Search Results - "LEBLANC, Yves"

Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials by Albrecht, Brian K, Gehling, Victor S, Hewitt, Michael C, Vaswani, Rishi G, Côté, Alexandre, Leblanc, Yves, Nasveschuk, Christopher G, Bellon, Steve, Bergeron, Louise, Campbell, Robert, Cantone, Nico, Cooper, Michael R, Cummings, Richard T, Jayaram, Hariharan, Joshi, Shivangi, Mertz, Jennifer A, Neiss, Adrianne, Normant, Emmanuel, O’Meara, Michael, Pardo, Eneida, Poy, Florence, Sandy, Peter, Supko, Jeffrey, Sims, Robert J, Harmange, Jean-Christophe, Taylor, Alexander M, Audia, James E

“…In recent years, inhibition of the interaction between the bromodomain and extra-terminal domain (BET) family of chromatin adaptors and acetyl-lysine residues…”
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Risk-Stratified Pathways for Cancer Survivorship Care: Insights from a Deliberative Multi-Stakeholder Consultation by Tremblay, Dominique, Touati, Nassera, Bilodeau, Karine, Prady, Catherine, Usher, Susan, Leblanc, Yves

“…Risk-stratified pathways of survivorship care seek to optimize coordination between cancer specialists and primary care physicians based on the whole person…”
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Solvent effects on differentiation of mouse brain tissue using laser microdissection ‘cut and drop’ sampling with direct mass spectral analysis by Cahill, John F., Kertesz, Vilmos, Porta, Tiffany, LeBlanc, J.C. Yves, Heeren, Ron M.A., Van Berkel, Gary J.

“…Rationale Laser microdissection‐liquid vortex capture/electrospray ionization mass spectrometry (LMD‐LVC/ESI‐MS) has potential for on‐line classification of…”
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Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637) by Taylor, Alexander M, Côté, Alexandre, Hewitt, Michael C, Pastor, Richard, Leblanc, Yves, Nasveschuk, Christopher G, Romero, F. Anthony, Crawford, Terry D, Cantone, Nico, Jayaram, Hariharan, Setser, Jeremy, Murray, Jeremy, Beresini, Maureen H, de Leon Boenig, Gladys, Chen, Zhongguo, Conery, Andrew R, Cummings, Richard T, Dakin, Leslie A, Flynn, E. Megan, Huang, Oscar W, Kaufman, Susan, Keller, Patricia J, Kiefer, James R, Lai, Tommy, Li, Yingjie, Liao, Jiangpeng, Liu, Wenfeng, Lu, Henry, Pardo, Eneida, Tsui, Vickie, Wang, Jian, Wang, Yongyun, Xu, Zhaowu, Yan, Fen, Yu, Dong, Zawadzke, Laura, Zhu, Xiaoqin, Zhu, Xiaoyu, Sims, Robert J, Cochran, Andrea G, Bellon, Steve, Audia, James E, Magnuson, Steven, Albrecht, Brian K

“…CBP and EP300 are highly homologous, bromodomain-containing transcription coactivators involved in numerous cellular pathways relevant to oncology. As part of…”
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Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors by Gehling, Victor S, Hewitt, Michael C, Vaswani, Rishi G, Leblanc, Yves, Côté, Alexandre, Nasveschuk, Christopher G, Taylor, Alexander M, Harmange, Jean-Christophe, Audia, James E, Pardo, Eneida, Joshi, Shivangi, Sandy, Peter, Mertz, Jennifer A, Sims, Robert J, Bergeron, Louise, Bryant, Barbara M, Bellon, Steve, Poy, Florence, Jayaram, Hariharan, Sankaranarayanan, Ravichandran, Yellapantula, Sreegouri, Bangalore Srinivasamurthy, Nandana, Birudukota, Swarnakumari, Albrecht, Brian K

“…The identification of a novel series of small molecule BET inhibitors is described. Using crystallographic binding modes of an amino-isoxazole fragment and…”
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Chemical Noise Reduction via Mass Spectrometry and Ion/Ion Charge Inversion: Amino Acids by Hassell, Kerry M, LeBlanc, Yves C, McLuckey, Scott A

“…Charge inversion ion/ion reactions can provide a significant reduction in chemical noise associated with mass spectra derived from complex mixtures for species…”
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Discovery of Benzotriazolo[4,3‑d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains by Taylor, Alexander M, Vaswani, Rishi G, Gehling, Victor S, Hewitt, Michael C, Leblanc, Yves, Audia, James E, Bellon, Steve, Cummings, Richard T, Côté, Alexandre, Harmange, Jean-Christophe, Jayaram, Hari, Joshi, Shivangi, Lora, Jose M, Mertz, Jennifer A, Neiss, Adrianne, Pardo, Eneida, Nasveschuk, Christopher G, Poy, Florence, Sandy, Peter, Setser, Jeremy W, Sims, Robert J, Tang, Yong, Albrecht, Brian K

“…Inhibition of the bromodomains of the BET family, of which BRD4 is a member, has been shown to decrease myc and interleukin (IL) 6 in vivo, markers that are of…”
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Kinetic Size-Exclusion Chromatography with Mass Spectrometry Detection: An Approach for Solution-Based Label-Free Kinetic Analysis of Protein–Small Molecule Interactions by Bao, Jiayin, Krylova, Svetlana M, Cherney, Leonid T, LeBlanc, J. C. Yves, Pribil, Patrick, Johnson, Philip E, Wilson, Derek J, Krylov, Sergey N

“…Studying the kinetics of reversible protein–small molecule binding is a major challenge. The available approaches require that either the small molecule or the…”
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Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold by BEAULIEU, Christian, GUAY, Daniel, DENIS, Danielle, GREIG, Gillian, MATHIEU, Marie-Claude, O'NEILL, Gary, ZHAOYIN WANG, LEBLANC, Yves, ROY, Patrick, DUFRESNE, Claude, ZAMBONI, Robert, BERTHELETTE, Carl, DAY, Stephen, TSOU, Nancy

“…A new series of indole-based antagonists of the PGD(2) receptor subtype 1 (DP1 receptor) was identified and the progress of the structure-activity relationship…”
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Conformation-assisted Inhibition of Protein-tyrosine Phosphatase-1B Elicits Inhibitor Selectivity over T-cell Protein-tyrosine Phosphatase by Asante-Appiah, Ernest, Patel, Sangita, Desponts, Caroline, Taylor, Jillian M., Lau, Cheuk, Dufresne, Claude, Therien, Michel, Friesen, Rick, Becker, Joseph W., Leblanc, Yves, Kennedy, Brian P., Scapin, Giovanna

“…PTP-1B represents an attractive target for the treatment of type 2 diabetes and obesity. Given the role that protein phosphatases play in the regulation of…”
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The development of potent non-peptidic PTP-1B inhibitors by DUFRESNE, Claude, ROY, Patrick, WADDLETON, Deena, RAMACHANDRAN, Chidambaram, KENNEDY, Brian P, LIJING XU, GORDON, Robert, CHI CHUNG CHAN, LEBLANC, Yves, ZHAOYIN WANG, ASANTE-APPIAH, Ernest, CROMLISH, Wanda, BOIE, Yves, FORGHANI, Farnaz, DESMARAIS, Sylvie, QINGPING WANG, SKOREY, Kathryn

“…The SAR from our peptide libraries was exploited to design a series of potent deoxybenzoin PTP-1B inhibitors. The introduction of an ortho bromo substituent…”
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Scout-multiple reaction monitoring: A liquid chromatography tandem mass spectrometry approach for multi-residue pesticide analysis without time scheduling by Salvador, Arnaud, Carrière, Romain, Ayciriex, Sophie, Margoum, Christelle, Leblanc, Yves, Lemoine, Jérôme

“…•A new LC/MS/MS method for pesticide analysis.•The method is insensitive to change in LC configuration.•Easy and quick LC/MS/MS method transfer between…”
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Determination of Pentachlorophenol and Its Oil Solvent in Wood Pole Samples by SFE and GC with Postcolumn Flow Splitting for Simultaneous Detection of the Species by Leblanc, Yves G, Gilbert, Roland, Hubert, Joseph

“…An alternative approach is described for the measurement of pentachlorophenol (PCP) and its oil solvent in wood samples by supercritical fluid extraction (SFE)…”
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Detection of Opioids on Mail/Packages Using Open Port Interface Mass Spectrometry (OPI-MS) by Metwally, Haidy, Agrawal, Prashant, Smith, Rachael, Liu, Chang, LeBlanc, Yves, Covey, Thomas R, Oleschuk, Richard

“…Opioids (and their more potent synthetic analogues) are used therapeutically as effective pain killers; however, recreational use and consequent overdoses are…”
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SpectraX: A Straightforward Tool for Principal Component Analysis-Based Spectral Analysis by Yu, Jian, Metwally, Haidy, Kolwich, Jennifer, Tomm, Hailey, Klotz, Rachel, Liu, Chang, LeBlanc, J. C. Yves, Covey, Thomas R., Ross, Avena C., Oleschuk, Richard D.

“…The analysis of complex spectra is an important component of direct/ambient mass spectrometry (MS) applications such as natural product screening. Unlike…”
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Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 and Cox-1 inhibitors by Leblanc, Yves, Gauthier, JacquesYves, Ethier, Diane, Guay, Jocelyne, Mancini, Joseph, Riendeau, Denis, Tagari, Philip, Vickers, Philip, Wong, Elizabeth, Prasit, Petpiboon

“…A series of 2,3-diarylthiophene compounds was prepared and their biological activities were evaluated against human Cox-1 and Cox-2 enzymes. It appears that…”
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The Integrated Psychological Treatment for Individuals With Schizophrenia in Correctional and Forensic Psychiatric Settings: An Implementation Study by Dumont, Mathieu, Briand, Catherine, Leblanc, Yves, Aubin, Ginette, Potvin, Stéphane, Dumais, Alexandre

“…This study aims to identify the factors that need to be considered in the implementation of the integrated psychological treatment (IPT), a…”
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Cold plasma oxidation of harmful algae and associated metabolite BMAA toxin in aqueous suspension by Nisol, Bernard, Watson, Sean, Leblanc, Yves, Moradinejad, Saber, Wertheimer, Michael R., Zamyadi, Arash

“…We report experiments in which reactive oxygen species (ROS) from a 20 kHz HV discharge in Ar/O2 (90/10) gas mixture at atmospheric pressure were directly…”
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Integrating community-based nonprofit organizations into the cancer care journey: how do connections and coordination take shape? by Tremblay, Dominique, Usher, Susan, Gentil, Barbara, Courval, Marie-Josée, Leblanc, Yves, Cournoyer, Johanne

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3D printer platform and conductance feedback loop for automated imaging of uneven surfaces by liquid microjunction-surface sampling probe mass spectrometry by Hermann, Matthias, Metwally, Haidy, Yu, Jian, Smith, Rachael, Tomm, Hailey, Kaufmann, Martin, Ren, Kevin Y M, Liu, Chang, LeBlanc, Yves, Covey, Thomas R, Ross, Avena C, Oleschuk, Richard D

“…Molecular imaging of samples using mass spectrometric techniques, such as matrix-assisted laser desorption ionization or desorption electrospray ionization,…”
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