Search Results - "LEGOUILL, Steven"

small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma by Podar, Klaus, Tonon, Giovanni, Sattler, Martin, Tai, Yu-Tzu, LeGouill, Steven, Yasui, Hiroshi, Ishitsuka, Kenji, Kumar, Shaji, Kumar, Rakesh, Pandite, Lini N, Hideshima, Teru, Chauhan, Dharminder, Anderson, Kenneth C

“…A critical role for vascular endothelial factor (VEGF) has been demonstrated in multiple myeloma (MM) pathogenesis. Here, we characterized the effect of the…”
Get full text

Bureaucracy is strangling clinical research by Rule, Simon, LeGouill, Steven

“…Legislation has not appreciably changed since 2001, but those administering it or working within it are producing more and more bureaucratic demands…”
Get full text

Canonical Nuclear Factor κB Pathway Inhibition Blocks Myeloma Cell Growth and Induces Apoptosis in Strong Synergy with TRAIL by ROMAGNOLI, Mathilde, DESPLANQUES, Gregoire, MAÏGA, Sophie, LEGOUILL, Steven, DREANO, Michel, BATAILLE, Régis, BARILLA-NION, Sophie

“…Purpose: Intrinsic activation of nuclear factor κB (NF-κB) characterizes various hematologic malignancies. In this study, we specifically address the role of…”
Get full text

Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial by Horwitz, Steven, O'Connor, Owen A, Advani, Ranjana, Rossi, Giuseppe, Kim, Won Seog, Illés, Árpád, Tobinai, Kensei, Yeh, Su-Peng, Shustov, Andrei, Yuen, Sam, Iyer, Swaminathan, Hua, Zhaowei, Little, Meredith, Rao, Shangbang, Woolery, Joseph, Manley, Thomas, Aboulafia, David, Bartlett, Nancy, Belada, David, Yehuda, Dina Ben, Benedetti, Fabio, Bordessoule, Dominique, Chang, Hung, Cheong, June Weon, Choi, Ilseung, Colita, Andrei, Congui, Angela Giovanna, Dang, Nam, Davison, Kelly, de Guibert, Sophie, Delwail, Vincent, di Raimondo, Francesco, Do, Young Rok, Domingo, Eva, Douvas, Michael, Dreyling, Martin, Fay, Keith, Ferrero, Silvia Fernandez, Flinn, Ian Winchester, Forero-Torres, Andres, Friedberg, Jonathan, Fukuhara, Noriko, Garcia-Marco, Jose, Cruz, Jorge Gayoso, Gurion, Ronit, Christensen, Jacob Haaber, Hajek, Roman, Hatake, Kiyohiko, Horowitz, Netanel, Illes, Arpad, Illidge, Tim, Ishizawa, Kenichi, Islas-Ohlmayer, Miguel, Jacobsen, Eric, Janakiram, Murali, Jurczak, Wojciech, Kaminski, Mark, Kato, Koji, Kim, Won Seog, Iyer, Swaminathan, Kuo, Ching-Yuan, Lazaroiu, Mihaela Cornelia, Lee, Jong-Seok, Lennard, Anne, LaRosee, Paul, Levi, Itai, Link, Brian, Maisonneuve, Herve, Maruyama, Dai, Mayer, Jiri, Mocikova, Heidi, Morra, Enrica, Morschhauser, Franck, Munoz, Javier, Nagai, Hirokazu, Opat, Stephen, Pettengell, Ruth, Pezzutto, Antonio, Pfreundschuh, Michael, Pro, Barbara, Reyes, Ruben, Izquierdo, Antonia Rodriguez, Rossi, Giuseppe, Ruan, Jia, Salles, Gilles, Sarriera, Jose, Shibayama, Hirohiko, Shustov, Andrei, Suh, Cheolwon, Sureda, Anna, Tanimoto, Mitsune, Taniwaki, Masafumi, Tilly, Herve, Tsukamoto, Norifumi, Wilhelm, Martin, Yamamoto, Kazuhito, Yeh, Su-Peng, Yun, Hwan Jung, Zain, Jasmine, Zinzani, Pier Luigi

“…Based on the encouraging activity and manageable safety profile observed in a phase 1 study, the ECHELON-2 trial was initiated to compare the efficacy and…”
Get full text

Characterization of peripheral blood stem cell grafts mobilized by granulocyte colony-stimulating factor and plerixafor compared with granulocyte colony-stimulating factor alone by Gaugler, Beatrice, Arbez, Jessy, Legouill, Steven, Tiberghien, Pierre, Moreau, Philippe, Derenne, Sophie, Saas, Philippe, Mohty, Mohamad

“…Abstract Background aims This study aimed to characterize the immune effectors contained in apheresis samples obtained from patients with grafts mobilized with…”
Get full text

The European Hematology Association Roadmap for European Hematology Research: a consensus document by Engert, Andreas, Balduini, Carlo, Brand, Anneke, Coiffier, Bertrand, Cordonnier, Catherine, Döhner, Hartmut, de Wit, Thom Duyvené, Eichinger, Sabine, Fibbe, Willem, Green, Tony, de Haas, Fleur, Iolascon, Achille, Jaffredo, Thierry, Rodeghiero, Francesco, Salles, Gilles, Schuringa, Jan Jacob

“…The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders…”
Get full text

Lenalidomide is safe and active in Waldenström macroglobulinemia by Fouquet, Guillemette, Guidez, Stéphanie, Petillon, Marie‐Odile, Louni, Chanaz, Ohyba, Bella, Dib, Malek, Poulain, Stéphanie, Herbaux, Charles, Martin, Audrey, Thielemans, Béatrice, Brice, Pauline, Choquet, Sylvain, Bakala, Jana, Bories, Claire, Demarquette, Hélène, Nudel, Morgane, Tournilhac, Olivier, Arnulf, Bertrand, LeGouill, Steven, Morel, Pierre, Banos, Anne, Karlin, Lionel, Salles, Gilles, Leblond, Véronique, Leleu, Xavier

“…Lenalidomide is manageable and effective in multiple myeloma, particularly in elderly patients. Surprisingly, the combination of lenalidomide with rituximab…”
Get full text

Lenalidomide Is Safe and Active in Waldenstrom Macroglobulinemia (WM) by Leleu, Xavier, Legouill, Steven, Louni, Chanaz, Lionel, Karlin, Banos, Anne, Arnulf, Bertrand, Petillon, Marie Odile, Tournilhac, Olivier, Morel, Pierre, Leblond, Veronique

“…Background. Lenalidomide has proved safe and effective in multiple myeloma (MM), particularly in elderly patients. Furthermore, it has been showed that…”
Get full text

Upfront Allogeneic-Stem Cell Transplantation for Patients with Non-Localized Untreated Peripheral T-Cell Lymphoma: An Intention-to-Treat Analysis from a Single Center by Loirat, Marion, Chevalier, Patrice, Leux, Christophe, Moreau, Anne, Bossard, Céline, Guillaume, Thierry, Gastinne, Thomas, Delaunay, Jacques, Blin, Nicolas, Mahe, Beatrice, Dubruille, Viviane, Augel-Meunier, Karine, Peterlin, Pierre, Maisonneuve, Herve, Morineau, Nadine, Moreau, Philippe, Jardel, Henry, Mohty, Mohamad, Moreau, Philippe, Legouill, Steven

“…Background. Peripheral T-cell lymphomas (PTCLs) are rare and heterogeneous diseases with dismal outcome when treated with chemotherapy alone. Because…”
Get full text

Relative Stability Of Plasma Cells Immunophenotype In Multiple Myeloma Over Time by Tessoulin, Benoit, Legouill, Steven, Eveillard, Marion, Robillard, Nelly, Wuilleme, Soraya, Gastinne, Thomas, Touzeau, Cyrille, Pellat-Deceunynck, Catherine, Bene, Marie C, Moreau, Philippe

“…Emerging evidence indicates that multiple myeloma (MM) can follow a number of evolutionary pathways over a patient's disease course. Recently, genomic data…”
Get full text

Outcome After 9/10 Mismatched Unrelated Donor or Cord Blood Cells Allogeneic Stem Cell Transplantation (allo-SCT) in the Setting of Reduced-Intensity Conditioning (RIC) by Malard, Florent, Furst, Sabine, Loirat, Marion, Chevallier, Patrice, El-Cheikh, Jean, Guillaume, Thierry, Delaunay, Jacques, Legouill, Steven, Moreau, Philippe, Blaise, Didier, Mohty, Mohamad

“…Abstract 956 Unrelated umbilical cord blood cells (UCB) have emerged as an alternative stem cell source for allo-SCT in patients who lack a matched-related or…”
Get full text

Fludarabine, IV Busulfan and Antithymocyte Globulins-Based Reduced-Toxicity Conditioning Regimen Prior to Allogeneic Stem Cell Transplantation (allo-SCT): Results of a Multicenter Prospective Trial by Mohty, Mohamad, Blaise, Didier, Labopin, Myriam, Milpied, Noel, Furst, Sabine, Tabrizi, Reza, Guillaume, Thierry, Vigouroux, Stephane, El-Cheikh, Jean, Delaunay, Jacques, Legouill, Steven, Moreau, Philippe, Chevallier, Patrice

“…Abstract 1926 In the last decade, the so-called reduced intensity or reduced-toxicity conditioning (RTC) regimens prior to allo-SCT have emerged as an…”
Get full text

Lenalidomide is safe and active in W aldenström macroglobulinemia by Fouquet, Guillemette, Guidez, Stéphanie, Petillon, Marie‐Odile, Louni, Chanaz, Ohyba, Bella, Dib, Malek, Poulain, Stéphanie, Herbaux, Charles, Martin, Audrey, Thielemans, Béatrice, Brice, Pauline, Choquet, Sylvain, Bakala, Jana, Bories, Claire, Demarquette, Hélène, Nudel, Morgane, Tournilhac, Olivier, Arnulf, Bertrand, LeGouill, Steven, Morel, Pierre, Banos, Anne, Karlin, Lionel, Salles, Gilles, Leblond, Véronique, Leleu, Xavier

“…Lenalidomide is manageable and effective in multiple myeloma, particularly in elderly patients. Surprisingly, the combination of lenalidomide with rituximab…”
Get full text

No Benefit of First-Line Rituximab (R) - High-Dose Therapy (R-HDT) Over R-CHOP14 for Young Adults with Diffuse Large B-Cell Lymphoma. Preliminary Results of the GOELAMS 075 Prospective Multicentre Randomized Trial by Milpied, Noel-Jean, Legouill, Steven, Lamy, Thierry, Delwail, Vincent, Gressin, Remy, Guyotat, Denis, Damaj, Gandhi, Foussard, Charles, Quittet, Philippe, Maisonneuve, Herve, Deconinck, Eric, Dreyfus, Francois, Gyan, Emmanuel, Sutton, Laurent, Morineau, Nadine, Alexis, Magda, Perry, Frederic, Sauvezie, Mathieu

“…Abstract 685 In 2004 we have shown that first-line intensive therapy plus transplantation of autologous hematopoietic stem cells lead to an improved EFS and OS…”
Get full text

Canonical nuclear factor kappaB pathway inhibition blocks myeloma cell growth and induces apoptosis in strong synergy with TRAIL by Romagnoli, Mathilde, Desplanques, Grégoire, Maïga, Sophie, Legouill, Steven, Dreano, Michel, Bataille, Régis, Barillé-Nion, Sophie

“…Intrinsic activation of nuclear factor kappaB (NF-kappaB) characterizes various hematologic malignancies. In this study, we specifically address the role of…”
Get full text

Late Relapse of Localized High-Grade Non-Hodgkin's Lymphoma: Clinical and Biological Features by Damaj, Gandhi, Bernard, Marc, Legouill, Steven, Cartron, Guillaume, Le Mevel, Annie, Dubus, Céline, Berthou, Christian, Colombat, Philippe, Milpied, Noel, Marolleau, Jean Pierre, Lamy, Thierry

“…Diffuse large cell lymphoma is the most common non-Hodgkin Lymphoma (NHL) that ranks among the most curable diffuse intermediate grade lymphomas. Most…”
Get full text

Impact of Cyclosporine a (CsA) Concentration on the Incidence of Severe Acute Graft-Versus-Host Disease (GVHD) after Allogeneic Stem Cell Transplantation (allo-SCT) by Mallard, Florent, Brissot, Eolia, Chevallier, Patrice, Guillaume, Thierry, Delaunay, Jacques, Ayari, Sameh, Dubruille, Viviane, Legouill, Steven, Mahe, Beatrice, Gastinne, Thomas, Blin, Nicolas, Saulquin, Beatrice, Moreau, Philippe, Harousseau, Jean-Luc, Mohty, Mohamad

“…CsA is widely used as the backbone immunosuppressive agent for GVHD prevention after allo-SCT. Previous studies have demonstrated that the immunosuppressive…”
Get full text

The Small-Molecule VEGF-Receptor Inhibitor Pazopanib (GW786034B) Targets Both Tumor and Endothelial Cells in Multiple Myeloma by Podar, Klaus, Tonon, Giovanni, Sattler, Martin, Tai, Yu-Tzu, LeGouill, Steven, Yasui, Hiroshi, Ishitsuka, Kenji, Kumar, Rakesh, Pandite, Lini N., Hideshima, Teru, Chauhan, Dharminder, Anderson, Kenneth C.

“…A critical role for vascular endothelial factor (VEGF) has been demonstrated in multiple myeloma (MM) pathogenesis. Here we characterized the effect of the…”
Get full text

The JAK Inhibitor INCB20 Induces Antiproliferative and Apoptotic Effects in Human Myeloma Cells In Vitro and In Vivo by Burger, Renate, Legouill, Steven, Tai, Yu-Tzu, Shringarpure, Reshma, Podar, Klaus, Catley, Laurence, Tassone, Pierfrancesco, Neri, Paola, Hideshima, Teru, Chauhan, Dharminder, Caulder, Eian, Vaddi, Kris, Neilan, Claire L., Gramatzki, Martin, Fridman, Jordan S., Anderson, Kenneth C.

“…In multiple myeloma (MM), IL-6 plays an important role for tumor cell growth, survival, and drug resistance. Janus kinases (JAKs) are protein tyrosine kinases…”
Get full text

Up-Regulation of c-Jun contributes to the Induction of Apoptosis by Adaphostin in Human Multiple Myeloma Cells by Podar, Klaus, Tonon, Giovanni, Raab, Marc S., Sattler, Martin, Abtahi, Dean, Tai, Yu-Tzu, LeGouill, Steven, Ishitsuka, Kenji, Yasui, Hiroshi, Depinho, Ron A., Hideshima, Teru, Chauhan, Dharminder, Anderson, Kenneth C.

“…Adaphostin (NCI, Bethesda, MD) has been examined as an alternative to the 2-phenylaminopyrimidine derivate imatinib mesylate, with remarkable efficacy in the…”
Get full text