Search Results - "LEBRUN, Philippe"

Testing the Value of Six Taxonomic Groups as Biodiversity Indicators at a Local Scale by KATI, VASSILIKI, DEVILLERS, PIERRE, DUFRÊNE, MARC, LEGAKIS, ANASTASIOS, VOKOU, DESPINA, LEBRUN, PHILIPPE

“…We examined six groups of taxa-woody plants, aquatic and terrestrial herpetofauna, small terrestrial birds, orchids, and Orthoptera-to determine their…”
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Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process by Florence, Xavier, Dilly, Sébastien, de Tullio, Pascal, Pirotte, Bernard, Lebrun, Philippe

“…The synthesis of different series of 4- and 6-substituted R/ S-3,4-dihydro-2,2-dimethyl-2 H-1-benzopyrans is described. All of these new benzopyran derivatives…”
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Soil biodiversity: myth, reality or conning? by André, Henri M., Ducarme, Xavier, Lebrun, Philippe

“…The study of soil microarthropod biodiversity is illustrative of problems that are related to other soil organisms (fungi, for instance) or that can be found…”
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KATP Channel Subunits Are Expressed in the Epididymal Epithelium in Several Mammalian Species by Lybaert, Pascale, Vanbellinghen, Anne Marie, Quertinmont, Eric, Petein, Michel, Meuris, Sylvain, Lebrun, Philippe

“…Adenosine triphosphate-sensitive K⁺⁺ (KATP) channels are poorly characterized in the reproductive tract. The present study was designed to evaluate the…”
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Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers by GILLOTIN, Florian, CHIAP, Patrice, FREDERICH, Michel, VAN HEUGEN, Jean-Claude, FRANCOTTE, Pierre, LEBRUN, Philippe, PIROTTE, Bernard, DE TULLIO, Pascal

“…SUR1-selective ATP-sensitive potassium channel openers (PCOs) have been shown to be of clinical value for the treatment of several metabolic disorders,…”
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Effect on KATP Channel Activation Properties and Tissue Selectivity of the Nature of the Substituent in the 7- and the 3-Position of 4H-1,2,4-Benzothiadiazine 1,1-Dioxides by BOVERIE, Stéphane, ANTOINE, Marie-Hélène, SOMERS, Fabian, BECKER, Bénédicte, SEBILLE, Sophie, OUEDRAOGO, Raogo, COUNEROTTE, Stéphane, PIROTTE, Bernard, LEBRUN, Philippe, DE TULLIO, Pascal

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The Novel Diazoxide Analog 3-Isopropylamino-7-Methoxy-4H-1,2,4-Benzothiadiazine 1,1-Dioxide Is a Selective Kir6.2/SUR1 Channel Opener by DABROWSKI, Michael, ASHCROFT, Frances M, ASHFIELD, Rebecca, LEBRUN, Philippe, PIROTTE, Bernard, EGEBJERG, Jan, BONDO HANSEN, John, WAHL, Philip

“…The Novel Diazoxide Analog 3-Isopropylamino-7-Methoxy- 4H -1,2,4-Benzothiadiazine 1,1-Dioxide Is a Selective Kir6.2/SUR1 Channel Opener Michael Dabrowski 1 ,…”
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Effect of IPs, cAMP, and cGMP on the hPL and hCG secretion from human term placenta by Lambot, Nathalie, Philippe, Lebrun, Christine, Delporte, Carine, De Vriese, Josiane, Delogne-Desnoeck, Marie, Vanbellinghen Anne, Guy, Graff, Sylvain, Meuris

“…The acute control of human placental lactogen (hPL) and chorionic gonadotrophin (hCG) secretion by the placenta remains elusive. The in vitro release of both…”
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Deciphering Structure–Activity Relationships in a Series of 2,2‐Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants by Pirotte, Bernard, Florence, Xavier, Goffin, Eric, Lebrun, Philippe

“…4,6‐Disubstituted 2,2‐dimethylchromans are reported as pharmacologically active compounds that mainly target the ATP‐sensitive potassium channels. The present…”
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2,2-Dimethyl-3,4-dihydro-2H-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants by Pirotte, Bernard, Florence, Xavier, Goffin, Eric, Lebrun, Philippe

“…The present study describes the synthesis and biological evaluation of 4-phenylureido/thioureido-substituted 2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazines as…”
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Characterization and potential roles of calretinin in rodent spermatozoa by Dressen, Cindy, Schwaller, Beat, Vegh, Grégory, Leleux, Fabienne, Gall, David, Lebrun, Philippe, Lybaert, Pascale

“…[Display omitted] •Calretinin was detected in the sperm principal piece.•Sperm motility parameters were modified in the absence of calretinin (CR−/− mice).•The…”
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2,2-Dimethyl-3,4-dihydro-2 H -1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants by Pirotte, Bernard, Florence, Xavier, Goffin, Eric, Lebrun, Philippe

“…The present study describes the synthesis and biological evaluation of 4-phenylureido/thioureido-substituted 2,2-dimethyl-3,4-dihydro-2 -1,4-benzoxazines as…”
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2,2-Dimethyl-3,4-dihydro-2-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants by Pirotte, Bernard, Florence, Xavier, Goffin, Eric, Lebrun, Philippe

“…The present study describes the synthesis and biological evaluation of 4-phenylureido/thioureido-substituted 2,2-dimethyl-3,4-dihydro-2 H -1,4-benzoxazines as…”
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Design and synthesis of new potassium channel activators derived from the ring opening of diazoxide: Study of their vasodilatory effect, stimulation of elastin synthesis and inhibitory effect on insulin release by Bouider, Nafila, Fhayli, Wassim, Ghandour, Zeinab, Boyer, Marjorie, Harrouche, Kamel, Florence, Xavier, Pirotte, Bernard, Lebrun, Philippe, Faury, Gilles, Khelili, Smail

“…[Display omitted] Benzenesulfonylureas and benzenesulfonylthioureas, as well as benzenecarbonylureas and benzenecarbonylthioureas, were prepared and evaluated…”
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Synthesis, characterization and biological evaluation of benzothiazoles and tetrahydrobenzothiazoles bearing urea or thiourea moieties as vasorelaxants and inhibitors of the insulin releasing process by Harrouche, Kamel, Renard, Jean-Francois, Bouider, Nafila, de Tullio, Pascal, Goffin, Eric, Lebrun, Philippe, Faury, Gilles, Pirotte, Bernard, Khelili, Smail

“…A series of 1,3-benzothiazoles (series I) and 4,5,6,7-tetrahydro-1,3-benzothiazoles (series II) bearing an urea or a thiourea moiety at the 2-position were…”
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Apoptosis in Human Term Placenta Is Not Increased during Labor but Can Be Massively Induced In Vitro by CIRELLI, N, MOENS, A, LEBRUN, P, GUEUNING, C, DELOGNE-DESNOECK, J, VANBELLINGHEN, A.-M, MEURIS, S

“…Apoptosis in human placental villi is reported to increase until close to delivery. However, the involvement of the apoptotic process in the initiation of…”
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4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky ‘carbamate’ moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion by Pirotte, Bernard, Florence, Xavier, Goffin, Eric, Medeiros, Marlen Borges, de Tullio, Pascal, Lebrun, Philippe

“…The synthesis of 2,2-dimethylchromans bearing a 3/4-chloro/cyano-substituted phenylureido or phenylthioureido moiety at the 4-position and an…”
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Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers? by Florence, Xavier, Desvaux, Vincent, Goffin, Eric, de Tullio, Pascal, Pirotte, Bernard, Lebrun, Philippe

“…The present study described the synthesis of original R/S-6-alkylsulfonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans bearing a 3- or 4-substituted…”
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Insulinotropic Action of White Lupine Seeds (Lupinus albus L.): Effects on Ion Fluxes and Insulin Secretion from Isolated Pancreatic Islets by PEREIRA, Frederico C., OUEDRAOGO, Raogo, LEBRUN, Philippe, BARBOSA, Rui M., CUNHA, Antonio P., SANTOS, Rosa M., ROSÁRIO, Luis M.

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Impact of the Nature of the Substituent at the 3-Position of 4H-1,2,4-Benzothiadiazine 1,1-Dioxides on Their Opening Activity toward ATP-Sensitive Potassium Channels by Pirotte, Bernard, de Tullio, Pascal, Boverie, Stéphane, Michaux, Catherine, Lebrun, Philippe

“…The synthesis of diversely substituted 3-isopropoxy-, 3-isopropylsulfanyl-, 3-isopropylsulfinyl-, and 3-isobutyl-4H-1,2,4-benzothiadiazine 1,1-dioxides is…”
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