Search Results - "LEE, Dean A"

The role of AhR in transcriptional regulation of immune cell development and function by Trikha, Prashant, Lee, Dean A.

“…The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor (TF) that is a member of the Per-Arnt-Sim family of proteins. AhR regulates…”
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Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models by Otegbeye, Folashade, Ojo, Evelyn, Moreton, Stephen, Mackowski, Nathan, Lee, Dean A, de Lima, Marcos, Wald, David N

“…Natural killer cells harnessed from healthy individuals can be expanded ex vivo using various platforms to produce large doses for adoptive transfer into…”
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Phase 1 clinical trial using mbIL21 ex vivo–expanded donor-derived NK cells after haploidentical transplantation by Ciurea, Stefan O., Schafer, Jolie R., Bassett, Roland, Denman, Cecele J., Cao, Kai, Willis, Dana, Rondon, Gabriela, Chen, Julianne, Soebbing, Doris, Kaur, Indreshpal, Gulbis, Alison, Ahmed, Sairah, Rezvani, Katayoun, Shpall, Elizabeth J., Lee, Dean A., Champlin, Richard E.

“…Relapse has emerged as the most important cause of treatment failure after allogeneic hematopoietic stem cell transplantation (HSCT). To test the hypothesis…”
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Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity by Caruso, Hillary G, Hurton, Lenka V, Najjar, Amer, Rushworth, David, Ang, Sonny, Olivares, Simon, Mi, Tiejuan, Switzer, Kirsten, Singh, Harjeet, Huls, Helen, Lee, Dean A, Heimberger, Amy B, Champlin, Richard E, Cooper, Laurence J N

“…Many tumors overexpress tumor-associated antigens relative to normal tissue, such as EGFR. This limits targeting by human T cells modified to express chimeric…”
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Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cells by Denman, Cecele J, Senyukov, Vladimir V, Somanchi, Srinivas S, Phatarpekar, Prasad V, Kopp, Lisa M, Johnson, Jennifer L, Singh, Harjeet, Hurton, Lenka, Maiti, Sourindra N, Huls, M Helen, Champlin, Richard E, Cooper, Laurence J N, Lee, Dean A

“…NK cells have therapeutic potential for a wide variety of human malignancies. However, because NK cells expand poorly in vitro, have limited life spans in…”
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Repression of GSK3 restores NK cell cytotoxicity in AML patients by Parameswaran, Reshmi, Ramakrishnan, Parameswaran, Moreton, Stephen A., Xia, Zhiqiang, Hou, Yongchun, Lee, Dean A., Gupta, Kalpana, deLima, Marcos, Beck, Rose C., Wald, David N.

“…Natural killer cells from acute myeloid leukaemia patients (AML-NK) show a dramatic impairment in cytotoxic activity. The exact reasons for this dysfunction…”
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Natural killer cell therapy for hematologic malignancies: successes, challenges, and the future by Lamb, Margaret G, Rangarajan, Hemalatha G, Tullius, Brian P, Lee, Dean A

“…The adoptive transfer of natural killer (NK) cells is an emerging therapy in the field of immuno-oncology. In the last 3 decades, NK cells have been utilized…”
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Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target by Dufva, Olli, Kankainen, Matti, Kelkka, Tiina, Sekiguchi, Nodoka, Awad, Shady Adnan, Eldfors, Samuli, Yadav, Bhagwan, Kuusanmäki, Heikki, Malani, Disha, Andersson, Emma I, Pietarinen, Paavo, Saikko, Leena, Kovanen, Panu E., Ojala, Teija, Lee, Dean A., Loughran, Thomas P., Nakazawa, Hideyuki, Suzumiya, Junji, Suzuki, Ritsuro, Ko, Young Hyeh, Kim, Won Seog, Chuang, Shih-Sung, Aittokallio, Tero, Chan, Wing C., Ohshima, Koichi, Ishida, Fumihiro, Mustjoki, Satu

“…Aggressive natural killer-cell (NK-cell) leukemia (ANKL) is an extremely aggressive malignancy with dismal prognosis and lack of targeted therapies. Here, we…”
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Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector by Colamartino, Aurelien B L, Lemieux, William, Bifsha, Panojot, Nicoletti, Simon, Chakravarti, Nitin, Sanz, Joaquín, Roméro, Hugo, Selleri, Silvia, Béland, Kathie, Guiot, Mélanie, Tremblay-Laganière, Camille, Dicaire, Renée, Barreiro, Luis, Lee, Dean A, Verhoeyen, Els, Haddad, Elie

“…NK-cell resistance to transduction is a major technical hurdle for developing NK-cell immunotherapy. By using Baboon envelope pseudotyped lentiviral vectors…”
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Toward eliminating HLA class I expression to generate universal cells from allogeneic donors by Torikai, Hiroki, Reik, Andreas, Soldner, Frank, Warren, Edus H., Yuen, Carrie, Zhou, Yuanyue, Crossland, Denise L., Huls, Helen, Littman, Nicholas, Zhang, Ziying, Tykodi, Scott S., Kebriaei, Partow, Lee, Dean A., Miller, Jeffrey C., Rebar, Edward J., Holmes, Michael C., Jaenisch, Rudolf, Champlin, Richard E., Gregory, Philip D., Cooper, Laurence J.N.

“…Long-term engraftment of allogeneic cells necessitates eluding immune-mediated rejection, which is currently achieved by matching for human leukocyte antigen…”
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Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection by Kumaresan, Pappanaicken R., Manuri, Pallavi R., Albert, Nathaniel D., Maiti, Sourindra, Singh, Harjeet, Mi, Tiejuan, Roszik, Jason, Rabinovich, Brian, Olivares, Simon, Krishnamurthy, Janani, Zhang, Ling, Najjar, Amer M., Huls, M. Helen, Lee, Dean A., Champlin, Richard E., Kontoyiannis, Dimitrios P., Cooper, Laurence J. N.

“…Clinical-grade T cells are genetically modified ex vivo to express chimeric antigen receptors (CARs) to redirect their specificity to target tumor-associated…”
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Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells by Cox, Charles S., Hetz, Robert A., Liao, George P., Aertker, Benjamin M., Ewing‐Cobbs, Linda, Juranek, Jenifer, Savitz, Sean I., Jackson, Margaret L., Romanowska‐Pawliczek, Anna M., Triolo, Fabio, Dash, Pramod K., Pedroza, Claudia, Lee, Dean A., Worth, Laura, Aisiku, Imoigele P., Choi, Huimahn A., Holcomb, John B., Kitagawa, Ryan S.

“…Preclinical studies using bone marrow derived cells to treat traumatic brain injury have demonstrated efficacy in terms of blood–brain barrier preservation,…”
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Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells by Romain, Gabrielle, Senyukov, Vladimir, Rey-Villamizar, Nicolas, Merouane, Amine, Kelton, William, Liadi, Ivan, Mahendra, Ankit, Charab, Wissam, Georgiou, George, Roysam, Badrinath, Lee, Dean A., Varadarajan, Navin

“…The efficacy of most therapeutic monoclonal antibodies (mAbs) targeting tumor antigens results primarily from their ability to elicit potent cytotoxicity…”
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Engineering lymph node homing of ex vivo–expanded human natural killer cells via trogocytosis of the chemokine receptor CCR7 by Somanchi, Srinivas S., Somanchi, Anitha, Cooper, Laurence J.N., Lee, Dean A.

“…Natural killer (NK) cells have gained significant attention in adoptive immunotherapy for cancer. Consequently, novel methods of clinical-grade expansion of NK…”
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Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations by Aggarwal, Payal, Luo, Wen, Pehlivan, Katherine C, Hoang, Hai, Rajappa, Prajwal, Cripe, Timothy P, Cassady, Kevin A, Lee, Dean A, Cairo, Mitchell S

“…High grade gliomas are identified as malignant central nervous tumors that spread rapidly and have a universally poor prognosis. Historically high grade…”
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A Novel Method for Assessment of Natural Killer Cell Cytotoxicity Using Image Cytometry by Somanchi, Srinivas S, McCulley, Kelsey J, Somanchi, Anitha, Chan, Leo L, Lee, Dean A

“…Natural killer (NK) cells belong to the innate arm of the immune system and though activated NK cells can modulate immune responses through the secretion of…”
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NKG2D-CAR-transduced natural killer cells efficiently target multiple myeloma by Leivas, Alejandra, Valeri, Antonio, Córdoba, Laura, García-Ortiz, Almudena, Ortiz, Alejandra, Sánchez-Vega, Laura, Graña-Castro, Osvaldo, Fernández, Lucía, Carreño-Tarragona, Gonzalo, Pérez, Manuel, Megías, Diego, Paciello, María Liz, Sánchez-Pina, Jose, Pérez-Martínez, Antonio, Lee, Dean A., Powell, Daniel J., Río, Paula, Martínez-López, Joaquín

“…CAR-T-cell therapy against MM currently shows promising results, but usually with serious toxicities. CAR-NK cells may exert less toxicity when redirected…”
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Clinical‐Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy by Knorr, David A., Ni, Zhenya, Hermanson, David, Hexum, Melinda K., Bendzick, Laura, Cooper, Laurence J.N., Lee, Dean A., Kaufman, Dan S.

“…This study used a two‐stage culture system to efficiently produce natural killer (NK) cells from human embryonic stem cells (hESCs) and induced pluripotent…”
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Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione by Bailey, Cavan P, Figueroa, Mary, Gangadharan, Achintyan, Lee, Dean A, Chandra, Joya

“…Cell therapies such as chimeric-antigen receptor (CAR) T-cells and NK cells are cutting-edge methods for treating cancer and other diseases. There is high…”
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Antigen presenting cell-mediated expansion of human umbilical cord blood yields log-scale expansion of natural killer cells with anti-myeloma activity by Shah, Nina, Martin-Antonio, Beatriz, Yang, Hong, Ku, Stephanie, Lee, Dean A, Cooper, Laurence J N, Decker, William K, Li, Sufang, Robinson, Simon N, Sekine, Takuya, Parmar, Simrit, Gribben, John, Wang, Michael, Rezvani, Katy, Yvon, Eric, Najjar, Amer, Burks, Jared, Kaur, Indreshpal, Champlin, Richard E, Bollard, Catherine M, Shpall, Elizabeth J

“…Natural killer (NK) cells are important mediators of anti-tumor immunity and are active against several hematologic malignancies, including multiple myeloma…”
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