Search Results - "LEMAÎTRE, Gilles"

Deciphering "Immaturity-Stemness" in Human Epidermal Stem Cells at the Levels of Protein-Coding and Non-Coding Genomes: A Prospective Computational Approach by Vinasco-Sandoval, Tatiana, Lemaître, Gilles, Soularue, Pascal, Martin, Michèle T, Fortunel, Nicolas O

“…The epidermis hosts populations of epithelial stem cells endowed with well-documented renewal and regenerative functions. This tissue thus constitutes a model…”
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MXD4/MAD4 Regulates Human Keratinocyte Precursor Fate by Coutier, Julien, Auvré, Frédéric, Lemaître, Gilles, Lataillade, Jean-Jacques, Deleuze, Jean-François, Roméo, Paul-Henri, Martin, Michèle T., Fortunel, Nicolas O.

“…Deciphering the pathways that regulate human epidermal precursor cell fate is necessary for future developments in skin repair and graft bioengineering. Among…”
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Concise Review: Epidermal Grafting: The Case for Pluripotent Stem Cells by Lemaître, Gilles, Nissan, Xavier, Baldeschi, Christine, Peschanski, Marc

“…Although cell therapy has been clinically implemented for several decades, its use is hampered by the difficulty in supplying the amount of epidermal…”
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KLF4 inhibition promotes the expansion of keratinocyte precursors from adult human skin and of embryonic-stem-cell-derived keratinocytes by Fortunel, Nicolas O., Chadli, Loubna, Coutier, Julien, Lemaître, Gilles, Auvré, Frédéric, Domingues, Sophie, Bouissou-Cadio, Emmanuelle, Vaigot, Pierre, Cavallero, Sophie, Deleuze, Jean-François, Roméo, Paul-Henri, Martin, Michèle T.

“…Expanded autologous skin keratinocytes are currently used in cutaneous cell therapy, and embryonic-stem-cell-derived keratinocytes could become a complementary…”
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Differentiation of nonhuman primate pluripotent stem cells into functional keratinocytes by Domingues, Sophie, Masson, Yolande, Marteyn, Aurore, Allouche, Jennifer, Perrier, Anselme L, Peschanski, Marc, Martinat, Cecile, Baldeschi, Christine, Lemaître, Gilles

“…Epidermal grafting using cells derived from pluripotent stem cells will change the face of this side of regenerative cutaneous medicine. To date, the safety of…”
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Mutations in GJB6 cause hidrotic ectodermal dysplasia by Laoudj, Dalila, Christianson, Arnold L, Kelsell, David P, Callouet, Edwige, Hand, Colette, Pitaval, Amandine, Lamartine, Jérôme, Radhakrishna, Uppala, Rouleau, Guy A, Waksman, Gilles, Antonarakis, Stylianos, Kibar, Zoha, Munhoz Essenfelder, Guilherme, Zonana, Jonathan, Blanchet-Bardon, Claudine, Fraser, Clarke, Lanneluc, Isabelle, Lemaître, Gilles, Hayflick, Susan J, Der Kaloustian, Vazken

“…Landouzy-Dejerine muscular dystrophy is a rare hereditary disease with prevalence of 0.9 to 1.4 in 100,000. Clinically the disease is characterized by weakness…”
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Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study by Guenou, Hind, PhD, Nissan, Xavier, Larcher, Fernando, PhD, Feteira, Jessica, Lemaitre, Gilles, PhD, Saidani, Manoubia, Del Rio, Marcela, PhD, Barrault, Christine C, Bernard, François-Xavier, PhD, Peschanski, Marc, MD, Baldeschi, Christine, Dr, Waksman, Gilles, Prof

“…Summary Background Cell therapy for large burns is dependent upon autologous epidermis reconstructed in vitro. However, the effectiveness of current procedures…”
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MALDI/MS peptide mass fingerprinting for proteome analysis: identification of hydrophobic proteins attached to eucaryote keratinocyte cytoplasmic membrane using different matrices in concert by Gonnet, Florence, Lemaître, Gilles, Waksman, Gilles, Tortajada, Jeanine

“…BACKGROUND: MALDI-TOF-MS has become an important analytical tool in the identification of proteins and evaluation of their role in biological processes. A…”
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CD98, a novel marker of transient amplifying human keratinocytes by Lemaître, Gilles, Gonnet, Florence, Vaigot, Pierre, Gidrol, Xavier, Martin, Michèle T., Tortajada, Jeanine, Waksman, Gilles

“…Identification of plasma membrane markers of basal keratinocytes is essential for sorting basal cells and, subsequently, adult epidermal stem cells. In this…”
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Generating Functional and Highly Proliferative Melanocytes Derived from Human Pluripotent Stem Cells: A Promising Tool for Biotherapeutic Approaches to Treat Skin Pigmentation Disorders by Saidani, Manoubia, Darle, Annabelle, Jarrige, Margot, Polveche, Hélène, El Kassar, Lina, Julié, Séverine, Bessou-Touya, Sandrine, Holic, Nathalie, Lemaitre, Gilles, Martinat, Cécile, Baldeschi, Christine, Allouche, Jennifer

“…Melanocytes are essential for skin homeostasis and protection, and their loss or misfunction leads to a wide spectrum of diseases. Cell therapy utilizing…”
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Expression profiling of genes and proteins in HaCaT keratinocytes: Proliferating versus differentiated state by Lemaître, Gilles, Lamartine, Jérôme, Pitaval, Amandine, Vaigot, Pierre, Garin, Jérôme, Bouet, Stephan, Petat, Cyrille, Soularue, Pascal, Gidrol, Xavier, Martin, Michèle T., Waksman, Gilles

“…The knowledge of the mechanism of keratinocyte differentiation in culture is still uncompleted. The emergence of new technologies, such as cDNA microarrays or…”
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Functional melanocytes derived from human pluripotent stem cells engraft into pluristratified epidermis by Nissan, Xavier, Larribere, Lionel, Saidani, Manoubia, Hurbain, Ilse, Delevoye, Cédric, Feteira, Jessica, Lemaitre, Gilles, Peschanski, Marc, Baldeschi, Christine

“…Melanocytes are essential for skin homeostasis and protection, and their defects in humans lead to a wide array of diseases that are potentially extremely…”
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In vitro modeling of hyperpigmentation associated to neurofibromatosis type 1 using melanocytes derived from human embryonic stem cells by Allouche, Jennifer, Nathalia Bellon, Manoubia Saidani, Laure Stanchina-Chatrousse, Yolande Masson, Anand Patwardhan, Floriane Gilles-Marsens, Cédric Delevoye, Sophie Domingues, Xavier Nissan, Céécile Martinat, Gilles Lemaitre, Marc Peschanski, Christine Baldeschi

“…“Cafééééééé-au-lait” macules (CALMs) and overall skin hyperpigmentation are early hallmarks of neurofibromatosis type 1 (NF1). One of the…”
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Fibroblast Growth Factor Receptors Participate in the Control of Mitogen-activated Protein Kinase Activity during Nerve Growth Factor-induced Neuronal Differentiation of PC12 Cells by Chevet, Eric, Lemaı̂tre, Gilles, Janjić, Neboǰa, Barritault, Denis, Bikfalvi, Andreas, Katinka, Michaël Doron

“…The current paradigm for the role of nerve growth factor (NGF) or FGF-2 in the differentiation of neuronal cells implies their binding to specific receptors…”
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Generation of heterozygous and homozygous NF1 lines from human-induced pluripotent stem cells using CRISPR/Cas9 to investigate bone defects associated with neurofibromatosis type 1 by Darle, Annabelle, Mahiet, Thibault, Aubin, Déborah, Doyen, Manon, El Kassar, Lina, Parfait, Béatrice, Lemaitre, Gilles, Baldeschi, Christine, Allouche, Jennifer, Holic, Nathalie

“…Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders caused by heterozygous germline mutations. NF1 affects many systems, including the…”
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Clinical Grade Human Pluripotent Stem Cell-Derived Engineered Skin Substitutes Promote Keratinocytes Wound Closure In Vitro by Domingues, Sophie, Darle, Annabelle, Masson, Yolande, Saidani, Manoubia, Lagoutte, Emilie, Bejanariu, Ana, Coutier, Julien, Ayata, Raif Eren, Bouschbacher, Marielle, Peschanski, Marc, Lemaitre, Gilles, Baldeschi, Christine

“…Chronic wounds, such as leg ulcers associated with sickle cell disease, occur as a consequence of a prolonged inflammatory phase during the healing process…”
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Glycosaminoglycans Promote HARP/PTN Dimerization by Bernard-Pierrot, Isabelle, Héroult, Mélanie, Lemaítre, Gilles, Barritault, Denis, Courty, José, Milhiet, Pierre Emmanuel

“…Heparin affin regulatory peptide (HARP), also called pleiotrophin (PTN), is a secreted polypeptide which binds to heparin and plays a key role in cellular…”
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Coloring skin with pluripotent stem cells by Nissan, Xavier, Lemaitre, Gilles, Peschanski, Marc, Baldeschi, Christine

“…Comment on: Nissan X, et al. Proc Natl Acad Sci USA 2011; 108:14861-6…”
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Fibroblast Growth Factor Type 2 Signaling Is Critical for DNA Repair in Human Keratinocyte Stem Cells by Harfouche, Ghida, Vaigot, Pierre, Rachidi, Walid, Rigaud, Odile, Moratille, Sandra, Marie, Mélanie, Lemaitre, Gilles, Fortunel, Nicolas O., Martin, Michèle T.

“…Tissue stem cells must be endowed with superior maintenance and repair systems to ensure genomic stability over multiple generations, which would be less…”
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CD98hc (SLC3A2) is a key regulator of keratinocyte adhesion by Lemaître, Gilles, Stella, Alexandre, Feteira, Jessica, Baldeschi, Christine, Vaigot, Pierre, Martin, Michèle T, Monsarrat, Bernard, Waksman, Gilles

“…Abstract Background Adhesion of keratinocytes is crucial for maintaining the integrity of the skin, as demonstrated by the number of dermatological disorders…”
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