Search Results - "LEES, K. R"

Functional outcome measures in contemporary stroke trials by Quinn, T. J., Dawson, J., Walters, M. R., Lees, K. R.

“…Various instruments are used to describe poststroke functional outcome, with limited consensus as to optimal end-point for clinical trial use. Many of the…”
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Interatrial septal abnormalities and stroke: A meta-analysis of case-control studies by OVERELL, J. R, BONE, I, LEES, K. R

“…To examine the association between patent foramen ovale (PFO) and atrial septal aneurysm (ASA) and stroke. Data from case-control studies that examined the…”
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Safety and outcomes of routine endovascular thrombectomy in large artery occlusion recorded in the SITS Register: An observational study by Ahmed, N., Mazya, M., Nunes, A. P., Moreira, T., Ollikainen, J. P., Escudero‐Martinez, I., Bigliardi, G., Dorado, L., Dávalos, A., Egido, J. A., Tassi, R., Strbian, D., Zini, A., Nichelli, P., Herzig, R., Jurák, L., Hurtikova, E., Tsivgoulis, G., Peeters, A., Nevšímalová, M., Brozman, M., Cavallo, R., Lees, K. R, Mikulik, R., Toni, D., Holmin, S.

“…Background and objective We aimed to evaluate the safety and outcomes of thrombectomy in anterior circulation acute ischaemic stroke recorded in the…”
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Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus by MISHRA, N. K, AHMED, N, DAVALOS, A, IVERSEN, H. K, MELO, T, SOINNE, L, WAHLGREN, N, LEES, K. R

“…Patients with concomitant diabetes mellitus (DM) and prior stroke (PS) were excluded from European approval of alteplase in stroke. We examined the influence…”
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Determinants of post‐stroke cognitive impairment: analysis from VISTA by Arba, F., Quinn, T., Hankey, G. J., Inzitari, D., Ali, M., Lees, K. R., Diener, H.‐C., Davis, S., Hankey, G., Ovbiagele, B., Weir, C.

“…Background Post‐stroke cognitive impairment (PSCI) occurs commonly and is linked with development of dementia. We investigated the relationship between…”
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Pneumonia and urinary tract infection after acute ischaemic stroke: a tertiary analysis of the GAIN International trial by Aslanyan, S., Weir, C. J., Diener, H.-C., Kaste, M., Lees, K. R.

“…The third most common stroke complication is infection. We studied the rates of aspiration pneumonia and urinary tract infection (UTI), their risk factors and…”
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Thrombolysis in very elderly people: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive by Mishra, Nishant K, Ahmed, Niaz, Andersen, Grethe, Egido, José A, Lindsberg, Perttu J, Ringleb, Peter A, Wahlgren, Nils G, Lees, Kennedy R

“…Objective To assess effect of age on response to alteplase in acute ischaemic stroke.Design Adjusted controlled comparison of outcomes between non-randomised…”
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Association of improved outcome in acute ischaemic stroke patients with atrial fibrillation who receive early antithrombotic therapy: analysis from VISTA by Abdul-Rahim, A. H., Fulton, R. L., Frank, B., Tatlisumak, T., Paciaroni, M., Caso, V., Diener, H.-C., Lees, K. R.

“…Background and purpose Ischaemic stroke patients with atrial fibrillation (AF) are at risk of early recurrent stroke (RS). However, antithrombotics commenced…”
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Impact of heart rate on admission on mortality and morbidity in acute ischaemic stroke patients - results from VISTA by Nolte, C. H., Erdur, H., Grittner, U., Schneider, A., Piper, S. K., Scheitz, J. F., Wellwood, I., Bath, P. M. W., Diener, H.-C., Lees, K. R., Endres, M.

“…Background and purpose Elevated heart rate (HR) is associated with worse outcomes in patients with cardiovascular disease. Its predictive value in acute stroke…”
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Thrombolytic therapy for acute stroke in the United Kingdom: experience from the safe implementation of thrombolysis in stroke (SITS) register by Lees, K.R., Ford, G.A., Muir, K.W., Ahmed, N., Dyker, A.G., Atula, S., Kalra, L., Warburton, E.A., Baron, J.-C., Jenkinson, D.F., Wahlgren, N.G., Walters, M.R.

“…Aim: To describe the United Kingdom (UK) experience with thrombolytic therapy with intravenous alteplase (rt-PA) for stroke, as captured by the Implementation…”
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Use of paracetamol in ischaemic stroke patients: evidence from VISTA by Frank, B., Fulton, R. L., Weimar, C., Lees, K. R., Sanders, R. D.

“…Objectives Paracetamol is frequently prescribed for pain and fever control in acute stroke patients, but its effect on stroke outcome is unclear. The aim was…”
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A recognition tool for transient ischaemic attack by Dawson, J., Lamb, K.E., Quinn, T.J., Lees, K.R., Horvers, M., Verrijth, M.J., Walters, M.R.

“…Background: Scoring systems exist to assist rapid identification of acute stroke but not for the more challenging diagnosis of transient ischaemic attack…”
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The ABCD and ABCD2 as predictors of stroke in transient ischemic attack clinic outpatients: a retrospective cohort study over 14 years by Harrison, J.K., Sloan, B., Dawson, J., Lees, K.R., Morrison, D.S.

“…Background: The ABCD and ABCD2 scores have been validated for use as predictors of stroke in community populations up to 90 days after a transient ischemic…”
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Tolerability of NXY-059 at higher target concentrations in patients with acute Stroke by LEES, K. R, BARER, D, FORD, G. A, HACKE, W, KOSTULAS, V, SHARMA, A. K, ODERGREN, T

“…NXY-059 is a nitrone-based free radical-trapping agent in development for acute stroke. In patients with acute stroke, NXY-059 is well tolerated at…”
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Cerestat and other NMDA antagonists in ischemic stroke by LEES, K. R

“…A wealth of experimental evidence demonstrates that cerebral ischemia causes excessive release of glutamate and that glutamate contributes to ischemic injury…”
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Selfotel in acute ischemic stroke : Possible neurotoxic effects of an NMDA antagonist by DAVIS, S. M, LEES, K. R, ALBERS, G. W, DIENER, H. C, MARKABI, S, KARLSSON, G, NORRIS, J

“…Based on neuroprotective efficacy in animal models, we evaluated the N-methyl D-aspartate antagonist Selfotel in patients with ischemic stroke, after doses up…”
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The prognostic value of the components of the Glasgow Coma Scale following acute stroke by WEIR, C.J., BRADFORD, A.P.J., LEES, K.R.

“…Background: The Glasgow Coma Scale (GCS) is widely used in assessing level of consciousness. The GCS verbal component may be misleading in acute stroke: a…”
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Tolerability and pharmacokinetics of the nitrone NXY-059 in patients with acute Stroke by LEES, K. R, SHARMA, A. K, BARER, D, FORD, G. A, KOSTULAS, V, CHENG, Y.-F, ODERGREN, T

“…Increased free radical formation contributes to the damage caused to the brain by acute ischemia. NXY-059 is a nitrone-based free radical trapping agent in…”
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Allopurinol reduces brachial and central blood pressure, and carotid intima-media thickness progression after ischaemic stroke and transient ischaemic attack: a randomised controlled trial by Higgins, P, Walters, M R, Murray, H M, McArthur, K, McConnachie, A, Lees, K R, Dawson, J

“…Central blood pressure (CBP) and carotid intima-media thickness (CIMT) are surrogate measures of cardiovascular risk. Allopurinol reduces serum uric acid and…”
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C-reactive protein and outcome after ischemic Stroke by MUIR, K. W, WEIR, C. J, ALWAN, W, SQUIRE, L. B, LEES, K. R

“…Elevated concentrations of the acute-phase reactant C-reactive protein (CRP) predict ischemic cardiac events in both hospital- and population-based studies and…”
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