Search Results - "LESLIE, I"

Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum by Michalak, Marek, Groenendyk, Jody, Szabo, Eva, Gold, Leslie I, Opas, Michal

“…Calreticulin is an ER (endoplasmic reticulum) luminal Ca2+-buffering chaperone. The protein is involved in regulation of intracellular Ca2+ homoeostasis and ER…”
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The Occupational Safety and Health Administration at 50-the Failure to Improve Workers' Compensation by Boden, Leslie I

“…In the 1950s and 1960s, it was widely recognized that workers’ compensation was failing in its mission to provide economic security for injured workers. After…”
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Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS) by Grad, Leslie I, Rouleau, Guy A, Ravits, John, Cashman, Neil R

“…Amyotrophic lateral sclerosis (ALS) is primarily characterized by progressive loss of motor neurons, although there is marked phenotypic heterogeneity between…”
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Racial And Ethnic Differences In The Frequency Of Workplace Injuries And Prevalence Of Work-Related Disability by Seabury, Seth A, Terp, Sophie, Boden, Leslie I

“…Occupational injuries and illnesses lead to significant health care costs and productivity losses for millions of workers each year. This study used national…”
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Association between Physical Performance and All-Cause Mortality in CKD by ROSHANRAVAN, Baback, ROBINSON-COHEN, Cassianne, SELIGER, Stephen, PATEL, Kushang V, AYERS, Ernest, LITTMAN, Alyson J, DE BOER, Ian H, IKIZLER, T. Alp, HIMMELFARB, Jonathan, KATZEL, Leslie I, KESTENBAUM, Bryan

“…In older adults, measurements of physical performance assess physical function and associate with mortality and disability. Muscle wasting and diminished…”
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Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms by Grad, Leslie I., Yerbury, Justin J., Turner, Bradley J., Guest, William C., Pokrishevsky, Edward, O'Neill, Megan A., Yanai, Anat, Silverman, Judith M., Zeineddine, Rafaa, Corcoran, Lisa, Kumita, Janet R., Luheshi, Leila M., Yousefi, Masoud, Coleman, Bradley M., Hill, Andrew F., Plotkin, Steven S., Mackenzie, Ian R., Cashman, Neil R.

“…Amyotrophic lateral sclerosis (ALS) is predominantly sporadic, but associated with heritable genetic mutations in 5–10% of cases, including those in Cu/Zn…”
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Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites by Bean, Björn D M, Dziurdzik, Samantha K, Kolehmainen, Kathleen L, Fowler, Claire M S, Kwong, Waldan K, Grad, Leslie I, Davey, Michael, Schluter, Cayetana, Conibear, Elizabeth

“…The regulated expansion of membrane contact sites, which mediate the nonvesicular exchange of lipids between organelles, requires the recruitment of additional…”
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From molecule to molecule and cell to cell: Prion-like mechanisms in amyotrophic lateral sclerosis by Grad, Leslie I, Fernando, Sarah M, Cashman, Neil R

“…Abstract Prions, self-proliferating infectious agents consisting of misfolded protein, are most often associated with aggressive neurodegenerative diseases in…”
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TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion by Pokrishevsky, Edward, Grad, Leslie I., Cashman, Neil R.

“…Amyotrophic lateral sclerosis (ALS), which appears to spread through the neuroaxis in a spatiotemporally restricted manner, is linked to heritable mutations in…”
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Capture–Recapture Estimates of Nonfatal Workplace Injuries and Illnesses by Boden, Leslie I., PhD, Ozonoff, Al, PhD

“…Purpose We examine reporting of nonfatal injury and illness reporting for the two most important sources of such data in the United States: workers'…”
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Capture-recapture estimates of the undercount of workplace injuries and illnesses: Sensitivity analysis by Boden, Leslie I.

“…Background In recent years, capture–recapture methods have been applied to state Survey of Occupational Injuries and Illnesses (SOII) and workers' compensation…”
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A hidden Markov model for estimating age-specific survival when age and size are uncertain by Gowan, Timothy A., Tringali, Michael D., Hostetler, Jeffrey A., Martin, Julien, Ward-Geiger, Leslie I., Johnson, Jennifer M.

“…Estimates of age-specific survival probabilities are needed for age-structured population models and to inform conservation decisions. However, determining the…”
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Intermolecular transmission of Superoxide dismutase 1 misfolding in living cells by Grad, Leslie I., Guest, Will C., Yanai, Anat, Pokrishevsky, Edward, O'Neill, Megan A., Gibbs, Ebrima, Semenchenko, Valentyna, Yousefi, Masoud, Wishart, David S., Plotkin, Steven S., Cashman, Neil R.

“…Human wild-type Superoxide dismutase-1 (wtSOD1) is known to coaggregate with mutant SOD1 in familial amyotrophic lateral sclerosis (FALS), in double transgenic…”
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Impact of workplace injury on opioid dependence, abuse, illicit use and overdose: a 36-month retrospective study of insurance claims by Asfaw, Abay, Boden, Leslie I

“…ObjectivesTo examine the impact of workplace injury on opioid dependence, abuse and overdose (opioid-related morbidity) and if severity of injury increases the…”
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Calreticulin accelerates corneal wound closure and mitigates fibrosis: Potential therapeutic applications by Mishra, Sarita, Manzanares, Miguel A., Prater, Justin, Culp, David, Gold, Leslie I.

“…The processes involved in regeneration of cutaneous compared to corneal tissues involve different intrinsic mechanisms. Importantly, cutaneous wounds involve…”
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Effect of Long-term Exercise Training on Physical Performance and Cardiorespiratory Function in Adults With CKD: A Randomized Controlled Trial by Weiner, Daniel E., Liu, Christine K., Miao, Shiyuan, Fielding, Roger, Katzel, Leslie I., Giffuni, Jamie, Well, Andrew, Seliger, Stephen L.

“…The safety and efficacy of long-term exercise training in reducing physical functional loss in older adults with advanced CKD and comorbidity is uncertain…”
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Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis by Pokrishevsky, Edward, Grad, Leslie I, Yousefi, Masoud, Wang, Jing, Mackenzie, Ian R, Cashman, Neil R

“…Amyotrophic lateral sclerosis (ALS) is incurable and characterized by progressive paralysis of the muscles of the limbs, speech and swallowing, and respiration…”
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Biomimetic Extracellular Matrix Nanofibers Electrospun with Calreticulin Promote Synergistic Activity for Tissue Regeneration by Stack, Mary E., Mishra, Sarita, Parimala Chelvi Ratnamani, Matangi, Wang, Haoyu, Gold, Leslie I., Wang, Hongjun

“…In recognition of the potential of calreticulin (CRT) protein in enhancing the rate and quality of wound healing in excisional animal wound models, this study…”
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Sarcopenia in Peripheral Arterial Disease: Prevalence and Effect on Functional Status by Addison, Odessa, Prior, Steven J., Kundi, Rishi, Serra, Monica C., Katzel, Leslie I., Gardner, Andrew W., Ryan, Alice S.

“…(1) To determine the prevalence of sarcopenia in older men with peripheral arterial disease (PAD); (2) to compare a subgroup of the group with age-, race-,…”
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Randomized clinical trial of 3 types of physical exercise for patients with Parkinson disease by Shulman, Lisa M, Katzel, Leslie I, Ivey, Frederick M, Sorkin, John D, Favors, Knachelle, Anderson, Karen E, Smith, Barbara A, Reich, Stephen G, Weiner, William J, Macko, Richard F

“…To compare the efficacy of treadmill exercises and stretching and resistance exercises in improving gait speed, strength, and fitness for patients with…”
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