Search Results - "LEE, William M. F"

Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy by Cerniglia, George J, Pore, Nabendu, Tsai, Jeff H, Schultz, Susan, Mick, Rosemarie, Choe, Regine, Xing, Xiaoman, Durduran, Turgut, Yodh, Arjun G, Evans, Sydney M, Koch, Cameron J, Hahn, Stephen M, Quon, Harry, Sehgal, Chandra M, Lee, William M F, Maity, Amit

“…Epidermal growth factor receptor (EGFR) inhibitors have shown only modest clinical activity when used as single agents to treat cancers. They decrease tumor…”
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Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis by CROFT, Daniel R, SAHAI, Erik, MAVRIA, Georgia, SHUIXING LI, TSAI, Jeff, LEE, William M. F, MARSHALL, Christopher J, OLSON, Michael F

“…Progression of tumors to invasive and metastatic forms requires that tumor cells undergo dramatic morphologic changes, a process regulated by Rho GTPases…”
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An active learning approach for rapid characterization of endothelial cells in human tumors by Padmanabhan, Raghav K, Somasundar, Vinay H, Griffith, Sandra D, Zhu, Jianliang, Samoyedny, Drew, Tan, Kay See, Hu, Jiahao, Liao, Xuejun, Carin, Lawrence, Yoon, Sam S, Flaherty, Keith T, Dipaola, Robert S, Heitjan, Daniel F, Lal, Priti, Feldman, Michael D, Roysam, Badrinath, Lee, William M F

“…Currently, no available pathological or molecular measures of tumor angiogenesis predict response to antiangiogenic therapies used in clinical practice…”
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The Antivascular Action of Physiotherapy Ultrasound on A Murine Tumor: Role of A Microbubble Contrast Agent by Wood, Andrew K.W, Bunte, Ralph M, Cohen, Jennie D, Tsai, Jeff H, Lee, William M.-F, Sehgal, Chandra M

“…Abstract This study investigated whether a microbubble-containing ultrasound contrast agent had a role in the antivascular action of physiotherapy ultrasound…”
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Oxygen distribution in murine tumors: characterization using oxygen-dependent quenching of phosphorescence by Ziemer, Lisa S, Lee, William M. F, Vinogradov, Sergei A, Sehgal, Chandra, Wilson, David F

“…1 Department of Clinical Studies, Philadelphia, School of Veterinary Medicine, 2 Department of Medicine and the Abramson Cancer Center, 3 Department of…”
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The Disruption of Murine Tumor Neovasculature by Low-intensity Ultrasound—Comparison Between 1- and 3-MHz Sonication Frequencies by Wood, Andrew K.W., DVSc, PhD, Bunte, Ralph M., DVM, Price, Heather E., BS, Deitz, Margaret S., BS, Tsai, Jeff H., BS, Lee, William M.-F., MD, Sehgal, Chandra M., PhD

“…Rationale and Objectives The goal was to determine whether the tumor vascular disrupting actions of low-intensity ultrasound were frequency dependent…”
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Inhibition of Tumor Endothelial ERK Activation, Angiogenesis, and Tumor Growth by Sorafenib (BAY43-9006) by Murphy, Danielle A., Makonnen, Sosina, Lassoued, Wiem, Feldman, Michael D., Carter, Christopher, Lee, William M.F.

“…Activation of the Raf-MEK-ERK signal transduction pathway in endothelial cells is required for angiogenesis. Raf is the kinase most efficiently inhibited by…”
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Oxygen pressures in the interstitial space and their relationship to those in the blood plasma in resting skeletal muscle by Wilson, David F, Lee, William M. F, Makonnen, Sosina, Finikova, Olga, Apreleva, Sofia, Vinogradov, Sergei A

“…Departments of 1 Biochemistry and Biophysics and 2 Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Submitted 3 April 2006 ; accepted in final…”
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Tumor Vessel Development and Maturation Impose Limits on the Effectiveness of Anti-Vascular Therapy by Gee, Michael S., Procopio, William N., Makonnen, Sosina, Feldman, Michael D., Yeilding, Newman M., Lee, William M.F.

“…The effect of anti-vascular agents on the growth of experimental tumors is well studied. Their impact on tumor vasculature, the primary therapeutic target of…”
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Cell-based quantification of molecular biomarkers in histopathology specimens by Al-Kofahi, Yousef, Lassoued, Wiem, Grama, Kedar, Nath, Sumit K, Zhu, Jianliang, Oueslati, Ridha, Feldman, Michael, Lee, William M F, Roysam, Badrinath

“…Al‐Kofahi Y, Lassoued W, Grama K, Nath S K, Zhu J, Oueslati R, Feldman M, Lee W M F & Roysam B
(2011) Histopathology59, 40–54 Cell‐based quantification of…”
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Effect of VEGF and VEGF Trap on vascular endothelial cell signaling in tumors by Lassoued, Wiem, Murphy, Danielle, Tsai, Jeff, Oueslati, Ridha, Thurston, Gavin, Lee, William M.F.

“…Vascular endothelial growth factor (VEGF) A is a major promoter of tumor angiogenesis and a prime target of antiangiogenic cancer therapy. To examine whether…”
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Involvement of the 'leucine zipper' region in the oligomerization and transforming activity of human c-myc protein by Dang, Chi V, McGuire, Maura, Buckmire, Michael, Lee, William M. F

“…c-Myc plays a part in the regulation of important cellular processes such as growth, differentiation and neoplastic transformation. Although c-myc gene…”
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Activated STAT3 is a mediator and biomarker of VEGF endothelial activation by Chen, Shao-Hua, Murphy, Danielle, Lassoued, Wiem, Thurston, Gavin, Feldman, Michael D., Lee, William M.F.

“…STAT3 plays important roles in cell proliferation and survival signaling and is often constitutively activated in transformed cells. In this study, we examined…”
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Antivascular Ultrasound Therapy Extends Survival of Mice With Implanted Melanomas by Wood, Andrew K.W, Schultz, Susan M, Lee, William M-F, Bunte, Ralph M, Sehgal, Chandra M

“…Abstract The goal of this murine investigation was to evaluate the effect of an antivascular ultrasound treatment on the growth of an implanted melanoma and…”
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Measuring oxygen in living tissue: intravascular, interstitial, and "tissue" oxygen measurements by Wilson, David F, Finikova, Olga S, Lebedev, Artem Y, Apreleva, Sophia, Pastuszko, Anna, Lee, William M F, Vinogradov, Sergei A

“…Oxygen dependent quenching of phosphorescence has been used to measure the oxygen pressure in both the vasculature of the microcirculation and the interstitial…”
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The antivascular action of physiotherapy ultrasound on murine tumors by Wood, Andrew K W, Ansaloni, Sara, Ziemer, Lisa S, Lee, William M-F, Feldman, Michael D, Sehgal, Chandra M

“…This study was aimed at determining if physiotherapy ultrasound (US) affected the fragile and leaky angiogenic blood vessels in a tumor. In 22 C3HV/HeN mice, a…”
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Tie2 in Tumor Endothelial Signaling and Survival: Implications for Antiangiogenic Therapy by Tsai, Jeff H, Lee, William M F

“…Signaling through the Tie2 receptor on endothelial cells has been shown to play an important role in normal and pathologic vascular development. We generated…”
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Adding Value to Liver (and Allograft) Biopsy Evaluation Using a Combination of Multiplex Quantum Dot Immunostaining, High-Resolution Whole-Slide Digital Imaging, and Automated Image Analysis by Isse, Kumiko, MD, PhD, Grama, Kedar, MS, Abbott, Isaac Morse, MS, Lesniak, Andrew, Lunz, John G., PhD, Lee, William M.F., MD, PhD, Specht, Susan, MS, Corbitt, Natasha, BS, Mizuguchi, Yoshiaki, MD, PhD, Roysam, Badrinath, PhD, Demetris, A.J., MD

“…Various technologies including nucleic acid, protein, and metabolic array analyses of blood, liver tissue, and bile are emerging as powerful tools in the study…”
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Oxygen pressures in the interstitial space of skeletal muscle and tumors in vivo by Wilson, David F, Lee, William M F, Makonnen, Sosina, Apreleva, Sophia, Vinogradov, Sergei A

“…A new Oxyphor (Oxyphor G3) has been used to selectively determine the oxygen pressure in interstitial (pericellular) spaces. Oxyphor G3 is a…”
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Doppler ultrasound imaging detects changes in tumor perfusion during antivascular therapy associated with vascular anatomic alterations by GEE, Michael S, SAUNDERS, H. Mark, LEE, James C, SANZO, James F, JENKINS, W. Timothy, EVANS, Sydney M, TRINCHIERI, Giorgio, SEHGAL, Chandra M, FELDMAN, Michael D, LEE, William M. F

“…Noninvasive monitoring of antiangiogenic therapy was performed by serial power Doppler ultrasound imaging of murine tumors treated with recombinant interleukin…”
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