Search Results - "LEJEUNE, Laurence"

Allogeneic marrow stromal cells are immune rejected by MHC class I– and class II–mismatched recipient mice by Eliopoulos, Nicoletta, Stagg, John, Lejeune, Laurence, Pommey, Sandra, Galipeau, Jacques

“…It has been suggested that marrow stromal cells (MSCs) may be immunoprivileged and can engraft in allogeneic recipients with intact immune systems. We…”
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Marrow stromal cells for interleukin-2 delivery in cancer immunotherapy by Stagg, John, Lejeune, Laurence, Paquin, André, Galipeau, Jacques

“…Marrow stromal cells (MSCs) can be easily gene-modified and clonally expanded making them ideal candidates for transgenic cell therapy. However, recent reports…”
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Plasminogen Kringle 5 blocks tumor progression by antiangiogenic and proinflammatory pathways by Perri, Sabrina R, Martineau, Daniel, François, Moïra, Lejeune, Laurence, Bisson, Louis, Durocher, Yves, Galipeau, Jacques

“…Proteolytic processing of human plasminogen generates potent antiangiogenic peptides such as angiostatin. The plasminogen kringle 5 (K5) domain, which is…”
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A self-inactivating retrovector incorporating the IL-2 promoter for activation-induced transgene expression in genetically engineered T-cells by Jaalouk, Diana E, Lejeune, Laurence, Couture, Clément, Galipeau, Jacques

“…T-cell activation leads to signaling pathways that ultimately result in induction of gene transcription from the interleukin-2 (IL-2) promoter. We hypothesized…”
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Cooperation of Matrix Metalloproteinases with the RhoA/Rho Kinase and Mitogen‐Activated Protein Kinase Kinase‐1/Extracellular Signal‐Regulated Kinase Signaling Pathways Is Required for the Sphingosine‐1‐Phosphate‐Induced Mobilization of Marrow‐Derived Stromal Cells by Meriane, Mayya, Duhamel, Stéphanie, Lejeune, Laurence, Galipeau, Jacques, Annabi, Borhane

“…The ease of isolation and ex vivo culture of marrow‐derived stromal cells (MSCs) from adult bone marrow renders them a very promising source of adult stem…”
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CD34 expression on murine marrow-derived mesenchymal stromal cells: impact on neovascularization by Copland, Ian, Sharma, Kapil, Lejeune, Laurence, Eliopoulos, Nicoletta, Stewart, Duncan, Liu, Peter, Lachapelle, Kevin, Galipeau, Jacques

“…Objective CD34 is a sialomucin often expressed by cells with hemangiopoietic potential and widely serves as a surrogate marker of stem cell potential…”
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A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex by Rafei, Moutih, Wu, Jian Hui, Annabi, Borhane, Lejeune, Laurence, François, Moïra, Galipeau, Jacques

“…We hypothesized that a granulocyte macrophage colony-stimulating factor (GMCSF) and interleukin 15 (IL-15) fusokine (GIFT15) would possess greater…”
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Human-Compatible Collagen Matrix for Prolonged and Reversible Systemic Delivery of Erythropoietin in Mice from Gene-Modified Marrow Stromal Cells by Eliopoulos, Nicoletta, Lejeune, Laurence, Martineau, Daniel, Galipeau, Jacques

“…Bone marrow stromal cells (MSCs) can be exploited therapeutically in transgenic cell therapy approaches. Our aim was to determine if gene-modified MSCs…”
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Plasminogen kringle 5-engineered glioma cells block migration of tumor-associated macrophages and suppress tumor vascularization and progression by PERRI, Sabrina R, NALBANTOGLU, Josephine, ANNABI, Borhane, KOTY, Zafiro, LEJEUNE, Laurence, FRANCOIS, Moira, DI FALCO, Marcos R, BELIVEAN, Richard, GALIPEAU, Jacques

“…Angiostatin, a well-characterized angiostatic agent, is a proteolytic cleavage product of human plasminogen encompassing the first four kringle structures. The…”
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A GMCSF & IL15 Fusokine Leads to Paradoxical Immunosuppression In Vivo Via Asymmetrical JAK/STAT Signalling through the IL15 Receptor Complex by Rafei, Moutih, Wu, Jian Hui, Annabi, Borhane, Lejeune, Laurence, Francois, Moira, Galipeau, Jacques

“…Immune stimulatory cytokines can be exploited to treat human ailments including cancer. Amongst cytokines identified for such use, granulocyte-macrophage…”
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911. MHC Class I and II Mismatched Marrow Stromal Cells from C57Bl/6 Mice Are Immune Rejected by Recipient Balb/c Mice by Eliopoulos, Nicoletta, Stagg, John, Lejeune, Laurence, Galipeau, Jacques

“…Bone marrow stromal cells (MSCs) can be easily harvested, culture expanded, and genetically engineered, and thus can be utilized therapeutically in…”
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Human CD4 Expression at the Late Single-Positive Stage of Thymic Development Supports T Cell Maturation and Peripheral Export in CD4-Deficient Mice by Boyer, Olivier, Marodon, Gilles, Cohen, Jose L, Lejeune, Laurence, Irinopoulou, Theano, Liblau, Roland, Bruneval, Patrick, Klatzmann, David

“…Positive selection of developing thymocytes is initiated at the double-positive (DP) CD4(+)CD8(+) stage of their maturation. Accordingly, expression of a human…”
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Preservation of graft-versus-infection effects after suicide gene therapy for prevention of graft-versus-host disease by Cohen, J L, Saron, M F, Boyer, O, Thomas-Vaslin, V, Bellier, B, Lejeune, L, Charlotte, F, Klatzmann, D

“…The main complications following allogeneic hematopoietic stem cell transplantation are graft-versus-host disease and poor immune reconstitution leading to…”
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Immunological defects after suicide gene therapy of experimental graft-versus-host disease by Cohen, J L, Lacroix-Desmazes, S, Charlotte, F, Lejeune, L, Martin, P J, Klatzmann, D, Boyer, O

“…Donor T cells are beneficial for engraftment, immune reconstitution, and antileukemic effects after allogeneic marrow transplantation, but they also cause…”
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Position-dependent variegation of a CD4 minigene with targeted expression to mature CD4+ T cells by Boyer, O, Zhao, JC, Cohen, JL, Depetris, D, Yagello, M, Lejeune, L, Bruel, S, Mattei, MG, Klatzmann, D

“…The CD4 gene follows a complex and highly regulated pattern of expression throughout T cell development. This expression is governed by different regulatory…”
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Fertile homozygous transgenic mice expressing a functional truncated Herpes simplex thymidine kinase ΔTK gene by COHEN, J. L, BOYER, O, KLATZMANN, D, SALOMON, B, ONCLERCQ, R, DEPETRIS, D, LEJEUNE, L, DUBUS-BONNET, V, BRUEL, S, CHARLOTTE, F, MATTEÏ, M.-G

“…Dividing cells expressing the Herpes simplex type 1 thymidine kinase (TK) can be killed upon ganciclovir treatment. Likewise, conditional cell knock-out can be…”
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Fertile Homozygous Transgenic Mice Expressing a Functional Truncated Herpes Simplex Thymidine Kinase [Delta]TK Gene by Cohen, Jose L, Boyer, Olivier, Salamon, Benoit, Onclercq, Rosine, Depetris, Daniele, Lejeune, Laurence, Dubus-bonnet, Vanessa, Bruel, Sylvie, Charlotte, Frederic, Mattei, Marie-genevieve, Klatzmann, David

“…Dividing cells expressing the Herpes simplex type 1 thymidine kinase (TK) can be killed upon ganciclovir treatment. Likewise, conditional cell knock-out can be…”
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