Search Results - "LEE, Byungkook"

Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes by Liu, Wenhai, Onda, Masanori, Lee, Byungkook, Kreitman, Robert J, Hassan, Raffit, Xiang, Laiman, Pastan, Ira

“…Recombinant immunotoxins (RITs) are hybrid proteins used to treat cancer. These proteins are composed of an Fv that reacts with cancer cells joined to a…”
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Assessment of template-free modeling in CASP10 and ROLL by Tai, Chin-Hsien, Bai, Hongjun, Taylor, Todd J., Lee, Byungkook

“…ABSTRACT We present the assessment of predictions for Template‐Free Modeling in CASP10 and a report on the first ROLL experiment wherein predictions are…”
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Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes by Mazor, Ronit, Eberle, Jaime A., Hu, Xiaobo, Vassall, Aaron N., Onda, Masanori, Beers, Richard, Lee, Elizabeth C., Kreitman, Robert J., Lee, Byungkook, Baker, David, King, Chris, Hassan, Raffit, Benhar, Itai, Ira

“…Nonhuman proteins have valuable therapeutic properties, but their efficacy is limited by neutralizing antibodies. Recombinant immunotoxins (RITs) are potent…”
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Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes by Onda, Masanori, Beers, Richard, Xiang, Laiman, Lee, Byungkook, Weldon, John E, Kreitman, Robert J, Pastan, Ira

“…Many nonhuman proteins have useful pharmacological activities, but are infrequently effective in humans because of their high immunogenicity. A recombinant…”
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A Binding Domain on Mesothelin for CA125/MUC16 by Kaneko, Osamu, Gong, Lucy, Zhang, Jingli, Hansen, Johanna K., Hassan, Raffit, Lee, Byungkook, Ho, Mitchell

“…Ovarian cancer and malignant mesothelioma frequently express both mesothelin and CA125 (also known as MUC16) at high levels on the cell surface. The…”
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Detecting internally symmetric protein structures by Kim, Changhoon, Basner, Jodi, Lee, Byungkook

“…Many functional proteins have a symmetric structure. Most of these are multimeric complexes, which are made of non-symmetric monomers arranged in a symmetric…”
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Accuracy of structure-based sequence alignment of automatic methods by Kim, Changhoon, Lee, Byungkook

“…Accurate sequence alignments are essential for homology searches and for building three-dimensional structural models of proteins. Since structure is better…”
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Effect of antigen shedding on targeted delivery of immunotoxins in solid tumors from a mathematical model by Pak, Youngshang, Pastan, Ira, Kreitman, Robert J, Lee, Byungkook

“…Most cancer-specific antigens used as targets of antibody-drug conjugates and immunotoxins are shed from the cell surface (Zhang & Pastan (2008) Clin. Cancer…”
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Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors by Gubbels, Jennifer A A, Belisle, Jennifer, Onda, Masanori, Rancourt, Claudine, Migneault, Martine, Ho, Mitchell, Bera, Tapan K, Connor, Joseph, Sathyanarayana, Bangalore K, Lee, Byungkook, Pastan, Ira, Patankar, Manish S

“…The mucin MUC16 and the glycosylphosphatidylinositol anchored glycoprotein mesothelin likely facilitate the peritoneal metastasis of ovarian tumors. The…”
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Molecular Models of STAT5A Tetramers Complexed to DNA Predict Relative Genome-Wide Frequencies of the Spacing between the Two Dimer Binding Motifs of the Tetramer Binding Sites by Sathyanarayana, Bangalore K, Li, Peng, Lin, Jian-Xin, Leonard, Warren J, Lee, Byungkook

“…STAT proteins bind DNA as dimers and tetramers to control cellular development, differentiation, survival, and expansion. The tetramer binding sites are…”
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Neighbor overlap is enriched in the yeast interaction network: analysis and implications by Feiglin, Ariel, Moult, John, Lee, Byungkook, Ofran, Yanay, Unger, Ron

“…The yeast protein-protein interaction network has been shown to have distinct topological features such as a scale free degree distribution and a high level of…”
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model for obesity and gigantism due to disruption of the Ankrd26 gene by Bera, Tapan K, Liu, Xiu-Fen, Yamada, Masanori, Gavrilova, Oksana, Mezey, Eva, Tessarollo, Lino, Anver, Miriam, Hahn, Yoonsoo, Lee, Byungkook, Pastan, Ira

“…Obesity is a major health hazard that is caused by a combination of genetic and behavioral factors. Several models of obesity have been described in mice that…”
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Site-Specific Chemical Modification with Polyethylene Glycol of Recombinant Immunotoxin Anti-Tac(Fv)-PE38 (LMB-2) Improves Antitumor Activity and Reduces Animal Toxicity and Immunogenicity by Tsutsumi, Yasuo, Onda, Masanori, Nagata, Satoshi, Lee, Byungkook, Kreitman, Robert J., Pastan, Ira

“…Chemical modification of proteins with polyethylene glycol (PEGylation) can increase plasma half-lives, stability, and therapeutic potency. To make a PEGylated…”
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PATE Gene Clusters Code for Multiple, Secreted TFP/Ly-6/uPAR Proteins That Are Expressed in Reproductive and Neuron-rich Tissues and Possess Neuromodulatory Activity by Levitin, Fiana, Weiss, Mordechai, Hahn, Yoonsoo, Stern, Omer, Papke, Roger L., Matusik, Robert, Nandana, Srinivas R., Ziv, Ravit, Pichinuk, Edward, Salame, Sharbel, Bera, Tapan, Vincent, James, Lee, Byungkook, Pastan, Ira, Wreschner, Daniel H.

“…We report here syntenic loci in humans and mice incorporating gene clusters coding for secreted proteins each comprising 10 cysteine residues. These conform to…”
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Iterative refinement of structure-based sequence alignments by Seed Extension by Kim, Changhoon, Tai, Chin-Hsien, Lee, Byungkook

“…Accurate sequence alignment is required in many bioinformatics applications but, when sequence similarity is low, it is difficult to obtain accurate alignments…”
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Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database by BRINKMANN, U, VASMATZIS, G, BYUNGKOOK LEE, PASTAN, I

“…We have developed a computer-based screening strategy to search the dbEST database to find differentiation antigens that are expressed by cancers arising in…”
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Circularly permuted proteins in the protein structure database by Jung, Jongsun, Lee, Byungkook

“…Some proteins are homologous to others after their sequence is circularly permuted. A few such proteins have been recognized, mainly by sequence comparison,…”
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Protein domain assignment from the recurrence of locally similar structures by Tai, Chin-Hsien, Sam, Vichetra, Gibrat, Jean-Francois, Garnier, Jean, Munson, Peter J., Lee, Byungkook

“…Domains are basic units of protein structure and essential for exploring protein fold space and structure evolution. With the structural genomics initiative,…”
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POTE paralogs are induced and differentially expressed in many cancers by BERA, Tapan K, FLEUR, Ashley Saint, LEE, Yoomi, KYDD, Andre, HAHN, Yoonsoo, POPESCU, Nicholas C, ZIMONJIC, Drazen B, LEE, Byungkook, PASTAN, Ira

“…To identify new antigens that are targets for the immunotherapy of prostate and breast cancer, we used expressed sequence tag and genomic databases and…”
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MRP9, An Unusual Truncated Member of the ABC Transporter Superfamily, is Highly Expressed in Breast Cancer by Bera, Tapan K., Iavarone, Carlo, Kumar, Vasantha, Lee, Sanghyuk, Lee, Byungkook, Pastan, Ira

“…Combining a computer-based screening strategy and functional genomics, we previously identified MRP9 (ABCC12), a member of the ATP-binding cassette (ABC)…”
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