Search Results - "LESLIE, Nick R."

MC1R Is a Potent Regulator of PTEN after UV Exposure in Melanocytes by Cao, Juxiang, Wan, Lixin, Hacker, Elke, Dai, Xiangpeng, Lenna, Stefania, Jimenez-Cervantes, Celia, Wang, Yongjun, Leslie, Nick R., Xu, George X., Widlund, Hans R., Ryu, Byungwoo, Alani, Rhoda M., Dutton-Regester, Ken, Goding, Colin R., Hayward, Nicholas K., Wei, Wenyi, Cui, Rutao

“…The individuals carrying melanocortin-1 receptor (MC1R) variants, especially those associated with red hair color, fair skin, and poor tanning ability (RHC…”
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The redox regulation of PI 3-kinase-dependent signaling by Leslie, Nick R

“…Signal transduction via PI 3-kinases plays an important role in regulating the cellular processes of cell growth, survival, proliferation, and motility. The…”
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PTEN function: how normal cells control it and tumour cells lose it by Leslie, Nick R, Downes, C Peter

“…The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular…”
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The PTEN protein: cellular localization and post-translational regulation by Leslie, Nick R, Kriplani, Nisha, Hermida, Miguel A, Alvarez-Garcia, Virginia, Wise, Helen M

“…The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatase dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and…”
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Mutant PTEN in Cancer: Worse Than Nothing by Leslie, Nick R., den Hertog, Jeroen

“…Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor…”
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The TSC1-2 Tumor Suppressor Controls Insulin-PI3K Signaling via Regulation of IRS Proteins by Harrington, Laura S., Findlay, Greg M., Gray, Alex, Tolkacheva, Tatiana, Wigfield, Simon, Rebholz, Heike, Barnett, Jill, Leslie, Nick R., Cheng, Susan, Shepherd, Peter R., Gout, Ivan, Downes, C. Peter, Lamb, Richard F.

“…Insulin-like growth factors elicit many responses through activation of phosphoinositide 3-OH kinase (PI3K). The tuberous sclerosis complex (TSC1-2) suppresses…”
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Cross Talk between the Akt and p38α Pathways in Macrophages Downstream of Toll-Like Receptor Signaling by McGuire, Victoria A., Gray, Alexander, Monk, Claire E., Santos, Susana G., Lee, Keunwook, Aubareda, Anna, Crowe, Jonathan, Ronkina, Natalia, Schwermann, Jessica, Batty, Ian H., Leslie, Nick R., Dean, Jonathan L. E., O'Keefe, Stephen J., Boothby, Mark, Gaestel, Matthias, Arthur, J. Simon C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Use of Akt Inhibitor and a Drug-resistant Mutant Validates a Critical Role for Protein Kinase B/Akt in the Insulin-dependent Regulation of Glucose and System A Amino Acid Uptake by Green, Charlotte J., Göransson, Olga, Kular, Gursant S., Leslie, Nick R., Gray, Alexander, Alessi, Dario R., Sakamoto, Kei, Hundal, Harinder S.

“…Protein kinase B (PKB)/Akt has been strongly implicated in the insulin-dependent stimulation of GLUT4 translocation and glucose transport in skeletal muscle…”
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PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate by Wise, Helen M, Harris, Adam, Kriplani, Nisha, Schofield, Adam, Caldwell, Helen, Arends, Mark J, Overton, Ian M, Leslie, Nick R

“…Loss PTEN function is one of the most common events driving aggressive prostate cancers and biochemically, PTEN is a lipid phosphatase which opposes the…”
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Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress by Maccario, Helene, Perera, Nevin M., Gray, Alexander, Downes, C. Peter, Leslie, Nick R.

“…The PTEN (phosphatase and tensin homolog) tumor suppressor is a phosphatase that inhibits phosphoinositide 3-kinase-dependent signaling by metabolizing the…”
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Hypomorphic Mutation of PDK1 Suppresses Tumorigenesis in PTEN+/− Mice by Bayascas, Jose R., Leslie, Nick R., Parsons, Ramon, Fleming, Stewart, Alessi, Dario R.

“…Many cancers possess elevated levels of PtdIns(3,4,5)P3, the second messenger that induces activation of the protein kinases PKB/Akt and S6K and thereby…”
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C1-Ten Is a Protein Tyrosine Phosphatase of Insulin Receptor Substrate 1 (IRS-1), Regulating IRS-1 Stability and Muscle Atrophy by Koh, Ara, Lee, Mi Nam, Yang, Yong Ryoul, Jeong, Heeyoon, Ghim, Jaewang, Noh, Jeongeun, Kim, Jaeyoon, Ryu, Dongryeol, Park, Sehoon, Song, Parkyong, Koo, Seung-Hoi, Leslie, Nick R., Berggren, Per-Olof, Choi, Jang Hyun, Suh, Pann-Ghill, Ryu, Sung Ho

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Non-genomic loss of PTEN function in cancer: not in my genes by Leslie, Nick R, Foti, Michelangelo

“…Loss of function of the phosphatase and tensin homolog (PTEN) tumour suppressor contributes to the development of many cancers. However, in contrast to…”
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GSK3 and its interactions with the PI3K/AKT/mTOR signalling network by Hermida, Miguel A., Dinesh Kumar, J., Leslie, Nick R.

“…Glycogen Synthase Kinase-3 (GSK3 or GSK-3) is a promiscuous protein kinase and its phosphorylation of its diverse substrates has major influences on many areas…”
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Importin-11 keeps PTEN safe from harm by Leslie, Nick R

“…In this issue, Chen et al. (2017. https://doi.org/10.1083/jcb.201604025) show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so…”
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Proteomic and yeast 2-hybrid screens to identify PTEN binding partners by Tibarewal, Priyanka, Spinelli, Laura, Maccario, Helene, Leslie, Nick R.

“…PTEN is a phosphoinositide lipid phosphatase and an important tumour suppressor protein. PTEN function is reduced or lost in around a third of all human…”
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PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability by Silva, Ana, Yunes, J Andrés, Cardoso, Bruno A, Martins, Leila R, Jotta, Patrícia Y, Abecasis, Miguel, Nowill, Alexandre E, Leslie, Nick R, Cardoso, Angelo A, Barata, Joao T

“…Mutations in the phosphatase and tensin homolog (PTEN) gene leading to PTEN protein deletion and subsequent activation of the PI3K/Akt signaling pathway are…”
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PTEN: an intercellular peacekeeper? by Leslie, Nick R

“…It is generally assumed that cells synthesize their own intracellular enzymes. Therefore, if expression of a specific gene is silenced in a potential cancer…”
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Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy by Watt, Stephen A, Kimber, Wendy A, Fleming, Ian N, Leslie, Nick R, Downes, C Peter, Lucocq, John M

“…PtdIns(3,4) P (2), a breakdown product of the lipid second messenger PtdIns(3,4,5) P (3), is a key signalling molecule in pathways controlling various cellular…”
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PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity by Tibarewal, Priyanka, Zilidis, Georgios, Spinelli, Laura, Schurch, Nick, Maccario, Helene, Gray, Alexander, Perera, Nevin M, Davidson, Lindsay, Barton, Geoffrey J, Leslie, Nick R

“…The tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) has a well-characterized lipid phosphatase activity and a poorly…”
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