Search Results - "LEE, Choogon"

CRY arrests Cop1 to regulate circadian rhythms in mammals by Lee, Choogon

“…Cryptochromes (CRYs) are UVA and blue light photoreceptors present in all major evolutionary lineages ranging from cyanobacteria to plants and animals,…”
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Generation of CRISPR-Cas9-mediated knockin mutant models in mice and MEFs for studies of polymorphism in clock genes by Lee, Kwangjun, Lee, Choogon

“…The creation of mutant mice has been invaluable for advancing biomedical science, but is too time- and resource-intensive for investigating the full range of…”
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Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis by Kettner, Nicole M., Voicu, Horatio, Finegold, Milton J., Coarfa, Cristian, Sreekumar, Arun, Putluri, Nagireddy, Katchy, Chinenye A., Lee, Choogon, Moore, David D., Fu, Loning

“…Chronic jet lag induces spontaneous hepatocellular carcinoma (HCC) in wild-type mice following a mechanism very similar to that observed in obese humans. The…”
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miRNAs Are Required for Generating a Time Delay Critical for the Circadian Oscillator by Chen, Rongmin, D’Alessandro, Matthew, Lee, Choogon

“…Circadian clocks coordinate an organism’s activities and regulate metabolic homeostasis in relation to daily environmental changes, most notably light/dark…”
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Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals by Koike, Nobuya, Yoo, Seung-Hee, Huang, Hung-Chung, Kumar, Vivek, Lee, Choogon, Kim, Tae-Kyung, Takahashi, Joseph S.

“…The mammalian circadian clock involves a transcriptional feedback loop in which CLOCK and BMAL1 activate the Period and Cryptochrome genes, which then feed…”
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mTOR signaling regulates central and peripheral circadian clock function by Ramanathan, Chidambaram, Kathale, Nimish D, Liu, Dong, Lee, Choogon, Freeman, David A, Hogenesch, John B, Cao, Ruifeng, Liu, Andrew C

“…The circadian clock coordinates physiology and metabolism. mTOR (mammalian/mechanistic target of rapamycin) is a major intracellular sensor that integrates…”
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NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging by Levine, Daniel C., Hong, Heekyung, Weidemann, Benjamin J., Ramsey, Kathryn M., Affinati, Alison H., Schmidt, Mark S., Cedernaes, Jonathan, Omura, Chiaki, Braun, Rosemary, Lee, Choogon, Brenner, Charles, Peek, Clara Bien, Bass, Joseph

“…Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with metabolic disease and reduced levels of NAD+, yet whether changes…”
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Circadian Dysfunction Induces Leptin Resistance in Mice by Kettner, Nicole M., Mayo, Sara A., Hua, Jack, Lee, Choogon, Moore, David D., Fu, Loning

“…Circadian disruption is associated with obesity, implicating the central clock in body weight control. Our comprehensive screen of wild-type and three…”
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Essential roles of CKIδ and CKIε in the mammalian circadian clock by Lee, Hyeongmin, Chen, Rongmin, Lee, Yongjin, Yoo, Seunghee, Lee, Choogon

“…Circadian rhythms in mammals are generated by a negative transcriptional feedback loop in which PERIOD (PER) is rate-limiting for feedback inhibition. Casein…”
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Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD⁺ Biosynthesis by Ramsey, Kathryn Moynihan, Yoshino, Jun, Brace, Cynthia S, Abrassart, Dana, Kobayashi, Yumiko, Marcheva, Biliana, Hong, Hee-Kyung, Chong, Jason L, Buhr, Ethan D, Lee, Choogon, Takahashi, Joseph S, Imai, Shin-ichiro, Bass, Joseph

“…The circadian clock is encoded by a transcription-translation feedback loop that synchronizes behavior and metabolism with the light-dark cycle. Here we report…”
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Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis by Beesley, Stephen, Kim, Dae Wook, D’Alessandro, Matthew, Jin, Yuanhu, Lee, Kwangjun, Joo, Hyunjeong, Young, Yang, Tomko, Robert J., Faulkner, John, Gamsby, Joshua, Kim, Jae Kyoung, Lee, Choogon

“…The circadian clock is based on a transcriptional feedback loop with an essential time delay before feedback inhibition. Previous work has shown that PERIOD…”
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Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture by Matsu-ura, Toru, Dovzhenok, Andrey, Aihara, Eitaro, Rood, Jill, Le, Hung, Ren, Yan, Rosselot, Andrew E., Zhang, Tongli, Lee, Choogon, Obrietan, Karl, Montrose, Marshall H., Lim, Sookkyung, Moore, Sean R., Hong, Christian I.

“…Circadian clock-gated cell division cycles are observed from cyanobacteria to mammals via intracellular molecular connections between these two oscillators…”
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period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1 by Lee, Hyeong-min, Chen, Rongmin, Kim, Hyukmin, Etchegaray, Jean-Pierre, Weaver, David R, Lee, Choogon

“…Mounting evidence suggests that PERIOD (PER) proteins play a central role in setting the speed (period) and phase of the circadian clock. Pharmacological and…”
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Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression by Siepka, Sandra M., Yoo, Seung-Hee, Park, Junghea, Song, Weimin, Kumar, Vivek, Hu, Yinin, Lee, Choogon, Takahashi, Joseph S.

“…Using a forward genetics ENU mutagenesis screen for recessive mutations that affect circadian rhythmicity in the mouse, we isolated a long period (∼26 hr)…”
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Stability of Wake-Sleep Cycles Requires Robust Degradation of the PERIOD Protein by D’Alessandro, Matthew, Beesley, Stephen, Kim, Jae Kyoung, Jones, Zachary, Chen, Rongmin, Wi, Julie, Kyle, Kathleen, Vera, Daniel, Pagano, Michele, Nowakowski, Richard, Lee, Choogon

“…Robustness in biology is the stability of phenotype under diverse genetic and/or environmental perturbations. The circadian clock has remarkable stability of…”
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Rhythmic PER Abundance Defines a Critical Nodal Point for Negative Feedback within the Circadian Clock Mechanism by Chen, Rongmin, Schirmer, Aaron, Lee, Yongjin, Lee, Hyeongmin, Kumar, Vivek, Yoo, Seung-Hee, Takahashi, Joseph S., Lee, Choogon

“…Circadian rhythms in mammals are generated by a transcriptional negative feedback loop that is driven primarily by oscillations of PER and CRY, which inhibit…”
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Light-regulated translational control of circadian behavior by eIF4E phosphorylation by Cao, Ruifeng, Gkogkas, Christos G, de Zavalia, Nuria, Blum, Ian D, Yanagiya, Akiko, Tsukumo, Yoshinori, Xu, Haiyan, Lee, Choogon, Storch, Kai-Florian, Liu, Andrew C, Amir, Shimon, Sonenberg, Nahum

“…Light controls animal circadian behavior by regulating gene expression in the circadian clock. Here, Cao et al. reports that a light-activated MAPK/MNK pathway…”
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Stoichiometric Relationship among Clock Proteins Determines Robustness of Circadian Rhythms by Lee, Yongjin, Chen, Rongmin, Lee, Hyeong-min, Lee, Choogon

“…The mammalian circadian oscillator is primarily driven by an essential negative feedback loop comprising a positive component, the CLOCK-BMAL1 complex, and a…”
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Streamlined procedure for gene knockouts using all-in-one adenoviral CRISPR-Cas9 by Jin, Yuan-Hu, Joo, Hyunjeong, Lee, Kwangjun, Kim, Hyeongseok, Didier, Ruth, Yang, Young, Shin, Heungsop, Lee, Choogon

“…CRISPR-Cas9 is a powerful gene editing technique that can induce mutations in a target gene of interest in almost any mammalian cell line. However, its…”
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A tunable artificial circadian clock in clock-defective mice by D’Alessandro, Matthew, Beesley, Stephen, Kim, Jae Kyoung, Chen, Rongmin, Abich, Estela, Cheng, Wayne, Yi, Paul, Takahashi, Joseph S., Lee, Choogon

“…Self-sustaining oscillations are essential for diverse physiological functions such as the cell cycle, insulin secretion and circadian rhythms. Synthetic…”
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