Search Results - "LEDERER, W. J"

Calcium Sparks by Cheng, Heping, Lederer, W. J

“…Institute of Molecular Medicine, National Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing, China; and Medical Biotechnology…”
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X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart by Prosser, Benjamin L., Ward, Christopher W., Lederer, W. J.

“…We report that in heart cells, physiologic stretch rapidly activates reduced-form nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) to…”
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Mitochondrial calcium uptake by Williams, George S. B., Boyman, Liron, Chikando, Aristide C., Khairallah, Ramzi J., Lederer, W. J.

“…Calcium (Ca²⁺) uptake into the mitochondrial matrix is critically important to cellular function. As a regulator of matrix Ca²⁺ levels, this flux influences…”
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STIM1 enhances SR Ca²⁺ content through binding phospholamban in rat ventricular myocytes by Zhao, Guiling, Li, Tianyu, Brochet, Didier X. P., Rosenberg, Paul B., Lederer, W. J.

“…In ventricular myocytes, the physiological function of stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum (ER/SR) Ca²⁺ sensor, is unclear…”
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Orphaned Ryanodine Receptors in the Failing Heart by Song, Long-Sheng, Sobie, Eric A., McCulle, Stacey, Lederer, W. J., Balke, C. William, Cheng, Heping

“…Heart muscle is characterized by a regular array of proteins and structures that form a repeating functional unit identified as the sarcomere. This regular…”
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Calmodulin kinase II inhibition protects against structural heart disease by Anderson, Mark E, Zhang, Rong, Khoo, Michelle S C, Wu, Yuejin, Yang, Yingbo, Grueter, Chad E, Ni, Gemin, Price, Edward E, Thiel, William, Guatimosim, Silvia, Song, Long-Sheng, Madu, Ernest C, Shah, Anisha N, Vishnivetskaya, Tatiana A, Atkinson, James B, Gurevich, Vsevolod V, Salama, Guy, Lederer, W J, Colbran, Roger J

“…Beta-adrenergic receptor (betaAR) stimulation increases cytosolic Ca(2+) to physiologically augment cardiac contraction, whereas excessive betaAR activation…”
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Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death by Bennett, Vann, Mohler, Peter J, Schott, Jean-Jacques, Gramolini, Anthony O, Dilly, Keith W, Guatimosim, Silvia, duBell, William H, Song, Long-Sheng, Haurogné, Karine, Kyndt, Florence, Ali, Mervat E, Rogers, Terry B, Lederer, W. J, Escande, Denis, Marec, Herve Le

“…Mutations in ion channels involved in the generation and termination of action potentials constitute a family of molecular defects that underlie fatal cardiac…”
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The growing importance of mitochondrial calcium in health and disease by Boyman, Liron, Williams, George S. B., Lederer, W. J.

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On the Adjacency Matrix of RyR2 Cluster Structures by Walker, Mark A, Kohl, Tobias, Lehnart, Stephan E, Greenstein, Joseph L, Lederer, W J, Winslow, Raimond L

“…In the heart, electrical stimulation of cardiac myocytes increases the open probability of sarcolemmal voltage-sensitive Ca2+ channels and flux of Ca2+ into…”
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STIM1–Ca2+signaling modulates automaticity of the mouse sinoatrial node by Zhang, Hengtao, Sun, Albert Y., Kim, Jong J., Graham, Victoria, Finch, Elizabeth A., Nepliouev, Igor, Zhao, Guiling, Li, Tianyu, Lederer, W. J., Stiber, Jonathan A., Pitt, Geoffrey S., Bursac, Nenad, Rosenberg, Paul B.

“…Cardiac pacemaking is governed by specialized cardiomyocytes located in the sinoatrial node (SAN). SAN cells (SANCs) integrate voltage-gated currents from…”
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Superresolution Modeling of Calcium Release in the Heart by Walker, Mark A., Williams, George S.B., Kohl, Tobias, Lehnart, Stephan E., Jafri, M. Saleet, Greenstein, Joseph L., Lederer, W.J., Winslow, Raimond L.

“…Stable calcium-induced calcium release (CICR) is critical for maintaining normal cellular contraction during cardiac excitation-contraction coupling. The…”
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Stabilization of Cardiac Ryanodine Receptor Prevents Intracellular Calcium Leak and Arrhythmias by Lehnart, Stephan E., Terrenoire, Cecile, Reiken, Steven, Wehrens, Xander H. T., Song, Long-Sheng, Tillman, Erik J., Mancarella, Salvatore, Coromilas, James, Lederer, W. J., Kass, Robert S., Marks, Andrew R.

“…Catecholaminergic polymorphic ventricular tachycardia is a form of exercise-induced sudden cardiac death that has been linked to mutations in the cardiac Ca²⁺…”
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Dynamics of Calcium Sparks and Calcium Leak in the Heart by Williams, George S.B., Chikando, Aristide C., Tuan, Hoang-Trong M., Sobie, Eric A., Lederer, W.J., Jafri, M. Saleet

“…We present what we believe to be a new mathematical model of Ca2+ leak from the sarcoplasmic reticulum (SR) in the heart. To our knowledge, it is the first to…”
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Relaxation of Arterial Smooth Muscle by Calcium Sparks by Nelson, M. T., Cheng, H., Rubart, M., Santana, L. F., Bonev, A. D., Knot, H. J., Lederer, W. J.

“…Local increases in intracellular calcium ion concentration ([Ca$^{2+}$]$_i$) resulting from activation of the ryanodine-sensitive calcium-release channel in…”
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Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling by Previs, Michael J, Prosser, Benjamin L, Mun, Ji Young, Previs, Samantha Beck, Gulick, James, Lee, Kyounghwan, Robbins, Jeffrey, Craig, Roger, Lederer, W J, Warshaw, David M

“…The beating heart exhibits remarkable contractile fidelity over a lifetime, which reflects the tight coupling of electrical, chemical, and mechanical elements…”
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Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle by Cheng, H., Lederer, W. J., Cannell, M. B.

“…Spontaneous local increases in the concentration of intracellular calcium, called "calcium sparks," were detected in quiescent rat heart cells with a laser…”
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Local recovery of Ca2+ release in rat ventricular myocytes by Sobie, Eric A., Song, Long‐Sheng, Lederer, W. J.

“…Excitation–contraction coupling in the heart depends on the positive feedback process of Ca 2 + -induced Ca 2 + release (CICR). While CICR provides for…”
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Heart failure after myocardial infarction : Altered excitation-contraction coupling by GOMEZ, A. M, GUATIMOSIM, S, DILLY, K. W, VASSORT, G, LEDERER, W. J

“…Heart failure (HF) frequently follows the occurrence of myocardial infarction (MI). Questions about how HF develops and what cellular defects contribute to…”
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Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure by Gómez, A. M., Valdivia, H. H., Cheng, H., Lederer, Miriam R., Santana, L. F., Cannell, M. B., McCune, S. A., Altschuld, R. A., Lederer, W. J.

“…Cardiac hypertrophy and heart failure caused by high blood pressure were studied in single myocytes taken from hypertensive rats (Dahl SS/Jr) and SH-HF rats in…”
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FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death by Wehrens, Xander H.T., Lehnart, Stephan E., Huang, Fannie, Vest, John A., Reiken, Steven R., Mohler, Peter J., Sun, Jie, Guatimosim, Silvia, Song, Long-Sheng, Rosemblit, Nora, D'Armiento, Jeanine M., Napolitano, Carlo, Memmi, Mirella, Priori, Silvia G., Lederer, W.J., Marks, Andrew R.

“…Arrhythmias, a common cause of sudden cardiac death, can occur in structurally normal hearts, although the mechanism is not known. In cardiac muscle, the…”
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