Search Results - "LENNERNÄS, H"

In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context by Lennernäs, H, Lindahl, A, Van Peer, A, Ollier, C, Flanagan, T, Lionberger, R, Nordmark, A, Yamashita, S, Yu, L, Amidon, G. L, Fischer, V, Sjögren, E, Zane, P, McAllister, M, Abrahamsson, B

“…The overall objective of OrBiTo, a project within Innovative Medicines Initiative (IMI), is to streamline and optimize the development of orally administered…”
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Oral biopharmaceutics tools – Time for a new initiative – An introduction to the IMI project OrBiTo by Lennernäs, H., Aarons, L., Augustijns, P., Beato, S., Bolger, M., Box, K., Brewster, M., Butler, J., Dressman, J., Holm, R., Julia Frank, K., Kendall, R., Langguth, P., Sydor, J., Lindahl, A., McAllister, M., Muenster, U., Müllertz, A., Ojala, K., Pepin, X., Reppas, C., Rostami-Hodjegan, A., Verwei, M., Weitschies, W., Wilson, C., Karlsson, C., Abrahamsson, B.

“…[Display omitted] OrBiTo is a new European project within the IMI programme in the area of oral biopharmaceutics tools that includes world leading scientists…”
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Intestinal permeability and its relevance for absorption and elimination by Lennernaes, H

“…Human jejunal permeability (Peff) is determined in the intestinal region with the highest expression of carrier proteins and largest surface area. Intestinal…”
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Increased Understanding of Intestinal Drug Permeability Determined by the LOC-I-GUT Approach Using Multislice Computed Tomography by Knutson, T, Fridblom, P, Ahlström, H, Magnusson, A, Tannergren, C, Lennernäs, H

“…This study further evaluated the in vivo single-pass perfusion technique (LOC-I-GUT) in three different ways. First, the intestinal radius of the human small…”
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Comparison between active and passive drug transport in human intestinal epithelial (caco-2) cells in vitro and human jejunum in vivo by Lennernäs, H., Palm, K., Fagerholm, U., Artursson, P.

“…Drug transport rates in Caco-2 monolayers were compared with those obtained in the human jejunum in vivo. Permeability coefficients unbiased by the…”
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Membrane transport of drugs in different regions of the intestinal tract of the rat by Ungell, A L, Nylander, S, Bergstrand, S, Sjöberg, A, Lennernäs, H

“…Regional permeability coefficients of 19 drugs with different physicochemical properties were determined using excised segments from three regions of rat…”
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Correlation of Human Jejunal Permeability (in Vivo) of Drugs with Experimentally and Theoretically Derived Parameters. A Multivariate Data Analysis Approach by Winiwarter, Susanne, Bonham, Nicholas M, Ax, Fredrik, Hallberg, Anders, Lennernäs, Hans, Karlén, Anders

“…The effective permeability (P eff) in the human jejunum (in vivo) of 22 structurally diverse compounds was correlated with both experimentally determined…”
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Jejunal permeability : A comparison between the ussing chamber technique and the single-pass perfusion in humans by LENNERNÄS, H, NYLANDER, S, UNGELL, A.-L

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Variable expression of CYP and Pgp genes in the human small intestine by Lindell, M., Karlsson, M. O., Lennernäs, H., Påhlman, L., Lang, M. A.

“…Background  The small intestine is receiving increased attention for its importance in drug metabolism. However, knowledge of the intervariability and…”
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Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations by Dahlgren, D., Sjöblom, M., Lennernäs, H.

“…[Display omitted] Pharmaceutical excipients in drug products are defined as pharmacologically inactive and are integral constituents of all types of oral…”
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Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport by Dahlgren, D., Roos, C., Lundqvist, A., Tannergren, C., Sjöblom, M., Sjögren, E., Lennernäs, H.

“…[Display omitted] The small intestine mucosal barrier is physiologically regulated by the luminal conditions, where intestinal factors, such as diet and…”
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The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs by Dahlgren, D., Roos, C., Johansson, P., Tannergren, C., Lundqvist, A., Langguth, P., Sjöblom, M., Sjögren, E., Lennernäs, H.

“…[Display omitted] Pharmaceutical excipients that may affect gastrointestinal (GI) drug absorption are called critical pharmaceutical excipients, or…”
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The effect of amiloride on the in vivo effective permeability of amoxicillin in human jejunum: experience from a regional perfusion technique by Lennernäs, H., Knutson, L., Knutson, T., Hussain, A., Lesko, L., Salmonson, T., Amidon, G.L.

“…The purpose of this human intestinal perfusion study (in vivo) was twofold. Firstly, we aimed to determine the effective in vivo jejunal permeability ( P eff)…”
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Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability by Dahlgren, D., Venczel, M., Ridoux, J.-P., Skjöld, C., Müllertz, A., Holm, R., Augustijns, P., Hellström, P.M., Lennernäs, H.

“…[Display omitted] Accurate in vivo predictions of intestinal absorption of low solubility drugs require knowing their solubility in physiologically relevant…”
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Characterization of fluids from the stomach and proximal jejunum in men and women by LINDAHL, A, UNGELL, A.-L, KNUTSON, L, LENNERNÄS, H

“…To chemically characterize the fluids available for drug dissolution in the upper gastrointestinal tract during the fasted state in humans, and to examine…”
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Improved Cortisol Exposure-Time Profile and Outcome in Patients with Adrenal Insufficiency: A Prospective Randomized Trial of a Novel Hydrocortisone Dual-Release Formulation by Johannsson, G, Nilsson, A. G, Bergthorsdottir, R, Burman, P, Dahlqvist, P, Ekman, B, Engström, B. E, Olsson, T, Ragnarsson, O, Ryberg, M, Wahlberg, J, Biller, B. M. K, Monson, J. P, Stewart, P. M, Lennernäs, H, Skrtic, S

“…Context: Patients with treated adrenal insufficiency (AI) have increased morbidity and mortality rate. Our goal was to improve outcome by developing a…”
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Mechanistic modelling of intestinal drug absorption – The in vivo effects of nanoparticles, hydrodynamics, and colloidal structures by Roos, C., Westergren, J., Dahlgren, D., Lennernäs, H., Sjögren, E.

“…[Display omitted] Particle size reduction is a traditional approach to increase the intestinal absorption of active pharmaceutical ingredients with poor…”
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Single bead investigation of a clinical drug delivery system – A novel release mechanism by Ahnfelt, E., Gernandt, J., Al-Tikriti, Y., Sjögren, E., Lennernäs, H., Hansson, P.

“…Microgels, such as polymeric hydrogels, are currently used as drug delivery devices (DDSs) for chemotherapeutics and/or unstable drugs. The clinical DDS DC…”
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Rat intestinal drug permeability: A status report and summary of repeated determinations by Dubbelboer, I.R., Dahlgren, D., Sjögren, E., Lennernäs, H.

“…[Display omitted] Intestinal permeability is a key biopharmaceutical variable in pharmaceutical research and development, and regulatory assessment. In situ…”
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Levodopa infusion combined with entacapone or tolcapone in Parkinson disease: a pilot trial by Nyholm, D., Johansson, A., Lennernäs, H., Askmark, H.

“…Background and purpose:  Catechol‐O‐methyltransferase inhibitors may be used to decrease levodopa requirement. The objective was to investigate whether the…”
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