Search Results - "LEFF, M. A"

Molecular Genetics and Epidemiology of the NAT1 and NAT2 Acetylation Polymorphisms by HEIN, D. W, DOLL, M. A, FRETLAND, A. J, LEFF, M. A, WEBB, S. J, XIAO, G. H, DEVANABOYINA, U.-S, NANGJU, N. A, YI FENG

“…The focus of this review is the molecular genetics, including consensus NAT1 and NAT2 nomenclature, and cancer epidemiology of the NAT1 and NAT2 acetylation…”
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N-Acetyltransferase-2 Genetic Polymorphism, Well-done Meat Intake, and Breast Cancer Risk among Postmenopausal Women by DEITZ, Anne C, ZHENG, Wei, LEFF, Matthew A, GROSS, Myron, WEN, Wan-Qing, DOLL, Mark A, XIAO, Gong H, FOLSOM, Aaron R, HEIN, David W

“…Heterocyclic amines found in well-done meat require host-mediated metabolic activation before initiating DNA mutations and tumors in target organs. Polymorphic…”
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Novel Human N-Acetyltransferase 2 Alleles That Differ in Mechanism for Slow Acetylator Phenotype by Leff, M A, Fretland, A J, Doll, M A, Hein, D W

“…Three novel human NAT2 alleles ( NAT2*5D , NAT2*6D , and NAT2*14G ) were identified and characterized in a yeast expression system. The common rapid ( NAT2*4 )…”
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Butyrate-induced reversal of dexamethasone resistance in autonomous rat Nb2 lymphoma cells by Buckley, A R, Krumenacker, J S, Buckley, D J, Leff, M A, Magnuson, N S, Reed, J C, Miyashita, T, de Jong, G, Gout, P W

“…The parental rat Nb2 lymphoma is a prolactin (PRL)-dependent T cell line. Exposure of a PRL-independent subline, Nb2-SFJCD1, to sodium butyrate (NaBT) causes…”
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Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms by FRETLAND, Adrian J, LEFF, Matthew A, DOLL, Mark A, HEIN, David W

“…N-Acetyltransferase 2 (NAT2) catalyses the activation and/or deactivation of a variety of aromatic amine drugs and carcinogens. Polymorphisms in the…”
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Rapid modulation of the apoptosis regulatory genes, bcl-2 and bax by prolactin in rat Nb2 lymphoma cells by Leff, M A, Buckley, D J, Krumenacker, J S, Reed, J C, Miyashita, T, Buckley, A R

“…The Nb2 rat lymphoma represents a useful model for investigation of molecular events coupled to PRL-induced proliferation. Moreover, recent evidence has also…”
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Prostate-specific human N-acetyltransferase 2 (NAT2) expression in the mouse by Leff, M A, Epstein, P N, Doll, M A, Fretland, A J, Devanaboyina, U S, Rustan, T D, Hein, D W

“…2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic amine identified in the human diet and in cigarette smoke that produces prostate…”
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Rapid induction of pim-1 expression by prolactin and interleukin-2 in rat Nb2 lymphoma cells by Buckley, A R, Buckley, D J, Leff, M A, Hoover, D S, Magnuson, N S

“…The lactogen-dependent Nb2 lymphoma line (Nb2-11) represents a useful pre-T cell model for investigation of early molecular events coupled to PRL-stimulated…”
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Prolactin-regulated apoptosis of Nb2 lymphoma cells: pim-1, bcl-2, and bax expression by Krumenacker, J S, Buckley, D J, Leff, M A, McCormack, J T, de Jong, G, Gout, P W, Reed, J C, Miyashita, T, Magnuson, N S, Buckley, A R

“…Lactogen-dependent Nb2 lymphoma cells, widely employed for studying prolactin (PRL) mitogenic mechanisms, are also useful for investigations of apoptosis in…”
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Oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) yields PhiP-DNA adducts but not tumors in male Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus by FRETLAND, Adrian J, DEVANABOYINA, Uday S, YI FENG, LEFF, Matthew A, XIAO, Gong H, WEBB, Stephanie J, HEIN, David W

“…2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic amine carcinogen present in well-done meat. PhIP must undergo host-mediated…”
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The State Mental Hospital: A Local Health Department's Role by Anthony, Nicholas, Leff, Arnold M

“…The publicizing of the abysmal conditions in state mental institutions and the problems precipitated by their deinstitutionalization programs, have challenged…”
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Alterations in pim-1 and c-myc expression associated with sodium butyrate-induced growth factor dependency in autonomous rat Nb2 lymphoma cells by BUCKLEY, A. R, LEFF, M. A, BUCKLEY, D. J, MAGNUSON, N. S, DE JONG, G, GOUT, P. W

“…Whereas Nb2-11 lymphoma cells critically require prolactin (PRL) for growth, Nb2-SFJCD1 subline cells are growth factor independent. Treatment with the…”
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Immunization: public health programming through law enforcement by Anthony, N, Reed, M, Leff, A M, Huffer, J, Stephens, B

“…The pre-inoculation program review of the school immunization records in fall, 1974 found that only 60 per cent of the 63,000 children in the Cincinnati…”
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DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by Fretland, Adrian J., Devanaboyina, Uday S., Nangju, Norma A., Leff, Matthew A., Xiao, Gong H., Webb, Stephanie J., Doll, Mark A., Hein, David W.

“…N‐acetyltransferases (EC 2.3.1.5) catalyze O‐acetylation of heterocyclic amine carcinogens to DNA‐reactive electrophiles that bind and mutate DNA. An…”
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Medical management of narcotic-addicted physicians: a practical review by Leff, A M

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Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1 by FRETLAND, Adrian J, DOLL, Mark A, LEFF, Matthew A, HEIN, David W

“…N-acetyltransferase 1 (NAT1) catalyses the activation and/or deactivation of aromatic and heterocyclic amine carcinogens. A genetic polymorphism in NAT1 is…”
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Rapid modulation of the apoptosis regulatory genes, bcl-2 and bax by prolactin in rat Nb2 lymphoma cells by Leff, M A, Buckley, D J, Krumenacker, J S, Reed, J C, Miyashita, T, Buckley, A R

“…The Nb2 rat lymphoma represents a useful model for investigation of molecular events coupled to PRL-induced proliferation. Moreover, recent evidence has also…”
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Physician drug addiction a challenge to medical educators by Borsay, M A, Leff, A M

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Private Practice in the Public Sector: A Unique Relationship among Local Government, Physicians, and Health Care Consumers in Cincinnati by Leff, Arnold M., Berger, Roger, Lotspeich, Edgar, Dillard, Charles O.

“…Because of health care inequities that still persist under federal and state sponsorship plans, many local government agencies are starting to consider ways of…”
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Tube Feeding in Dementia: How Incentives Undermine Health Care Quality and Patient Safety by Finucane, Thomas E., MD, Christmas, Colleen, MD, Leff, Bruce A., MD

“…For nursing home residents with advanced dementia, very little evidence is available to show clinical benefit from enteral tube feeding. Although no randomized…”
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