Search Results - "LEE, Suining"

Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening by Guzi, Timothy J, Paruch, Kamil, Dwyer, Michael P, Labroli, Marc, Shanahan, Frances, Davis, Nicole, Taricani, Lorena, Wiswell, Derek, Seghezzi, Wolfgang, Penaflor, Ervin, Bhagwat, Bhagyashree, Wang, Wei, Gu, Danling, Hsieh, Yunsheng, Lee, Suining, Liu, Ming, Parry, David

“…Checkpoint kinase 1 (CHK1) is an essential serine/threonine kinase that responds to DNA damage and stalled DNA replication. CHK1 is essential for maintenance…”
Get full text

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice by MING LIU, BRYANT, M. S, DELL, J, SINHA, D, SYED, J, KORFMACHER, W. A, NOMEIR, A. A, LIN, C.-C, WANG, L, TAVERAS, A. G, DOLL, R. J, NJOROGE, F. G, JIANPING CHEN, MALLAMS, A. K, REMISZEWSKI, S, CATINO, J. J, GIRIJAVALLABHAN, V. M, KIRSCHMEIER, P, BISHOP, W. R, SUINING LEE, YAREMKO, B, LIPARI, P, MALKOWSKI, M, FERRARI, E, NIELSEN, L, PRIOLI, N

“…We have been developing a series of nonpeptidic, small molecule farnesyl protein transferase inhibitors that share a common tricyclic nucleus and compete with…”
Get full text

Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core by Yu, Tao, Tagat, Jayaram R, Kerekes, Angela D, Doll, Ronald J, Zhang, Yonglian, Xiao, Yushi, Esposite, Sara, Belanger, David B, Curran, Patrick J, Mandal, Amit K, Siddiqui, M. Arshad, Shih, Neng-Yang, Basso, Andrea D, Liu, Ming, Gray, Kimberly, Tevar, Seema, Jones, Jennifer, Lee, Suining, Liang, Lianzhu, Ponery, Samad, Smith, Elizabeth B, Hruza, Alan, Voigt, Johannes, Ramanathan, Lata, Prosise, Winifred, Hu, Mengwei

“…The imidazo-[1,2-a]-pyrazine (1) is a dual inhibitor of Aurora kinases A and B with modest cell potency (IC50 = 250 nM) and low solubility (5 μM). Lead…”
Get full text

Aurora Kinase Inhibitors Based on the Imidazo[1,2-a]pyrazine Core: Fluorine and Deuterium Incorporation Improve Oral Absorption and Exposure by Kerekes, Angela D, Esposite, Sara J, Doll, Ronald J, Tagat, Jayaram R, Yu, Tao, Xiao, Yushi, Zhang, Yonglian, Prelusky, Dan B, Tevar, Seema, Gray, Kimberly, Terracina, Gaby A, Lee, Suining, Jones, Jennifer, Liu, Ming, Basso, Andrea D, Smith, Elizabeth B

“…Aurora kinases are cell cycle regulated serine/threonine kinases that have been linked to cancer. Compound 1 was identified as a potent Aurora inhibitor but…”
Get full text

Comparison of fast liquid chromatography/tandem mass spectrometric methods for simultaneous determination of cladribine and clofarabine in mouse plasma by Hsieh, Yunsheng, Duncan, Christine J.G., Lee, Suining, Liu, Ming

“…Several fast high performance liquid chromatography/atmospheric pressure ionization/tandem mass spectrometric (HPLC-API/MS/MS) methods were evaluated for the…”
Get full text

SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics by Basso, Andrea D, Liu, Ming, Dai, Chaoyang, Gray, Kimberly, Nale, Lissette, Tevar, Seema, Lee, Suining, Liang, Lianzhu, Ponery, Abdul, Yaremko, Bohdan, Smith, Elizabeth, Tang, Huadong, Sheth, Payal R, Siddiqui, M Arshad, Hicklin, Daniel J, Kirschmeier, Paul

“…Kinesin spindle protein (KSP) is a mitotic kinesin required for the formation of the bipolar mitotic spindle, and inhibition of this motor protein results in…”
Get full text

Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors by Belanger, David B., Williams, Michael J., Curran, Patrick J., Mandal, Amit K., Meng, Zhaoyang, Rainka, Matthew P., Yu, Tao, Shih, Neng-Yang, Siddiqui, M. Arshad, Liu, Ming, Tevar, Seema, Lee, Suining, Liang, Lianzhu, Gray, Kimberly, Yaremko, Bohdan, Jones, Jennifer, Smith, Elizabeth B., Prelusky, Dan B., Basso, Andrea D.

“…We report a series of potent imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. Optimization of the solvent accessible 8-position led to improvements in…”
Get full text

Comparison of fast liquid chromatography/tandem mass spectrometric methods for simultaneous determination of cladribine and clofarabine in mouse plasma: Hyphenated techniques in pharmaceutical and biomedical analysis 2006 by HSIEH, Yunsheng, DUNCAN, Christine J. G, LEE, Suining, MING LIU

Get full text

Abstract 1648: SCH 1473759, a novel aurora inhibitor, demonstrates enhanced antitumor activity in combination with taxanes and KSP inhibitors by Basso, Andrea D., Gray, Kimberly, Tevar, Seema, Ponery, Samad, Lee, Suining, Liu, Ming, Smith, Elizabeth, Yu, Tao, Tagat, Jay, Doll, Ronald, Belanger, David, Siddiqui, Arshad, Zhang, Yonglain, Xiao, Yushi, Esposite, Sara, Monsma, Fredrick, Hicklin, Dan, Kirschmeier, Paul

“…Abstract Aurora kinases are required for orderly progression of cells through mitosis. Inhibition of these kinases by siRNA or a small molecule inhibitors…”
Get full text

SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors by Basso, Andrea D., Liu, Ming, Gray, Kimberly, Tevar, Seema, Lee, Suining, Liang, Lianzhu, Ponery, Abdul, Smith, Elizabeth B., Monsma, Frederick J., Yu, Tao, Zhang, Yonglian, Kerekes, Angela D., Esposite, Sara, Xiao, Yushi, Tagat, Jayaram R., Hicklin, Daniel J., Kirschmeier, Paul

“…Purpose Aurora kinases are required for orderly progression of cells through mitosis, and inhibition of these kinases by siRNA or small molecule inhibitors…”
Get full text

Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, Mac-1, αmβ2) on human neutrophils by LO, S. K, LEE, S, RAMOS, R. A, LOBB, R, ROSA, M, CHI-ROSSO, G, WRIGHT, S. D

“…Two classes of adhesion molecules have well-defined roles in the attachment of unstimulated polymorphonuclear leukocytes (PMN) to cytokine-treated endothelial…”
Get full text

Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase:  Design and Synthesis of in Vivo Active Antitumor Compounds by Njoroge, F. George, Vibulbhan, Bancha, Rane, Dinananth F, Bishop, W. Robert, Petrin, Joanne, Patton, Robert, Bryant, Mathew S, Chen, K.-J, Nomeir, Amin A, Lin, C.-C, Liu, Ming, King, Ivan, Chen, Jianping, Lee, Suining, Yaremko, Bohdan, Dell, Janet, Lipari, Philip, Malkowski, Michael, Li, Zujun, Catino, Joseph, Doll, Ronald J, Girijavallabhan, V, Ganguly, Ashit K

“…Novel tricyclic Ras farnesyl-protein transferase (FPT) inhibitors are described. A comprehensive structure−activity relationship (SAR) study of compounds…”
Get full text

Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice by MING LIU, BRYANT, M. S, ROSSMAN, R. R, KORFMACHER, W. A, NOMEIR, A. A, LIN, C.-C, MALLAMS, A. K, DOLL, R. J, CATINO, J. J, GIRIJAVALLABHAN, V. M, KIRSCHMEIER, P, BISHOP, W. R, JIANPING CHEN, SUININHG LEE, YAREMKO, B, ZUJUN LI, DELL, J, LIPARI, P, MALKOWSKI, M, PRIOLI, N

“…The products of the Ha-, Ki-, and N-ras proto-oncogenes comprise a family of 21 kDa guanine nucleotide-binding proteins which play a crucial role in growth…”
Get full text

Inhibitors of farnesyl protein transferase. 4-Amido, 4-carbamoyl, and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b] pyridin-11-yl)piperazine and 1-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)pip erazine by MALLAMS, A. K, ROSSMAN, R. R, KIRSCHMEIER, P, CATINO, J. J, BRYANT, M. S, CHEN, K.-J, KORFMACHER, W. A, NARDO, C, SHIYONG WANG, NOMEIR, A. A, LIN, C.-C, ZUJUN LI, DOLL, R. J, JIANPING CHEN, SUINING LEE, DELL, J, LIPARI, P, MALKOWSKI, M, YAREMKO, B, KING, I, MING LIU, GIRIJAVALLABHAN, V. M, GANGULY, A. K, PETRIN, J, WANG, L, PATTON, R, BISHOP, W. R, CARR, D. M

Get full text

Recombinant human tumor necrosis factor alpha promotes adherence of Staphylococcus aureus to cultured human endothelial cells by CHEUNG, A. L, KOOMEY, J. M, SUINING LEE, JAFFE, E. A, FISCHETTI, V. A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, Mac-1, alpha sub(m) beta 2) on human neutrophils by Lo, Siu K, Lee, Suining, Ramos, R A, Lobb, R, Rosa, M, Chi-Rosso, Gloria, Wright, S D

“…Endothelial-leukocyte adhesion molecule 1 (ELAM-1) on endothelial cells interacts with specific carbohydrate residues on the PMN, and the leukocyte integrins…”
Get full text