Search Results - "LEI, Qun"
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Hydrodynamics of random-organizing hyperuniform fluids
Published in Proceedings of the National Academy of Sciences - PNAS (12-11-2019)“…Disordered hyperuniform structures are locally random while uniform like crystals at large length scales. Recently, an exotic hyperuniform fluid state was…”
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2
Par complex cluster formation mediated by phase separation
Published in Nature communications (08-05-2020)“…The evolutionarily conserved Par3/Par6/aPKC complex regulates the polarity establishment of diverse cell types and distinct polarity-driven functions. However,…”
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3
Targeting stromal metabolism in pancreatic ductal adenocarcinoma
Published in Nature cell biology (01-04-2024)“…The tumour microenvironment produces nutrients that propel cancer development. New work finds that pancreatic ductal adenocarcinoma cells use one such…”
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Metabolite sensing and signaling in cell metabolism
Published in Signal transduction and targeted therapy (09-11-2018)“…Metabolite sensing is one of the most fundamental biological processes. During evolution, multilayered mechanisms developed to sense fluctuations in a wide…”
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Thermal‐Disrupting Interface Mitigates Intercellular Cohesion Loss for Accurate Topical Antibacterial Therapy
Published in Advanced materials (Weinheim) (01-03-2020)“…Bacterial infections remain a leading threat to global health because of the misuse of antibiotics and the rise in drug‐resistant pathogens. Although several…”
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D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1
Published in Proceedings of the National Academy of Sciences - PNAS (22-02-2022)“…Breast cancer is the most frequent malignancy in women worldwide, and triple-negative breast cancer (TNBC) patients have the worst prognosis and highest risk…”
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BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma
Published in Nature cell biology (01-02-2020)“…Branched-chain amino acid (BCAA) metabolism is potentially linked with development of pancreatic ductal adenocarcinoma (PDAC) 1 - 4 . BCAA transaminase 2…”
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Mechanical Tolerance of Cascade Bioreactions via Adaptive Curvature Engineering for Epidermal Bioelectronics
Published in Advanced materials (Weinheim) (01-06-2020)“…Epidermal bioelectronics that can monitor human health status non‐invasively and in real time are core to wearable healthcare equipment. Achieving mechanically…”
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Nonequilibrium strongly hyperuniform fluids of circle active particles with large local density fluctuations
Published in Science advances (01-01-2019)“…Disordered hyperuniform structures are an exotic state of matter having vanishing long-wavelength density fluctuations similar to perfect crystals but without…”
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10
Metabolic recoding of epigenetics in cancer
Published in Cancer communications (London, England) (21-05-2018)“…Dysregulation of metabolism allows tumor cells to generate needed building blocks as well as to modulate epigenetic marks to support cancer initiation and…”
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The Hippo–YAP pathway: new connections between regulation of organ size and cancer
Published in Current opinion in cell biology (01-12-2008)“…The control of organ size is a basic biological question. In the past several years, the Hippo signaling pathway has been delineated and shown to be crucial in…”
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Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis
Published in EMBO reports (01-12-2018)“…Sirtuins (SIRTs) are a class of lysine deacylases that regulate cellular metabolism and energy homeostasis. Although sirtuins have been proposed to function in…”
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Oxidative Stress Activates SIRT2 to Deacetylate and Stimulate Phosphoglycerate Mutase
Published in Cancer research (Chicago, Ill.) (01-07-2014)“…Glycolytic enzyme phosphoglycerate mutase (PGAM) plays an important role in coordinating energy production with generation of reducing power and the…”
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Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth
Published in Molecular cell (22-08-2013)“…Increased fatty acid synthesis is required to meet the demand for membrane expansion of rapidly growing cells. ATP-citrate lyase (ACLY) is upregulated or…”
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Metabolite sensing and signaling in cancer
Published in The Journal of biological chemistry (14-08-2020)“…Metabolites are not only substrates in metabolic reactions, but also signaling molecules controlling a wide range of cellular processes. Discovery of the…”
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AHCYL1 senses SAH to inhibit autophagy through interaction with PIK3C3 in an MTORC1-independent manner
Published in Autophagy (01-02-2022)“…S-adenosyl-l-homocysteine (SAH), an amino acid derivative, is a key intermediate metabolite in methionine metabolism, which is normally considered as a harmful…”
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Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer
Published in Cancer cell (15-04-2013)“…Tumor cells commonly have increased glucose uptake and lactate accumulation. Lactate is produced from pyruvate by lactate dehydrogenase A (LDH-A), which is…”
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18
Self-Assembled Chiral Photonic Crystals from a Colloidal Helix Racemate
Published in ACS nano (24-07-2018)“…Chiral crystals consisting of microhelices have many optical properties, while presently available fabrication processes limit their large-scale applications…”
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19
A metabolic clue for STING suppression
Published in Trends in cell biology (01-07-2023)“…A recent report by Heath et al. reveals that obesity could impair cancer immunogenicity and foster a type I interferon (IFN-I)-deprived tumor microenvironment…”
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Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer
Published in Molecular cell (17-11-2016)“…Distinctive from their normal counterparts, cancer cells exhibit unique metabolic dependencies on glutamine to fuel anabolic processes. Specifically,…”
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