Search Results - "LEDENT, C"

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy by Laurent, C., Burnouf, S., Ferry, B., Batalha, Vânia, Coelho, Joana, Baqi, Y., Malik, E., Mariciniak, E., Parrot, S., Van der Jeugd, A., Faivre, E., Flaten, V., Ledent, C., D'Hooge, R., Sergeant, N., Hamdane, M., Humez, S., Müller, C. E., Lopes, Luisa, Buée, L., Blum, D.

“…© 2016 Macmillan Publishers Limited All rights reserved. This work is licensed under a Creative Commons Attribution- NonCommercial-NoDerivs 4.0 International…”
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The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety by Haller, J., Bakos, N., Szirmay, M., Ledent, C., Freund, T. F.

“…The aim of this study was to compare the effects of the genetic and pharmacological disruption of CB1 cannabinoid receptors on the elevated plus‐maze test of…”
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Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus by Hájos, N, Ledent, C, Freund, T.F

“…Psychoactive effects of cannabinoids are thought to be mediated, at least in part, by suppression of both glutamate and GABA release via CB1 cannabinoid…”
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Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice by Haller, J., Varga, B., Ledent, C., Barna, I., Freund, T. F.

“…Contrasting data were reported regarding the effects of cannabinoids on anxiety and social behaviour in both animals and humans. The cognitive effects of…”
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Presynaptic adenosine A 2A receptors dampen cannabinoid CB 1 receptor‐mediated inhibition of corticostriatal glutamatergic transmission by Ferreira, S G, Gonçalves, F Q, Marques, J M, Tomé, Â R, Rodrigues, R J, Nunes‐Correia, I, Ledent, C, Harkany, T, Venance, L, Cunha, R A, Köfalvi, A

“…Background and Purpose Both cannabinoid CB 1 and adenosine A 2A receptors ( CB 1 receptors and A 2A receptors) control synaptic transmission at corticostriatal…”
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Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations by Hájos, N., Katona, I., Naiem, S. S., Mackie, K., Ledent, C., Mody, I., Freund, T. F.

“…Using a new antibody developed against the C‐terminus of the cannabinoid receptor (CB1), the immunostaining in the hippocampus revealed additional axon…”
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Marijuana smoke induces severe pulmonary hyperresponsiveness, inflammation, and emphysema in a predictive mouse model not via CB1 receptor activation by Helyes, Z, Kemény, Á, Csekő, K, Szőke, É, Elekes, K, Mester, M, Sándor, K, Perkecz, A, Kereskai, L, Márk, L, Bona, Á, Benkő, A, Pintér, E, Szolcsányi, J, Ledent, C, Sperlágh, B, Molnár, T F

“…Sporadic clinical reports suggested that marijuana smoking induces spontaneous pneumothorax, but no animal models were available to validate these observations…”
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Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A(2A)R KO mice by Pardo, M, López-Cruz, L, Valverde, O, Ledent, C, Baqi, Y, Müller, C E, Salamone, J D, Correa, M

“…Behavioral activation is regulated by dopamine (DA) in striatal areas. At low doses, while typical antipsychotic drugs produce psychomotor slowing,…”
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The role of endogenous cannabinoids in the hypothalamo-pituitary-adrenal axis regulation: in vivo and in vitro studies in CB1 receptor knockout mice by Barna, I., Zelena, D., Arszovszki, A.C., Ledent, C.

“…Exogenous cannabinoids affect multiple hormonal systems including the hypothalamo-pituitary-adrenocortical (HPA) axis. These data suggest that endogenous…”
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Distribution of CB1 Cannabinoid Receptors in the Amygdala and their Role in the Control of GABAergic Transmission by Katona, Istvan, Rancz, Ede A, Acsady, Laszlo, Ledent, Catherine, Mackie, Ken, Hajos, Norbert, Freund, Tamas F

“…Cannabinoids are the most popular illicit drugs used for recreational purposes worldwide. However, the neurobiological substrate of their mood-altering…”
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CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents by Haller, J, Varga, B, Ledent, C, Freund, T. F

“…Cannabinoids are known to modulate GABAergic and glutamatergic transmission in cortical areas, the former via CB1 and the latter via a novel receptor…”
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Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence by Castañé, A, Valjent, E, Ledent, C, Parmentier, M, Maldonado, R, Valverde, O

“…Cannabis is the most widely consumed illicit drug and its consumption is currently associated with tobacco, which contains another psychoactive compound,…”
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Role of Cannabinoid Type 1 Receptors in Locomotor Activity and Striatal Signaling in Response to Psychostimulants by Corbille, Anne-Gaelle, Valjent, Emmanuel, Marsicano, Giovanni, Ledent, Catherine, Lutz, Beat, Herve, Denis, Girault, Jean-Antoine

“…A single administration of cocaine or D-amphetamine produces acute hyperlocomotion and long-lasting increased sensitivity to subsequent injections. This…”
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Metabotropic Glutamate Receptors Drive the Endocannabinoid System in Hippocampus by Varma, Namita, Carlson, Gregory C, Ledent, Catherine, Alger, Bradley E

“…Endocannabinoids are key intercellular signaling molecules in the brain, but the physiological regulation of the endocannabinoid system is not understood. We…”
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Cannabinoids inhibit neurodegeneration in models of multiple sclerosis by Pryce, Gareth, Ahmed, Zubair, Hankey, Deborah J. R., Jackson, Samuel J., Croxford, J. Ludovic, Pocock, Jennifer M., Ledent, Catherine, Petzold, Axel, Thompson, Alan J., Giovannoni, Gavin, Cuzner, M. Louise, Baker, David

“…Multiple sclerosis is increasingly being recognized as a neurodegenerative disease that is triggered by inflammatory attack of the CNS. As yet there is no…”
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Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: Studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A2AR KO mice by Pardo, M., López-Cruz, L., Valverde, O., Ledent, C., Baqi, Y., Müller, C.E., Salamone, J.D., Correa, M.

“…•Low doses of theophylline and A2A receptor antagonists induce exploration in mice.•These pharmacological agents can reverse antipsychotic-induce psychomotor…”
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Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors by Svenningsson, P, Lindskog, M, Ledent, C, Parmentier, M, Greengard, P, Fredholm, B B, Fisone, G

“…Dopamine D 1 , dopamine D 2 , and adenosine A 2A receptors are highly expressed in striatal medium-sized spiny neurons. We have examined, in vivo , the…”
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Deletion of the adenosine A(2A) receptor in mice enhances spinal cord neurochemical responses to an inflammatory nociceptive stimulus by Hussey, M J, Clarke, G D, Ledent, C, Kitchen, I, Hourani, S M O

“…Knockout mice lacking the adenosine A(2A) receptor are less sensitive to nociceptive stimuli, and this may be due to the presence of pronociceptive A(2A)…”
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Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse by COSSU, Gregorio, LEDENT, Catherine, FATTORE, Liana, IMPERATO, Assunta, BÖHME, Georg A, PARMENTIER, Mare, FRATTA, Walter

“…The rewarding effects of morphine, cocaine, amphetamine and nicotine were evaluated in CB1 receptor knockout mice by means of an intravenous…”
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Involvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice by Houchi, H., Warnault, V., Barbier, E., Dubois, C., Pierrefiche, O., Ledent, C., Daoust, M., Naassila, M.

“…We have shown previously that mice lacking the adenosine A2A receptor (A2AR) generated on a CD1 background self‐administer more ethanol and exhibit…”
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