Search Results - "LEREN, P"

Flavonoids regulate LDLR through different mechanisms tied to their specific structures by Bjune, Katrine, Halvorsen, Pia Skovholt, Wangensteen, Helle, Leren, Trond P., Bogsrud, Martin Prøven, Strøm, Thea Bismo

“…Flavonoids, polyphenolic compounds found in plant-based diets, are associated with reduced risk of cardiovascular disease and longevity. These components are…”
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Functional characterization of missense variants affecting the extracellular domains of ABCA1 using a fluorescence-based assay by Teigen, Marianne, Ølnes, Åsa Schawlann, Bjune, Katrine, Leren, Trond P, Bogsrud, Martin Prøven, Strøm, Thea Bismo

“…Excess cholesterol originating from nonhepatic tissues is transported within HDL particles to the liver for metabolism and excretion. Cholesterol efflux is…”
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Variants in the CETP gene affect levels of HDL cholesterol by reducing the amount, and not the specific lipid transfer activity, of secreted CETP by Ølnes, Åsa Schawlann, Teigen, Marianne, Laerdahl, Jon K, Leren, Trond P, Strøm, Thea Bismo, Bjune, Katrine

“…Background Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters in plasma from high density lipoprotein (HDL) to very low density lipoprotein…”
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MK-2206, an allosteric inhibitor of AKT, stimulates LDLR expression and LDL uptake: A potential hypocholesterolemic agent by Bjune, Katrine, Sundvold, Hilde, Leren, Trond P., Naderi, Soheil

“…Induction of low-density lipoprotein receptor (LDLR) plays a significant role in reduction of plasma LDL-cholesterol (LDL-C) levels. Therefore, strategies that…”
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Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies by Whitlock, Gary, Lewington, Sarah, Sherliker, Paul, Clarke, Robert, Emberson, Jonathan, Halsey, Jim, Qizilbash, Nawab, Collins, Rory, Peto, Richard

“…Summary Background The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective…”
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Right ventricular mechanical dispersion is related to malignant arrhythmias: a study of patients with arrhythmogenic right ventricular cardiomyopathy and subclinical right ventricular dysfunction by Sarvari, Sebastian I, Haugaa, Kristina H, Anfinsen, Ole-Gunnar, Leren, Trond P, Smiseth, Otto A, Kongsgaard, Erik, Amlie, Jan P, Edvardsen, Thor

“…We evaluated if right ventricular (RV) mechanical dispersion by strain was related to ventricular arrhythmias (VT/VF) in patients with arrhythmogenic right…”
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Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia by Leren, TP

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) is at a locus for autosomal dominant hypercholesterolemia, and recent data indicate that the PCSK9 gene…”
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Effect of mutations in the PCSK9 gene on the cell surface LDL receptors by Cameron, Jamie, Holla, Øystein L., Ranheim, Trine, Kulseth, Mari Ann, Berge, Knut Erik, Leren, Trond P.

“…The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene is involved in the post-transcriptional regulation of the low-density lipoprotein (LDL)…”
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Risk prediction of ventricular arrhythmias and myocardial function in Lamin A/C mutation positive subjects by Hasselberg, Nina E, Edvardsen, Thor, Petri, Helle, Berge, Knut E, Leren, Trond P, Bundgaard, Henning, Haugaa, Kristina H

“…Mutations in the Lamin A/C gene may cause atrioventricular block, supraventricular arrhythmias, ventricular arrhythmias (VA), and dilated cardiomyopathy. We…”
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PCSK9 acts as a chaperone for the LDL receptor in the endoplasmic reticulum by Strøm, Thea Bismo, Tveten, Kristian, Leren, Trond P

“…PCSK9 (proprotein convertase subtilisin/kexin type 9) binds to the LDLR (low-density lipoprotein receptor) at the cell surface and disrupts recycling of the…”
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Missense mutation Q384K in the APOB gene affecting the large lipid transfer module of apoB reduces the secretion of apoB-100 in the liver without reducing the secretion of apoB-48 in the intestine by Strøm, Thea Bismo, Asprusten, Emil, Laerdahl, Jon K., Øygard, Irene, Hussain, M. Mahmood, Bogsrud, Martin Prøven, Leren, Trond P.

“…•Homozygosity for mutation Q384K in the APOB gene causes hypobetalipoproteinemia.•Mutation Q384K disrupts the structure of the large lipid transfer (LLT)…”
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Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds by Skinner, Jonathan R., MD, Crawford, Jackie, NZCS, Smith, Warren, FRACP, Aitken, Andrew, FRACP, Heaven, David, FRACP, Evans, Cary-Anne, MSc(Med), Hayes, Ian, FRACP, Neas, Katherine R., FRACP, Stables, Simon, FRCPA, Koelmeyer, Timothy, FRCPA, Denmark, Lloyd, FRCP, Vuletic, Jane, FRACP, Maxwell, Fraser, FRACP, White, Kate, FRCPA, Yang, Tao, PhD, Roden, Dan M., MD, Leren, Trond P., MD, Shelling, Andrew, PhD, Love, Donald R., PhD

“…Background Retrospective investigation of sudden unexplained death in the young (SUDY) reveals that a high proportion is due to inherited heart disease…”
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The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis by Mousavi, S. A., Berge, K. E., Leren, T. P.

“… The LDL receptor (LDLR) plays an essential role in the regulation of plasma (LDL) cholesterol concentrations by virtue of its ability to clear plasma LDL…”
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The risk of various types of cardiovascular diseases in mutation positive familial hypercholesterolemia; a review by Hovland, Anders, Mundal, Liv J, Veierød, Marit B, Holven, Kirsten B, Bogsrud, Martin Prøven, Tell, Grethe S, Leren, Trond P, Retterstøl, Kjetil

“…Familial hypercholesterolemia (FH) is a common, inherited disease characterized by high levels of low-density lipoprotein Cholesterol (LDL-C) from birth. Any…”
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Subjects with molecularly defined familial hypercholesterolemia or familial defective apoB-100 are not being adequately treated by Leren, Trond P, Berge, Knut Erik

“…To study whether subjects with a molecular genetic diagnosis of familial hypercholesterolemia (FH) or familial defective apoB-100 (FDB) are being adequately…”
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PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment by Tveten, Kristian, Str⊘m, Thea Bismo, Berge, Knut Erik, Leren, Trond P.

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the LDL receptor (LDLR) at the cell surface and reroutes the internalized LDLR to intracellular…”
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Left ventricular mechanical dispersion by tissue Doppler imaging: a novel approach for identifying high-risk individuals with long QT syndrome by Haugaa, Kristina Hermann, Edvardsen, Thor, Leren, Trond P., Gran, Jon Michael, Smiseth, Otto A., Amlie, Jan P.

“…Aims The aim of this study was to investigate whether prolonged and dispersed myocardial contraction duration assessed by tissue Doppler imaging (TDI) may…”
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Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors by Holla, Øystein L., Cameron, Jamie, Tveten, Kristian, Str⊘m, Thea Bismo, Berge, Knut Erik, Laerdahl, Jon K., Leren, Trond P.

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low density lipoprotein receptor (LDLR) at the cell surface and disrupts the normal…”
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Missense Mutations in the PCSK9 Gene Are Associated With Hypocholesterolemia and Possibly Increased Response to Statin Therapy by Berge, Knut Erik, Ose, Leiv, Leren, Trond P

“…OBJECTIVE—The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene encodes a proprotein convertase that causes degradation of cell surface low-density…”
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Cascade genetic screening for familial hypercholesterolemia by Leren, TP

“…Familial hypercholesterolemia (FH) is caused by a mutation in the low‐density lipoprotein receptor gene and is characterized by hypercholesterolemia,…”
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