Search Results - "LEES, K.R."

THRIVE Score Predicts Ischemic Stroke Outcomes and Thrombolytic Hemorrhage Risk in VISTA by Flint, Alexander C, Faigeles, Bonnie S, Cullen, Sean P, Kamel, Hooman, Rao, Vivek A, Gupta, Rishi, Smith, Wade S, Bath, Philip M, Donnan, Geoffrey A, Lees, K.R, Alexandrov, A, Bath, P.M, Bluhmki, E, Bornstein, N, Claesson, L, Davis, S.M, Donnan, G, Diener, H.C, Fisher, M, Gregson, B, Grotta, J, Hacke, W, Hennerici, M.G, Hommel, M, Kaste, M, Lyden, P, Marler, J, Muir, K, Sacco, R, Shuaib, A, Teal, P, Wahlgren, N.G, Warach, S, Weimar, C

“…BACKGROUND AND PURPOSE—In previous studies, the Totaled Health Risks in Vascular Events (THRIVE) score has shown broad utility, allowing prediction of clinical…”
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Antiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional Outcomes by Murthy, Santosh B, Biffi, Alessandro, Falcone, Guido J, Sansing, Lauren H, Torres Lopez, Victor, Navi, Babak B, Roh, David J, Mandava, Pitchaiah, Hanley, Daniel F, Ziai, Wendy C, Kamel, Hooman, Rosand, Jonathan, Sheth, Kevin N, Butcher, K, Davis, S, Gregson, B, Lees, K.R, Lyden, P, Mayer, S, Muir, K, Steiner, T

“…BACKGROUND AND PURPOSE—Observational data suggest that antiplatelet therapy after intracerebral hemorrhage (ICH) alleviates thromboembolic risk without…”
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β-Blockers, Pneumonia, and Outcome After Ischemic Stroke: Evidence From Virtual International Stroke Trials Archive by Sykora, Marek, Siarnik, Pavel, Diedler, Jennifer, Lees, K.R, Alexandrov, A, Bath, P.M, Bluhmki, E, Bornstein, N, Claesson, L, Davis, S.M, Donnan, G, Diener, H C, Fisher, M, Ginsberg, M, Gregson, B, Grotta, J, Hacke, W, Hennerici, M.G, Hommel, M, Kaste, M, Lyden, P, Marler, J, Muir, K, Sacco, R, Shuaib, A, Teal, P, Wahlgren, N.G, Warach, S, Weimar, C

“…BACKGROUND AND PURPOSE—Increased sympathetic drive after stroke is involved in the pathophysiology of several complications including poststroke…”
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Tolerability of NXY-059 at higher target concentrations in patients with acute Stroke by LEES, K. R, BARER, D, FORD, G. A, HACKE, W, KOSTULAS, V, SHARMA, A. K, ODERGREN, T

“…NXY-059 is a nitrone-based free radical-trapping agent in development for acute stroke. In patients with acute stroke, NXY-059 is well tolerated at…”
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The Incidence and Associated Factors of Early Neurological Deterioration After Thrombolysis: Results From SITS Registry by Yu, Wai M., Abdul-Rahim, Azmil H., Cameron, Alan C., Kõrv, Janika, Sevcik, Petr, Toni, Danilo, Lees, Kennedy R.

“…BACKGROUND AND PURPOSE:Early neurological deterioration (END) after stroke onset may predict severe outcomes. Estimated rates of END after intravenous…”
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Glycine antagonist (GV150526) in acute stroke: a multicentre, double-blind placebo-controlled phase II trial by Lees, K R, Lavelle, J F, Cunha, L, Diener, H C, Sanders, E A, Tack, P, Wester, P

“…GV150526 is a novel glycine antagonist at the NMDA receptor complex. It is a potent neuroprotective agent in animal models of acute stroke including permanent…”
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Temporal Profile of Pneumonia After Stroke by de Jonge, Jeroen C., van de Beek, Diederik, Lyden, Patrick, Brady, Marian C., Bath, Philip M., van der Worp, H. Bart

“…The occurrence of pneumonia after stroke is associated with a higher risk of poor outcome or death. We assessed the temporal profile of pneumonia after stroke…”
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Validating and comparing stroke prognosis scales by Quinn, Terence J, Singh, Sarjit, Lees, Kennedy R, Bath, Philip M, Myint, Phyo K

“…OBJECTIVE:To compare the prognostic accuracy of various acute stroke prognostic scales using a large, independent, clinical trials dataset. METHODS:We directly…”
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Incidence and Outcomes of Patients With Early Cardiac Complications After Intracerebral Hemorrhage: A Report From VISTA by Ishiguchi, Hironori, Huang, Bi, El-Bouri, Wahbi K, Dawson, Jesse, Lip, Gregory Y H, Abdul-Rahim, Azmil H

“…The incidence and outcomes of early cardiac complications in patients with intracerebral hemorrhage (ICH) are poorly understood. These cardiac complications…”
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METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research by Dichgans, Martin, Wardlaw, Joanna, Smith, Eric, Zietemann, Vera, Seshadri, Sudha, Sachdev, Perminder, Biessels, Geert Jan, Fazekas, Franz, Benavente, Oscar, Pantoni, Leonardo, De Leeuw, Frank-Erik, Norrving, Bo, Matthews, Paul, Chen, Christopher, Mok, Vincent, Düring, Marco, Whiteley, Will, Shuler, Kirsten, Alonso, Alvaro, Black, Sandra E, Brayne, Carol, Chabriat, Hugues, Cordonnier, Charlotte, Doubal, Fergus, Duzel, Emrah, Ewers, Michael, Frayne, Richard, Hachinski, Vladimir, Ikram, Mohammad Arfan, Jessen, Frank, Jouvent, Eric, Linn, Jennifer, O'Brien, John, van Oostenbrugge, Robert, Malik, Rainer, Mazoyer, Bernard, Schmidt, Reinhold, Sposato, Luciano A, Stephan, Blossom, Swartz, Richard H, Vernooij, Meike, Viswanathan, Anand, Werring, David, Abe, Koji, Allan, Louise, Arba, Francesco, Diener, H.-C, Davis, S, Hankey, G, Lees, K.R, Ovbiagele, B, Weir, C, Bae, Hee-Joon, Bath, Philip MW, Bordet, Regis, Breteler, Monique, Choi, Seong, Deary, Ian, DeCarli, Charles, Ebmeier, Klaus, Feng, Lei, Greenberg, Steven M, Ihara, Masafumi, Kalaria, Rajesh, Kim, SanYun, Lim, Jae-Sung, Lindley, Richard I, Mead, Gillian, Murray, Alison, Quinn, Terry, Ritchie, Craig, Sacco, Ralph, Al-Shahi Salman, Rustam, Sprigg, Nikola, Sudlow, Cathie, Thomas, Alan, van Boxtel, Martin, van der Grond, Jeroen, van der Lugt, Aad, Yang, Yuan-Han

“…Abstract Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular…”
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Prevalence, Trajectory, and Predictors of Poststroke Pain: Retrospective Analysis of Pooled Clinical Trial Data Set by Ali, Myzoon, Tibble, Holly, Brady, Marian C, Quinn, Terence J, Sunnerhagen, Katharina S, Venketasubramanian, Narayanaswamy, Shuaib, Ashfaq, Pandyan, Anand, Mead, Gillian

“…Poststroke pain remains underdiagnosed and inadequately managed. To inform the optimum time to initiate interventions, we examined prevalence, trajectory, and…”
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Interatrial septal abnormalities and stroke: A meta-analysis of case-control studies by OVERELL, J. R, BONE, I, LEES, K. R

“…To examine the association between patent foramen ovale (PFO) and atrial septal aneurysm (ASA) and stroke. Data from case-control studies that examined the…”
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Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus by MISHRA, N. K, AHMED, N, DAVALOS, A, IVERSEN, H. K, MELO, T, SOINNE, L, WAHLGREN, N, LEES, K. R

“…Patients with concomitant diabetes mellitus (DM) and prior stroke (PS) were excluded from European approval of alteplase in stroke. We examined the influence…”
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Statins and risk of poststroke hemorrhagic complications by Scheitz, Jan F, MacIsaac, Rachael L, Abdul-Rahim, Azmil H, Siegerink, Bob, Bath, Philip M, Endres, Matthias, Lees, Kennedy R, Nolte, Christian H

“…OBJECTIVE:To assess whether statin treatment before or after acute ischemic stroke (AIS) affects the risk of acute intracerebral hemorrhage (ICH), postacute…”
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Hyperglycaemia in acute stroke--to treat or not to treat by Quinn, T J, Lees, K R

“…Diabetes is common amongst patients with stroke and is associated with poorer outcome. Post-stroke hyperglycaemia is also recognised in up to half of the…”
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A randomised, controlled pilot study to investigate the potential benefit of intervention with insulin in hyperglycaemic acute ischaemic stroke patients by Walters, M R, Weir, C J, Lees, K R

“…Hyperglycaemia on presentation with acute ischaemic stroke (AIS) is associated with poor outcome, but intervention is unproven. We investigated the safety and…”
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Preoperative risk factors in 10 418 patients with prior myocardial infarction and 5241 patients with prior unstable angina undergoing elective coronary artery bypass graft surgery by Bottle, A, Mozid, A, Grocott, H.P., Walters, M.R., Lees, K.R., Aylin, P, Sanders, R.D.

“…The EuroSCORE associates coronary artery bypass graft (CABG) surgery with higher perioperative risk in the first 3 months after a myocardial infarction (MI)…”
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A body-worn gait analysis system for evaluating hemiplegic gait by Granat, M.H., Maxwell, D.J., Bosch, C.J., Ferguson, A.C.b., Lees, K.R., Barbenel, J.C.

“…This paper describes a system for measuring the temporal parameters of hemiplegic gait. This system uses shoe insoles with sensors, acting as switches, placed…”
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NXY-059 for acute ischemic stroke by Lees, K.R., Zivin, J.A., Ashwood, T.

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NXY-059 for acute ischemic stroke by Lees, K.R., Zivin, J.A., Ashwood, T.

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