Search Results - "LEIGH, P. N"

An estimate of amyotrophic lateral sclerosis heritability using twin data by Al-Chalabi, A, Fang, F, Hanby, M F, Leigh, P N, Shaw, C E, Ye, W, Rijsdijk, F

“…BackgroundCausative gene mutations have been identified in about 2% of those with amyotrophic lateral sclerosis (ALS), often, but not always, when there is a…”
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Natural history and clinical features of the flail arm and flail leg ALS variants by WIJESEKERA, L. C, MATHERS, S, AL-CHALABI, A, LEIGH, P. N, TALMAN, P, GALTREY, C, PARKINSON, M. H, GANESALINGAM, J, WILLEY, E, AMPONG, M. A, ELLIS, C. M, SHAW, C. E

“…We sought to define the significance of brachial amyotrophic diplegia (flail arm syndrome [FA]) and the pseudopolyneuritic variant (flail leg syndrome [FL]) of…”
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Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study by Abrahams, S., Goldstein, L. H., Simmons, A., Brammer, M., Williams, S. C. R., Giampietro, V., Leigh, P. N.

“…The cognitive impairment revealed in some non‐ demented amyotrophic lateral sclerosis (ALS) patients is characterized by executive dysfunction with widely…”
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Accepting or declining non-invasive ventilation or gastrostomy in amyotrophic lateral sclerosis: patients’ perspectives by Greenaway, L. P., Martin, N. H., Lawrence, V., Janssen, A., Al-Chalabi, A., Leigh, P. N., Goldstein, L. H.

“…The objective was to identify factors associated with decisions made by patients with amyotrophic lateral sclerosis (ALS) to accept or decline non-invasive…”
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Cognitive change in ALS : A prospective study by ABRAHAMS, S, LEIGH, P. N, GOLDSTEIN, L. H

“…To investigate longitudinally the profile of cognitive impairment in nondemented patients with ALS. Twenty nondemented patients with ALS and 18 controls were…”
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Respiratory muscle strength and ventilatory failure in amyotrophic lateral sclerosis by Lyall, R. A., Donaldson, N., Polkey, M. I., Leigh, P. N., Moxham, J.

“…Although ventilatory failure is the most common cause of death in amyotrophic lateral sclerosis (ALS) and measurement of respiratory muscle strength (RMS) has…”
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The effect of noninvasive ventilation on ALS patients and their caregivers by MUSTFA, N, WALSH, E, BRYANT, V, LYALL, R. A, ADDINGTON-HALL, J, GOLDSTEIN, L. H, DONALDSON, N, POLKEY, M. I, MOXHAM, J, LEIGH, P. N

“…Noninvasive ventilation (NIV) reduces mortality and improves some aspects of quality of life (QoL) in ALS. However, concerns remain that progressive disability…”
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Measuring brain stem and cerebellar damage in parkinsonian syndromes using diffusion tensor MRI by BLAIN, C. R. V, BARKER, G. J, LEIGH, P. N, JAROSZ, J. M, COYLE, N. A, LANDAU, S, BROWN, R. G, CHAUDHURI, K. R, SIMMONS, A, JONES, D. K, WILLIAMS, S. C. R

“…To use diffusion tensor MRI to quantify and compare degeneration of the pons and cerebellar peduncles in multiple system atrophy (MSA), progressive…”
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Cortical selective vulnerability in motor neuron disease: a morphometric study by Maekawa, S., Al‐Sarraj, S., Kibble, M., Landau, S., Parnavelas, J., Cotter, D., Everall, I., Leigh, P. N.

“…Neuroimaging and neuropsychological studies have revealed that the primary motor cortex (PMC) and the extramotor cortical areas are functionally abnormal in…”
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SOD1 and cognitive dysfunction in familial amyotrophic lateral sclerosis by Wicks, P., Abrahams, S., Papps, B., Al-Chalabi, A., Shaw, C. E., Leigh, P. N., Goldstein, L. H.

“…Background Sporadic Amyotrophic Lateral Sclerosis (sALS) is associated with frontotemporal dementia (ALS-FTD) or milder deficits of cognitive (predominantly…”
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Predictors of psychological distress in carers of people with amyotrophic lateral sclerosis: a longitudinal study by Goldstein, L H, Atkins, L, Landau, S, Brown, R, Leigh, P N

“…The majority of people providing informal care for people with amyotrophic lateral sclerosis (ALS) are spouses. This prospective study set out to examine…”
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Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype by Lambrechts, D, Poesen, K, Fernández-Santiago, R, Al-Chalabi, A, Del Bo, R, Van Vught, P W J, Khan, S, Marklund, S L, Brockington, A, van Marion, I, Anneser, J, Shaw, C, Ludolph, A C, Leigh, N P, Comi, G P, Gasser, T, Shaw, P J, Morrison, K E, Andersen, P M, Van den Berg, L H, Thijs, V, Siddique, T, Robberecht, W, Carmeliet, P

“…Targeted delivery of the angiogenic factor, vascular endothelial growth factor (VEGF), to motor neurons prolongs survival in rodent models of amyotrophic…”
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Prevalence of depression in amyotrophic lateral sclerosis and other motor disorders by Taylor, L., Wicks, P., Leigh, P. N., Goldstein, L. H.

“…Background:  Research suggests the prevalence of severe depression in ALS is <20%. In contrast, studies have reported that severe depression affects 40–50% of…”
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Differential corticospinal tract degeneration in homozygous ‘D90A’ SOD-1 ALS and sporadic ALS by Blain, C R V, Brunton, S, Williams, V C, Leemans, A, Turner, M R, Andersen, P M, Catani, M, Stanton, B R, Ganesalingham, J, Jones, D K, Williams, S C R, Leigh, P N, Simmons, A

“…BackgroundThe homogeneous genotype and stereotyped phenotype of a unique familial form of amyotrophic lateral sclerosis (ALS) (patients homozygous for…”
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Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS) by Abrahams, S, Leigh, P.N, Harvey, A, Vythelingum, G.N, Grisé, D, Goldstein, L.H

“…Neuropsychological investigations of amyotrophic lateral sclerosis (ALS) patients have revealed variable results on specific tests, despite a similar overall…”
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Volumetric analysis reveals corticospinal tract degeneration and extramotor involvement in ALS by ELLIS, C. M, SUCKLING, J, AMARO, E. JR, BULLMORE, E. T, SIMMONS, A, WILLIAMS, S. C. R, LEIGH, P. N

“…Pathologic changes in the motor cortex and corticospinal tracts in ALS may be reflected by abnormal signal intensities on conventional MRI. The sensitivity of…”
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A prospective study of quality of life in ALS patients treated with noninvasive ventilation by LYALL, R. A, DONALDSON, N, FLEMING, T, WOOD, C, NEWSOM-DAVIS, I, POLKEY, M. I, LEIGH, P. N, MOXHAM, J

“…Noninvasive positive pressure ventilation prolongs survival in ALS but its effect on quality of life is unknown. The authors prospectively studied quality of…”
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Altered patterns of cortical activation in ALS patients during attention and cognitive response inhibition tasks by Goldstein, L. H., Newsom-Davis, I. C., Bryant, V., Brammer, M., Leigh, P. N., Simmons, A.

“…Since amyotrophic lateral sclerosis (ALS) can be accompanied by executive dysfunction, it is hypothesised that ALS patients will have impaired performance on…”
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Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology by Tudor, E.L, Galtrey, C.M, Perkinton, M.S, Lau, K.-F, De Vos, K.J, Mitchell, J.C, Ackerley, S, Hortobágyi, T, Vámos, E, Leigh, P.N, Klasen, C, McLoughlin, D.M, Shaw, C.E, Miller, C.C.J

“…Abstract Cytoplasmic ubiquitin-positive inclusions containing TAR-DNA-binding protein-43 (TDP-43) within motor neurons are the hallmark pathology of sporadic…”
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Cough augmentation in amyotrophic lateral sclerosis by MUSTFA, N, AIELLO, M, LYALL, R. A, NIKOLETOU, D, OLIVIERI, D, LEIGH, P. N, DAVIDSON, A. C, POLKEY, M. I, MOXHAM, J

“…Cough flows and pressures were measured during cough augmentation in healthy subjects and patients with bulbar and nonbulbar amyotrophic lateral sclerosis…”
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