Search Results - "LEARY, Robert"

Population PBPK modeling using parametric and nonparametric methods of the Simcyp Simulator, and Bayesian samplers by Wedagedera, Janak R., Afuape, Anthonia, Chirumamilla, Siri Kalyan, Momiji, Hiroshi, Leary, Robert, Dunlavey, Mike, Matthews, Richard, Abduljalil, Khaled, Jamei, Masoud, Bois, Frederic Y.

“…Physiologically‐based pharmacokinetic (PBPK) models usually include a large number of parameters whose values are obtained using in vitro to in vivo…”
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An Algorithm for Nonparametric Estimation of a Multivariate Mixing Distribution with Applications to Population Pharmacokinetics by Yamada, Walter M, Neely, Michael N, Bartroff, Jay, Bayard, David S, Burke, James V, Guilder, Mike van, Jelliffe, Roger W, Kryshchenko, Alona, Leary, Robert, Tatarinova, Tatiana, Schumitzky, Alan

“…Population pharmacokinetic (PK) modeling has become a cornerstone of drug development and optimal patient dosing. This approach offers great benefits for…”
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Global Optimization on Funneling Landscapes by Leary, Robert H

“…Molecular conformation problems arising in computational chemistry require the global minimization of a non-convex potential energy function representing the…”
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Impact of Sample Size on the Performance of Multiple-Model Pharmacokinetic Simulations by TAM, Vincent H, KABBARA, Samer, YEH, Rosa F, LEARY, Robert H

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Global Optima of Lennard-Jones Clusters by Leary, Robert H

“…This paper summarizes the current state of knowledge concerning putative global minima of the potential energy function for Lennard-Jones clusters, an…”
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Flirting with Catastrophe by Leary, Robert H.

“…The behavior of atomic and molecular assemblies is governed by potential energy surfaces. Wales brings a new analytical tool--catastrophe theory--to the study…”
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Two general methods for population pharmacokinetic modeling: non-parametric adaptive grid and non-parametric Bayesian by Tatarinova, Tatiana, Neely, Michael, Bartroff, Jay, van Guilder, Michael, Yamada, Walter, Bayard, David, Jelliffe, Roger, Leary, Robert, Chubatiuk, Alyona, Schumitzky, Alan

“…Population pharmacokinetic (PK) modeling methods can be statistically classified as either parametric or nonparametric (NP). Each classification can be divided…”
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Map-Based Vehicle State Estimation Using a Spatiotemporal Preview Filter by Leary, Robert Daniel

“…The primary focus of this work is to develop a vehicle state estimation algorithm using a-priori knowledge of the environment. Specifically, this work focuses…”
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Parametric and nonparametric population methods : Their comparative performance in analysing a clinical dataset and two monte carlo simulation studies by BUSTAD, Aida, TERZIIVANOV, Dimiter, LEARY, Robert, PORT, Ruediger, SCHUMITZKY, Alan, JELLIFFE, Roger

“…This study examined parametric and nonparametric population modelling methods in three different analyses. The first analysis was of a real, although small,…”
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Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy by Jumbe, Nelson, Louie, Arnold, Leary, Robert, Liu, Weiguo, Deziel, Mark R, Tam, Vincent H, Bachhawat, Reetu, Freeman, Christopher, Kahn, James B, Bush, Karen, Dudley, Michael N, Miller, Michael H, Drusano, George L

“…The worldwide increase in the prevalence of multi-antibiotic-resistant bacteria has threatened the physician's ability to provide appropriate therapy for…”
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Bacterial-Population Responses to Drug-Selective Pressure: Examination of Garenoxacin’s Effect on Pseudomonas aeruginosa by Tam, Vincent H., Louie, Arnold, Deziel, Mark R., Liu, Weiguo, Leary, Robert, Drusano, George L.

“…The emergence of resistance to antibiotics is a serious problem often related to suboptimal drug dosing; such suboptimal dosing results in the preferential…”
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Extracting Geometric Road Centerline and Lane Edges from Single-Scan LiDAR Intensity Using Optimally Filtered Extrema Features by Leary, Robert D., Brennan, Sean N.

“…This paper presents a methodology for determining the geometric center and edges of a lane using intensity scans from a downward-facing LiDAR. This method is…”
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Parametric And Nonparametric Population Modeling: An Impression And A Fact About Parameter Precision: 145 by Bustad, Aida, Terziivanov, Dimiter, Leary, Robert, Port, Ruediger, Jelliffe, Roger

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Hospitals: get ready for severity-adjusted reimbursement by Leary, Robert J

“…Hospitals remain in a holding pattern as the Centers for Medicare & Medicaid Services (CMS) formulates the final details of how it will implement…”
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A giant step forward. Healthcare organizations can expect error-free coding and reimbursement from a carefully planned use of Web services by Leary, Robert J

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The CMS update cycle: short, short-sighted and short-changing the industry by Leary, Robert J

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Learning of Detour Problems by Lemurs and Seven Species of Monkeys by Davis, Roger T., Leary, Robert W.

“…40 Ss drawn from 7 species of monkey, and Lemur catta were trained to solve bent-wire detour problems. Old World monkeys were significantly more proficient…”
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The Reactions of 3-Phenyl-1-butylamine-3-14C and 3-p-Anisyl-1-butylamine-3-14C with Nitrous Acid1,2 by Fort, Arthur W, Leary, Robert E

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REINFORCEMENT EFFECTS IN THE DISCRIMINATION LEARNING OF BURMESE CATS by STEVENS, DAVID A., LEARY, ROBERT W.

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Species Differences in the Gross Behaviour of Nonhuman Primates by Davis, Roger T, Leary, Robert W, Dell Casebeer Smith, Mary, Thompson, Richard F

“…Abstract 1. Lemurs (Lemur catta) and six groups of monkeys - three groups of Old World and three of New World monkeys were compared by means of gross…”
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