Search Results - "LEBOEUF, Christophe"

Targeting Cancer Stem Cells to Overcome Chemoresistance by Nunes, Toni, Hamdan, Diaddin, Leboeuf, Christophe, El Bouchtaoui, Morad, Gapihan, Guillaume, Nguyen, Thi Thuy, Meles, Solveig, Angeli, Eurydice, Ratajczak, Philippe, Lu, He, Di Benedetto, Mélanie, Bousquet, Guilhem, Janin, Anne

“…Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer heterogeneity could be clonal evolution or cancer stem cells. Cancer stem…”
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Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in β-thalassemic mice by Mattè, Alessandro, Kosinski, Penelope A, Federti, Enrica, Dang, Lenny, Recchiuti, Antonio, Russo, Roberta, Siciliano, Angela, Riccardi, Veronica, Janin, Anne, Mucci, Matteo, Leboeuf, Christophe, Iolascon, Achille, Brugnara, Carlo, De Franceschi, Lucia

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Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified by Ji, Meng-Meng, Huang, Yao-Hui, Huang, Jin-Yan, Wang, Zhao-Fu, Fu, Di, Liu, Han, Liu, Feng, Leboeuf, Christophe, Wang, Li, Ye, Jing, Lu, Yi-Ming, Janin, Anne, Cheng, Shu, Zhao, Wei-Li

“…Due to heterogeneous morphological and immunophenotypic features, approximately 50% of peripheral T-cell lymphomas are unclassifiable and categorized as…”
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A novel prognostic model based on four circulating miRNA in diffuse large B‐cell lymphoma: implications for the roles of MDSC and Th17 cells in lymphoma progression by Sun, Rui, Zheng, Zhong, Wang, Li, Cheng, Shu, Shi, Qing, Qu, Bin, Fu, Di, Leboeuf, Christophe, Zhao, Yan, Ye, Jing, Janin, Anne, Zhao, Wei‐Li

“…A novel prognostic model based on four circulating miRNA (miR21, miR155, miR130 and miR28) showed independent prognostic significance in diffuse large B‐cell…”
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A Sub-Group of Kidney-Transplant Recipients with Highly Aggressive Squamous Cell Carcinoma Expressing Phosphorylated Serine392p53 by Hamdan, Diaddin, Gardair, Charlotte, Pamoukdjian, Frédéric, Peraldi Gardin, Marie-Noëlle, Nakouri, Inès, Leboeuf, Christophe, Janin, Anne, Lebbé, Céleste, Battistella, Maxime, Bousquet, Guilhem

“…Cutaneous squamous cell carcinomas in kidney-transplant recipients are frequent, with an increasing incidence linked to long immunosuppression durations and…”
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Stem cells increase in numbers in perinecrotic areas in human renal cancer by Varna, Mariana, Gapihan, Guillaume, Feugeas, Jean-Paul, Ratajczak, Philippe, Tan, Sophie, Ferreira, Irmine, Leboeuf, Christophe, Setterblad, Niclas, Duval, Arnaud, Verine, Jérôme, Germain, Stéphane, Mongiat-Artus, Pierre, Janin, Anne, Bousquet, Guilhem

“…Developing strategies to overcome resistance to sunitinib is a major challenge in human renal cell carcinoma (RCC). We hypothesized that sunitinib-induced…”
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Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension by Federti, Enrica, Matté, Alessandro, Ghigo, Alessandra, Andolfo, Immacolata, James, Cimino, Siciliano, Angela, Leboeuf, Christophe, Janin, Anne, Manna, Francesco, Choi, Soo Young, Iolascon, Achille, Beneduce, Elisabetta, Melisi, Davide, Kim, Dae Won, Levi, Sonia, De Franceschi, Lucia

“…Pulmonary-artery-hypertension (PAH) is a life-threatening and highly invalidating chronic disorder. Chronic oxidation contributes to lung damage and disease…”
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Pulsed-laser irradiation of multifunctional gold nanoshells to overcome trastuzumab resistance in HER2-overexpressing breast cancer by Nunes, Toni, Pons, Thomas, Hou, Xue, Van Do, Khanh, Caron, Benoît, Rigal, Marthe, Di Benedetto, Mélanie, Palpant, Bruno, Leboeuf, Christophe, Janin, Anne, Bousquet, Guilhem

“…HER2-overexpressing metastatic breast cancers are challenging practice in oncology when they become resistant to anti-HER2 therapies such as trastuzumab. In…”
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Th17/Treg ratio in human graft-versus-host disease by Ratajczak, Philippe, Janin, Anne, Peffault de Latour, Regis, Leboeuf, Christophe, Desveaux, Allison, Keyvanfar, Keyvan, Robin, Marie, Clave, Emmanuel, Douay, Corine, Quinquenel, Anne, Pichereau, Claire, Bertheau, Philippe, Mary, Jean Yves, Socié, Gérard

“…Th17 cells have never been explored in human graft-versus-host disease (GVHD). We studied the correlation between the presence of Th17 cells with histologic…”
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Targeting autophagic cancer stem-cells to reverse chemoresistance in human triple negative breast cancer by Bousquet, Guilhem, El Bouchtaoui, Morad, Sophie, Tan, Leboeuf, Christophe, de Bazelaire, Cédric, Ratajczak, Philippe, Giacchetti, Sylvie, de Roquancourt, Anne, Bertheau, Philippe, Verneuil, Laurence, Feugeas, Jean-Paul, Espié, Marc, Janin, Anne

“…There is growing evidence for the role of cancer stem-cells in drug resistance, but with few in situ studies on human tumor samples to decipher the mechanisms…”
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BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome by Gorombei, Petra, Guidez, Fabien, Ganesan, Saravanan, Chiquet, Mathieu, Pellagatti, Andrea, Goursaud, Laure, Tekin, Nilgun, Beurlet, Stephanie, Patel, Satyananda, Guerenne, Laura, Le Pogam, Carole, Setterblad, Niclas, de la Grange, Pierre, LeBoeuf, Christophe, Janin, Anne, Noguera, Maria-Elena, Sarda-Mantel, Laure, Merlet, Pascale, Boultwood, Jacqueline, Konopleva, Marina, Andreeff, Michael, West, Robert, Pla, Marika, Adès, Lionel, Fenaux, Pierre, Krief, Patricia, Chomienne, Christine, Omidvar, Nader, Padua, Rose Ann

“…During transformation, myelodysplastic syndromes (MDS) are characterized by reducing apoptosis of bone marrow (BM) precursors. Mouse models of high risk…”
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The germline genetics of mild-to-moderate penetrance: An intriguing role of PRAME in multiple carcinogenesis by Hamdan, Diaddin, Nguyen, Van Tai, Paris, Justine, Leboeuf, Christophe, El Bouchtaoui, Morad, Espié, Marc, Janin, Anne, Falgarone, Géraldine, Di Benedetto, Mélanie, Bousquet, Guilhem

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JAM-A overexpression is related to disease progression in diffuse large B-cell lymphoma and downregulated by lenalidomide by Xu, Peng-Peng, Sun, Yi-Feng, Fang, Ying, Song, Qi, Yan, Zi-Xun, Chen, Yi, Jiang, Xu-Feng, Fei, Xiao-Chun, Zhao, Yan, Leboeuf, Christophe, Li, Biao, Wang, Chao-Fu, Janin, Anne, Wang, Li, Zhao, Wei-Li

“…Cancer stem cells play an important role on tumor progression. Biomarkers of stem cell property and their relationship to extranodal involvement of malignant…”
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Re‐exploring immune‐related side effects of docetaxel in an observational study: Blood hypereosinophilia by Hamdan, Diaddin, Leboeuf, Christophe, Le Foll, Christine, Bousquet, Guilhem, Janin, Anne

“…Docetaxel is a major anticancer drug that can induce hypersensitivity reactions leading to deleterious treatment interruptions. Blood hypereosinophilia could…”
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Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease by Sabaa, Nathalie, de Franceschi, Lucia, Bonnin, Philippe, Castier, Yves, Malpeli, Giorgio, Debbabi, Haythem, Galaup, Ariane, Maier-Redelsperger, Micheline, Vandermeersch, Sophie, Scarpa, Aldo, Janin, Anne, Levy, Bernard, Girot, Robert, Beuzard, Yves, Leboeuf, Christophe, Henri, Annie, Germain, Stéphane, Dussaule, Jean-Claude, Tharaux, Pierre-Louis

“…Patients with sickle-cell disease (SCD) suffer from tissue damage and life-threatening complications caused by vasoocclusive crisis (VOC). Endothelin receptors…”
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Metastatic clear-cell renal cell carcinoma: a frequent NOTCH1 mutation predictive of response to anti-NOTCH1 CB-103 treatment by Bui, Thi Oanh, Angeli, Eurydice, El Bouchtaoui, Morad, Gapihan, Guillaume, Dao, Van Tu, Paris, Justine, Leboeuf, Christophe, Soussan, Michael, Villarese, Patrick, Ziol, Marianne, Van Glabeke, Emmanuel, Le, Thi Huong, Feugeas, Jean-Paul, Janin, Anne, Bousquet, Guilhem

“…Clear-cell renal cell carcinomas (ccRCCs) are malignant tumors with high metastatic potential and resistance to treatments occurs almost constantly. Compared…”
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PROM2 overexpression induces metastatic potential through epithelial‐to‐mesenchymal transition and ferroptosis resistance in human cancers by Paris, Justine, Wilhelm, Claire, Lebbé, Celeste, Elmallah, Mohammed, Pamoukdjian, Frédéric, Héraud, Audrey, Gapihan, Guillaume, Walle, Aurore Van De, Tran, Van Nhan, Hamdan, Diaddin, Allayous, Clara, Battistella, Maxime, Van Glabeke, Emmanuel, Lim, Kah Wai, Leboeuf, Christophe, Roger, Sébastien, Falgarone, Géraldine, Phan, Anh Tuan, Bousquet, Guilhem

“…Introduction Despite considerable therapeutic advances in the last 20 years, metastatic cancers remain a major cause of death. We previously identified…”
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Mitapivat reprograms the RBC metabolome and improves anemia in a mouse model of hereditary spherocytosis by Matte, Alessandro, Wilson, Anand B., Gevi, Federica, Federti, Enrica, Recchiuti, Antonio, Ferri, Giulia, Brunati, Anna Maria, Pagano, Mario Angelo, Russo, Roberta, Leboeuf, Christophe, Janin, Anne, Timperio, Anna Maria, Iolascon, Achille, Gremese, Elisa, Dang, Lenny, Mohandas, Narla, Brugnara, Carlo, De Franceschi, Lucia

“…Hereditary spherocytosis (HS) is the most common, nonimmune, hereditary, chronic hemolytic anemia after hemoglobinopathies. The genetic defects in membrane…”
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Muc5b-deficient mice develop early histological lung abnormalities by Valque, Hélène, Gouyer, Valérie, Duez, Catherine, Leboeuf, Christophe, Marquillies, Philippe, Le Bert, Marc, Plet, Ségolène, Ryffel, Bernhard, Janin, Anne, Gottrand, Frédéric, Desseyn, Jean-Luc

“…Gel-forming mucins are the main organic component responsible for physical properties of the mucus hydrogels. While numerous biological functions of these…”
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Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation by Janin, Anne, Murata, Hideyuki, Leboeuf, Christophe, Cayuela, Jean-Michel, Gluckman, Eliane, Legrès, Luc, Desveaux, Allison, Varna, Mariana, Ratajczak, Philippe, Soulier, Jean, de Thé, Hugues, Bertheau, Philippe, Socié, Gérard

“…In animal models, tissue stem cells were proposed to exhibit an unexpected level of plasticity, although issues on cell fusions have lead to some…”
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