Search Results - "LENZ, Guido"

The Epithelial‐to‐Mesenchymal Transition‐Like Process in Glioblastoma: An Updated Systematic Review and In Silico Investigation by Iser, Isabele C., Pereira, Mariana B., Lenz, Guido, Wink, Márcia R.

“…Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer due to its highly invasive nature that impedes the surgical removal of all tumor…”
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Ratiometric analysis of Acridine Orange staining in the study of acidic organelles and autophagy by Thomé, Marcos P, Filippi-Chiela, Eduardo C, Villodre, Emilly S, Migliavaca, Celina B, Onzi, Giovana R, Felipe, Karina B, Lenz, Guido

“…Acridine Orange is a cell-permeable green fluorophore that can be protonated and trapped in acidic vesicular organelles (AVOs). Its metachromatic shift to red…”
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Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries? by Ledur, Pítia Flores, Onzi, Giovana Ravizzoni, Zong, Hui, Lenz, Guido

“…In cancer research, the use of established cell lines has gradually been replaced by primary cell cultures due to their better representation of cancer cell…”
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Resveratrol and quercetin cooperate to induce senescence‐like growth arrest in C6 rat glioma cells by Zamin, Lauren L., Filippi‐Chiela, Eduardo C., Dillenburg‐Pilla, Patricia, Horn, Fabiana, Salbego, Christianne, Lenz, Guido

“…Glioma is the most frequent and malignant primary human brain tumor with dismal prognosis despite multimodal therapy. Resveratrol and quercetin, two…”
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Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cells by Filippi-Chiela, Eduardo C, Villodre, Emilly Schlee, Zamin, Lauren L, Lenz, Guido

“…Prognosis of patients with glioblastoma (GBM) remains very poor, thus making the development of new drugs urgent. Resveratrol (Rsv) is a natural compound that…”
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Nuclear morphometric analysis (NMA): screening of senescence, apoptosis and nuclear irregularities by Filippi-Chiela, Eduardo C, Oliveira, Manuel M, Jurkovski, Bruno, Callegari-Jacques, Sidia Maria, da Silva, Vinicius Duval, Lenz, Guido

“…Several cellular mechanisms affect nuclear morphology which can therefore be used to assess certain processes. Here, we present an analytic tool to quantify…”
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Glutamatergic Regulation of the p70S6 Kinase in Primary Mouse Neurons by Lenz, Guido, Avruch, Joseph

“…Brief glutamatergic stimulation of neurons from fetal mice, cultured in vitro for 6 days, activates the mTOR-S6 kinase, ERK1/2 and Akt pathways, to an extent…”
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Dipyridamole impairs autophagic flux and exerts antiproliferative activity on prostate cancer cells by Thomé, Marcos P., Pereira, Luiza C., Onzi, Giovana R., Rohden, Francieli, Ilha, Mariana, Guma, Fátima T., Wink, Márcia R., Lenz, Guido

“…Autophagy is a cellular bulk degradation process used as an alternative source of energy and metabolites and implicated in various diseases. Inefficient…”
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Resveratrol abrogates the temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the temozolomide-induced senescence in glioma cells by Filippi-Chiela, Eduardo C, Thomé, Marcos Paulo, Bueno e Silva, Mardja Manssur, Pelegrini, Alessandra Luíza, Ledur, Pitia Flores, Garicochea, Bernardo, Zamin, Lauren L, Lenz, Guido

“…Temozolomide (TMZ) is the most widely used drug to treat glioblastoma (GBM), which is the most common and aggressive primary tumor of the Central Nervous…”
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CD73 mitigates ZEB1 expression in papillary thyroid carcinoma by Vedovatto, Samlai, Oliveira, Fernanda Dittrich, Pereira, Luiza Cherobini, Scheffel, Thamiris Becker, Beckenkamp, Liziane Raquel, Bertoni, Ana Paula Santin, Wink, Márcia Rosângela, Lenz, Guido

“…ZEB1, a core transcription factor involved in epithelial-mesenchymal transition (EMT), is associated with aggressive cancer cell behavior, treatment…”
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esiCancer: Evolutionary In Silico Cancer Simulator by Minussi, Darlan Conterno, Henz, Bernardo, Dos Santos Oliveira, Mariana, Filippi-Chiela, Eduardo C, Oliveira, Manuel M, Lenz, Guido

“…The evolution of cancer is inferred mainly from samples taken at discrete points that represent glimpses of the complete process. In this study, we present…”
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Expression of key unfolded protein response genes predicts patient survival and an immunosuppressive microenvironment in glioblastoma by Oliveira, Fernanda Dittrich, de Campos, Rafael Paschoal, Pereira, Luiza Cherobini, Meira, Lisiane B., Lenz, Guido

“…Abstract Background Dysregulation of cellular processes related to protein folding and trafficking leads to the accumulation of misfolded proteins in the…”
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NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin by Melo-Hanchuk, Talita D., Slepicka, Priscila Ferreira, Meirelles, Gabriela Vaz, Basei, Fernanda Luisa, Lovato, Diogo Ventura, Granato, Daniela Campos, Pauletti, Bianca Alves, Domingues, Romenia Ramos, Leme, Adriana Franco Paes, Pelegrini, Alessandra Luiza, Lenz, Guido, Knapp, Stefan, Elkins, Jonathan M., Kobarg, Jörg

“…NEK family kinases are serine/threonine kinases that have been functionally implicated in the regulation of the disjunction of the centrosome, the assembly of…”
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PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines by Izetti, Patricia, Hautefeuille, Agnes, Abujamra, Ana Lucia, de Farias, Caroline Brunetto, Giacomazzi, Juliana, Alemar, Bárbara, Lenz, Guido, Roesler, Rafael, Schwartsmann, Gilberto, Osvaldt, Alessandro Bersch, Hainaut, Pierre, Ashton-Prolla, Patricia

“…Summary TP53 mutation is a common event in many cancers, including pancreatic adenocarcinoma, where it occurs in 50–70 % of cases. In an effort to reactivate…”
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Transcriptional characterization of immunological infiltrates and their relation with glioblastoma patients overall survival by Pereira, Mariana Brutschin, Barros, Luciana Rodrigues Carvalho, Bracco, Paula A., Vigo, Alvaro, Boroni, Mariana, Bonamino, Martín Hernán, Lenz, Guido

“…Introduction: Several cell populations from the peripheral immune system interact to create a complex immunologic status during glioblastoma growth and…”
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Manganese Superoxide Dismutase Gene Expression Is Induced by Nanog and Oct4, Essential Pluripotent Stem Cells' Transcription Factors by Solari, Claudia, Vázquez Echegaray, Camila, Cosentino, María Soledad, Petrone, María Victoria, Waisman, Ariel, Luzzani, Carlos, Francia, Marcos, Villodre, Emilly, Lenz, Guido, Miriuka, Santiago, Barañao, Lino, Guberman, Alejandra

“…Pluripotent stem cells possess complex systems that protect them from oxidative stress and ensure genomic stability, vital for their role in development. Even…”
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Mesenchymal Stem Cells From Different Murine Tissues Have Differential Capacity to Metabolize Extracellular Nucleotides by Iser, Isabele C., Bracco, Paula A., Gonçalves, Carlos E.I., Zanin, Rafael F., Nardi, Nance B., Lenz, Guido, Battastini, Ana Maria O., Wink, Márcia R.

“…ABSTRACT Mesenchymal stem cells (MSCs) have shown a great potential for cell‐based therapy and many different therapeutic purposes. Despite the recent advances…”
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Heterogeneity generating capacity in tumorigenesis and cancer therapeutics by Lenz, Guido

“…Cells of multicellular organisms generate heterogeneity in a controlled and transient fashion during embryogenesis, which can be reactivated in pathologies…”
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Protocol to segment and characterize the morphometry of individual cross-sectioned striated muscle fibers from adult murine models by Bartikoski, Bárbara Jonson, Longo, Larisse, Gabriel de Souza, Valessa Emanoele, Salvati, Fernando, Uribe-Cruz, Carolina, Lenz, Guido, Xavier, Ricardo Machado, Álvares-da-Silva, Mário Reis, Visioli, Fernanda, Filippi-Chiela, Eduardo Cremonese

“…The muscle fiber morphometric analysis (MusMA) is a protocol to segment and characterize the morphometry of individual cross-sectioned striated muscle fibers…”
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The inhibitory effects of phenolic and terpenoid compounds from Baccharis trimera in Siha cells: differences in their activity and mechanism of action by de Oliveira, Cristiane B, Comunello, Lucimara N, Maciel, Erica S, Giubel, Scheron R, Bruno, Alessandra N, Chiela, Eduardo C F, Lenz, Guido, Gnoatto, Simone C B, Buffon, Andréia, Gosmann, Grace

“…Baccharis trimera is used in folk medicine as a tea for digestive and liver diseases. It possesses anti-inflammatory and antioxidant properties that are…”
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