Search Results - "LEITER, E. H."

Mice with targeted gene, disruptions or gene insertions for diabetes research: problems, pitfalls, and potential solutions by LEITER, E. H

“…The mouse has been a favoured organism for molecular manipulation in studies seeking to establish the genetic bases and pathophysiologic mechanisms underlying…”
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The NOD mouse model of type 1 diabetes: As good as it gets? by Atkinson, Mark A, Leiter, Edward H

“…Of the two well-known rodent models of human type 1 diabetes (the non-obese diabetic mouse and the BioBreeding rat) the mouse has become the model of choice…”
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Maternal environment and genotype interact to establish diabesity in mice by Reifsnyder, P C, Churchill, G, Leiter, E H

“…Obesity, a major risk factor for type II diabetes, is becoming more prevalent in Western populations consuming high calorie diets while expending less energy…”
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mt-Nd2 allele of the ALR/Lt mouse confers resistance against both chemically induced and autoimmune diabetes by MATHEWS, C. E, LEITER, E. H, SPIRINA, O, BYKHOVSKAYA, Y, GUSDON, A. M, RINGQUIST, S, FISCHEL-GHODSIAN, N

“…ALR/Lt, a mouse strain with strong resistance to type 1 diabetes, is closely related to autoimmune type 1 diabetes-prone NOD/Lt mice. ALR pancreatic beta cells…”
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Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease by Jurisic, G, Sundberg, J P, Bleich, A, Leiter, E H, Broman, K W, Buechler, G, Alley, L, Vestweber, D, Detmar, M

“…Inflammatory bowel disease (IBD) is a chronic debilitating disease resulting from a complex interaction of multiple genetic factors with the environment. To…”
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Animal models have little to teach us about type 1 diabetes: 2. In opposition to this proposal by Leiter, E H, von Herrath, M

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Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice by Serreze, DV, Gaskins, HR, Leiter, EH

“…Although T lymphocytes are the ultimate effectors of pancreatic beta cell destruction in autoimmune insulin-dependent diabetes, previous work has established…”
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Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes by Wicker, L S, Leiter, E H, Todd, J A, Renjilian, R J, Peterson, E, Fischer, P A, Podolin, P L, Zijlstra, M, Jaenisch, R, Peterson, L B

“…Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. L S Wicker , E H Leiter , J A Todd , R J Renjilian , E Peterson , P A Fischer , P…”
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Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors by Christianson, S. W., Shultz, L. D., Leiter, E. H.

“…Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic…”
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The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency by PROCHAZKA, M, REX GASKINS, H, SHULTZ, L. D, LEITER, E. H

“…Homozygosity for the severe combined immunodeficiency (scid) mutation results in a block in T- and B-lymphocyte development. An unusually high incidence of…”
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Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice by RAPOPORT, M. J, JARAMILLO, A, ZIPRIS, D, LAZARUS, A. H, SERREZE, D. V, LEITER, E. H, CYOPICK, P, DANSKA, J. S, DELOVITCH, T. L

“…Beginning at the time of insulitis (7 wk of age), CD4+ and CD8+ mature thymocytes from nonobese diabetic (NOD) mice exhibit a proliferative unresponsiveness in…”
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Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait by MATHEWS, C. E, LEITER, E. H

“…Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. C E Mathews and E H Leiter The Jackson Laboratory,…”
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Hematopoietic Stem-Cell Defects Underlying Abnormal Macrophage Development and Maturation in NOD/Lt Mice: Defective Regulation of Cytokine Receptors and Protein Kinase C by Serreze, David V., Gaedeke, Jens W., Leiter, Edward H.

“…The immunopathogenesis of autoimmune insulin-dependent diabetes in NOD mice entails defects in the development of macrophages (Mos) from hematopoietic…”
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The genetics of diabetes susceptibility in mice by Leiter, E H

“…The factors associated with a diabetes-susceptible genotype in mice exhibiting various forms of heritable glucose intolerance syndromes are discussed. Genetic…”
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Metalloprotease-Mediated Shedding of Enzymatically Active Mouse ecto-ADP-ribosyltransferase ART2.2 Upon T Cell Activation by Kahl, Sarah, Nissen, Marion, Girisch, Roman, Duffy, Ted, Leiter, Edward H, Haag, Friedrich, Koch-Nolte, Friedrich

“…T cells proteolytically shed the ectodomains of several cell surface proteins and, thereby, can alter their responsiveness and can release soluble…”
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Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells by BRIDGETT, M, CETKOVIC-CVRLJE, M, O'ROURKE, R, YUGUANG SHI, NARAYANSWAMI, S, LAMBERT, J, RAMIYA, V, BAEKKESKOV, S, LEITER, E. H

“…Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells. M Bridgett , M Cetkovic-Cvrlje ,…”
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Experimental Models to Study Molecular Mechanisms Underlying Intestinal Inflammation by ELSON, C. O., CONG, Y., BRANDWEIN, S., WEAVER, C. T., McCABE, R. P., MÄHLER, M., SUNDBERG, J. P., LEITER, E. H.

“…Experimental animal models, particularly the newer mouse models, have convincingly demonstrated that CD+ T cells play a central role in chronic intestinal…”
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NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse by Hamaguchi, K., Gaskins, H. R., Leiter, E. H.

“…NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse. K Hamaguchi , H R Gaskins and E H Leiter Jackson Laboratory, Bar Harbor, Maine…”
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Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR Lt mice by Reifsnyder, P C, Li, R, Silveira, P A, Churchill, G, Serreze, D V, Leiter, E H

“…While sharing the H2g7 MHC and many other important Type I diabetes susceptibility (Idd) genes with NOD mice, the NOR strain remains disease free due to…”
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Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies by Serreze, D.V, Leiter, E.H

“…Nonobese diabetic (NOD) is an inbred mouse strain susceptible to development of T cell-mediated autoimmune diabetes. The strain is characterized by high…”
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