Search Results - "LE CRAS, T. D"

Diesel exhaust particle exposure increases severity of allergic asthma in young mice by Acciani, T. H., Brandt, E. B., Khurana Hershey, G. K., Le Cras, T. D.

“…Summary Background Epidemiologic studies have reported an association between diesel exhaust particle (DEP) exposure, allergic sensitization, and childhood…”
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VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice by Le Cras, T D, Spitzmiller, R E, Albertine, K H, Greenberg, J M, Whitsett, J A, Akeson, A L

“…To determine whether increased levels of VEGF disrupt postnatal lung formation or function, conditional transgenic mice in which VEGF 164 expression was…”
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Epidermal growth factor receptor signalling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease by Acciani, T. H., Suzuki, T., Trapnell, B. C., Le Cras, T. D.

“…Summary Background Airway epithelial cells (AEC) are increasingly recognized as a major signalling centre in the pathogenesis of allergic asthma. A previous…”
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Distribution of NOS in normoxic vs. hypoxic rat lung: upregulation of NOS by chronic hypoxia by Xue, C, Rengasamy, A, Le Cras, T D, Koberna, P A, Dailey, G C, Johns, R A

“…Expression and localization of nitric oxide synthase (NOS) in the lungs of chronically hypoxic and normoxic rats were studied using both immunohistochemistry…”
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Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung by Le Cras, T D, Xue, C, Rengasamy, A, Johns, R A

“…The effect of chronic hypoxia-induced pulmonary hypertension on nitric oxide synthase (NOS) in the lung is controversial. To clarify the regulation of…”
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Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood by Le Cras, T D, Hardie, W D, Deutsch, G H, Albertine, K H, Ikegami, M, Whitsett, J A, Korfhagen, T R

“…Clinical studies have associated increased transforming growth factor (TGF)-alpha and EGF receptor with lung remodeling in diseases including bronchopulmonary…”
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Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus by Villamor, E, Le Cras, T D, Horan, M P, Halbower, A C, Tuder, R M, Abman, S H

“…Endothelial (e) nitric oxide synthase (NOS) activity modulates pulmonary vascular tone in the normal fetus and decreases pulmonary vascular resistance (PVR) at…”
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Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung by Le Cras, T D, Tyler, R C, Horan, M P, Morris, K G, Tuder, R M, McMurtry, I F, Johns, R A, Abman, S H

“…Mechanisms that regulate endothelial nitric oxide synthase (eNOS) expression in normal and hypoxic pulmonary circulation are poorly understood. Lung eNOS…”
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p27(Kip1) is important in modulating pulmonary artery smooth muscle cell proliferation by Fouty, B W, Grimison, B, Fagan, K A, Le Cras, T D, Harral, J W, Hoedt-Miller, M, Sclafani, R A, Rodman, D M

“…Vascular remodeling due to pulmonary arterial smooth muscle cell (PASMC) proliferation is central to the development of pulmonary hypertension. Cell…”
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Inhibition of VEGF receptors causes lung cell apoptosis and emphysema by Kasahara, Y, Tuder, R M, Taraseviciene-Stewart, L, Le Cras, T D, Abman, S, Hirth, P K, Waltenberger, J, Voelkel, N F

“…Pulmonary emphysema, a significant global health problem, is characterized by a loss of alveolar structures. Because VEGF is a trophic factor required for the…”
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Growth requirements and expression of LDL receptor and HMG-CoA reductase in Hep G2 hepatoblastoma cells cultured in a chemically defined medium by GHERARDI, E, THOMAS, K, LE CRAS, T. D, FITZSIMMONS, C, MOORBY, C. D, BOWYER, D. E

“…A serum-free chemically defined medium (CDM) has been developed which sustains the growth in culture of the highly differentiated human hepatoma cell line Hep…”
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Inhibition of angiogenesis decreases alveolarization in the developing rat lung by Jakkula, M, Le Cras, T D, Gebb, S, Hirth, K P, Tuder, R M, Voelkel, N F, Abman, S H

“…To determine whether angiogenesis is necessary for normal alveolarization, we studied the effects of two antiangiogenic agents, thalidomide and fumagillin, on…”
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Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase and preproendothelin-1 expression in the adult rat lung by Le Cras, T D, Tyler, R C, Horan, M P, Morris, K G, McMurty, I F, Johns, R A, Abman, S H

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Nitric oxide production in the hypoxic lung by Le Cras, T D, McMurtry, I F

“…Nitric oxide (NO) is a potent vasodilator and inhibitor of vascular remodeling. Reduced NO production has been implicated in the pathophysiology of pulmonary…”
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Repetitive prenatal glucocorticoids increase lung endothelial nitric oxide synthase expression in ovine fetuses delivered at term by GROVER, T. R, ACKERMAN, K. G, LE CRAS, T. D, JOBE, A. H, ABMAN, S. H

“…Antenatal administration of glucocorticoids has been shown to improve postnatal lung function after preterm birth in the ovine fetus. Mechanisms of…”
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Prolonged infusions of estradiol dilate the ovine fetal pulmonary circulation by PARKER, T. A, KINSELLA, J. P, GALAN, H. L, LE CRAS, T. D, RICHTER, G. T, MARKHAM, N. E, ABMAN, S. H

“…Factors mediating both the rapid and sustained fall in pulmonary vascular resistance (PVR) at birth are incompletely understood. Acute or prolonged estrogen…”
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Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction by Ivy, D, McMurtry, I F, Yanagisawa, M, Gariepy, C E, Le Cras, T D, Gebb, S A, Morris, K G, Wiseman, R C, Abman, S H

“…Endothelin (ET)-1 contributes to the regulation of pulmonary vascular tone by stimulation of the ET(A) and ET(B) receptors. Although activation of the ET(A)…”
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Developmental changes in endothelial nitric oxide synthase expression and activity in ovine fetal lung by Parker, T A, le Cras, T D, Kinsella, J P, Abman, S H

“…Endothelial nitric oxide (NO) synthase (eNOS) produces NO, which contributes to vascular reactivity in the fetal lung. Pulmonary vasoreactivity develops during…”
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Early abnormalities of pulmonary vascular development in the Fawn-Hooded rat raised at Denver's altitude by Le Cras, T D, Kim, D H, Markham, N E, Abman, A S

“…The Fawn-Hooded rat (FHR) is a genetic strain that has been extensively studied as a model of primary pulmonary hypertension in adult rats. Based on our recent…”
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Abnormal lung growth and the development of pulmonary hypertension in the Fawn-Hooded rat by Le Cras, T D, Kim, D H, Gebb, S, Markham, N E, Shannon, J M, Tuder, R M, Abman, S H

“…The Fawn-Hooded rat (FHR) strain develops accelerated and severe pulmonary hypertension when exposed to slight decreases in alveolar PO(2). We recently…”
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