes within monozygotic twin pairs points to the importance of environmental factors. The aim…”
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Stiff person syndrome by Hadavi, Shahrzad, Noyce, Alastair J, Leslie, R David, Giovannoni, Gavin

“…Stiff person syndrome (SPS) is a rare disorder, characterised by fluctuating rigidity and stiffness of the axial and proximal lower limb muscles, with…”
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