Search Results - "LE ROITH, D"

New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia by Werner, H, Le Roith, D

“…The insulin-like growth factors (IGFs) are a ubiquitous family of growth factors, binding proteins and receptors that are involved in normal growth and…”
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Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: new insights into their synergistic effects by Dupont, J, Le Roith, D

“…In MCF-7 breast cancer cells, the insulin-like growth factor 1 receptor (IGF-1R) and the oestrogen receptor (ER) are coexpressed and the two signalling systems…”
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The Somatomedin Hypothesis: 2001 by Le Roith, Derek, Bondy, Carolyn, Yakar, Shoshana, Liu, Jun-Li, Butler, Andrew

“…Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify the concept. Originally somatic…”
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Control of growth by the somatropic axis: growth hormone and the insulin-like growth factors have related and independent roles by Butler, A A, Le Roith, D

“…The traditionally accepted theory has been that most of the biological effects of growth hormone (GH) are mediated by circulating (endocrine) insulin-like…”
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The growth hormone/insulin-like growth factor-I system: implications for organ growth and development by Yakar, S, Liu, J L, Le Roith, D

“…Growth hormone (GH) and insulin-like growth factors (IGFs) are essential for normal growth and development during embryonic stages as well as postnatally…”
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proposed terminology 'A₁c-derived average glucose' is inherently imprecise and should not be adopted by Bloomgarden, Z. T, Inzucchi, S. E, Karnieli, E, Le Roith, D

“…The proposed use of a more precise standard for glycated (A₁c) and non-glycated haemoglobin would lead to an A₁c value, when expressed as a percentage, that is…”
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Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes by Fernández, A M, Kim, J K, Yakar, S, Dupont, J, Hernandez-Sanchez, C, Castle, A L, Filmore, J, Shulman, G I, Le Roith, D

“…Peripheral insulin resistance and impaired insulin action are the primary characteristics of type 2 diabetes. The first observable defect in this major…”
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The proposed terminology 'A(1c)-derived average glucose' is inherently imprecise and should not be adopted by Bloomgarden, Z T, Inzucchi, S E, Karnieli, E, Le Roith, D

“…The proposed use of a more precise standard for glycated (A(1c)) and non-glycated haemoglobin would lead to an A(1c) value, when expressed as a percentage,…”
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Tumor-Induced Hypoglycemia by Le Roith, Derek

“…Hypoglycemia is a common medical emergency. Among hospitalized patients, it is most common in those with diabetes mellitus, but it also occurs in patients with…”
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Evolutionary Origins of Vertebrate Hormones: Substances Similar to Mammalian Insulins are Native to Unicellular Eukaryotes by Le Roith, Derek, Shiloach, Joseph, Roth, Jesse, Lesniak, Maxine A.

“…Tetrahymena pyriformis, Neurospora crassa, and Aspergillus fumigatus that had been grown in simple defined media were extracted with acid ethanol by a classic…”
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Regulation of proliferation and apoptosis by the insulin-like growth factor I receptor by Roith, Derek Le

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Insulin-like growth factor by Le Roith, D

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The effect of abdominal pressure on plasma antidiuretic hormone levels in the dog by Le Roith, D, Bark, H, Nyska, M, Glick, S M

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Although both rhGh and rhIGF-I have the potential to provide clinical benefit, each also has the potential to produce unwanted side-effects by Le Roith, D

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Multiple signaling pathways are involved in the regulation of IGF-I receptor inhibition of PTEN-enhanced apoptosis by Wu, Yiping, Karas, Michael, Dupont, Joelle, Zhao, Hong, Toyoshima, Yuka, Roith, Derek Le

“…PTEN is a dual protein and lipid phosphatase that dephosphorylates PIP3 at the 3 ′position, thereby antagonizing PI3-kinase activity. A reduction in PI3…”
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Differential modulation of cellular and viral promoters by p73 and p53 by Deb, D, Lanyi, A, Scian, M, Keiger, J, Brown, D R, Le Roith, D, Deb, S P, Deb, S

“…p73 has been shown to transcriptionally activate genes positively responsive to wild-type p53. In order to undertake a comparative study of functions of p53…”
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Tumor necrosis factor α and interferon γ– induced cell growth arrest is mediated via insulin-like growth factor binding protein-3 by Katz, J, Nasatzky, E, Werner, H, Roith, D.Le, Shemer, J

“…Retinoic acid (RA), and the combination of TNFα and Interferon (IFN-γ) inhibit human salivary gland tumor (HSG) cell growth with the combination of all three…”
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Recent Advances in Our Understanding of Insulin Action and Insulin Resistance by LE ROITH, Derek, ZICK, Yehiel

“…Recent Advances in Our Understanding of Insulin Action and Insulin Resistance Derek Le Roith , MD, PHD 1 and Yehiel Zick , PHD 2 1 Clinical Endocrinology…”
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The yin and the yang of the IGF system: immunological manifestations of GH resistance by LE ROITH, D, BLAKESLEY, V. A

“…The insulin-like growth factors (IGFs) are widely expressed and modulate the activity of most functions in the body (1). Circulating (endocrine) IGF-I is…”
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PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells by HONG ZHAO, DUPONT, Joelle, YAKAR, Shoshana, KARAS, Michael, LEROITH, Derek

“…PTEN is a tumor suppressor gene that is frequently mutated in human tumors. It functions primarily as a lipid phosphatase and plays a key role in the…”
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