Search Results - "LEE, CLARE"

Gut microbiome and its role in obesity and insulin resistance by Lee, Clare J., Sears, Cynthia L., Maruthur, Nisa

“…Obesity is a complex metabolic disease caused, in part, by the interaction between an individual's genetics, metabolism, and environment. Emerging evidence…”
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Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial by Rosenstock, Julio, Wysham, Carol, Frías, Juan P, Kaneko, Shizuka, Lee, Clare J, Fernández Landó, Laura, Mao, Huzhang, Cui, Xuewei, Karanikas, Chrisanthi A, Thieu, Vivian T

“…Despite advancements in care, many people with type 2 diabetes do not meet treatment goals; thus, development of new therapies is needed. We aimed to assess…”
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Humanizing the yeast origin recognition complex by Lee, Clare S. K., Cheung, Ming Fung, Li, Jinsen, Zhao, Yongqian, Lam, Wai Hei, Ho, Vincy, Rohs, Remo, Zhai, Yuanliang, Leung, Danny, Tye, Bik-Kwoon

“…The Origin Recognition Complex (ORC) is an evolutionarily conserved six-subunit protein complex that binds specific sites at many locations to coordinately…”
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Global potential for harvesting drinking water from air using solar energy by Lord, Jackson, Thomas, Ashley, Treat, Neil, Forkin, Matthew, Bain, Robert, Dulac, Pierre, Behroozi, Cyrus H., Mamutov, Tilek, Fongheiser, Jillia, Kobilansky, Nicole, Washburn, Shane, Truesdell, Claudia, Lee, Clare, Schmaelzle, Philipp H.

“…Access to safely managed drinking water (SMDW) remains a global challenge, and affects 2.2 billion people 1 , 2 . Solar-driven atmospheric water harvesting…”
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The Association of Severe Hypoglycemia With Incident Cardiovascular Events and Mortality in Adults With Type 2 Diabetes by Lee, Alexandra K, Warren, Bethany, Lee, Clare J, McEvoy, John W, Matsushita, Kunihiro, Huang, Elbert S, Sharrett, A Richey, Coresh, Josef, Selvin, Elizabeth

“…There is suggestive evidence linking hypoglycemia with cardiovascular disease, but few data have been collected in a community-based setting. Information is…”
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The human pre-replication complex is an open complex by Li, Jian, Dong, Jiangqing, Wang, Weitao, Yu, Daqi, Fan, Xinyu, Hui, Yan Chit, Lee, Clare S.K., Lam, Wai Hei, Alary, Nathan, Yang, Yang, Zhang, Yingyi, Zhao, Qian, Chen, Chun-Long, Tye, Bik-Kwoon, Dang, Shangyu, Zhai, Yuanliang

“…In eukaryotes, DNA replication initiation requires assembly and activation of the minichromosome maintenance (MCM) 2–7 double hexamer (DH) to melt origin DNA…”
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Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes by Lee, Clare S.K., Weiβ, Matthias, Hamperl, Stephan

“…In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication named origins are dispersed across each of the linear chromosomes…”
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Risk Factors for Severe Hypoglycemia in Black and White Adults With Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study by Lee, Alexandra K, Lee, Clare J, Huang, Elbert S, Sharrett, A Richey, Coresh, Josef, Selvin, Elizabeth

“…Severe hypoglycemia is a rare but important complication of type 2 diabetes. Few studies have examined the epidemiology of hypoglycemia in a community-based…”
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Efficacy of commercial weight-loss programs: an updated systematic review by Gudzune, Kimberly A, Doshi, Ruchi S, Mehta, Ambereen K, Chaudhry, Zoobia W, Jacobs, David K, Vakil, Rachit M, Lee, Clare J, Bleich, Sara N, Clark, Jeanne M

“…Commercial and proprietary weight-loss programs are popular obesity treatment options, but their efficacy is unclear. To compare weight loss, adherence, and…”
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Prevalence of and risk factors for hypoglycemic symptoms after gastric bypass and sleeve gastrectomy by Lee, Clare J., Clark, Jeanne M., Schweitzer, Michael, Magnuson, Thomas, Steele, Kimberley, Koerner, Olivia, Brown, Todd T.

“…Objective To determine the prevalence of and risk factors for postprandial hypoglycemic symptoms among bariatric surgery patients. Methods A questionnaire…”
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Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency by Chanou, Anna, Weiβ, Matthias, Holler, Karoline, Sajid, Atiqa, Straub, Tobias, Krietsch, Jana, Sanchi, Andrea, Ummethum, Henning, Lee, Clare S K, Kruse, Elisabeth, Trauner, Manuel, Werner, Marcel, Lalonde, Maxime, Lopes, Massimo, Scialdone, Antonio, Hamperl, Stephan

“…Abstract Stochastic origin activation gives rise to significant cell-to-cell variability in the pattern of genome replication. The molecular basis for…”
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The Effect of Vitamin D Supplementation on Glucose Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Intervention Studies by Lee, Clare J, Iyer, Geetha, Liu, Yang, Kalyani, Rita R, Bamba, N’ Dama, Ligon, Colin B, Varma, Sanskriti, Mathioudakis, Nestoras

“…Abstract Aims We aimed to assess whether vitamin D supplementation improves glucose metabolism in adults with type 2 diabetes. Methods PubMed and Cochrane…”
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Changes in Gut Microbiome after Bariatric Surgery Versus Medical Weight Loss in a Pilot Randomized Trial by Lee, Clare J., Florea, Liliana, Sears, Cynthia L., Maruthur, Nisa, Potter, James J., Schweitzer, Michael, Magnuson, Thomas, Clark, Jeanne M.

“…Background Gut microbiota likely impact obesity and metabolic diseases. We evaluated the changes in gut microbiota after surgical versus medical weight loss in…”
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Severe hypoglycaemia, mild cognitive impairment, dementia and brain volumes in older adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) cohort study by Lee, Alexandra K., Rawlings, Andreea M., Lee, Clare J., Gross, Alden L., Huang, Elbert S., Sharrett, A. Richey, Coresh, Josef, Selvin, Elizabeth

“…Aims/hypothesis We aimed to evaluate the link between severe hypoglycaemia and domain-specific cognitive decline, smaller brain volumes and dementia in adults…”
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Impact on glycated haemoglobin and body weight changes after stopping tirzepatide for 4 weeks in the SURPASS‐1 monotherapy trial by Rosenstock, Julio, Lee, Clare J., Fernández Landó, Laura, Liu, Minzhi, Karanikas, Chrisanthi A., Thieu, Vivian T.

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Comparative Efficacy and Safety of Neuroprotective Therapies for Neonates With Hypoxic Ischemic Encephalopathy: A Network Meta-Analysis by Lee, Clare Yuen Zen, Chakranon, Pairote, Lee, Shaun Wen Huey

“…Context: Several interventions are available for the management of hypoxic ischemic encephalopathy (HIE), but no studies have compared their relative efficacy…”
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Levothyroxine Dosing Following Bariatric Surgery by Gadiraju, Silpa, Lee, Clare J., Cooper, David S.

“…Background Based on the mechanisms of drug absorption, increased levothyroxine requirements are expected after bariatric surgery. However, there are…”
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Improved HbA1c and body weight in GADA-positive individuals treated with tirzepatide: A post hoc analysis of SURPASS by Peters, Anne L, Buzzetti, Raffaella, Lee, Clare J, Pavo, Imre, Liu, Minzhi, Karanikas, Chrisanthi A, Paik, Jim S

“…People with clinically diagnosed type 2 diabetes (T2D) but positive anti-glutamic acid decarboxylase autoantibodies (GADA), referred to here as latent…”
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RE: Author Response to Reader Comment by Lee, Clare J.

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Severe Hypoglycemia and Risk of Falls in Type 2 Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study by Lee, Alexandra K, Juraschek, Stephen P, Windham, B Gwen, Lee, Clare J, Sharrett, A Richey, Coresh, Josef, Selvin, Elizabeth

“…Hypoglycemia has been postulated to contribute to falls risk in older adults with type 2 diabetes. However, few studies have prospectively examined the…”
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