Search Results - "LE Ludivine, DRET"

Dual inhibition using cabozantinib overcomes HGF/MET signaling mediated resistance to pan-VEGFR inhibition in orthotopic and metastatic neuroblastoma tumors by Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Bawa, Olivia, Opolon, Paule, Vievard, Albane, Villa, Irène, Bosq, Jacques, Vassal, Gilles, Geoerger, Birgit

“…MET is expressed on neuroblastoma cells and may trigger tumor growth, neoangiogenesis and metastasis. MET upregulation further represents an escape mechanism…”
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Functionally defined therapeutic targets in diffuse intrinsic pontine glioma by Grasso, Catherine S, Tang, Yujie, Truffaux, Nathalene, Berlow, Noah E, Liu, Lining, Debily, Marie-Anne, Quist, Michael J, Davis, Lara E, Huang, Elaine C, Woo, Pamelyn J, Ponnuswami, Anitha, Chen, Spenser, Johung, Tessa B, Sun, Wenchao, Kogiso, Mari, Du, Yuchen, Qi, Lin, Huang, Yulun, Hütt-Cabezas, Marianne, Warren, Katherine E, Le Dret, Ludivine, Meltzer, Paul S, Mao, Hua, Quezado, Martha, van Vuurden, Dannis G, Abraham, Jinu, Fouladi, Maryam, Svalina, Matthew N, Wang, Nicholas, Hawkins, Cynthia, Nazarian, Javad, Alonso, Marta M, Raabe, Eric H, Hulleman, Esther, Spellman, Paul T, Li, Xiao-Nan, Keller, Charles, Pal, Ranadip, Grill, Jacques, Monje, Michelle

“…The study describes the use of integrative approaches to search for candidate therapeutic targets for DIPG, and the identification of an HDAC inhibitor as a…”
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Regorafenib: Antitumor Activity upon Mono and Combination Therapy in Preclinical Pediatric Malignancy Models by Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Lanvers-Kaminsky, Claudia, Bawa, Olivia, Opolon, Paule, Vievard, Albane, Villa, Irène, Pagès, Mélanie, Bosq, Jacques, Vassal, Gilles, Zopf, Dieter, Geoerger, Birgit

“…The multikinase inhibitor regorafenib (BAY 73-4506) exerts both anti-angiogenic and anti-tumorigenic activity in adult solid malignancies mainly advanced…”
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New in vivo avatars of diffuse intrinsic pontine gliomas (DIPG) from stereotactic biopsies performed at diagnosis by Plessier, Alexandre, Le Dret, Ludivine, Varlet, Pascale, Beccaria, Kévin, Lacombe, Joëlle, Mériaux, Sébastien, Geffroy, Françoise, Fiette, Laurence, Flamant, Patricia, Chrétien, Fabrice, Blauwblomme, Thomas, Puget, Stéphanie, Grill, Jacques, Debily, Marie-Anne, Castel, David

“…Diffuse Instrinsic Pontine Glioma is the most aggressive form of High Grade Gliomas in children. The lack of biological material and the absence of relevant…”
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VRK3 depletion induces cell cycle arrest and metabolic reprogramming of pontine diffuse midline glioma - H3K27 altered cells by Menez, Virginie, Kergrohen, Thomas, Shasha, Tal, Silva-Evangelista, Claudia, Le Dret, Ludivine, Auffret, Lucie, Subecz, Chloé, Lancien, Manon, Ajlil, Yassine, Vilchis, Irma Segoviano, Beccaria, Kévin, Blauwblomme, Thomas, Oberlin, Estelle, Grill, Jacques, Castel, David, Debily, Marie-Anne

“…We previously identified VRK3 as a specific vulnerability in DMG-H3K27M cells in a synthetic lethality screen targeting the whole kinome. The aim of the…”
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Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes by Castel, David, Philippe, Cathy, Calmon, Raphaël, Le Dret, Ludivine, Truffaux, Nathalène, Boddaert, Nathalie, Pagès, Mélanie, Taylor, Kathryn R., Saulnier, Patrick, Lacroix, Ludovic, Mackay, Alan, Jones, Chris, Sainte-Rose, Christian, Blauwblomme, Thomas, Andreiuolo, Felipe, Puget, Stephanie, Grill, Jacques, Varlet, Pascale, Debily, Marie-Anne

“…Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no significant therapeutic progress made in the past 50 years. Recent…”
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Polo-like Kinase Inhibitor Volasertib Exhibits Antitumor Activity and Synergy with Vincristine in Pediatric Malignancies by Abbou, Samuel, Lanvers-Kaminsky, Claudia, Daudigeos-Dubus, Estelle, LE Dret, Ludivine, Laplace-Builhe, Corinne, Molenaar, Jan, Vassal, Gilles, Geoerger, Birgit

“…Polo-like kinase 1 (PLK1) controls the main cell-cycle checkpoints, suggesting utility of its inhibition for cancer treatment, including of highly…”
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Rapid and Sensitive Drug Quantification in Tissue Sections Using Matrix Assisted Laser Desorption Ionization-Ion Mobility-Mass Spectrometry Profiling by Fresnais, Margaux, Muck, Alexander, Majewsky, Marius, Statz, Britta, Krausert, Sonja, Benzel, Julia, Castel, David, Le Dret, Ludivine, Pfister, Stefan, Haefeli, Walter E, Burhenne, Jürgen, Longuespée, Rémi

“…Ion mobility spectrometry (IMS) represents a considerable asset for analytics of complex samples as it allows for rapid mass spectrometric separation of…”
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Functionally defined therapeutic targets in diffuse intrinsic pontine glioma by Grasso, Catherine S, Tang, Yujie, Truffaux, Nathalene, Berlow, Noah E, Liu, Lining, Debily, Marie-Anne, Quist, Michael J, Davis, Lara E, Huang, Elaine C, Woo, Pamelyn J, Ponnuswami, Anitha, Chen, Spenser, Johung, Tessa B, Sun, Wenchao, Kogiso, Mari, Du, Yuchen, Qi, Lin, Huang, Yulun, Hütt-Cabezas, Marianne, Warren, Katherine E, Le Dret, Ludivine, Meltzer, Paul S, Mao, Hua, Quezado, Martha, van Vuurden, Dannis G, Abraham, Jinu, Fouladi, Maryam, Svalina, Matthew N, Wang, Nicholas, Hawkins, Cynthia, Nazarian, Javad, Alonso, Marta M, Raabe, Eric H, Hulleman, Esther, Spellman, Paul T, Li, Xiao-Nan, Keller, Charles, Pal, Ranadip, Grill, Jacques, Monje, Michelle

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DIPG-56. EXPLORATION OF TUMOR/STROMA INTERACTIONS IN DIPG XENOGRAFT BY SPECIES-SPECIFIC RNA-SEQ DECONVOLUTION INDICATES A ROLE OF MICROGLIA CELL IN DIPG DEVELOPMENT by Merlevede, Jane, Plessier, Alexandre, Felix, Arthur, Philippe, Cathy, Dret, Ludivine Le, Hardy, David, Beccaria, Kevin, Grill, Jacques, Castel, David, Varlet, Pascale, Debily, Marie-Anne

“…Abstract Diffuse Intrinsic Pontine Glioma (DIPG) and more largely Diffuse Midline Gliomas H3 K27M-mutant (DMG) harbor a unique property of infiltration. Our…”
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Systematic identification of suspected anthelmintic benzimidazole metabolites using LC–MS/MS by Majewsky, Marius, Castel, David, Le Dret, Ludivine, Johann, Pascal, Jones, David T., Pfister, Stefan M., Haefeli, Walter E., Burhenne, Jürgen

“…•MS/MS spectra of benzimidazoles were structurally elucidated.•Characteristic product ions were predicted for unknown metabolites.•Predicted product ions were…”
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Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma by Truffaux, Nathalène, Philippe, Cathy, Paulsson, Janna, Andreiuolo, Felipe, Guerrini-Rousseau, Léa, Cornilleau, Gaétan, Le Dret, Ludivine, Richon, Catherine, Lacroix, Ludovic, Puget, Stéphanie, Geoerger, Birgit, Vassal, Gilles, Östman, Arne, Grill, Jacques

“…Platelet-derived growth factor receptor A is altered by amplification and/or mutation in diffuse intrinsic pontine glioma (DIPG). We explored in vitro on new…”
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Establishment and characterization of new orthotopic and metastatic neuroblastoma models by Daudigeos-Dubus, Estelle, LE Dret, Ludivine, Rouffiac, Valérie, Bawa, Olivia, Leguerney, Ingrid, Opolon, Paule, Vassal, Gilles, Geoerger, Birgit

“…Treatment of metastatic neuroblastoma remains a challenge in pediatric oncology. Relevant preclinical models may improve exploration of oncogenesis and new…”
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Abstract 4537: Geranyloxy-ifosfamide: A pre-activated ifosfamide analogue showing an increased therapeutic index by Skarbek, Charles, Desmaele, Didier, Deroussent, Alain, Lesueur, Lea, Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Rivard, Michael, Martens, Thierry, Vassal, Gilles, Couvreur, Patrick, PACI, Angelo

“…Ifosfamide (IFO) is an alkylating agent used in routine clinical practices for treatment of cancer for many years. As a prodrug it requires cytochrome P450…”
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Simultaneous quantification of preactivated ifosfamide derivatives and of 4-hydroxyifosfamide by high performance liquid chromatography–tandem mass spectrometry in mouse plasma and its application to a pharmacokinetic study by Deroussent, Alain, Skarbek, Charles, Maury, Adeline, Chapuis, Hubert, Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Durand, Sylvère, Couvreur, Patrick, Desmaële, Didier, Paci, Angelo

“…•A LC–MS/MS assay for quantification of ifosfamide conjugates and hydroxy metabolite.•The hydroxyifosfamide is stabilized as semicarbazone derivative in…”
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Abstract 2763: Activity of dasatinib and potential escape mechanisms in diffuse intrinsic pontine glioma (DIPG) models by Truffaux, Nathalene, Dret, Ludivine Le, Puget, Stephanie, Vassal, Gilles, Geoerger, Birgit, Grill, Jacques

“…Background Diffuse intrinsic pontine glioma (DIPG) have a dismal prognosis and their biology is not yet well explored. Using an integrated molecular profiling…”
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HG-55DEVELOPMENT OF IN VIVO MODELS OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) FROM STEREOTACTIC BIOPSIES PERFORMED AT DIAGNOSIS by Plessier, Alexandre, Le Dret, Ludivine, Fiette, Laurence, Mériaux, Sébastien, Beccaria, Kévin, Varlet, Pascale, Puget, Stéphanie, Grill, Jacques, Debily, Marie-Anne, Castel, David

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DIPG-21. GENOMIC LANDSCAPE OF THE FIRST 100 TUMORS REGISTERED IN THE BIOLOGICAL MEDICINE FOR DIPG ERADICATION (BIOMEDE) TRIAL by Castel, David, Barret, Emilie, Picot, Stephanie, Plessier, Alexandre, Le Dret, Ludivine, Nysom, Karsten, Huybrechts, Sophie, Capolino, Perrine, Le Deley, Marie-Cecile, Vassal, Gilles, Puget, Stephanie, Varlet, Pascale, Grill, Jacques, Debily, Marie-Anne

“…BACKGROUND: Genomic analyses of DIPG have been so far mostly performed on autopsy samples or in retrospective studies. In the frame of the BIOMEDE randomized…”
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Regorafenib antitumor activity alone and in combination with radio or chemotherapy in preclinical models of pediatric solid tumors by Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Lanvers-Kaminsky, Claudia, Bawa, Olivia, Opolon, Paule, Villa, Irene, Bosq, Jacques, Vassal, Gilles, Zopf, Dieter, Geoerger, Birgit

“…Abstract only…”
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Erratum: Functionally defined therapeutic targets in diffuse intrinsic pontine glioma by Grasso, Catherine S, Tang, Yujie, Truffaux, Nathalene, Berlow, Noah E, Liu, Lining, Debily, Marie-Anne, Quist, Michael J, Davis, Lara E, Huang, Elaine C, Woo, Pamelyn J, Ponnuswami, Anitha, Chen, Spenser, Johung, Tessa B, Sun, Wenchao, Kogiso, Mari, Du, Yuchen, Qi, Lin, Huang, Yulun, Hütt-Cabezas, Marianne, Warren, Katherine E, Le Dret, Ludivine, Meltzer, Paul S, Mao, Hua, Quezado, Martha, van Vuurden, Dannis G, Abraham, Jinu, Fouladi, Maryam, Svalina, Matthew N, Wang, Nicholas, Hawkins, Cynthia, Nazarian, Javad, Alonso, Marta M, Raabe, Eric H, Hulleman, Esther, Spellman, Paul T, Li, Xiao-Nan, Keller, Charles, Pal, Ranadip, Grill, Jacques, Monje, Michelle

“…Nat. Med. 21, 555–559 (2015); doi:10.1038/nm.3855; published online 4 May 2015; corrected after print 15 June 2015 In the version of this article initially…”
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