Search Results - "LEE, Susan J"

Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events by ARASTU-KAPUR, Shirin, ANDERL, Janet L, KIRK, Christopher J, KRAUS, Marianne, PARLATI, Francesco, SHENK, Kevin D, LEE, Susan J, MUCHAMUEL, Tony, BENNETT, Mark K, DRIESSEN, Christoph, BALL, Andrew J

“…Bortezomib (Velcade), a dipeptide boronate 20S proteasome inhibitor and an approved treatment option for multiple myeloma, is associated with a…”
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Safety and Efficacy of Filgotinib: Up to 4-year Results From an Open-label Extension Study of Phase II Rheumatoid Arthritis Programs by Kavanaugh, Arthur, Westhovens, Rene R, Winthrop, Kevin L, Lee, Susan J, Tan, YingMeei, An, Di, Ye, Lei, Sundy, John S, Besuyen, Robin, Meuleners, Luc, Stanislavchuk, Mykola, Spindler, Alberto J, Greenwald, Maria, Alten, Rieke, Genovese, Mark C

“…The long-term safety and efficacy of filgotinib (from phase II studies), with or without methotrexate (MTX), for the treatment of patients with rheumatoid…”
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Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome by Parlati, Francesco, Lee, Susan J., Aujay, Monette, Suzuki, Erika, Levitsky, Konstantin, Lorens, James B., Micklem, David R., Ruurs, Paulina, Sylvain, Catherine, Lu, Yan, Shenk, Kevin D., Bennett, Mark K.

“…Carfilzomib is a proteasome inhibitor in clinical development that primarily targets the chymotrypsin-like (CT-L) subunits in both the constitutive proteasome…”
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The impact of filgotinib on patient-reported outcomes and health-related quality of life for patients with active rheumatoid arthritis: a post hoc analysis of Phase 3 studies by Bingham, 3rd, Clifton O, Walker, David, Nash, Peter, Lee, Susan J, Ye, Lei, Hu, Hao, Khalid, Javaria Mona, Combe, Bernard

“…The effects of filgotinib on patient-reported outcomes (PROs) from 3 trials in patients with active rheumatoid arthritis were investigated. Methotrexate…”
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A Randomized Trial of Two Methods to Disclose Prognosis to Surrogate Decision Makers in Intensive Care Units by CHAR, Susan J. Lee, EVANS, Leah R, MALVAR, Grace L, WHITE, Douglas B

“…Surrogate decision makers and clinicians often have discordant perceptions about a patient's prognosis. There is a paucity of empirical data to guide…”
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Metadata Framework to Support Deployment of Digital Health Technologies in Clinical Trials in Parkinson's Disease by Hill, Derek L, Stephenson, Diane, Brayanov, Jordan, Claes, Kasper, Badawy, Reham, Sardar, Sakshi, Fisher, Katherine, Lee, Susan J, Bannon, Anthony, Roussos, George, Kangarloo, Tairmae, Terebaite, Viktorija, Müller, Martijn L T M, Bhatnagar, Roopal, Adams, Jamie L, Dorsey, E Ray, Cosman, Josh

“…Sensor data from digital health technologies (DHTs) used in clinical trials provides a valuable source of information, because of the possibility to combine…”
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Informed consent for innovative surgery: A survey of patients and surgeons by Char, Susan J. Lee, JD, MD, Hills, Nancy K., MBA, MA, PhD, Lo, Bernard, MD, Kirkwood, Kimberly S., MD

“…Background Unlike new drugs and medical devices, most surgical procedures are developed outside clinical trials and without regulatory oversight. Surgical…”
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The modified Nail Psoriasis Severity Index: validation of an instrument to assess psoriatic nail involvement in patients with psoriatic arthritis by CASSELL, Sarah E, BIEBER, Jeffry D, RICH, Phoebe, TUTUNCU, Zuhre N, LEE, Susan J, KALUNIAN, Kenneth C, WU, Christopher W, KAVANAUGH, Arthur

“…OBJECTIVE: Patients with psoriasis and psoriatic arthritis (PsA) commonly have nail involvement. There is no validated psoriatic nail assessment tool…”
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Immunomodulator therapy: Monoclonal antibodies, fusion proteins, cytokines, and immunoglobulins by Lee, Susan J., MD, Chinen, Javier, MD, PhD, Kavanaugh, Arthur, MD

“…The immune system consists of a diverse array of immunocompetent cells and inflammatory mediators that exist in complex networks. These components interact…”
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Utilization Trends of Tumor Necrosis Factor Inhibitors Among Patients with Rheumatoid Arthritis in a United States Observational Cohort Study by LEE, Susan J, HONG CHANG, YAZICI, Yusuf, GREENBERG, Jeffrey D, KREMER, Joel M, KAVANAUGH, Arthur

“…Objective. Studies have suggested that early institution of tumor necrosis factor (TNF) inhibitors improves functional status and slows radiographic…”
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Evaluation of an Instrument Assessing Influence of Gout on Health-Related Quality of Life by HIRSCH, Jan D, LEE, Susan J, TERKELTAUB, Robert, KHANNA, Dinesh, SINGH, Jasvinder, SARKIN, Andrew, HARVEY, Jodi, KAVANAUGH, Arthur

“…Objective To evaluate the reliability and validity of an instrument assessing the influence of gout (acute and chronic) on health-related quality of life…”
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Oligonucleotide Array and VITEK Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry in Species Identification of Blood Yeast Isolates by Li, Ming-Chi, Chang, Tsung C, Chen, Hung-Mo, Wu, Chi-Jung, Su, Shu-Li, Lee, Susan S-J, Chen, Po-Lin, Lee, Nan-Yao, Lee, Ching-Chi, Li, Chia-Wen, Syue, Ling-Shan, Ko, Wen-Chien

“…We evaluated matrix-assisted laser desorption ionization time-of-flight mass spectrometry using VITEK MS (IVD database) and an oligonucleotide array based on…”
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Patient-derived Joint Counts Are a Potential Alternative for Determining Disease Activity Score by KAVANAUGH, Arthur, LEE, Susan J, WENG, Haoling H, YUN CHON, HUANG, Xing-Yue, LIN, Shao-Lee

“…To investigate the correlation between the Disease Activity Score using a 28-joint count (DAS28) based on physician-derived joint counts and the DAS28 based on…”
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Disease Severity and Pregnancy Outcomes in Women with Rheumatoid Arthritis: Results from the Organization of Teratology Information Specialists Autoimmune Diseases in Pregnancy Project by Bharti, Balambal, Lee, Susan J, Lindsay, Suzanne P, Wingard, Deborah L, Jones, Kenneth L, Lemus, Hector, Chambers, Christina D

“…To determine the effect of rheumatoid arthritis (RA) disease severity on pregnancy outcomes in pregnant women with and without autoimmune diseases. A…”
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Electronic and computer-generated patient questionnaires in standard care by Lee, Susan J., MD, Kavanaugh, Arthur, MD, Lenert, Leslie, MD, MS

“…Patient-derived measures of disease activity have been proven to be reliable, valid, sensitive to change, and less susceptible to placebo effects in the…”
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Does titration of mitomycin C as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome? by Lee, Susan J, Paranhos, Augusto, Shields, M Bruce

“…To evaluate the benefit of titrating the concentration and exposure time of mitomycin C (MMC) as an adjunct to trabeculectomy. This report consists of a…”
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Fetal Pain: A Systematic Multidisciplinary Review of the Evidence by Lee, Susan J, Ralston, Henry J. Peter, Drey, Eleanor A, Partridge, John Colin, Rosen, Mark A

“…CONTEXT Proposed federal legislation would require physicians to inform women seeking abortions at 20 or more weeks after fertilization that the fetus feels…”
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Factors affecting rheumatoid arthritis patients' decisions to participate in clinical trials by LEE, Susan J, LENERT, Leslie, WEISMAN, Stuart, KAVANAUGH, Arthur

“…OBJECTIVE: To delineate the personal, psychosocial, and disease-related factors that may influence rheumatoid arthritis (RA) patients' decisions to participate…”
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Discontinuation of tumour necrosis factor inhibitors in patients with rheumatoid arthritis in low-disease activity: persistent benefits. Data from the Corrona registry by Kavanaugh, Arthur, Lee, Susan J, Curtis, Jeffrey R, Greenberg, Jeffrey D, Kremer, Joel M, Soto, Lilian, Etzel, Carol J, Cox, Vanessa, Yoshida, Kazuki, Reed, George W, Solomon, Daniel H

“…There is increasing interest in discontinuing biological therapies for patients with rheumatoid arthritis (RA) achieving good clinical responses, provided…”
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New developments in clinically relevant mechanisms and treatment of hyperuricemia by Lee, Susan J, Terkeltaub, Robert A

“…The prevalence of gout has increased markedly in the United States in the past two decades, and new treatments for hyperuricemia are being developed. Recent…”
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