Search Results - "LEEN, René"

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering by Milanese, Chiara, Bombardieri, Cíntia R., Sepe, Sara, Barnhoorn, Sander, Payán-Goméz, César, Caruso, Donatella, Audano, Matteo, Pedretti, Silvia, Vermeij, Wilbert P., Brandt, Renata M. C., Gyenis, Akos, Wamelink, Mirjam M., de Wit, Annelieke S., Janssens, Roel C., Leen, René, van Kuilenburg, André B. P., Mitro, Nico, Hoeijmakers, Jan H. J., Mastroberardino, Pier G.

“…Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations…”
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Repeat expansions nested within tandem CNVs: a unique structural change in GLS exemplifies the diagnostic challenges of non-coding pathogenic variation by Fazal, Sarah, Danzi, Matt C, van Kuilenburg, André B P, Reich, Selina, Traschütz, Andreas, Bender, Benjamin, Leen, René, Toro, Camilo, Usdin, Karen, Hayward, Bruce, Adams, David R, van Karnebeek, Clara D M, Ferreira, Carlos R, D'Sousa, Precilla, Network, Undiagnosed Diseases, Tekin, Mustafa, Züchner, Stephan, Synofzik, Matthis

“…Glutaminase deficiency has recently been associated with ataxia and developmental delay due to repeat expansions in the 5'UTR of the glutaminase (GLS) gene…”
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Development of a Biosimilar of Agalsidase Beta for the Treatment of Fabry Disease: Preclinical Evaluation by van Kuilenburg, André B. P., Hollak, Carla E. M., Travella, Ana, Jacobs, Melisa, Gentilini, Lucas D., Leen, René, der Vlugt, Karen M. M. Ghauharali-van, Stet, Femke S. Beers, Goorden, Susan M. I., van der Veen, Sanne, Criscuolo, Marcelo, Papouchado, Mariana

“…Background and Objective Fabry disease (FD) is a rare lysosomal storage disorder caused by a deficiency of the enzyme α-galactosidase A (aGal A). Since 2001,…”
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Multi-OMIC profiling of survival and metabolic signaling networks in cells subjected to photodynamic therapy by Weijer, Ruud, Clavier, Séverine, Zaal, Esther A., Pijls, Maud M. E., van Kooten, Robert T., Vermaas, Klaas, Leen, René, Jongejan, Aldo, Moerland, Perry D., van Kampen, Antoine H. C., van Kuilenburg, André B. P., Berkers, Celia R., Lemeer, Simone, Heger, Michal

“…Photodynamic therapy (PDT) is an established palliative treatment for perihilar cholangiocarcinoma that is clinically promising. However, tumors tend to regrow…”
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Hypothermic perfusion with retrograde outflow during right hepatectomy is safe and feasible by Reiniers, Megan J., MD, Olthof, Pim. B., MD, van Golen, Rowan F., MD, Heger, Michal, PhD, van Beek, Adriaan A., PhD, Meijer, Ben, PhD, Leen, René, BS, van Kuilenburg, André B.P., PhD, Mearadji, Banafsche, MD, PhD, Bennink, Roelof J., MD, PhD, Verheij, Joanne, MD, PhD, van Gulik, Thomas M., MD, PhD

“…Background In situ hypothermic perfusion during liver resection performed under vascular inflow occlusion decreases hepatic ischemia-reperfusion injury, but…”
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Synergistic interaction between cisplatin and gemcitabine in neuroblastoma cell lines and multicellular tumor spheroids by Besançon, Odette G, Tytgat, Godelieve A.M, Meinsma, Rutger, Leen, René, Hoebink, Jerry, Kalayda, Ganna V, Jaehde, Ulrich, Caron, Huib N, van Kuilenburg, André B.P

“…Abstract The efficacy and mechanism of action of cisplatin and gemcitabine were investigated in a panel of neuroblastoma cell lines and multicellular tumor…”
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Determination of the deoxycytidine kinase activity in cell homogenates with a non-radiochemical assay using reversed-phase high performance liquid chromatography: Identification of a novel metabolite of 2-chlorodeoxyadenosine by Bierau, Jörgen, Leen, René, Gennip, Albert H.van, Caron, Huib N., Kuilenburg, André B.P.van

“…A non-radioactive procedure to measure the deoxycytidine kinase (dCK) activity in crude cell free homogenates was developed. 2-Chlorodeoxyadenosine (CdA) was…”
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Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma by Cuperus, Roos, Leen, René, Tytgat, Godelieve A. M, Caron, Huib N, van Kuilenburg, André B. P

“…Fenretinide induces apoptosis in neuroblastoma by induction of reactive oxygen species (ROS). In this study, we investigated the role of mitochondria in…”
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Dopamine induces lipid accumulation, NADPH oxidase-related oxidative stress, and a proinflammatory status of the plasma membrane in H9c2 cells by Begieneman, Mark P V, Ter Horst, Ellis N, Rijvers, Liza, Meinster, Elisa, Leen, René, Pankras, Jeannette E, Fritz, Jan, Kubat, Bela, Musters, René J P, van Kuilenburg, André B P, Stap, Jan, Niessen, Hans W M, Krijnen, Paul A J

“…Excess catecholamine levels are suggested to be cardiotoxic and to underlie stress-induced heart failure. The cardiotoxic effects of norepinephrine and…”
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Urinary 3-Methoxytyramine Is a Biomarker for MYC Activity in Patients With Neuroblastoma by Verly, Iedan R N, Matser, Yvette A H, Leen, René, Meinsma, Rutger, Fiocco, Marta, Koster, Jan, Volckmann, Richard, Savci-Heijink, Dilara, Cangemi, Giuliana, Barco, Sebastiano, Valentijn, Linda J, Tytgat, Godelieve A M, van Kuilenburg, André B P

“…Elevated urinary 3-methoxytyramine (3MT) level at diagnosis was recently put forward as independent risk factor for poor prognosis in neuroblastoma. Here, we…”
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CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders by van Karnebeek, Clara D.M., Tarailo-Graovac, Maja, Leen, René, Meinsma, Rutger, Correard, Solenne, Jansen-Meijer, Judith, Prykhozhij, Sergey V., Pena, Izabella A., Ban, Kevin, Schock, Sarah, Saxena, Vishal, Pras-Raves, Mia L., Drögemöller, Britt I., Grootemaat, Anita E., van der Wel, Nicole N., Dobritzsch, Doreen, Roseboom, Winfried, Schomakers, Bauke V., Jaspers, Yorrick R.J., Zoetekouw, Lida, Roelofsen, Jeroen, Ferreira, Carlos R., van der Lee, Robin, Ross, Colin J., Kochan, Jakub, McIntyre, Rebecca L., van Klinken, Jan B., van Weeghel, Michel, Kramer, Gertjan, Weschke, Bernhard, Labrune, Philippe, Willemsen, Michèl A., Riva, Daria, Garavaglia, Barbara, Moeschler, John B., Filiano, James J., Ekker, Marc, Berman, Jason N., Dyment, David, Vaz, Frédéric M., Wasserman, Wyeth W., Houtkooper, Riekelt H., van Kuilenburg, André B.P.

“…The functionality of many cellular proteins depends on cofactors; yet, they have only been implicated in a minority of Mendelian diseases. Here, we describe…”
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Promising effects of the 4HPR–BSO combination in neuroblastoma monolayers and spheroids by Cuperus, Roos, van Kuilenburg, André B.P., Leen, René, Bras, Johannes, Caron, Huib N., Tytgat, Godelieve A.M.

“…To enhance the efficacy of fenretinide (4HPR)-induced reactive oxygen species (ROS) in neuroblastoma, 4HPR was combined with buthionine sulfoximine (BSO), an…”
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Pleiotropic effects of fenretinide in neuroblastoma cell lines and multicellular tumor spheroids by CUPERUS, Roos, TYTGAT, Godelieve A. M, LEEN, Rene, BRITES, Pedro, BRAS, Johannes, CARON, Huib N, VAN KUILENBURG, Andre B. P

“…The efficacy and mechanism of action of fenretinide (4-HPR), a vitamin A analogue, was investigated in a panel of six neuroblastoma cell lines and…”
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Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity by Ofman, Rob, Speijer, Dave, Leen, René, Wanders, Ronald J A

“…Proteomic analysis of mouse kidney peroxisomes resulted in the identification of a novel nudix hydrolase designated RP2p, which is encoded by the D7RP2e gene…”
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Cyclopentenyl cytosine has biological and anti-tumour activity, but does not enhance the efficacy of gemcitabine and radiation in two animal tumour models by VAN BREE, Chris, BARTEN-VAN RIJBROEK, Angeliqué D, LEEN, René, RODERMOND, Hans M, VAN KUILENBURG, André B. P, KAL, Henk B

“…Cyclopentenyl cytosine (CPEC), targetting the de novo biosynthesis of cytidine triphosphate (CTP), increases the cytotoxicity of gemcitabine…”
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Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma by BIERAU, Jörgen, VAN GENNIP, Albert H, LEEN, René, MEINSMA, Rutger, CARON, Huib N, VAN KUILENBURG, André B. P

“…The effect of the CTP synthetase inhibitor cyclopentenyl cytosine (CPEC) on the metabolism and cytotoxicity of 2',2'-difluorodeoxycytidine (dFdC, gemcitabine)…”
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Antagonistic effects of sequential administration of BL1521, a histone deacetylase inhibitor, and gemcitabine to neuroblastoma cells by de Ruijter, Annemieke J.M., Leen, René, Hoebink, Jerry, Caron, Huib N., van Kuilenburg, André B.P.

“…Additive to synergistic induction of apoptosis has been reported as a result of sequential incubation of cancer cells with a histone deacetylase inhibitor…”
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CIAO1 and MMS19 de fi ciency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders by van Karnebeek, Clara D. M., Tarailo-Graovac, Maja, Leen, Rene, Meinsma, Rutger, Correard, Solenne, Jansen-Meijer, Judith, Prykhozhij, Sergey V., Pena, Izabella A., Ban, Kevin, Schock, Sarah, Saxena, Vishal, Pras-Raves, Mia L., Drogemoller, Britt I., Grootemaat, Anita E., van der Wel, Nicole N., Dobritzsch, Doreen, Roseboom, Winfried, Schomakers, Bauke V., Jaspers, Yorrick R. J., Zoetekouw, Lida, Roelofsen, Jeroen, Ferreira, Carlos R., van der Lee, Robin, Ross, Colin J., Kochan, Jakub, McIntyre, Rebecca L., van Klinken, Jan B., van Weeghel, Michel, Kramer, Gertjan, Weschke, Bernhard, Labrune, Philippe, Willemsen, Michel A., Riva, Daria, Garavaglia, Barbara, Moeschler, John B., Filiano, James J., Ekker, Marc, Berman, Jason N., Dyment, David, Vaz, Frederic M., Wassermann, Wyeth W., Houtkooper, Riekelt H., van Kuilenburg, Andre B. P.

“…Purpose: The functionality of many cellular proteins depends on cofactors; yet, they have only been implicated in a minority of Mendelian diseases. Here, we…”
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Determination of the deoxycytidine kinase activity in cell homogenates with a non-radiochemical assay using reversed-phase high performance liquid chromatography by Bierau, Jörgen, Leen, René, Gennip, Albert H.van, Caron, Huib N., Kuilenburg, André B.P.van

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Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1‐β‐D‐arabinofuranosyl cytosine in a human T‐lymphoblastic cell line by Verschuur, Arnauld C., Van Gennip, Albert H., Leen, René, Voûte, P.A., Brinkman, Josanne, Van Kuilenburg, André B.P.

“…The cytotoxic effect of 1‐β‐D‐arabinofuranosyl cytosine (araC) depends on the intracellular phosphorylation into its active compound araCTP, on the degree of…”
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