Search Results - "LE MOAL, Michel"

Addiction and the Brain Antireward System by KOOB, George F, LE MOAL, Michel

“…A neurobiological model of the brain emotional systems has been proposed to explain the persistent changes in motivation that are associated with vulnerability…”
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Drug Abuse: Hedonic Homeostatic Dysregulation by Koob, George F., Le Moal, Michel

“…Understanding the neurobiological mechanisms of addiction requires an integration of basic neuroscience with social psychology, experimental psychology, and…”
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Neurobiological mechanisms for opponent motivational processes in addiction by Koob, George F, Le Moal, Michel

“…The conceptualization of drug addiction as a compulsive disorder with excessive drug intake and loss of control over intake requires motivational mechanisms…”
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Individual vulnerabilities relative for potential pathological conditions by Moal, Michel Le

“…Abstract It is not a usual venture to review experiments conducted decades ago in the context of interests of that time and replace them in a long-term…”
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Plasticity of reward neurocircuitry and the 'dark side' of drug addiction by Koob, George F, Le Moal, Michel

“…Drug seeking is associated with activation of reward neural circuitry. Here we argue that drug addiction also involves a 'dark side'--a decrease in the…”
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Adult Neurogenesis: From Precursors to Network and Physiology by Abrous, Djoher Nora, Koehl, Muriel, Le Moal, Michel

“…Laboratoire de Physiopathologie des Comportements, Institut National de la Santé et de la Recherche Médicale, U588, Université de Bordeaux 2, Bordeaux, France…”
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Individual differences in stress-induced dopamine release in the nucleus accumbens are influenced by corticosterone by Rougé-Pont, Françoise, Deroche, Véronique, Moal, Michel Le, Piazza, Pier Vincenzo

“…Stressful experiences, glucocorticoids hormones and dopaminergic neurons seems to interact in determining a higher propensity to develop drug abuse. In this…”
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Drug Addiction, Dysregulation of Reward, and Allostasis by Koob, George F, Le Moal, Michel

“…This paper reviews recent developments in the neurocircuitry and neurobiology of addiction from a perspective of allostasis. A model is proposed for brain…”
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Spatial Memory Performances of Aged Rats in the Water Maze Predict Levels of Hippocampal Neurogenesis by Drapeau, Elodie, Mayo, Willy, Aurousseau, Catherine, Le Moal, Michel, Piazza, Pier-Vincenzo, Abrous, Djoher Nora

“…Neurogenesis occurs within the adult dentate gyrus of the hippocampal formation and it has been proposed that the newly born neurons, recruited into the…”
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Postnatal Stimulation of the Pups Counteracts Prenatal Stress-Induced Deficits in Hippocampal Neurogenesis by Lemaire, Valerie, Lamarque, Stephanie, Le Moal, Michel, Piazza, Pier-Vincenzo, Abrous, Djoher Nora

“…Prenatal stress constitutes a developmental risk factor for later psychopathology. The behavioral disorders are sustained by neurobiological alterations…”
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Suppression of Glucocorticoid Secretion and Antipsychotic Drugs have Similar Effects on the Mesolimbic Dopaminergic Transmission by Piazza, Pier Vincenzo, Barrot, Michel, Rouge-Pont, Francoise, Marinelli, Michela, Maccari, Stefania, Abrous, Djoher Nora, Simon, Herve, Le Moal, Michel

“…Specific antagonists of central dopaminergic receptors constitute the major class of antipsychotic drugs (APD). Two principal effects of APD are used as…”
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Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes by George, Olivier, Vallée, Monique, Le Moal, Michel, Mayo, Willy

“…The neurosteroids pregnenolone sulfate (PREGS), dehydroepiandrosterone sulfate (DHEAS) and allopregnanolone (3alpha,5alpha THPROG) have been implicated as…”
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Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons by Piazza, P V, Le Moal, M L

“…Research on drug abuse has recently focused on understanding the vulnerability to develop addiction that is present in certain individuals. These…”
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Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome by MUSCATELLI, Francoise, DJOHER NORA ABROUS, MASSACRIER, Annick, BOCCACCIO, Irène, LE MOAL, Michel, CAU, Pierrre, CREMER, Harold

“…Prader-Willi syndrome (PWS) is a complex neurogenetic disorder with considerable clinical variability that is thought in large part to be the result of a…”
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Progressive Enhancement of Delayed Hyperalgesia Induced by Repeated Heroin Administration: A Sensitization Process by Celerier, Evelyne, Laulin, Jean-Paul, Corcuff, Jean-Benoit, Le Moal, Michel, Simonnet, Guy

“…It is difficult to conceive that tolerance and sensitization processes, two apparently opposite phenomena, can concomitantly modify one given biological…”
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Nicotine Self-Administration Impairs Hippocampal Plasticity by Abrous, Djoher Nora, Adriani, Walter, Montaron, Marie-Francoise, Aurousseau, Catherine, Rougon, Genevieve, Le Moal, Michel, Piazza, Pier Vincenzo

“…Nicotine, the neuroactive compound responsible for tobacco addiction, is primarily believed to have beneficial effects on the adult brain. However, in heavy…”
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Prenatal Stress Induces High Anxiety and Postnatal Handling Induces Low Anxiety in Adult Offspring: Correlation with Stress-Induced Corticosterone Secretion by Vallee, Monique, Mayo, Willy, Dellu, Francoise, Le Moal, Michel, Simon, Herve, Maccari, Stefania

“…It is well known that the hypothalamo-pituitary-adrenal (HPA) axis is altered by early environmental experiences, particularly in the perinatal period. This…”
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Abolition and Reversal of Strain Differences in Behavioral Responses to Drugs of Abuse after a Brief Experience by Cabib, Simona, Orsini, Cristina, Le Moal, Michel, Piazza, Pier Vincenzo

“…Inbred strains of mice are largely used to identify the genetic basis of normal and pathological behaviors. This report demonstrates that a moderate period of…”
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Long-term effects of prenatal stress and postnatal handling on age-related glucocorticoid secretion and cognitive performance: a longitudinal study in the rat by Vallée, Monique, Maccari, Stefania, Dellu, Françoise, Simon, Hervé, Le Moal, Michel, Mayo, Willy

“…There is growing evidence that stress during prenatal and postnatal periods of life can modify adaptive capacities in adulthoods. The…”
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Maternal Glucocorticoid Secretion Mediates Long-Term Effects of Prenatal Stress by Barbazanges, Arnaud, Piazza, Pier Vincenzo, Le Moal, Michel, Maccari, Stefania

“…There is growing evidence that stressors occurring during pregnancy can impair biological and behavioral adaptation to stress in the adult offspring…”
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