Search Results - "LENGELE, Sébastien"

Towards a KCC2 blocker pharmacophore model by Lebon, Florence, Pégurier, Cécile, Ledecq, Marie, Mathieu, Benoit, Bosman, Nathalie, Frycia, Anne, Lengelé, Sébastien, Dhurke, Kashinath, Kanduluru, Ananda Kumar, Meunier, Stéphane, Wagner, Alain, Wolff, Christian, Provins, Laurent

“…The first pharmacophore model for KCC2 blockers was identified using a multi-disciplinary approach combining molecular modelling techniques, XRD, NMR, SAR…”
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Benzyl prolinate derivatives as novel selective KCC2 blockers by Pégurier, Cécile, Bosman, Nathalie, Collart, Philippe, Delporte, Marie-Laure, Leclercq, Karine, Lengelé, Sébastien, Kanduluru, Ananda Kumar, Meunier, Stéphane, Pacico, Nathalie, Vadali, Lakshmana Rao, Wagner, Alain, Wolff, Christian, Provins, Laurent

“…The benzyl prolinate 13 has been identified as a potent KCC2 blocker with selectivity versus NKCC1 and favorable ADME properties. It was evaluated in an in…”
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First dual M3 antagonists-PDE4 inhibitors : Synthesis and SAR of 4,6-diaminopyrimidine derivatives by PROVINS, Laurent, CHRISTOPHE, Bernard, DANHAIVE, Pierre, DULIEU, Jacques, DURIEU, Véronique, GILLARD, Michel, LEBON, Florence, LENGELE, Sébastien, QUERE, Luc, VAN KEULEN, Berendjan

“…SAR around 4,6-diaminopyrimidine derivatives allowed the discovery of the first potent dual M(3) antagonists and PDE4 inhibitors. Various chemical modulations…”
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First dual M 3 antagonists-PDE4 inhibitors: Synthesis and SAR of 4,6-diaminopyrimidine derivatives by Provins, Laurent, Christophe, Bernard, Danhaive, Pierre, Dulieu, Jacques, Durieu, Véronique, Gillard, Michel, Lebon, Florence, Lengelé, Sébastien, Quéré, Luc, van Keulen, BerendJan

“…The synthesis and SAR around 4,6-diaminopyrimidine derivatives as dual M3 antagonists and PDE4 inhibitors are reported. SAR around 4,6-diaminopyrimidine…”
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First dual M sub(3) antagonists-PDE4 inhibitors: Synthesis and SAR of 4,6- diaminopyrimidine derivatives by Provins, Laurent, Christophe, Bernard, Danhaive, Pierre, Dulieu, Jacques, Durieu, Veronique, Gillard, Michel, Lebon, Florence, Lengele, Sebastien, Quere, Luc, Van Keulen, BerendJan

“…SAR around 4,6-diaminopyrimidine derivatives allowed the discovery of the first potent dual M sub(3) antagonists and PDE4 inhibitors. Various chemical…”
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