Search Results - "LEE, Lydia"

Adolescent Idiopathic Scoliosis: Common Questions and Answers by Kuznia, Angela L, Hernandez, Anita K, Lee, Lydia U

“…Adolescent idiopathic scoliosis affects 1% to 3% of U.S. adolescents. It is defined by a lateral curvature of the spine (Cobb angle) of at least 10 degrees in…”
Get full text

The Tyrian King in MT and LXX Ezekiel 28:12b–15 by Lee, Lydia

“…The biblical prophecy in Ezekiel 28:11–19 records a dirge against the king from Tyre. While the Hebrew Masoretic Text (MT) identifies the monarch as a cherub,…”
Get full text

Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment by Quevedo, Camilo E., Cruz-Migoni, Abimael, Bery, Nicolas, Miller, Ami, Tanaka, Tomoyuki, Petch, Donna, Bataille, Carole J. R., Lee, Lydia Y. W., Fallon, Phillip S., Tulmin, Hanna, Ehebauer, Matthias T., Fernandez-Fuentes, Narcis, Russell, Angela J., Carr, Stephen B., Phillips, Simon E. V., Rabbitts, Terence H.

“…Targeting specific protein–protein interactions (PPIs) is an attractive concept for drug development, but hard to implement since intracellular antibodies do…”
Get full text

Mapping human haematopoietic stem cells from haemogenic endothelium to birth by Calvanese, Vincenzo, Capellera-Garcia, Sandra, Ma, Feiyang, Fares, Iman, Liebscher, Simone, Ng, Elizabeth S., Ekstrand, Sophia, Aguadé-Gorgorió, Júlia, Vavilina, Anastasia, Lefaudeux, Diane, Nadel, Brian, Li, Jacky Y., Wang, Yanling, Lee, Lydia K., Ardehali, Reza, Iruela-Arispe, M. Luisa, Pellegrini, Matteo, Stanley, Ed G., Elefanty, Andrew G., Schenke-Layland, Katja, Mikkola, Hanna K. A.

“…The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the inability to identify HSCs as they emerge and mature at different…”
Get full text

Trends in New Use of Disease-Modifying Antirheumatic Drugs in Juvenile Idiopathic Arthritis Among Commercially Insured Children in the United States from 2001-2022 by Yalamanchili, Priyanka, Lee, Lydia Y, Bushnell, Greta, Mannion, Melissa L, Dave, Chintan V, Horton, Daniel B

“…To describe recent trends in DMARD use for children with juvenile idiopathic arthritis (JIA) in the US. We used commercial claims data (2000-2022) to perform a…”
Get full text

Deep Learning Enables Spatial Mapping of the Mosaic Microenvironment of Myeloma Bone Marrow Trephine Biopsies by Hagos, Yeman Brhane, Lecat, Catherine S Y, Patel, Dominic, Mikolajczak, Anna, Castillo, Simon P, Lyon, Emma J, Foster, Kane, Tran, Thien-An, Lee, Lydia S H, Rodriguez-Justo, Manuel, Yong, Kwee L, Yuan, Yinyin

“…Bone marrow trephine biopsy is crucial for the diagnosis of multiple myeloma. However, the complexity of bone marrow cellular, morphologic, and spatial…”
Get full text

The enemies within: Gog of Magog in Ezekiel 38–39 by Lee, Lydia

“…The most extensive descriptions of Gog and Magog in the Hebrew Bible appear in Ezekiel 38–39. At various stages of their political career, both Reagan and Bush…”
Get full text

c-Met-Dependent Multipotent Labyrinth Trophoblast Progenitors Establish Placental Exchange Interface by Ueno, Masaya, Lee, Lydia K., Chhabra, Akanksha, Kim, Yeon Joo, Sasidharan, Rajkumar, Van Handel, Ben, Wang, Ying, Kamata, Masakazu, Kamran, Paniz, Sereti, Konstantina-Ioanna, Ardehali, Reza, Jiang, Meisheng, Mikkola, Hanna K.A.

“…The placenta provides the interface for gas and nutrient exchange between the mother and the fetus. Despite its critical function in sustaining pregnancy, the…”
Get full text

Total Synthesis of Aplyronine C by Paterson, Ian, Fink, Sarah J, Lee, Lydia Y. W, Atkinson, Stephen J, Blakey, Simon B

“…A highly stereocontrolled total synthesis of the cytotoxic marine macrolide aplyronine C is described. The route exploits aldol methodology to install the…”
Get full text

Neurodevelopmental marker for limbic maldevelopment in antisocial personality disorder and psychopathy by Raine, Adrian, Lee, Lydia, Yang, Yaling, Colletti, Patrick

“…Antisocial personality disorder and psychopathy have been hypothesised to have a neurodevelopmental basis, but this proposition has not been formally tested…”
Get full text

Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) by Woolford, Alison J.-A, Day, Philip J, Bénéton, Véronique, Berdini, Valerio, Coyle, Joseph E, Dudit, Yann, Grondin, Pascal, Huet, Pascal, Lee, Lydia Y. W, Manas, Eric S, McMenamin, Rachel L, Murray, Christopher W, Page, Lee W, Patel, Vipulkumar K, Potvain, Florent, Rich, Sharna J, Sang, Yingxia, Somers, Don O, Trottet, Lionel, Wan, Zehong, Zhang, Xiaomin

“…Lp-PLA2 has been explored as a target for a number of inflammation associated diseases, including cardiovascular disease and dementia. This article describes…”
Get full text

Single-cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson’s disease by Khan, Arshad H., Lee, Lydia K., Smith, Desmond J.

“…Exposure to pesticides in humans increases the risk of Parkinson’s disease (PD), but the mechanisms remain poorly understood. To elucidate these pathways, we…”
Get full text

LYVE1 Marks the Divergence of Yolk Sac Definitive Hemogenic Endothelium from the Primitive Erythroid Lineage by Lee, Lydia K., Ghorbanian, Yasamine, Wang, Wenyuan, Wang, Yanling, Kim, Yeon Joo, Weissman, Irving L., Inlay, Matthew A., Mikkola, Hanna K.A.

“…The contribution of the different waves and sites of developmental hematopoiesis to fetal and adult blood production remains unclear. Here, we identify…”
Get full text

How healthcare systems evaluate their advance care planning initiatives: Results from a systematic review by Biondo, Patricia D, Lee, Lydia D, Davison, Sara N, Simon, Jessica E

“…Background: Advance care planning initiatives are being implemented across healthcare systems around the world, but how best to evaluate their implementation…”
Get full text

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X‑ray Fragment Screening by Woolford, Alison J.-A, Pero, Joseph E, Aravapalli, Sridhar, Berdini, Valerio, Coyle, Joseph E, Day, Philip J, Dodson, Andrew M, Grondin, Pascal, Holding, Finn P, Lee, Lydia Y. W, Li, Peng, Manas, Eric S, Marino, Joseph, Martin, Agnes C. L, McCleland, Brent W, McMenamin, Rachel L, Murray, Christopher W, Neipp, Christopher E, Page, Lee W, Patel, Vipulkumar K, Potvain, Florent, Rich, Sharna, Rivero, Ralph A, Smith, Kirsten, Somers, Donald O, Trottet, Lionel, Velagaleti, Ranganadh, Williams, Glyn, Xie, Ren

“…Elevated levels of human lipoprotein-associated phospholipase A2 (Lp-PLA2) are associated with cardiovascular disease and dementia. A fragment screen was…”
Get full text

Under-representation of ethnic minorities in early phase clinical trials for multiple myeloma by Asher, Samir, Kazantzi, Aikaterini, Dekaj, Fatjon, Steventon, Luke, Khatun, Aisha, Ainley, Louise, McMillan, Annabel, Rabin, Neil, Wechalekar, Ashu, Sive, Jonathan, Kyriakou, Charalampia, Papanikolaou, Xenofon, Xu, Ke, Mahmood, Shameem, Wisniowski, Brendan, Lee, Lydia, Yong, Kwee, Popat, Rakesh

Get full text

Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors by Murray, Christopher W, Berdini, Valerio, Buck, Ildiko M, Carr, Maria E, Cleasby, Anne, Coyle, Joseph E, Curry, Jayne E, Day, James E. H, Day, Phillip J, Hearn, Keisha, Iqbal, Aman, Lee, Lydia Y. W, Martins, Vanessa, Mortenson, Paul N, Munck, Joanne M, Page, Lee W, Patel, Sahil, Roomans, Susan, Smith, Kirsten, Tamanini, Emiliano, Saxty, Gordon

“…The DDR1 and DDR2 receptor tyrosine kinases are activated by extracellular collagen and have been implicated in a number of human diseases including cancer. We…”
Get full text

Nutritional model of steatohepatitis and metabolic syndrome in the Ossabaw miniature swine by Lee, Lydia, Alloosh, Mouhamad, Saxena, Romil, Van Alstine, William, Watkins, Bruce A., Klaunig, James E., Sturek, Michael, Chalasani, Naga

“…Miniature pigs residing in the Ossabaw Island (Ossabaw pigs) exhibit a thrifty genotype, and when fed a high‐calorie diet they consistently develop metabolic…”
Get full text

Characterization of Organic Phosphorus Form and Bioavailability in Lake Sediments using P Nuclear Magnetic Resonance and Enzymatic Hydrolysis by Giles, Courtney D, Lee, Lydia G, Cade-Menun, Barbara J, Hill, Jane E, Isles, Peter D F, Schroth, Andrew W, Druschel, Gregory K

“…Lake sediments are known to be a significant source of phosphorus (P) to plankton populations under certain biogeochemical conditions; however, the…”
Get full text

NINA-LAMP compared to microscopy, RDT, and nested PCR for the detection of imported malaria by Mohon, Abu Naser, Lee, LydiaDa-Yeong, Bayih, AbebeGenetu, Folefoc, Asongna, Guelig, Dylan, Burton, Robert, LaBarre, Paul, Chan, Wilson, Meatherall, Bonnie, Pillai, Dylan R

“…Abstract Microscopy and field adaptable rapid diagnostic tests (RDTs) are not sensitive and specific in certain conditions such as poor training of…”
Get full text