Search Results - "LECLERC, L"

Role of Interleukin-10 in Acute Brain Injuries by Garcia, Joshua M, Stillings, Stephanie A, Leclerc, Jenna L, Phillips, Harrison, Edwards, Nancy J, Robicsek, Steven A, Hoh, Brian L, Blackburn, Spiros, Doré, Sylvain

“…Interleukin-10 (IL-10) is an important anti-inflammatory cytokine expressed in response to brain injury, where it facilitates the resolution of inflammatory…”
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Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage by Leclerc, Jenna L, Santiago-Moreno, Juan, Dang, Alex, Lampert, Andrew S, Cruz, Pedro E, Rosario, Awilda M, Golde, Todd E, Doré, Sylvain

“…Following intracerebral hemorrhage (ICH), extracellular heme precipitates secondary brain injury, which results in irreversible brain damage and enduring…”
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Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis by Kwiatkowski, T.J. Jr, Bosco, D.A, LeClerc, A.L, Tamrazian, E, Vanderburg, C.R, Russ, C, Davis, A, Gilchrist, J, Kasarskis, E.J, Munsat, T, Valdmanis, P, Rouleau, G.A, Hosler, B.A, Cortelli, P, de Jong, P.J, Yoshinaga, Y, Haines, J.L, Pericak-Vance, M.A, Yan, J, Ticozzi, N, Siddique, T, McKenna-Yasek, D, Sapp, P.C, Horvitz, H.R, Landers, J.E, Brown, R.H. Jr

“…Amyotrophic lateral sclerosis (ALS) is a fatal degenerative motor neuron disorder. Ten percent of cases are inherited; most involve unidentified genes. We…”
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Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke by Frankowski, Jan C., DeMars, Kelly M., Ahmad, Abdullah S., Hawkins, Kimberly E., Yang, Changjun, Leclerc, Jenna L., Doré, Sylvain, Candelario-Jalil, Eduardo

“…Cyclooxygenase-2 (COX-2) is activated in response to ischemia and significantly contributes to the neuroinflammatory process. Accumulation of COX-2-derived…”
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Physical, morphological and chemical modification of Al-based nanofillers in by-products of incinerated nanocomposites and related biological outcome by Chivas-Joly, C., Longuet, C., Pourchez, J., Leclerc, L., Sarry, G., Lopez-Cuesta, J-M.

“…[Display omitted] •Toxicological risk is linked to the physico-chemical parameters that can be modified during incineration process.•The incineration can lead…”
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Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage by Leclerc, Jenna L., Blackburn, Spiros, Neal, Dan, Mendez, Nicholas V., Wharton, Jeffrey A., Waters, Michael F., Doré, Sylvain

“…Cerebral vasospasm (CV) and the resulting delayed cerebral ischemia (DCI) significantly contribute to poor outcomes following aneurysmal subarachnoid…”
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Analysis of FUS gene mutation in familial amyotrophic lateral sclerosis within an Italian cohort by TICOZZI, N, SILANI, V, BROWN, R. H, LANDERS, J. E, LECLERC, A. L, KEAGLE, P, GELLERA, C, RATTI, A, TARONI, F, KWIATKOWSKI, T. J, MCKENNA-YASEK, D. M, SAPP, P. C

“…Mutations in the FUS gene on chromosome 16 have been recently discovered as a cause of familial amyotrophic lateral sclerosis (FALS). This study determined the…”
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Temporal and age-dependent effects of haptoglobin deletion on intracerebral hemorrhage-induced brain damage and neurobehavioral outcomes by Leclerc, Jenna L., Li, Chris, Jean, Stacy, Lampert, Andrew S., Amador, Claudia Loyola, Diller, Matthew A., Tolosano, Emanuela, Doré, Sylvain

“…Intracerebral hemorrhage (ICH) is a devastating stroke subtype and the presence of extracorpuscular hemoglobin (Hb) exacerbates brain damage. Haptoglobin (Hp)…”
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A Comparison of Pathophysiology in Humans and Rodent Models of Subarachnoid Hemorrhage by Leclerc, Jenna L, Garcia, Joshua M, Diller, Matthew A, Carpenter, Anne-Marie, Kamat, Pradip K, Hoh, Brian L, Doré, Sylvain

“…Non-traumatic subarachnoid hemorrhage (SAH) affects an estimated 30,000 people each year in the United States, with an overall mortality of ~30%. Most cases of…”
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Multi-pathogen serological survey of migratory caribou herds: A snapshot in time by Carlsson, A M, Curry, P, Elkin, B, Russell, D, Veitch, A, Branigan, M, Campbell, M, Croft, B, Cuyler, C, Côté, S D, Leclerc, L-M, Tryland, M, Nymo, I H, Kutz, S J

“…Pathogens can impact host survival, fecundity, and population dynamics even when no obvious disease is observed. Few baseline data on pathogen prevalence and…”
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Genetic deletion of the prostaglandin E2 E prostanoid receptor subtype 3 improves anatomical and functional outcomes after intracerebral hemorrhage by Leclerc, Jenna L., Lampert, Andrew S., Diller, Matthew A., Doré, Sylvain

“…Intracerebral hemorrhage (ICH) is a stroke subtype associated with high mortality and morbidity. Following ICH, excitotoxicity and inflammation significantly…”
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Effect of Experimental Ischemic Stroke and PGE2 EP1 Selective Antagonism in Alzheimer's Disease Mouse Models by Mendes, Fúlvio R, Leclerc, Jenna L, Liu, Lei, Kamat, Pradip K, Naziripour, Arash, Hernandez, Damian, Li, Chris, Ahmad, Abdullah S, Doré, Sylvain

“…Neuroinflammation has been recognized as an important factor in the pathogenesis of Alzheimer's disease (AD). One of the most recognized pathways in mediating…”
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Pregnant women's use of tobacco and electronic cigarettes: A cross sectional survey by Rousseau, C, Pourchez, J, Leclerc, L, Nekaa, M, Raia-Barjat, T

“…The article aims to describe tobacco and e-cigarette use among pregnant women: estimate the prevalence, identify the determinants and motivations of these…”
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Mutational analysis reveals the FUS homolog TAF15 as a candidate gene for familial amyotrophic lateral sclerosis by Ticozzi, N., Vance, C., LeClerc, A.L., Keagle, P., Glass, J.D., McKenna-Yasek, D., Sapp, P.C., Silani, V., Bosco, D.A., Shaw, C.E., Brown Jr, R.H., Landers, J.E.

“…FUS, EWS, and TAF15 belong to the TET family of structurally similar DNA/RNA‐binding proteins. Mutations in the FUS gene have recently been discovered as a…”
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PGE2-EP3 signaling exacerbates intracerebral hemorrhage outcomes in 24-mo-old mice by Leclerc, Jenna L, Lampert, Andrew S, Diller, Matthew A, Doré, Sylvain

“…With the population aging at an accelerated rate, the prevalence of stroke and financial burden of stroke-related health care costs are expected to continue to…”
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The effect of α-tocopherol on the oxidation of mackerel oil by Zuta, P.C., Simpson, B.K., Zhao, X., Leclerc, L.

“…Mackerel oil is prone to autooxidation because it has a high content of polyunsaturated fatty acids. Antioxidants therefore have to be added to the oil to…”
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Prostaglandin E2 EP2 Receptor Deletion Attenuates Intracerebral Hemorrhage-Induced Brain Injury and Improves Functional Recovery by Leclerc, Jenna L., Lampert, Andrew S., Diller, Matthew A., Immergluck, Joshua B., Doré, Sylvain

“…Intracerebral hemorrhage (ICH) is a devastating type of stroke characterized by bleeding into the brain parenchyma and secondary brain injury resulting from…”
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Eculizumab and thrombotic microangiopathy after hematopoietic stem cell transplantation: A report on its efficacy and safety in two pediatric patients by Genere, L., Bacchetta, J., Bertrand, Y., Javouhey, E., Cheikh, N., Sellier-Leclerc, A.-L.

“…Thrombotic microangiopathy (TMA) is a severe complication after hematopoietic stem cell transplantation (HSCT), with the reported mortality rate in such cases…”
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Hydration and electrolyte balance in horses during an endurance season by ROBERT, C., GOACHET, A.-G., FRAIPONT, A., VOTION, D.-M., Van ERCK, E., LECLERC, J.-L.

“…Summary Reasons for performing study: Limited information exists about the physiological training‐induced changes in electrolyte balance of horses competing in…”
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Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies by Wan, S, LeClerc, J L, Vincent, J L

“…Recent study of the inflammatory reactions occurring during and after cardiopulmonary bypass (CPB) has improved our understanding of the involvement of the…”
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