Search Results - "LEJNINE, Serguei"

An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies by O'Neil, Jennifer, Benita, Yair, Feldman, Igor, Chenard, Melissa, Roberts, Brian, Liu, Yaping, Li, Jing, Kral, Astrid, Lejnine, Serguei, Loboda, Andrey, Arthur, William, Cristescu, Razvan, Haines, Brian B, Winter, Christopher, Zhang, Theresa, Bloecher, Andrew, Shumway, Stuart D

“…Combination drug therapy is a widely used paradigm for managing numerous human malignancies. In cancer treatment, additive and/or synergistic drug combinations…”
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Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma by Stoeck, Alexander, Lejnine, Serguei, Truong, Andrew, Pan, Li, Wang, Hongfang, Zang, Chongzhi, Yuan, Jing, Ware, Chris, MacLean, John, Garrett-Engele, Philip W, Kluk, Michael, Laskey, Jason, Haines, Brian B, Moskaluk, Christopher, Zawel, Leigh, Fawell, Stephen, Gilliland, Gary, Zhang, Theresa, Kremer, Brandon E, Knoechel, Birgit, Bernstein, Bradley E, Pear, Warren S, Liu, X Shirley, Aster, Jon C, Sathyanarayanan, Sriram

“…Next-generation sequencing was used to identify Notch mutations in a large collection of diverse solid tumors. NOTCH1 and NOTCH2 rearrangements leading to…”
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High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide by Guertin, Amy D, O'Neil, Jennifer, Stoeck, Alexander, Reddy, Joseph A, Cristescu, Razvan, Haines, Brian B, Hinton, Marlene C, Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Vetzel, Marilynn, Lejnine, Serguei, Nebozhyn, Michael, Zhang, Theresa, Loboda, Andrey, Picard, Kristen L, Schmidt, Emmett V, Dussault, Isabelle, Leamon, Christopher P

“…Targeting surface receptors overexpressed on cancer cells is one way to specifically treat cancer versus normal cells. Vintafolide (EC145), which consists of…”
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Identification of Diagnostic Biomarkers for Infection in Premature Neonates by Kingsmore, Stephen F., Kennedy, Neil, Halliday, Henry L., Van Velkinburgh, Jennifer C., Zhong, Shengiang, Gabriel, Vanessa, Grant, Judith, Beavis, William D., Tchernev, Velizar T., Perlee, Lorah, Lejnine, Serguei, Grimwade, Brian, Sorette, Martin, Edgar, J. David M.

“…Infection is a leading cause of neonatal morbidity and mortality worldwide. Premature neonates are particularly susceptible to infection because of physiologic…”
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Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration by Hageman, Gregory S, Gehrs, Karen, Lejnine, Serguei, Bansal, Aruna T, Deangelis, Margaret M, Guymer, Robyn H, Baird, Paul N, Allikmets, Rando, Deciu, Cosmin, Oeth, Paul, Perlee, Lorah T

“…Predictive tests for estimating the risk of developing late-stage neovascular age-related macular degeneration (AMD) are subject to unique challenges. AMD…”
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cDNA targets improve whole blood gene expression profiling and enhance detection of pharmocodynamic biomarkers: a quantitative platform analysis by Parrish, Mark L, Wright, Chris, Rivers, Yarek, Argilla, David, Collins, Heather, Leeson, Brendan, Loboda, Andrey, Nebozhyn, Michael, Marton, Matthew J, Lejnine, Serguei

“…Genome-wide gene expression profiling of whole blood is an attractive method for discovery of biomarkers due to its non-invasiveness, simple clinical site…”
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Development of a microarray platform for FFPET profiling: application to the classification of human tumors by Duenwald, Sven, Zhou, Mingjie, Wang, Yanqun, Lejnine, Serguei, Kulkarni, Amit, Graves, Jaime, Smith, Ryan, Castle, John, Tokiwa, George, Fine, Bernard, Dai, Hongyue, Fare, Thomas, Marton, Matthew

“…mRNA profiling has become an important tool for developing and validating prognostic assays predictive of disease treatment response and outcome. Archives of…”
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Nucleosomal organization of telomere-specific chromatin in rat by Makarov, V L, Lejnine, S, Bedoyan, J, Langmore, J P

“…Rat liver interphase chromosomes have telomeres 20-100 kb in length. Micrococcal nuclease digestion of nuclei cleaves telomeres with a uniform 157 bp…”
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Condensation of Rat Telomere-specific Nucleosomal Arrays Containing Unusually Short DNA Repeats and Histone H1 by Bedoyan, Jirair K., Lejnine, Serguei, Makarov, Vladimir L., Langmore, John P.

“…Vertebrate telomeres contain arrays of nucleosomes with unusually short and regular repeat lengths (Makarov, V. L., Lejnine, S., Bedoyan, J., and Langmore, J…”
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A candidate plasma protein classifier to identify Alzheimer's disease by Zhao, Xuemei, Lejnine, Serguei, Spond, Jeffrey, Zhang, Chunsheng, Ramaraj, T C, Holder, Daniel J, Dai, Hongyue, Weiner, Russell, Laterza, Omar F

“…Biomarkers currently used in the aid for the diagnosis of Alzheimer's disease (AD) are cerebrospinal fluid (CSF) protein markers and brain neuroimaging…”
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Abstract B65: High levels of expression of P-glycoprotein/multidrug resistance protein result in resistance to vintafolide by Guertin, Amy D., O'Neil, Jennifer, Stoeck, Alexander, Reddy, Joseph A., Cristescu, Razvan, Haines, Brian B., Hinton, Marlene C., Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Vetzel, Marilynn, Lejnine, Serguei, Nebozhyn, Michael, Zhang, Theresa, Loboda, Andrey, Picard, Kristen L., Schmidt, Emmett V., Dussault, Isabelle, Leamon, Christopher P.

“…Abstract Targeting surface receptors overexpressed on cancer cells is one way to specifically treat cancer versus normal cells. Vintafolide (EC145), which…”
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Conserved Nucleoprotein Structure at the Ends of Vertebrate and Invertebrate Chromosomes by Lejnine, Serguei, Makarov, Vladimir L., Langmore, John P.

“…Eukaryotic chromosomes terminate with telomeres, nucleoprotein structures that are essential for chromosome stability. Vertebrate telomeres consist of terminal…”
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Protein Microarray Analysis of Disease Activity in Pediatric Inflammatory Bowel Disease Demonstrates Elevated Serum PLGF, IL-7, TGF-[beta]1, and IL-12p40 Levels in Crohn's Disease and Ulcerative Colitis Patients in Remission versus Active Disease by Kader, Howard A, Tchernev, Velizar T, Satyaraj, Ebenezer, Lejnine, Serguei, Kotler, Gregory, Kingsmore, Stephen F, Patel, Dhavalkumar D

“…OBJECTIVES:Cytokines and growth factors play a major role in the dysregulated immune response in inflammatory bowel disease (IBD). We hypothesized that…”
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Protein microarray analysis of disease activity in pediatric inflammatory bowel disease demonstrates elevated serum PLGF, IL-7, TGF-β1, and IL-12p40 levels in Crohn's disease and ulcerative colitis patients in remission versus active disease by KADER, Howard A, TCHERNEV, Velizar T, SATYARAJ, Ebenezer, LEJNINE, Serguei, KOTLER, Gregory, KINGSMORE, Stephen F, PATEL, Dhavalkumar D

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Protein microarray analysis of disease activity in pediatric inflammatory bowel disease demonstrates elevated serum PLGF, IL-7, TGF-beta1, and IL-12p40 levels in Crohn's disease and ulcerative colitis patients in remission versus active disease by Kader, Howard A, Tchernev, Velizar T, Satyaraj, Ebenezer, Lejnine, Serguei, Kotler, Gregory, Kingsmore, Stephen F, Patel, Dhavalkumar D

“…Cytokines and growth factors play a major role in the dysregulated immune response in inflammatory bowel disease (IBD). We hypothesized that significant…”
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Organization of mammalian telomere chromatin by Lejnine, Serguei

“…Telomeres are specialized nucleoprotein structures at the ends of eukaryotic chromosomes. They protect ends of chromosomes from fusion and degradation. The…”
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In vitro and in vivo reconstitution and stability of vertebrate chromosome ends by Li, Liwu, Lejnine, Serguei, Makarov, Vladimir, Langmore, John P.

“…Telomeres are essential repetitive sequences at the ends of chromosomes that prevent chromosome fusion and degradation. We have successfully recapitulated…”
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