Search Results - "LEE, Peter P"

B cell receptor signaling strength modulates cancer immunity by Ye, Jian, Lee, Peter P

“…Tumor-infiltrating B cells exert antitumor effects by producing antibodies against tumor-associated antigens. Conversely, B cells may promote tumors through…”
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Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer by Wang, Lei, Simons, Diana L., Lu, Xuyang, Tu, Travis Y., Solomon, Shawn, Wang, Roger, Rosario, Anthony, Avalos, Christian, Schmolze, Daniel, Yim, John, Waisman, James, Lee, Peter P.

“…Regulatory T (T reg ) cells play a major role in the development of an immunosuppressive tumor microenvironment. The origin of intratumoral T reg cells and…”
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Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression by Egelston, Colt A., Avalos, Christian, Tu, Travis Y., Simons, Diana L., Jimenez, Grecia, Jung, Jae Y., Melstrom, Laleh, Margolin, Kim, Yim, John H., Kruper, Laura, Mortimer, Joanne, Lee, Peter P.

“…Functional CD8 + T cells in human tumors play a clear role in clinical prognosis and response to immunotherapeutic interventions. PD-1 expression in T cells…”
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Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death by Draganov, Dobrin, Gopalakrishna-Pillai, Sailesh, Chen, Yun-Ru, Zuckerman, Neta, Moeller, Sara, Wang, Carrie, Ann, David, Lee, Peter P.

“…Overexpression of P2X7 receptors correlates with tumor growth and metastasis. Yet, release of ATP is associated with immunogenic cancer cell death as well as…”
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On the mechanism of long-range orientational order of fibroblasts by Li, Xuefei, Balagam, Rajesh, He, Ting-Fang, Lee, Peter P., Igoshin, Oleg A., Levine, Herbert

“…Long-range alignment ordering of fibroblasts have been observed in the vicinity of cancerous tumors and can be recapitulated with in vitro experiments…”
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Tumor draining lymph nodes connected to cold triple-negative breast cancers are characterized by Th2-associated microenvironment by Guo, Weihua, Tan, Jiayi, Wang, Lei, Egelston, Colt A., Simons, Diana L., Ochoa, Aaron, Lim, Min Hui, Wang, Lu, Solomon, Shawn, Waisman, James, Wei, Christina H., Hoffmann, Caroline, Song, Joo, Schmolze, Daniel, Lee, Peter P.

“…Tumor draining lymph nodes (TDLN) represent a key component of the tumor-immunity cycle. There are few studies describing how TDLNs impact lymphocyte…”
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Breast cancer induces systemic immune changes on cytokine signaling in peripheral blood monocytes and lymphocytes by Wang, Lei, Simons, Diana L., Lu, Xuyang, Tu, Travis Y., Avalos, Christian, Chang, Andrew Y., Dirbas, Frederick M., Yim, John H., Waisman, James, Lee, Peter P.

“…It is increasingly recognized that cancer progression induces systemic immune changes in the host. Alterations in number and function of immune cells have been…”
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Warburg Effect Is a Cancer Immune Evasion Mechanism Against Macrophage Immunosurveillance by Chen, Jing, Cao, Xu, Li, Bolei, Zhao, Zhangchen, Chen, Siqi, Lai, Seigmund W T, Muend, Sabina A, Nossa, Gianna K, Wang, Lei, Guo, Weihua, Ye, Jian, Lee, Peter P, Feng, Mingye

“…Evasion of immunosurveillance is critical for cancer initiation and development. The expression of "don't eat me" signals protects cancer cells from being…”
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Dissecting Response to Cancer Immunotherapy by Applying Bayesian Network Analysis to Flow Cytometry Data by Rodin, Andrei S, Gogoshin, Grigoriy, Hilliard, Seth, Wang, Lei, Egelston, Colt, Rockne, Russell C, Chao, Joseph, Lee, Peter P

“…Cancer immunotherapy, specifically immune checkpoint blockade, has been found to be effective in the treatment of metastatic cancers. However, only a subset of…”
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Mature Dendritic Cells May Promote High-Avidity Tuning of Vaccine T Cell Responses by Kumbhari, Adarsh, Egelston, Colt A, Lee, Peter P, Kim, Peter S

“…Therapeutic vaccines can elicit tumor-specific cytotoxic T lymphocytes (CTLs), but durable reductions in tumor burden require vaccines that stimulate…”
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Impaired Interferon Signaling Is a Common Immune Defect in Human Cancer by Critchley-Thorne, Rebecca J., Simons, Diana L., Yan, Ning, Miyahira, Andrea K., Dirbas, Frederick M., Johnsons, Denise L., Swelter, Susan M., Carlson, Robert W., Fisher, George A., Koong, Albert, Holmes, Susan, Lee, Peter P., Marrack, Phillippa

“…Immune dysfunction develops in patients with many cancer types and may contribute to tumor progression and failure of immunotherapy. Mechanisms underlying…”
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PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages by Yamaguchi, Yukiko, Gibson, Jackson, Ou, Kevin, Lopez, Lupita S, Ng, Rachel H, Leggett, Neena, Jonsson, Vanessa D, Zarif, Jelani C, Lee, Peter P, Wang, Xiuli, Martinez, Catalina, Dorff, Tanya B, Forman, Stephen J, Priceman, Saul J

“…BackgroundThe immune suppressive tumor microenvironment (TME) that inhibits T cell infiltration, survival, and antitumor activity has posed a major challenge…”
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Modeling protective anti-tumor immunity via preventative cancer vaccines using a hybrid agent-based and delay differential equation approach by Kim, Peter S, Lee, Peter P

“…A next generation approach to cancer envisions developing preventative vaccinations to stimulate a person's immune cells, particularly cytotoxic T lymphocytes…”
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Editorial: Systems Biology Methods in Computational Immuno-Oncology by Rodin, Andrei S, Uduman, Mohamed, Lee, Peter P, Marincola, Francesco Maria, Branciamore, Sergio

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Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer by Draganov, Dobrin, Han, Zhen, Rana, Aamir, Bennett, Nitasha, Irvine, Darrell J., Lee, Peter P.

“…We show that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell infiltration into…”
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Robust vaginal colonization of macaques with a novel vaginally disintegrating tablet containing a live biotherapeutic product to prevent HIV infection in women by Lagenaur, Laurel A, Swedek, Iwona, Lee, Peter P, Parks, Thomas P

“…MucoCept is a biotherapeutic for prevention of HIV-1 infection in women and contains a human, vaginal Lactobacillus jensenii that has been genetically enhanced…”
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Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets by Du, Xiao-Yan, Zabel, Brian A., Myles, Timothy, Allen, Samantha J., Handel, Tracy M., Lee, Peter P., Butcher, Eugene C., Leung, Lawrence L.

“…Chemerin is a potent chemoattractant for cells expressing the serpentine receptor CMKLR1 (chemokine-like receptor 1), such as plasmacytoid dendritic cells and…”
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Lymph Node Cellular Dynamics in Cancer and HIV: What Can We Learn for the Follicular CD4 (Tfh) Cells? by Poultsidi, Antigoni, Dimopoulos, Yiannis, He, Ting-Fang, Chavakis, Triantafyllos, Saloustros, Emmanouil, Lee, Peter P, Petrovas, Constantinos

“…Lymph nodes (LNs) are central in the generation of adaptive immune responses. Follicular helper CD4 T (Tfh) cells, a highly differentiated CD4 population,…”
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A self-directed method for cell-type identification and separation of gene expression microarrays by Zuckerman, Neta S, Noam, Yair, Goldsmith, Andrea J, Lee, Peter P

“…Gene expression analysis is generally performed on heterogeneous tissue samples consisting of multiple cell types. Current methods developed to separate…”
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In vivo evaluation of safety and toxicity of a Lactobacillus jensenii producing modified cyanovirin-N in a rhesus macaque vaginal challenge model by Brichacek, Beda, Lagenaur, Laurel A, Lee, Peter P, Venzon, David, Hamer, Dean H

“…Sexual transmission of human immunodeficiency virus type 1 (HIV-1) across the cervicovaginal mucosa in women is influenced by many factors including the…”
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