Search Results - "LEE, Paul R"

Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β by Lee, Paul R, Johnson, Tory P, Gnanapavan, Sharmilee, Giovannoni, Gavin, Wang, Tongguang, Steiner, Joseph P, Medynets, Marie, Vaal, Mark J, Gartner, Valerie, Nath, Avindra

“…The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human…”
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Novel variants in SPTAN1 without epilepsy: An expansion of the phenotype by Gartner, Valerie, Markello, Thomas C., Macnamara, Ellen, De Biase, Andrea, Thurm, Audrey, Joseph, Lisa, Beggs, Alan H., Schmahmann, Jeremy D., Berry, Gerard T., Anselm, Irina, Boslet, Emma, Tifft, Cynthia J., Gahl, William A., Lee, Paul R.

“…We describe two unrelated children with de novo variants in the non‐erythrocytic alpha‐II‐spectrin (SPTAN1) gene who have hypoplastic brain structures,…”
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Social Interaction Deficits Caused by Chronic Phencyclidine Administration are Reversed by Oxytocin by LEE, Paul R, BRADY, Dana L, SHAPIRO, Robert A, DORSA, Daniel M, KOENIG, James I

“…Chronic administration of phencyclidine (PCP) has been advanced as a valid animal model of the social deficit symptoms of schizophrenia. In these studies, the…”
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Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia by Koenig, James I., Elmer, Gregory I., Shepard, Paul D., Lee, Paul R., Mayo, Cheryl, Joy, Brian, Hercher, Ericka, Brady, Dana L.

“…Exposure to stress during gestation induces marked changes in the behavior of the affected offspring. Examining the consequences of prenatal stress may prove…”
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Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus by Johnson, Tory P, Tyagi, Richa, Lee, Paul R, Lee, Myoung-Hwa, Johnson, Kory R, Kowalak, Jeffrey, Elkahloun, Abdel, Medynets, Marie, Hategan, Alina, Kubofcik, Joseph, Sejvar, James, Ratto, Jeffrey, Bunga, Sudhir, Makumbi, Issa, Aceng, Jane R, Nutman, Thomas B, Dowell, Scott F, Nath, Avindra

“…Nodding syndrome is an epileptic disorder of unknown etiology that occurs in children in East Africa. There is an epidemiological association with , the…”
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Child Neurology: Zellweger syndrome by Lee, Paul R, Raymond, Gerald V

“…Zellweger syndrome (ZS) is a severe manifestation of disease within the spectrum of peroxisome biogenesis disorders that includes neonatal…”
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Expanding spectrum of opportunistic infections associated with dimethyl fumarate by Kim, Tiffany, Croteau, David, Brinker, Allen, Jones, David E, Lee, Paul R, Kortepeter, Cindy M

“…Background: Only progressive multifocal leukoencephalopathy (PML) is currently described in the dimethyl fumarate (DMF) prescribing information. Objectives: To…”
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Immune-mediated colitis associated with ocrelizumab: A new safety risk by Kim, Tiffany, Brinker, Allen, Croteau, David, Lee, Paul R, Baldassari, Laura E, Stevens, Jessica, Hughes, Alice, Tomaino, Juli, deFonseka, Arushi, Altepeter, Tara, Kortepeter, Cindy M

“…Background: An association between certain immunomodulatory therapies (rituximab, ipilimumab, and other immune checkpoint inhibitors) and inflammatory…”
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Child Neurology: Medium-chain acyl-coenzyme A dehydrogenase deficiency by Gartner, Valerie, McGuire, Peter J, Lee, Paul R

“…Medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency (MCADD) is an autosomal recessive inherited fatty acid oxidation disorder. In MCADD, mitochondria…”
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Risks and benefits of anesthesia for combined pediatric procedures in the NIH undiagnosed diseases program by Macnamara, Ellen F., Loydpierson, Amelia, Latour, Yvonne L., D'Souza, Precilla, Murphy, Jennifer, Wolfe, Lynne, Estwick, Tyra, Johnston, Jean M., Yang, John, Acosta, Maria T., Lee, Paul R., Pierson, Tyler Mark, Soldatos, Ariane, Toro, Camilo, Markello, Tom, Adams, David R., Gahl, William A., Yousef, Muhammad, Tifft, Cynthia J.

“…The NIH Undiagnosed Diseases Program (UDP) aims to provide diagnoses to patients who have previously received exhaustive evaluations yet remain undiagnosed…”
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Dietary treatments for epilepsy: Management guidelines for the general practitioner by Lee, Paul R, Kossoff, Eric H

“…Abstract As ketogenic diets become more frequently used as a standard treatment for epilepsy in children and adults, hospital and community neurologists,…”
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Prenatal stress generates deficits in rat social behavior: Reversal by oxytocin by Lee, Paul R, Brady, Dana L, Shapiro, Robert A, Dorsa, Daniel M, Koenig, James I

“…Abstract Neurodevelopmental changes induced by environmental stress exposure play a significant but poorly defined role in the etiology of schizophrenia…”
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Progressive multifocal leukoencephalopathy associated with sphingosine-1-phosphate receptor modulators: A large case series by Croteau, David, Kim, Tiffany, Chan, Vicky, Stevens, Jessica, Pimentel Maldonado, Daniela A., Baldassari, Laura E., Lee, Paul R., Hughes, Alice, Brinker, Allen

“…•Additional factors may influence the risk of PML associated with MS therapies and can be used to stratify and mitigate the risk of PML.•In this large case…”
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Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice by Amico, Janet A, Vollmer, Regis R, Karam, Joseph R, Lee, Paul R, Li, Xia, Koenig, James I, McCarthy, Margaret M

“…Experiments were conducted to determine if the chronic absence of the neurotransmitter oxytocin (OT) in null mice resulted in alterations in the responsiveness…”
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TUBB3 Arg262His causes a recognizable syndrome including CFEOM3, facial palsy, joint contractures, and early-onset peripheral neuropathy by Whitman, Mary C., Barry, Brenda J., Robson, Caroline D., Facio, Flavia M., Van Ryzin, Carol, Chan, Wai-Man, Lehky, Tanya J., Thurm, Audrey, Zalewski, Christopher, King, Kelly A., Brewer, Carmen, Almpani, Konstantinia, Lee, Janice S., Delaney, Angela, FitzGibbon, Edmond J., Lee, Paul R., Toro, Camilo, Paul, Scott M., Abdul-Rahman, Omar A., Webb, Bryn D., Jabs, Ethylin Wang, Moller, Hans Ulrik, Larsen, Dorte Ancher, Antony, Jayne H., Troedson, Christopher, Ma, Alan, Ragnhild, Glad, Wirgenes, Katrine V., Tham, Emma, Kvarnung, Malin, Maarup, Timothy James, MacKinnon, Sarah, Hunter, David G., Collins, Francis S., Manoli, Irini, Engle, Elizabeth C.

“…Microtubules are formed from heterodimers of alpha- and beta-tubulin, each of which has multiple isoforms encoded by separate genes. Pathogenic missense…”
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Opinion & Special Articles: Mentoring in neurology: Filling the residency gap in academic mentoring by Lee, Paul R, Marsh, Elisabeth B

“…Effective academic mentoring significantly affects a physicianʼs choice of career, academic productivity, and professional trajectory. The mentoring…”
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Aberrant splicing induced by the most common EPG5 mutation in an individual with Vici syndrome by Kane, Megan S, Vilboux, Thierry, Wolfe, Lynne A, Lee, Paul R, Wang, Yupeng, Huddleston, Kathi C, Vockley, Joseph G, Niederhuber, John E, Solomon, Benjamin D

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MED23-associated intellectual disability in a non-consanguineous family by Trehan, Aditi, Brady, Jacqueline M., Maduro, Valerie, Bone, William P., Huang, Yan, Golas, Gretchen A., Kane, Megan S., Lee, Paul R., Thurm, Audrey, Gropman, Andrea L., Paul, Scott M., Vezina, Gilbert, Markello, Thomas C., Gahl, William A., Boerkoel, Cornelius F., Tifft, Cynthia J.

“…Intellectual disability (ID) is a heterogeneous condition arising from a variety of environmental and genetic factors. Among these causes are defects in…”
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Detection of auto-antibodies to leiomodin-1 in patients with nodding syndrome by Johnson, Tory, Tyagi, Richa, Lee, Paul R, Lee, Myoung-hwa, Johnson, Kory R, Kowalak, Jeffery, Medynets, Marie, Hategan, Alina, Nutman, Thomas B, Sejvar, James, Makumbi, Issa, Aceng, Jane R, Dowell, Scott F, Nath, Avindra

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The Living Matrix: a Model for the Primary Respiratory Mechanism by Lee, R. Paul

“…Presented here is a physiological model for the primary respiratory mechanism, palpable fluctuations in the tissues to which practitioners of cranial…”
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