Search Results - "LENZ, Oliver"

Catalytic Production of Hydrogen Peroxide and Water by Oxygen-Tolerant [NiFe]-Hydrogenase during H2 Cycling in the Presence of O2 by Lauterbach, Lars, Lenz, Oliver

“…Hydrogenases control the H2-related metabolism in many microbes. Most of these enzymes are prone to immediate inactivation by O2. However, a few members of the…”
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Structure, function and biosynthesis of O2-tolerant hydrogenases by Fritsch, Johannes, Lenz, Oliver, Friedrich, Bärbel

“…Key Points Molecular hydrogen (H 2 ) is used as a valuable energy source or a way to deposit excess reducing power by a wide range of microorganisms. The…”
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Hepatitis C virus drug resistance–associated substitutions: State of the art summary by Lontok, Erik, Harrington, Patrick, Howe, Anita, Kieffer, Tara, Lennerstrand, Johan, Lenz, Oliver, McPhee, Fiona, Mo, Hongmei, Parkin, Neil, Pilot‐Matias, Tami, Miller, Veronica

“…Hepatitis C virus (HCV) drug development has resulted in treatment regimens composed of interferon‐free, all‐oral combinations of direct‐acting antivirals…”
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How to make the reducing power of H2 available for in vivo biosyntheses and biotransformations by Lauterbach, Lars, Lenz, Oliver

“…Solar-driven electrolysis enables sustainable production of molecular hydrogen (H2), which represents a cheap and carbon-free reductant. Knallgas bacteria like…”
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Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial by Jacobson, Ira M, Prof, Dore, Gregory J, Prof, Foster, Graham R, Prof, Fried, Michael W, Prof, Radu, Monica, MD, Rafalsky, Vladimir V, Prof, Moroz, Larysa, Prof, Craxi, Antonio, Prof, Peeters, Monika, MSc, Lenz, Oliver, PhD, Ouwerkerk-Mahadevan, Sivi, PhD, De La Rosa, Guy, MD, Kalmeijer, Ronald, MD, Scott, Jane, PhD, Sinha, Rekha, PhD, Beumont-Mauviel, Maria, PhD

“…Summary Background Although the addition of the HCV NS3/4A protease inhibitors boceprevir and telaprevir to pegylated interferon (peginterferon) alfa plus…”
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Heterologous Hydrogenase Overproduction Systems for Biotechnology-An Overview by Fan, Qin, Neubauer, Peter, Lenz, Oliver, Gimpel, Matthias

“…Hydrogenases are complex metalloenzymes, showing tremendous potential as H -converting redox catalysts for application in light-driven H production, enzymatic…”
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Simeprevir plus sofosbuvir (12 and 8 weeks) in hepatitis C virus genotype 1‐infected patients without cirrhosis: OPTIMIST‐1, a phase 3, randomized study by Kwo, Paul, Gitlin, Norman, Nahass, Ronald, Bernstein, David, Etzkorn, Kyle, Rojter, Sergio, Schiff, Eugene, Davis, Mitchell, Ruane, Peter, Younes, Ziad, Kalmeijer, Ronald, Sinha, Rekha, Peeters, Monika, Lenz, Oliver, Fevery, Bart, De La Rosa, Guy, Scott, Jane, Witek, James

“…Effective antiviral therapy is essential for achieving sustained virological response (SVR) in hepatitis C virus (HCV)‐infected patients. The phase 2 COSMOS…”
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Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind, placebo-controlled phase 3 trial by Manns, Michael, Prof, Marcellin, Patrick, Prof, Poordad, Fred, Prof, de Araujo, Evaldo Stanislau Affonso, PhD, Buti, Maria, Prof, Horsmans, Yves, Prof, Janczewska, Ewa, MD, Villamil, Federico, Prof, Scott, Jane, PhD, Peeters, Monika, MSc, Lenz, Oliver, PhD, Ouwerkerk-Mahadevan, Sivi, PhD, De La Rosa, Guy, MD, Kalmeijer, Ronald, MD, Sinha, Rekha, PhD, Beumont-Mauviel, Maria, PhD

“…Summary Background Pegylated interferon (peginterferon) alfa 2a or 2b plus ribavirin regimens were the standard of care in patients with hepatitis C virus…”
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Novel, Oxygen-Insensitive Group 5 [NiFe]-Hydrogenase in Ralstonia eutropha by SCHÄFER, Caspar, FRIEDRICH, Bärbel, LENZ, Oliver

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Photosynthetic Hydrogen Production by a Hybrid Complex of Photosystem I and [NiFe]-Hydrogenase by Krassen, Henning, Schwarze, Alexander, Friedrich, Bärbel, Ataka, Kenichi, Lenz, Oliver, Heberle, Joachim

“…Nature provides key components for generating fuels from renewable resources in the form of enzymatic nanomachines which catalyze crucial steps in biological…”
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Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor by Rosenquist, Åsa, Samuelsson, Bertil, Johansson, Per-Ola, Cummings, Maxwell D., Lenz, Oliver, Raboisson, Pierre, Simmen, Kenny, Vendeville, Sandrine, de Kock, Herman, Nilsson, Magnus, Horvath, Andras, Kalmeijer, Ronald, de la Rosa, Guy, Beumont-Mauviel, Maria

“…Hepatitis C virus is a blood-borne infection and the leading cause of chronic liver disease (including cirrhosis and cancer) and liver transplantation. Since…”
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Podocytopathy in Diabetes: A Metabolic and Endocrine Disorder by Diez-Sampedro, Ana, PhD, Lenz, Oliver, MD, Fornoni, Alessia, MD, PhD

“…Diabetic nephropathy (DN) represents a major public health cost. Tight glycemic and blood pressure control can dramatically slow, but not stop, the progression…”
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Growth of the facultative chemolithoautotroph Ralstonia eutropha on organic waste materials: growth characteristics, redox regulation and hydrogenase activity by Poladyan, Anna, Blbulyan, Syuzanna, Sahakyan, Mayramik, Lenz, Oliver, Trchounian, Armen

“…The chemolithoautotrophic β-proteobacterium Ralstonia eutropha H16 (Cupriavidus necator) is one of the most studied model organisms for growth on H and CO . R…”
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Exploring Structure and Function of Redox Intermediates in [NiFe]‐Hydrogenases by an Advanced Experimental Approach for Solvated, Lyophilized and Crystallized Metalloenzymes by Lorent, Christian, Pelmenschikov, Vladimir, Frielingsdorf, Stefan, Schoknecht, Janna, Caserta, Giorgio, Yoda, Yoshitaka, Wang, Hongxin, Tamasaku, Kenji, Lenz, Oliver, Cramer, Stephen P., Horch, Marius, Lauterbach, Lars, Zebger, Ingo

“…To study metalloenzymes in detail, we developed a new experimental setup allowing the controlled preparation of catalytic intermediates for characterization by…”
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CO synthesized from the central one-carbon pool as source for the iron carbonyl in O₂-tolerant [NiFe]-hydrogenase by Bürstel, Ingmar, Siebert, Elisabeth, Frielingsdorf, Stefan, Zebger, Ingo, Friedrich, Bärbel, Lenz, Oliver

“…Hydrogenases are nature’s key catalysts involved in both microbial consumption and production of molecular hydrogen. H₂ exhibits a strongly bonded, almost…”
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Prevalence of the hepatitis C virus NS3 polymorphism Q80K in genotype 1 patients in the European region by Sarrazin, Christoph, Lathouwers, Erkki, Peeters, Monika, Daems, Bjorn, Buelens, Annemie, Witek, James, Wyckmans, Yves, Fevery, Bart, Verbinnen, Thierry, Ghys, Anne, Schlag, Michael, Baldini, Alessandra, De Meyer, Sandra, Lenz, Oliver

“…•Q80K polymorphism is associated with reduced treatment response to simeprevir with pegylated interferon and ribavirin.•Q80K prevalence in Europe in HCV…”
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High-Yield Production of Catalytically Active Regulatory [NiFe]-Hydrogenase From Cupriavidus necator in Escherichia coli by Fan, Qin, Caserta, Giorgio, Lorent, Christian, Zebger, Ingo, Neubauer, Peter, Lenz, Oliver, Gimpel, Matthias

“…Hydrogenases are biotechnologically relevant metalloenzymes that catalyze the reversible conversion of molecular hydrogen into protons and electrons. The O…”
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Tracking the route of molecular oxygen in O₂-tolerant membrane-bound [NiFe] hydrogenase by Kalms, Jacqueline, Schmidt, Andrea, Frielingsdorf, Stefan, Utesch, Tillmann, Gotthard, Guillaume, von Stetten, David, van der Linden, Peter, Royant, Antoine, Mroginski, Maria Andrea, Carpentier, Philippe, Lenz, Oliver, Scheerer, Patrick

“…[NiFe] hydrogenases catalyze the reversible splitting of H₂ into protons and electrons at a deeply buried active site. The catalytic center can be accessed by…”
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Reversible Glutamate Coordination to High-Valent Nickel Protects the Active Site of a [NiFe] Hydrogenase from Oxygen by Kulka-Peschke, Catharina J., Schulz, Anne-Christine, Lorent, Christian, Rippers, Yvonne, Wahlefeld, Stefan, Preissler, Janina, Schulz, Claudia, Wiemann, Charlotte, Bernitzky, Cornelius C. M., Karafoulidi-Retsou, Chara, Wrathall, Solomon L. D., Procacci, Barbara, Matsuura, Hiroaki, Greetham, Gregory M., Teutloff, Christian, Lauterbach, Lars, Higuchi, Yoshiki, Ishii, Masaharu, Hunt, Neil T., Lenz, Oliver, Zebger, Ingo, Horch, Marius

“…NAD+-reducing [NiFe] hydrogenases are valuable biocatalysts for H2-based energy conversion and the regeneration of nucleotide cofactors. While most…”
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Enzyme-Modified Particles for Selective Biocatalytic Hydrogenation by Hydrogen-Driven NADH Recycling by Reeve, Holly A., Lauterbach, Lars, Lenz, Oliver, Vincent, Kylie A.

“…We describe a new approach to selective H2‐driven hydrogenation that exploits a sequence of enzymes immobilised on carbon particles. We used a catalyst system…”
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