Search Results - "LEINO, LASSE"

Injectable Biodegradable Silica Depot: Two Months of Sustained Release of the Blood Glucose Lowering Peptide, Pramlintide by Tyagi, Puneet, Koskinen, Mika, Mikkola, Jari, Sarkhel, Sanjay, Leino, Lasse, Seth, Asha, Madalli, Shimona, Will, Sarah, Howard, Victor G, Brant, Helen, Corkill, Dominic

“…Diabetes mellitus is a major healthcare challenge. Pramlintide, a peptide analogue of the hormone amylin, is currently used as an adjunct with insulin for…”
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Sustained In-Vivo Release of Triptorelin Acetate from a Biodegradable Silica Depot: Comparison to Pamorelin® LA by Forsback, Ari-Pekka, Noppari, Panu, Viljanen, Jesse, Mikkola, Jari, Jokinen, Mika, Leino, Lasse, Bjerregaard, Simon, Borglin, Camilla, Halliday, Janet

“…Triptorelin acetate was encapsulated into silica microparticles by spray-drying a mixture of colloidal silica sol and triptorelin acetate solution. The…”
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Protodynamic Intracellular Acidification by cis-Urocanic Acid Promotes Apoptosis of Melanoma Cells In Vitro and In Vivo by Laihia, Jarmo K., Kallio, Janne P., Taimen, Pekka, Kujari, Harry, Kähäri, Veli-Matti, Leino, Lasse

“…The extracellular tumor microenvironment is acidified, whereas the intracellular pH of tumor and stromal cells is neutral. cis-Urocanic acid (cis-UCA), an…”
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Molecular targets for the protodynamic action of cis-urocanic acid in human bladder carcinoma cells by Peuhu, Emilia, Kaunisto, Aura, Laihia, Jarmo K, Leino, Lasse, Eriksson, John E

“…cis-urocanic acid (cis-UCA) is an endogenous amino acid metabolite capable of transporting protons from the mildly acidic extracellular medium into the cell…”
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Clinical phase 1 safety and tolerability evaluation of sustained release silica composite eye drops in human subjects by Kaarniranta, Kai, Reay, Marcus, Leino, Lasse, Kievari, Sari, Hartikainen, Arto, Martikainen, Oona, Kemiläinen, Benjam

“…Aims/Purpose: Most ocular disease is managed at least in part by use of eye drops. Many of these eye drops require multiple doses per day, as well as good…”
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Tolerability of silica microparticle gels as drug delivery vehicles by Poluianova, Aleksandra, Robciuc, Alexandra, Moilanen, Jukka, Kaarniranta, Kai, Leino, Lasse, Pollari, Ville, Dargelas, Frederic, Reay, Marcus

“…Aims/Purpose: Over the past decades, polymeric particles have become widespread in the field of drug delivery. Silica microparticles (SiMPs) are…”
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Development of injectable long‐acting controlled release intravitreal depot of BAY224 using biodegradable silica microparticle‐silica hydrogel composite by Dargelas, Frederic, Forsback, Aripekka, Mattila, Aarne, Leino, Lasse, Noppari, Panu, Reay, Marcus, Terjung, Carsten, Unger, Florian, Baerfacker, Lars

“…Purpose Intravitreal (IVT) therapies are a standard of care for many ocular diseases. Frequent administration and injection‐based adverse events pose a hurdle…”
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Silica microparticles for sustained zero-order release of an anti-CD40L antibody by Tyagi, Puneet, Koskinen, Mika, Mikkola, Jari, Leino, Lasse, Schwarz, Alexander

“…Silica microparticle hydrogel depot (HG) formulation was prepared using spray drying of silica-based sol–gels for the sustained delivery of MR1 antibody which…”
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Injectable Biodegradable Silica Depot for Controlled Subcutaneous Delivery of Antisense Oligonucleotides with beyond Monthly Administration by McGowan, Asmaa, Gennemark, Peter, Akieh-Pirkanniemi, Marceline, Wirman, Linda, Davies, Nigel, Elebring, Marie, Tivesten, Anna, Strimfors, Marie, Hölttä, Mikko, Söderberg, Magnus, Berntsson, Veronica, Balas, Daniela, Koskinen, Mika, Leino, Lasse, Abrahmsén-Alami, Susanna

“…Single-stranded antisense oligonucleotides (ASOs) are typically administered subcutaneously once per week or monthly. Less frequent dosing would have strong…”
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Intravesical treatment with cis-urocanic acid improves bladder function in rat model of acute bladder inflammation by Konkol, Yvonne, Bernoulli, Jenni, Streng, Tomi, Jääskeläinen, Katarina, Laihia, Jarmo, Leino, Lasse

“…Aims The aim was to study the effect of intravesically instilled cis‐urocanic acid (cis‐UCA) on bladder function in an experimental rat model of acute bladder…”
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Topical cis-urocanic acid prevents ocular surface irritation in both IgE -independent and -mediated rat model by Jauhonen, Hanna-Mari, Laihia, Jarmo, Oksala, Olli, Viiri, Johanna, Sironen, Reijo, Alajuuma, Päivi, Kaarniranta, Kai, Leino, Lasse

“…Purpose Our purpose was to investigate the effect of locally administered cis-urocanic (cis-UCA) in two experimental models of allergic conjunctivitis. Methods…”
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Intravesical treatment with cis-urocanic acid improves bladder function in rat model of acute bladder inflammation: Cis -Urocanic Acid for Intravesical Treatment by Konkol, Yvonne, Bernoulli, Jenni, Streng, Tomi, Jääskeläinen, Katarina, Laihia, Jarmo, Leino, Lasse

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A randomized phase I clinical study of cis‐urocanic acid eye drops in healthy adult subjects by Jauhonen, Hanna‐Mari, Kari, Eeva, Pylkkänen, Liisa, Poutanen, Jutta, Laihia, Jarmo, Kaarniranta, Kai, Leino, Lasse

“…Purpose To evaluate safety, ocular tolerability and pharmacokinetics of 0.5% and 2.5% cis‐urocanic acid (cis‐UCA) eye drops. Methods In this phase I,…”
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Comparison of the chemiluminescence responses of bovine neutrophils to differently opsonized zymosan particles by Leino, L, Paape, M J

“…Stimulatory effects of 6 zymosan preparations on luminol-dependent chemiluminescence (CL) responses of isolated bovine neutrophils were compared. Unopsonized…”
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Three randomised phase I/IIa trials of 5% cis-urocanic acid emulsion cream in healthy adult subjects and in patients with atopic dermatitis by Peltonen, Juha M, Pylkkänen, Liisa, Jansén, Christer T, Volanen, Iina, Lehtinen, Terhi, Laihia, Jarmo K, Leino, Lasse

“…New treatment modalities are needed in atopic dermatitis. We evaluated the pharmacokinetics, safety, tolerability, and efficacy of topical cis-urocanic acid…”
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Antitumor effects of cis-urocanic acid on experimental urothelial cell carcinoma of the bladder by Arentsen, Harm C, Jansen, Cornelius F J, Hulsbergen-van de Kaa, Christina A, Laihia, Jarmo K, Pylkkänen, Liisa, Leino, Lasse, Oosterwijk, Egbert, Witjes, J Alfred

“…We determined the effect of protodynamic therapy against bladder cancer cells in vitro and in vivo. We investigated cis-urocanic acid in rat bladder cancer…”
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Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro by Jauhonen, Hanna-Mari, Kauppinen, Anu, Paimela, Tuomas, Laihia, Jarmo K, Leino, Lasse, Salminen, Antero, Kaarniranta, Kai

“…The cornea is sensitive to ultraviolet B (UV-B) radiation-induced oxidative stress and inflammation. Its clinical manifestations are photokeratitis and…”
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Protodynamic therapy for bladder cancer: in vitro results of a novel treatment concept by Laihia, Jarmo K., Pylkkänen, Liisa, Laato, Matti, Boström, Peter J., Leino, Lasse

“…OBJECTIVE To present a novel treatment approach for urinary bladder cancer, protodynamic therapy, which comprises inhibition of cancer cell proliferation by…”
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Determination of the Dissociation Constants of Urocanic Acid Isomers in Aqueous Solutions by Juusola, Pekka, Minkkinen, Pentti, Leino, Lasse, Laihia, Jarmo K.

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Effects of intramammary infusion of cis-urocanic acid on mastitis-associated inflammation and tissue injury in dairy cows by Bannerman, Douglas D, Rinaldi, Manuela, Vinyard, Bryan T, Laihia, Jarmo, Leino, Lasse

“…To evaluate the effects of cis-urocanic acid (cis-UCA) on mammary gland (MG) inflammation and injury associated with Escherichia coli-induced mastitis in dairy…”
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