Search Results - "LEBASTCHI, JASMIN"

A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes by Batista, Thiago M., Jayavelu, Ashok Kumar, Wewer Albrechtsen, Nicolai J., Iovino, Salvatore, Lebastchi, Jasmin, Pan, Hui, Dreyfuss, Jonathan M., Krook, Anna, Zierath, Juleen R., Mann, Matthias, Kahn, C. Ronald

“…Skeletal muscle insulin resistance is the earliest defect in type 2 diabetes (T2D), preceding and predicting disease development. To what extent this reflects…”
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Detection of β cell death in diabetes using differentially methylated circulating DNA by Akirav, Eitan M, Lebastchi, Jasmin, Galvan, Eva M, Henegariu, Octavian, Akirav, Michael, Ablamunits, Vitaly, Lizardi, Paul M, Herold, Kevan C

“…In diabetes mellitus, β cell destruction is largely silent and can be detected only after significant loss of insulin secretion capacity. We have developed a…”
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Predictors of readmission and mortality in adults with diabetes or stress hyperglycemia after initial hospitalization for COVID-19 by Chaugule, Akshata, Howard, Kyra, Simonson, Donald C, McDonnell, Marie E, Garg, Rajesh, Gopalakrishnan, Geetha, Mitri, Joanna, Lebastchi, Jasmin, Palermo, Nadine E, Westcott, Gregory, Weinstock, Ruth S

“…IntroductionWe previously reported predictors of mortality in 1786 adults with diabetes or stress hyperglycemia (glucose>180 mg/dL twice in 24 hours) admitted…”
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A Humanized Mouse Model of Autoimmune Insulitis by MILAM, Ashley A. Viehmann, MAHER, Stephen E, GIBSON, Joanna A, LEBASTCHI, Jasmin, LI WEN, RUDDLE, Nancy H, HEROLD, Kevan C, BOTHWELL, Alfred L. M

“…Many mechanisms of and treatments for type 1 diabetes studied in the NOD mouse model have not been replicated in human disease models. Thus, the field of…”
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Take It with a Grain of Salt by Phadke, Neelam, Lebastchi, Jasmin, Torre, Matthew, Dunn, Ian, Vaidya, Anand

“…This interactive case features a 56-year-old woman who presents to the ED with a 1-week history of frontotemporal headaches and nausea. Test your diagnostic…”
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Take It with a Grain of Salt by Phadke, Neelam, Lebastchi, Jasmin, Torre, Matthew, Dunn, Ian, Vaidya, Anand

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Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice by Rui, Jinxiu, Deng, Songyan, Lebastchi, Jasmin, Clark, Pamela L., Usmani-Brown, Sahar, Herold, Kevan C.

“…Aims/hypothesis Type 1 diabetes is caused by the immunological destruction of pancreatic beta cells. Preclinical and clinical data indicate that there are…”
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Signaling defects associated with insulin resistance in nondiabetic and diabetic individuals and modification by sex by Haider, Nida, Lebastchi, Jasmin, Jayavelu, Ashok Kumar, Batista, Thiago M, Pan, Hui, Dreyfuss, Jonathan M, Carcamo-Orive, Ivan, Knowles, Joshua W, Mann, Matthias, Kahn, C Ronald

“…Insulin resistance is present in one-quarter of the general population, predisposing these people to a wide range of diseases. Our aim was to identify…”
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β cell death and dysfunction during type 1 diabetes development in at-risk individuals by Herold, Kevan C, Usmani-Brown, Sahar, Ghazi, Tara, Lebastchi, Jasmin, Beam, Craig A, Bellin, Melena D, Ledizet, Michel, Sosenko, Jay M, Krischer, Jeffrey P, Palmer, Jerry P

“…Role of the funding source: Funding from the NIH was used for support of the participating clinical centers and the coordinating center. The funding source did…”
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A Report of Three Cases With Acquired Generalized Lipodystrophy With Distinct Autoimmune Conditions Treated With Metreleptin by Lebastchi, Jasmin, Ajluni, Nevin, Neidert, Adam, Oral, Elif A

“…Context: Acquired generalized lipodystrophy (AGL) is associated with leptin deficiency as a result of adipose tissue loss and hypertriglyceridemia, insulin…”
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Signaling defects associated with insulin resistance in nondiabetic and diabetic individuals and modification by sex by Haider, Nida, Lebastchi, Jasmin, Jayavelu, Ashok Kumar, Batista, Thiago M, Pan, Hui, Dreyfuss, Jonathan M, Carcamo-Orive, Ivan, Knowles, Joshua W, Mann, Matthias, Kahn, C Ronald

“…Insulin resistance is present in one-quarter of the general population, predisposing these people to a wide range of diseases. Our aim was to identify…”
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Glycemic Gap Predicts Mortality in a Large Multicenter Cohort Hospitalized With COVID-19 by McDonnell, Marie E, Garg, Rajesh, Gopalakrishnan, Geetha, Mitri, Joanna, Weinstock, Ruth S, Greenfield, Margaret, Katta, Sai, Lebastchi, Jasmin, Palermo, Nadine E, Radhakrishnan, Ramya, Westcott, Gregory P, Johnson, Matthew, Simonson, Donald C

“…Context: Diabetes or hyperglycemia at admission are established risk factors for adverse outcomes during hospitalization for COVID-19, but the impact of prior…”
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334-OR: Sex Differences in Protein Phosphorylation in Insulin Resistance in Humans at the Cellular Level by HAIDER, NIDA, LEBASTCHI, JASMIN, BATISTA, THIAGO M., PAN, HUI, DREYFUSS, JONATHAN, CARCAMO-ORIVE, IVAN, KNOWLES, JOSH, KAHN, C. RONALD

“…Insulin resistance in muscle precedes and predicts type 2 diabetes in offspring of diabetic parents and is also observed in ~25% of the general population…”
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Glycemic Gap Predicts Mortality in a Large Multicenter Cohort Hospitalized With COVID-19 by McDonnell, Marie E, Garg, Rajesh, Gopalakrishnan, Geetha, Mitri, Joanna, Weinstock, Ruth S, Greenfield, Margaret, Katta, Sai, Lebastchi, Jasmin, Palermo, Nadine E, Radhakrishnan, Ramya, Westcott, Gregory P, Johnson, Matthew, Simonson, Donald C

“…Abstract Context Diabetes or hyperglycemia at admission are established risk factors for adverse outcomes during hospitalization for COVID-19, but the impact…”
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1420-P: Predictors of Readmission and Mortality in Adults with Diabetes or Stress Hyperglycemia after Initial Hospitalization for COVID-19 by CHAUGULE, AKSHATA S., HOWARD, KYRA, SIMONSON, DONALD C., MCDONNELL, MARIE E., GARG, RAJESH K., GOPALAKRISHNAN, GEETHA, MITRI, JOANNA, LEBASTCHI, JASMIN, PALERMO, NADINE E., WESTCOTT, GREGORY P., WEINSTOCK, RUTH S.

“…Our consortium previously reported that older age, elevated glycemic gap, higher BMI and DKA on admission predicted mortality in adults with diabetes or stress…”
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277-LB: Weight Cycling Is Associated with ICU Admission and Mechanical Ventilation in Adults with Diabetes Hospitalized with COVID-19 by MI KANG, YU, SIMONSON, DONALD C., CHAUGULE, AKSHATA S., GARG, RAJESH K., GOPALAKRISHNAN, GEETHA, HOWARD, KYRA, LEBASTCHI, JASMIN, MITRI, JOANNA, PALERMO, NADINE E., WEINSTOCK, RUTH S., MCDONNELL, MARIE E.

“…Weight variability in diabetes is an emerging risk factor for macrovascular complications and mortality, potentially via increased inflammation. We examined…”
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1733-P: Phosphoproteomic Analysis of Insulin Action Using Human IPS-Derived Myoblasts Reveals Important Interactions between Differences Based on Insulin Sensitivity and Sex by HAIDER, NIDA, LEBASTCHI, JASMIN, BATISTA, THIAGO M., KNOWLES, JOSH, PAN, HUI, DREYFUSS, JONATHAN, KAHN, C. RONALD

“…To identify disease-specific indicators associated with insulin resistance by using human induced pluripotent stem cells (iPSCs) as a “disease-in-a-dish”…”
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Immune Therapy and β-Cell Death in Type 1 Diabetes by LEBASTCHI, Jasmin, SONGYAN DENG, LEBASTCHI, Amir H, BESHAR, Isabel, GITELMAN, Stephen, WILLI, Steven, GOTTLIEB, Peter, AKIRAV, Eitan M, BLUESTONE, Jeffrey A, HEROLD, Kevan C

“…Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing β-cells. The killing of β-cells is not currently measurable; β-cell…”
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Analysis of β-Cell Death in Type 1 Diabetes by Droplet Digital PCR by Usmani-Brown, Sahar, Lebastchi, Jasmin, Steck, Andrea K, Beam, Craig, Herold, Kevan C, Ledizet, Michel

“…Type 1 diabetes (T1D) and other forms of diabetes are due to the killing of β-cells. However, the loss of β-cells has only been assessed by functional studies…”
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Modeling the Spectrum of Human Insulin Resistance Using Induced Pluripotent Stem Cells by LEBASTCHI, JASMIN, BATISTA, THIAGO M., CARCAMO-ORIVE, IVAN, KROOK, ANNA, ZIERATH, JULEEN R., KNOWLES, JOSH, RONALD KAHN, C.

“…Induced pluripotent stem cells (iPSCs) represent a unique model to study the genetic components of insulin resistant states in vitro and can be studied in both…”
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