Search Results - "LEI, Chon Lok"

3D printed biomimetic cochleae and machine learning co-modelling provides clinical informatics for cochlear implant patients by Lei, Iek Man, Jiang, Chen, Lei, Chon Lok, de Rijk, Simone Rosalie, Tam, Yu Chuen, Swords, Chloe, Sutcliffe, Michael P. F., Malliaras, George G., Bance, Manohar, Huang, Yan Yan Shery

“…Cochlear implants restore hearing in patients with severe to profound deafness by delivering electrical stimuli inside the cochlea. Understanding stimulus…”
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Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells by Meng, Ya, Song, Chengcheng, Ren, Zhili, Li, Xiaohong, Yang, Xiangyu, Ai, Nana, Yang, Yang, Wang, Dongjin, Zhan, Meixiao, Wang, Jiaxian, LEI, Chon Lok, Liu, Weiwei, Ge, Wei, Lu, Ligong, Chen, Guokai

“…Nicotinamide, the amide form of Vitamin B3, is a common nutrient supplement that plays important role in human fetal development. Nicotinamide has been widely…”
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Calibration of ionic and cellular cardiac electrophysiology models by Whittaker, Dominic G., Clerx, Michael, Lei, Chon Lok, Christini, David J., Mirams, Gary R.

“…Cardiac electrophysiology models are among the most mature and well‐studied mathematical models of biological systems. This maturity is bringing new challenges…”
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Ten simple rules for training scientists to make better software by Gallagher, Kit, Creswell, Richard, Lambert, Ben, Robinson, Martin, Lok Lei, Chon, Mirams, Gary R, Gavaghan, David J

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A hackable, multi-functional, and modular extrusion 3D printer for soft materials by Lei, Iek Man, Sheng, Yaqi, Lei, Chon Lok, Leow, Cillian, Huang, Yan Yan Shery

“…Three-dimensional (3D) printing has emerged as a powerful tool for material, food, and life science research and development, where the technology’s…”
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Neural Network Differential Equations For Ion Channel Modelling by Lei, Chon Lok, Mirams, Gary R

“…Mathematical models of cardiac ion channels have been widely used to study and predict the behaviour of ion currents. Typically models are built using…”
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Classification of MLH1 Missense VUS Using Protein Structure-Based Deep Learning-Ramachandran Plot-Molecular Dynamics Simulations Method by Tam, Benjamin, Qin, Zixin, Zhao, Bojin, Sinha, Siddharth, Lei, Chon Lok, Wang, San Ming

“…Pathogenic variation in DNA mismatch repair (MMR) gene is associated with Lynch syndrome (LS), an autosomal dominant hereditary cancer. Of the 3798 germline…”
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Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics by Shuttleworth, Joseph G., Lei, Chon Lok, Whittaker, Dominic G., Windley, Monique J., Hill, Adam P., Preston, Simon P., Mirams, Gary R.

“…When using mathematical models to make quantitative predictions for clinical or industrial use, it is important that predictions come with a reliable estimate…”
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Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment by Farm, Hui Jia, Clerx, Michael, Cooper, Fergus, Polonchuk, Liudmila, Wang, Ken, Gavaghan, David J, Lei, Chon Lok

“…Reduction of the rapid delayed rectifier potassium current ( ) drug binding to the human Ether-à-go-go-Related Gene (hERG) channel is a well recognised…”
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Corrigendum: Heterologous vaccination with inactivated vaccine and mRNA vaccine augments antibodies against both spike and nucleocapsid proteins of SARS-CoV-2: a local study in Macao by Ng, Hoi Man, Lei, Chon Lok, Fu, Siyi, Li, Enqin, Leong, Sek In, Nip, Chu Iong, Choi, Nga Man, Lai, Kai Seng, Tang, Xi Jun, Lei, Chon Leng, Xu, Ren-He

“…[This corrects the article DOI: 10.3389/fimmu.2023.1131985.]…”
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Heterologous vaccination with inactivated vaccine and mRNA vaccine augments antibodies against both spike and nucleocapsid proteins of SARS-CoV-2: a local study in Macao by Ng, Hoi Man, Lei, Chon Lok, Fu, Siyi, Li, Enqin, Leong, Sek In, Nip, Chu Iong, Choi, Nga Man, Lai, Kai Seng, Tang, Xi Jun, Lei, Chon Leng, Xu, Ren-He

“…The mRNA vaccines (RVs) can reduce the severity and mortality of severe acute respiratory syndrome coronavirus (SARS-CoV-2). However, almost only the…”
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Integration of deep learning with Ramachandran plot molecular dynamics simulation for genetic variant classification by Tam, Benjamin, Qin, Zixin, Zhao, Bojin, Wang, San Ming, Lei, Chon Lok

“…Functional classification of genetic variants is a key for their clinical applications in patient care. However, abundant variant data generated by the…”
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Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology by Lei, Chon Lok, Wang, Ken, Clerx, Michael, Johnstone, Ross H, Hortigon-Vinagre, Maria P, Zamora, Victor, Allan, Andrew, Smith, Godfrey L, Gavaghan, David J, Mirams, Gary R, Polonchuk, Liudmila

“…Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) have applications in disease modeling, cell therapy, drug screening and personalized…”
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Probabilistic Inference on Noisy Time Series (PINTS) by Clerx, Michael, Robinson, Martin, Lambert, Ben, Lei, Chon Lok, Ghosh, Sanmitra, Mirams, Gary R., Gavaghan, David J.

“…Time series models are ubiquitous in science, arising in any situation where researchers seek to understand how a system’s behaviour changes over time. A key…”
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A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer by Lei, Chon Lok, Fabbri, Alan, Whittaker, Dominic G., Clerx, Michael, Windley, Monique J., Hill, Adam P., Mirams, Gary R., de Boer, Teun P.

“…Automated patch-clamp platforms are widely used and vital tools in both academia and industry to enable high-throughput studies such as drug screening. A leak…”
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The impact of uncertainty in hERG binding mechanism on in silico predictions of drug‐induced proarrhythmic risk by Lei, Chon Lok, Whittaker, Dominic G., Mirams, Gary R.

“…Background and Purpose Drug‐induced reduction of the rapid delayed rectifier potassium current carried by the human Ether‐à‐go‐go‐Related Gene (hERG) channel…”
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Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System by Lei, Chon Lok, Clerx, Michael, Gavaghan, David J., Polonchuk, Liudmila, Mirams, Gary R., Wang, Ken

“…Predicting how pharmaceuticals may affect heart rhythm is a crucial step in drug development and requires a deep understanding of a compound’s action on ion…”
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A Bayesian nonparametric method for detecting rapid changes in disease transmission by Creswell, Richard, Robinson, Martin, Gavaghan, David, Parag, Kris V., Lei, Chon Lok, Lambert, Ben

“…Whether an outbreak of infectious disease is likely to grow or dissipate is determined through the time-varying reproduction number, Rt. Real-time or…”
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Autocorrelated measurement processes and inference for ordinary differential equation models of biological systems by Lambert, Ben, Lei, Chon Lok, Robinson, Martin, Clerx, Michael, Creswell, Richard, Ghosh, Sanmitra, Tavener, Simon, Gavaghan, David J.

“…Ordinary differential equation models are used to describe dynamic processes across biology. To perform likelihood-based parameter inference on these models,…”
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Model-driven optimal experimental design for calibrating cardiac electrophysiology models by Lei, Chon Lok, Clerx, Michael, Gavaghan, David J., Mirams, Gary R.

“…•Current models of cardiac action potentials reflect only an average cell behaviour and ignore cell-to-cell variability.•Optimal single-cell experiments are…”
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