Search Results - "LEHENKARI, Petri P"

Effect of bioactive extruded PLA/HA composite films on focal adhesion formation of preosteoblastic cells by Persson, Maria, Lorite, Gabriela S., Kokkonen, Hanna E., Cho, Sung-Woo, Lehenkari, Petri P., Skrifvars, Mikael, Tuukkanen, Juha

“…•Bioactive PLA/HA composite films were done via melt extrusion.•HA particles enhanced protein adsorption as well as attachment of MC3T3-cells.•HA particles…”
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Tenascin C, Fibronectin, and Tumor-Stroma Ratio in Pancreatic Ductal Adenocarcinoma by Leppänen, Joni, Lindholm, Ville, Isohookana, Joel, Haapasaari, Kirsi-Maria, Karihtala, Peeter, Lehenkari, Petri P, Saarnio, Juha, Kauppila, Joonas H, Karttunen, Tuomo J, Helminen, Olli, Huhta, Heikki

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma with increased expression of tenascin C and fibronectin. Their role and…”
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The Expression of Toll-like Receptors in Normal Human and Murine Gastrointestinal Organs and the Effect of Microbiome and Cancer by Huhta, Heikki, Helminen, Olli, Kauppila, Joonas H., Salo, Tuula, Porvari, Katja, Saarnio, Juha, Lehenkari, Petri P., Karttunen, Tuomo J.

“…Toll-like receptors (TLRs) are innate immune receptors expressed in all parts of the alimentary tract. However, analyses comparing expression in different…”
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A single intra-articular dose of vitamin D analog calcipotriol alleviates synovitis without adverse effects in rats by Huhtakangas, Johanna A, Huovinen, Jere, Laaksonen, Sakari, Voipio, Hanna-Marja, Vuolteenaho, Olli, Finnilä, Mikko A J, Thevenot, Jérôme, Lehenkari, Petri P

“…1,25-dihydroxyvitamin-D3 and its derivatives have shown anti-arthritic and chondroprotective effects in experimental animal models with prophylactic dosing…”
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Nucleic acid-sensing toll-like receptors 3, 7 and 8 in esophageal epithelium, barrett's esophagus, dysplasia and adenocarcinoma by Helminen, Olli, Huhta, Heikki, Lehenkari, Petri P., Saarnio, Juha, Karttunen, Tuomo J., Kauppila, Joonas H.

“…Toll-like receptors (TLRs) are immunological receptors recognizing various microbial and endogenous ligands, such as DNA, RNA, and other microbial and host…”
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Doublecortin-like kinase 1-positive enterocyte - a new cell type in human intestine by Leppänen, Joni, Helminen, Olli, Huhta, Heikki, Kauppila, Joonas H., Miinalainen, Ilkka, Ronkainen, Veli-Pekka, Saarnio, Juha, Lehenkari, Petri P., Karttunen, Tuomo J.

“…Doublecortin‐like kinase 1 (DCLK1) is a microtubule‐associated kinase. In murine intestine, DCLK1 marks tuft cells with characteristic microvilli, features of…”
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Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite by Lehenkari, Petri P, Kellinsalmi, Maarit, Näpänkangas, Juha P, Ylitalo, Kari V, Mönkkönen, Jukka, Rogers, Michael J, Azhayev, Alex, Väänänen, H Kalervo, Hassinen, Ilmo E

“…Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of diseases with excess bone resorption. Recent studies…”
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Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma by Leppänen, Joni, Helminen, Olli, Huhta, Heikki, Kauppila, Joonas H, Isohookana, Joel, Haapasaari, Kirsi-Maria, Parkkila, Seppo, Saarnio, Juha, Lehenkari, Petri P, Karttunen, Tuomo J

“…HIF-1alpha and CAIX proteins are commonly expressed under hypoxic conditions, but other regulatory factors have been described as well. Pancreatic ductal…”
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Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells by Merrell, Melinda A., Wakchoure, Savita, Lehenkari, Petri P., Harris, Kevin W., Selander, Katri S.

“…Bisphosphonates are widely used inhibitors of bone resorption. They also inhibit the growth of various cancer cells in vitro, but the clinical significance of…”
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Osteogenic Differentiation of Human Mesenchymal Stem cells in a 3D Woven Scaffold by Persson, Maria, Lehenkari, Petri P., Berglin, Lena, Turunen, Sanna, Finnilä, Mikko A. J., Risteli, Juha, Skrifvars, Mikael, Tuukkanen, Juha

“…Fiber-based scaffolds produced by textile manufacturing technology offer versatile materials for tissue engineering applications since a wide range of crucial…”
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Toll-like receptors 1, 2, 4 and 6 in esophageal epithelium, Barrett's esophagus, dysplasia and adenocarcinoma by Huhta, Heikki, Helminen, Olli, Lehenkari, Petri P, Saarnio, Juha, Karttunen, Tuomo J, Kauppila, Joonas H

“…Toll-like receptors (TLRs) recognize microbial and endogenous ligands and have already shown to play a role in esophageal cancer. In this study, we evaluated…”
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Differential effects of Ca2+ on bisphosphonate-induced growth inhibition in breast cancer and mesothelioma cells by MERRELL, Melinda A, WAKCHOURE, Savita, ILVESARO, Joanna M, ZINN, Kurt, GEHRS, Bradley, LEHENKARI, Petri P, HARRIS, Kevin W, SELANDER, Katri S

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Increased Toll-like receptor 9 expression indicates adverse prognosis in oesophageal adenocarcinoma by Kauppila, Joonas H, Takala, Heikki, Selander, Katri S, Lehenkari, Petri P, Saarnio, Juha, Karttunen, Tuomo J

“…Kauppila J H, Takala H, Selander K S, Lehenkari P P, Saarnio J & Karttunen T J
(2011) Histopathology59, 643–649 Increased Toll‐like receptor 9 expression…”
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Increased Toll-like receptor 5 expression indicates esophageal columnar dysplasia by Helminen, Olli, Huhta, Heikki, Takala, Heikki, Lehenkari, Petri P., Saarnio, Juha, Kauppila, Joonas H., Karttunen, Tuomo J.

“…Toll-like receptor 5 (TLR5) is an immune receptor, which recognizes bacterial flagellin. Increased expression has been reported in various premalignant and…”
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Intratumoral lactate metabolism in Barrett's esophagus and adenocarcinoma by Huhta, Heikki, Helminen, Olli, Palomäki, Sami, Kauppila, Joonas H, Saarnio, Juha, Lehenkari, Petri P, Karttunen, Tuomo J

“…Monocarboxylate transporters (MCTs) are cell membrane proteins which transport pyruvate, lactate and ketone bodies across the plasma membrane. MCTs are…”
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Nuclear localization of Toll-like receptor 5 in Barrett’s esophagus and esophageal adenocarcinoma is associated with metastatic behavior by Helminen, Olli, Huhta, Heikki, Leppänen, Joni, Kauppila, Joonas H, Takala, Heikki, Lehenkari, Petri P, Saarnio, Juha, Karttunen, Tuomo J

“…Toll-like receptor 5 (TLR5) recognizes bacterial flagellin. Increased cytoplasmic and nuclear expression of some TLRs has been previously reported in dysplasia…”
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Localization of nucleic acid‐sensing toll‐like receptors in human and mouse pancreas by Helminen, Olli, Huhta, Heikki, Kauppila, Joonas H., Lehenkari, Petri P., Saarnio, Juha, Karttunen, Tuomo J.

“…Nucleic acid‐sensing toll‐like receptors (TLRs) (3, 7, 8, 9) have a role both in antiviral innate immunity and in autoimmune disorders. We assessed the…”
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Toll‐like receptors 2, 4 and 9 and hypoxia markers HIF‐1alpha and CAIX in pancreatic intraepithelial neoplasia by Leppänen, Joni, Helminen, Olli, Huhta, Heikki, Kauppila, Joonas H., Isohookana, Joel, Haapasaari, Kirsi‐Maria, Karihtala, Peeter, Parkkila, Seppo, Saarnio, Juha, Lehenkari, Petri P., Karttunen, Tuomo J.

“…Pancreatic cancer arises from precursor lesions called pancreatic intraepithelial neoplasia (PanIN) characterized by inflammatory microenvironment. In…”
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Telomeric G-quadruplex-forming DNA fragments induce TLR9-mediated and LL-37-regulated invasion in breast cancer cells in vitro by Tuomela, Johanna M., Sandholm, Jouko A., Kaakinen, Mika, Hayden, Katherine L., Haapasaari, Kirsi-Maria, Jukkola-Vuorinen, Arja, Kauppila, Joonas H., Lehenkari, Petri P., Harris, Kevin W., Graves, David E., Selander, Katri S.

“…Toll-like receptor 9 (TLR9) is a cellular DNA-receptor widely expressed in cancers. We previously showed that synthetic and self-derived DNA fragments induce…”
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Short DNA sequences and bacterial DNA induce esophageal, gastric, and colorectal cancer cell invasion by Kauppila, Joonas H., Karttunen, Tuomo J., Saarnio, Juha, Nyberg, Pia, Salo, Tuula, Graves, David E., Lehenkari, Petri P., Selander, Katri S.

“…Toll‐like receptor 9 (TLR9) recognizes both bacterial and self‐DNA and it is abundantly expressed in the gastrointestinal tract. In this study, we investigated…”
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