Search Results - "LENZE, D"

A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance by Dietel, M, Jöhrens, K, Laffert, M V, Hummel, M, Bläker, H, Pfitzner, B M, Lehmann, A, Denkert, C, Darb-Esfahani, S, Lenze, D, Heppner, F L, Koch, A, Sers, C, Klauschen, F, Anagnostopoulos, I

“…In April 2013 our group published a review on predictive molecular pathology in this journal. Although only 2 years have passed many new facts and stimulating…”
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Differential regulation of miR-21 and miR-146a by Epstein–Barr virus-encoded EBNA2 by Rosato, P, Anastasiadou, E, Garg, N, Lenze, D, Boccellato, F, Vincenti, S, Severa, M, Coccia, E M, Bigi, R, Cirone, M, Ferretti, E, Campese, A F, Hummel, M, Frati, L, Presutti, C, Faggioni, A, Trivedi, P

“…The discovery of microRNA (miR) represents a novel paradigm in RNA-based regulation of gene expression and their dysregulation has become a hallmark of many a…”
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Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma by Aukema, Sietse M, Kreuz, Markus, Kohler, Christian W, Rosolowski, Maciej, Hasenclever, Dirk, Hummel, Michael, Küppers, Ralf, Lenze, Dido, Ott, German, Pott, Christiane, Richter, Julia, Rosenwald, Andreas, Szczepanowski, Monika, Schwaenen, Carsten, Stein, Harald, Trautmann, Heiko, Wessendorf, Swen, Trümper, Lorenz, Loeffler, Markus, Spang, Rainer, Kluin, Philip M, Klapper, Wolfram, Siebert, Reiner

“…Chromosomal translocations affecting the MYC oncogene are the biological hallmark of Burkitt lymphomas but also occur in a subset of other mature B-cell…”
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Specific T-cell receptor beta-rearrangements of gluten-triggered CD8+ T-cells are enriched in celiac disease patients' duodenal mucosa by Seitz, V., Gennermann, K., Elezkurtaj, S., Groth, D., Schaper, S., Dröge, A., Lachmann, N., Berg, E., Lenze, D., Kühl, A.A., Husemann, C., Kleo, K., Horst, D., Lennerz, V., Hennig, S., Hummel, M., Schumann, M.

“…Celiac disease (CeD) is an autoimmune disorder affecting the small intestine with gluten as disease trigger. Infections including Influenza A, increase the CeD…”
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Differences between BCL2-break positive and negative follicular lymphoma unraveled by whole-exome sequencing by Zamò, A, Pischimarov, J, Schlesner, M, Rosenstiel, P, Bomben, R, Horn, H, Grieb, T, Nedeva, T, López, C, Haake, A, Richter, J, Trümper, L, Lawerenz, C, Klapper, W, Möller, P, Hummel, M, Lenze, D, Szczepanowski, M, Flossbach, L, Schreder, M, Gattei, V, Ott, G, Siebert, R, Rosenwald, A, Leich, E

“…Depending on disease stage follicular lymphoma (FL) lack the t(14;18) in ~15–~50% of cases. Nevertheless, most of these cases express BCL2. To elucidate…”
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Similar clinical features in follicular lymphomas with and without breaks in the BCL2 locus by Leich, E, Hoster, E, Wartenberg, M, Unterhalt, M, Siebert, R, Koch, K, Klapper, W, Engelhard, M, Puppe, B, Horn, H, Staiger, A M, Stuhlmann-Laeisz, C, Bernd, H W, Feller, A C, Hummel, M, Lenze, D, Stein, H, Hartmann, S, Hansmann, M L, Möller, P, Hiddemann, W, Dreyling, M, Ott, G, Rosenwald, A

“…Approximately 15% of follicular lymphomas (FLs) lack breaks in the BCL2 locus. The aim of this study was to better define molecular and clinical features of…”
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Cellular senescence predicts treatment outcome in metastasised colorectal cancer by Haugstetter, A M, Loddenkemper, C, Lenze, D, Gröne, J, Standfuß, C, Petersen, I, Dörken, B, Schmitt, C A

“…Background: Cellular senescence is a terminal cell-cycle arrest that occurs in response to activated oncogenes and DNA-damaging chemotherapy. Whether cancer…”
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The different epidemiologic subtypes of Burkitt lymphoma share a homogenous micro RNA profile distinct from diffuse large B-cell lymphoma by Lenze, D, Leoncini, L, Hummel, M, Volinia, S, Liu, C G, Amato, T, De Falco, G, Githanga, J, Horn, H, Nyagol, J, Ott, G, Palatini, J, Pfreundschuh, M, Rogena, E, Rosenwald, A, Siebert, R, Croce, C M, Stein, H

“…Sporadic Burkitt lymphoma (sBL) can be delineated from diffuse large B-cell lymphoma (DLBCL) by a very homogeneous mRNA expression signature. However, it…”
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Different biological risk factors in young poor-prognosis and elderly patients with diffuse large B-cell lymphoma by Horn, H, Ziepert, M, Wartenberg, M, Staiger, A M, Barth, T F E, Bernd, H-W, Feller, A C, Klapper, W, Stuhlmann-Laeisz, C, Hummel, M, Stein, H, Lenze, D, Hartmann, S, Hansmann, M-L, Möller, P, Cogliatti, S, Pfreundschuh, M, Trümper, L, Loeffler, M, Glass, B, Schmitz, N, Ott, G, Rosenwald, A

“…Prognostically relevant risk factors in patients with diffuse large B-cell lymphoma (DLBCL) have predominantly been evaluated in elderly populations. We tested…”
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Cytoplasmic mutated nucleophosmin (NPM) defines the molecular status of a significant fraction of myeloid sarcomas by FALINI, B, LENZE, D, PETTIROSSI, V, SANTUCCI, A, MARTELLI, M. F, PILERI, S, STEIN, H, HASSERJIAN, R, COUPLAND, S, JAEHNE, D, SOUPIR, C, LISO, A, MARTELLI, M. P, BOLLI, N, BACCI, F

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Development of tripe palms and soles in a patient with long pre‐existing systemic mastocytosis and newly developed non‐small cell lung cancer by Bonnekoh, H., Ohanyan, T., Lenze, D., Krause, K., Maurer, M., Zuberbier, T., Siebenhaar, F.

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RNA-based analysis of anaplastic lymphoma kinase (ALK) fusions in non-small cell lung cancer (NSCLC) cases showing immunohistochemistry/fluorescence in-situ hybridisation (IHC/FISH) discordance by Vollbrecht, C., Lenze, D., Hummel, M., Lehmann, A., Moebs, M., Frost, N., Jurmeister, P., Schweizer, L., Kellner, U., Dietel, M., von Laffert, M.

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Donor CD4 T Cell Diversity Determines Virus Reactivation in Patients After HLA‐Matched Allogeneic Stem Cell Transplantation by Ritter, J., Seitz, V., Balzer, H., Gary, R., Lenze, D., Moi, S., Pasemann, S., Seegebarth, A., Wurdack, M., Hennig, S., Gerbitz, A., Hummel, M.

“…Delayed reconstitution of the T cell compartment in recipients of allogeneic stem cell grafts is associated with an increase of reactivation of latent viruses…”
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The metastatic cascade is reflected in the transcriptome of metastatic canine mammary carcinomas by Klopfleisch, R., Lenze, D., Hummel, M., Gruber, A.D.

“…Proliferation, dedifferentiation and loss of cell–cell contacts are amongst the first steps of the metastatic cascade. The complex molecular pathways and gene…”
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Evidence for a role of RUNX1 as recombinase cofactor for TCRβ rearrangements and pathological deletions in ETV6-RUNX1 ALL by Seitz, V., Kleo, K., Dröge, A., Schaper, S., Elezkurtaj, S., Bedjaoui, N., Dimitrova, L., Sommerfeld, A., Berg, E., von der Wall, E., Müller, U., Joosten, M., Lenze, D., Heimesaat, M. M., Baldus, C., Zinser, C., Cieslak, A., Macintyre, E., Stocking, C., Hennig, S., Hummel, M.

“…T-cell receptor gene beta (TCRβ) gene rearrangement represents a complex, tightly regulated molecular mechanism involving excision, deletion and recombination…”
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The IL-15 cytokine system provides growth and survival signals in Hodgkin lymphoma and enhances the inflammatory phenotype of HRS cells by Ullrich, K, Blumenthal-Barby, F, Lamprecht, B, Köchert, K, Lenze, D, Hummel, M, Mathas, S, Dörken, B, Janz, M

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Dose dependent molecular effects of acrylamide and glycidamide in human cancer cell lines and human primary hepatocytes by Ehlers, A., Lenze, D., Broll, H., Zagon, J., Hummel, M., Lampen, A.

“…► Molecular effects of low level acrylamide exposure are not well understood. ► We analyzed gene expression after low and high dose exposure in cell lines. ►…”
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PAX5 overexpression is not enough to reestablish the mature B-cell phenotype in classical Hodgkin lymphoma by Dimitrova, L, Seitz, V, Hecht, J, Lenze, D, Hansen, P, Szczepanowski, M, Ma, L, Oker, E, Sommerfeld, A, Jundt, F, Klapper, W, Hummel, M

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Histone acetylation and DNA demethylation of B cells result in a Hodgkin-like phenotype by Ehlers, A, Oker, E, Bentink, S, Lenze, D, Stein, H, Hummel, M

“…A unique feature of the tumor cells (Hodgkin/Reed-Sternberg (HRS)) of classical Hodgkin lymphoma (cHL) is the loss of their B-cell phenotype despite their…”
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Canine Cutaneous Peripheral Nerve Sheath Tumours versus Fibrosarcomas can be Differentiated by Neuroectodermal Marker Genes in their Transcriptome by Klopfleisch, R., Meyer, A., Lenze, D., Hummel, M., Gruber, A.D.

“…The diagnostic differentiation between canine fibrosarcomas and peripheral nerve sheath tumours (PNSTs) is based on histopathological phenotype. Histological…”
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