Search Results - "LENAZ, G"

The Mitochondrial Production of Reactive Oxygen Species: Mechanisms and Implications in Human Pathology by Lenaz, Giorgio

“…Mitochondria are major sources of reactive oxygen species (ROS); the main sites of superoxide radical production in the respiratory chain are Complexes III and…”
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Is supercomplex organization of the respiratory chain required for optimal electron transfer activity? by Genova, M.L., Baracca, A., Biondi, A., Casalena, G., Faccioli, M., Falasca, A.I., Formiggini, G., Sgarbi, G., Solaini, G., Lenaz, G.

“…The supra-molecular assembly of the main respiratory chain enzymatic complexes in the form of “supercomplexes” has been proved by structural and functional…”
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The primary role of glutathione against nuclear DNA damage of striatum induced by permethrin in rats by Falcioni, M.L, Nasuti, C, Bergamini, C, Fato, R, Lenaz, G, Gabbianelli, R

“…Abstract Pyrethroids are one of the most widely used class of insecticides and their toxicity is dominated by pharmacological actions upon the CNS. This study…”
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Role of Mitochondria in Oxidative Stress and Aging by LENAZ, GIORGIO, BOVINA, CARLA, D'AURELIO, MARILENA, FATO, ROMANA, FORMIGGINI, GABRIELLA, GENOVA, MARIA LUISA, GIULIANO, GIOVANNI, PICH, MILENA MERLO, PAOLUCCI, UGO, CASTELLI, GIOVANNA PARENTI, VENTURA, BARBARA

“…The mitochondrial respiratory chain is a powerful source of reactive oxygen species (ROS), considered as the pathogenic agent of many diseases and of aging. We…”
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The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron–sulfur cluster N2 by Genova, Maria Luisa, Ventura, Barbara, Giuliano, Giovanni, Bovina, Carla, Formiggini, Gabriella, Parenti Castelli, Giovanna, Lenaz, Giorgio

“…The mitochondrial respiratory chain is a powerful source of reactive oxygen species, considered as the pathogenic agent of many diseases and of aging. We have…”
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Increased state 4 mitochondrial respiration and swelling in early post-ischemic reperfusion of rat heart by Bosetti, F, Baracca, A, Lenaz, G, Solaini, G

“…Isolated rat hearts were exposed to 30 min ischemia or to 30 min ischemia followed by 2, 5 or 40 min reperfusion and mitochondria were isolated at these…”
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Modification of respiratory-chain enzyme activities in brown adipose tissue mitochondria by idebenone (hydroxydecyl-ubiquinone) by Rauchová, H., Drahota, Z., Bergamini, C., Fato, R., Lenaz, G.

“…Idebenone (IDE), a synthetic analog of coenzyme Q, strongly activates glycerol phosphate (GP) oxidation in brown adipose tissue mitochondria. GP oxidase, GP…”
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Mitochondrial bioenergetics in aging by Lenaz, G, D'Aurelio, M, Merlo Pich, M, Genova, M L, Ventura, B, Bovina, C, Formiggini, G, Parenti Castelli, G

“…Mitochondria are strongly involved in the production of reactive oxygen species, considered as the pathogenic agent of many diseases and of aging. The…”
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Hyperoxia fully protects mitochondria of explanted livers by Sgarbi, G., Giannone, F., Casalena, G. A., Baracca, A., Baldassare, M., Longobardi, P., Caraceni, P., Derenzini, M., Lenaz, G., Trerè, D., Solaini, Giancarlo

“…Liver ischemia-reperfusion injury is still an open problem in many clinical circumstances, including surgery and transplantation. This study investigates how…”
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An Open-Label, Dose-Escalating Phase I Study of Elsamitrucin (SPI 28090) in Treatment of Malignant Solid Tumors in Dogs by Fiocchi, S.C., Selting, K.A., Rosenberg, M.P., Kolli, P., Lenaz, G., Henry, C.

“…Background: Elsamitrucin, the most potent topoisomerase II inhibitor available, is unique in that it does not cause neutropenia or cardiotoxicosis. It has…”
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The Role of DT-Diaphorase in the Maintenance of the Reduced Antioxidant Form of Coenzyme Q in Membrane Systems by Beyer, Robert E., Segura-Aguilar, Juan, Di Bernardo, Salvatore, Cavazzoni, Marika, Fato, Romana, Fiorentini, Diana, Galli, Maria Cristina, Setti, Massimo, Landi, Laura, Lenaz, Giorgio

“…The experiments reported here were designed to test the hypothesis that the two-electron quinone reductase DT-diaphorase [NAD(P)H:(quinone-acceptor)…”
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Inhibition of glycerophosphate-dependent H2O2 generation in brown fat mitochondria by idebenone by Rauchová, Hana, Vrbacký, Marek, Bergamini, Christian, Fato, Romana, Lenaz, Giorgio, Houstek, Josef, Drahota, Zdenek

“…The established protective effect of coenzyme Q (CoQ) analogs is dependent on the location of reactive oxygen species (ROS) generation. One of these…”
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Biochemical features of mtDNA 14484 (ND6/m64V) point mutation associated with Leber's hereditary optic neuropathy by Carelli, V., Ghelli, A., Bucchi, L., Montagna, P., De Negri, A., Leuzzi, V., Carducci, C., Lenaz, G., Lugaresi, E., Degli Esposti, M.

“…We report the effect on complex I function of the 14484 Leber's hereditary optic neuropathy (LHON) mutation affecting the ND6 subunit gene. The same gene was…”
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Role of mitochondria in oxidative stress and ageing by Lenaz, Giorgio

“…Mitochondria are deeply involved in the production of reactive oxygen species through one-electron carriers in the respiratory chain; mitochondrial structures…”
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Control of respiration by nitric oxide in Keilin-Hartree particles, mitochondria and SH-SY5Y neuroblastoma cells by Mastronicola, D, Genova, M L, Arese, M, Barone, M C, Giuffrè, A, Bianchi, C, Brunori, M, Lenaz, G, Sarti, P

“…The pattern of cytochrome c oxidase inhibition by nitric oxide (NO) was investigated polarographically using Keilin-Hartree particles, mitochondria and human…”
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Hyperbaric oxygen reduces rat liver preservation injury preserved in a hypotermic machine perfusion by Giannone, F, Caraceni, P, Sgarbi, G, Baracca, A, Solaini, G, Domenicali, M, Grattagliano, I, Lenaz, G, Trerè, D, Bernardi, M

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Apoptosis-resistant phenotype in HL-60-derived cells HCW-2 is related to changes in expression of stress-induced proteins that impact on redox status and mitochondrial metabolism by Salvioli, S, Storci, G, Pinti, M, Quaglino, D, Moretti, L, Merlo-Pich, M, Lenaz, G, Filosa, S, Fico, A, Bonafè, M, Monti, D, Troiano, L, Nasi, M, Cossarizza, A, Franceschi, C

“…The onset of resistance to drug-induced apoptosis of tumour cells is a major problem in cancer therapy. We studied a drug-selected clone of promyelocytic HL-60…”
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Virgin olive oil and coenzyme Q10 protect heart mitochondria from peroxidative damage during aging by Huertas, J. R., Martinez-Velasco, E., Ibáñez, S., López-Frias, M., Ochoa, J. J., Quiles, J., Castelli, G. Parenti, Mataix, J., Lenaz, G.

“…The mitochondrial theory of aging suggests that this phenomenon is the consequence of random somatic mutations in mitochondrial DNA, induced by long‐term…”
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Major changes in complex I activity in mitochondria from aged rats may not be detected by direct assay of NADH:coenzyme Q reductase by Genova, M L, Castelluccio, C, Fato, R, Parenti Castelli, G, Merlo Pich, M, Formiggini, G, Bovina, C, Marchetti, M, Lenaz, G

“…We have investigated the respiratory activities and the concentrations of respiratory chain components of mitochondria isolated from the livers and hearts of…”
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Rhodamine 123 as a probe of mitochondrial membrane potential: evaluation of proton flux through F 0 during ATP synthesis by Baracca, Alessandra, Sgarbi, Gianluca, Solaini, Giancarlo, Lenaz, Giorgio

“…Rhodamine 123 (RH-123) was used to monitor the membrane potential of mitochondria isolated from rat liver. Mitochondrial energization induces quenching of…”
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