Search Results - "LAWSON, Terence A"

Species Differences in the Distribution of Drug-Metabolizing Enzymes in the Pancreas by Ulrich, Alexis B., Standop, Jens, Schmied, Bruno M., Schneider, Matthias B., Lawson, Terence A., Pour, Parviz M.

“…We investigated the cellular expression of 9 cytochrome P450-isozymes (CYP1A1, CYP1A2, CYP2B6, CYP2C8,9,19, CYP2D1, CYP2E1, CYP3A1, CYP3A2, CYP3A4) and 3…”
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Meat intake and risk of non-Hodgkin lymphoma by Aschebrook-Kilfoy, Briseis, Ollberding, Nicholas J., Kolar, Carol, Lawson, Terence A., Smith, Sonali M., Weisenburger, Dennis D., Chiu, Brian C.-H.

“…We conducted a population-based, case—control study to test the hypothesis that consumption of meat and meat-related mutagens increases the risk of non-Hodgkin…”
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Differences in the expression of glutathione S-transferases in normal pancreas, chronic pancreatitis, secondary chronic pancreatitis, and pancreatic cancer by ULRICH, Alexis B, SCHMIED, Bruno M, STANDOP, Jens, SCHNEIDER, Matthias B, LAWSON, Terence A, FRIESS, Helmut, ANDREN-SANDBERG, Ake, BÜCHLER, Markus W, POUR, Parviz M

“…In our previous study, glutathione S-transferase-pi (GST-pi), a phase II drug metabolizing enzyme, was found to be expressed in pancreatic ductal and ductular…”
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Increased expression of glutathione S-transferase-π in the islets of patients with primary chronic pancreatitis but not secondary chronic pancreatitis by ULRICH, Alexis B, SCHMIED, Bruno M, MATSUZAKI, Hosei, LAWSON, Terence A, FRIESS, Helmut, ANDREN-SANDBERG, Ke, BÜCHLER, Markus W, POUR, Parviz M

“…The mechanism of tissue alteration in chronic pancreatitis (CP) is still unclear. Different hypotheses have been discussed, including increasing oxidant stress…”
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Expression of drug-metabolizing enzymes in the pancreas of hamster, mouse, and rat, responding differently to the pancreatic carcinogenicity of BOP by Ulrich, Alexis B., Standop, Jens, Schmied, Bruno M., Schneider, Matthias B., Lawson, Terence A., Pour, Parviz M.

“…Background/Methods: N-nitroso-bis(2-oxopropyl)amine (BOP) induces pancreatic ductal adenocarcinoma in Syrian golden hamsters, but not in rats or mice. To…”
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In vitro pharmacokinetics and pharmacodynamics of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) by Ueda-Kawamitsu, Hiroko, Lawson, Terence A., Gwilt, Peter R.

“…The relationship between treatment efficacy and the pharmacokinetics (PK) and pharmacodynamics (PD) of anticancer drugs is poorly defined…”
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Nitrosation of Glycine Ethyl Ester and Ethyl Diazoacetate To Give the Alkylating Agent and Mutagen Ethyl Chloro(hydroximino)acetate by Zhou, Lin, Haorah, James, Chen, Sheng C, Wang, Xiaojie, Kolar, Carol, Lawson, Terence A, Mirvish, Sidney S

“…Whereas nitrosation of secondary amines produces nitrosamines, amino acids with primary amino groups and glycine ethyl ester were reported to react with…”
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Inhibition by dietary selenium of colon cancer induced in the rat by bis(2-oxopropyl)nitrosamine by Birt, D F, Lawson, T A, Julius, A D, Runice, C E, Salmasi, S

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Metabolism of the hamster pancreatic carcinogen methyl-2-oxopropylnitrosamine by hamster liver and pancreas by Chen, S C, Wang, X, Zhou, L, Kolar, C, Lawson, T A, Mirvish, S S

“…The mechanism whereby methyl-2-oxopropylnitrosamine (MOP) is activated remains unknown. To begin investigating this mechanism, we followed MOP disappearance…”
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Rodent bladder tumors do not always predict for humans by Cohen, Samuel M., Lawson, Terence A.

“…Dr. David Clayson, 20 years ago, suggested that chemicals which lead to the formation of calculi in rodents might pose an artifact with respect to…”
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Effects of oltipraz, BHA, ADT and cabbage on glutathione metabolism, DNA damage and lipid peroxidation in old mice by Stohs, S J, Lawson, T A, Anderson, L, Bueding, E

“…Eighteen-month-old female mice were fed defined diets for 2 weeks which contained 0.05% or 0.10% oltipraz, 0.10% anethole dithione (ADT), 0.10% butylated…”
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Cholecystokinin inhibits DNA alkylation induced by N-nitrosobis (2-oxopropyl)amine (BOP) in hamster pancreas by Corra, S, Kazakoff, K, Lawson, T A, Adrian, T E, Pour, P M

“…Cholecystokinin (CCK) inhibits pancreatic cancer but not hepatic tumor induction by N-nitrosobis (2-oxopropyl) amine (BOP) in hamsters when administered with…”
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Test of catechol, tannic acid, Bidens pilosa, croton oil, and phorbol for cocarcinogenesis of esophageal tumors induced in rats by methyl-n-amylnitrosamine by Mirvish, S S, Salmasi, S, Lawson, T A, Pour, P, Sutherland, D

“…Catechol (CAS: 120-80-9), given in drinking water to rats, was the most effective of 5 phenols in enhancing [3H]thymidine incorporation [( 3H]dThd-l) into…”
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Proliferative changes in the prostate by Pour, P, Lawson, T A, Cohen, S M

“…The prostate of the rat has several lobes which have variable responsiveness to estrogens and testosterone. Testosterone is a major stimulant of cell…”
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Ketonitrosamines as metabolites of methyl-n-amylnitrosamine (MNAN) and its hydroxy derivatives in the rat by Mirvish, S S, Makary, M, Issenberg, P, Deshpande, A, Ji, C A, Lawson, T A, Babcook, D M, Rosinsky, S

“…In a previous study of the metabolism of methyl-n-amylnitrosamine (MNAN) in the rat, 2- to 5-hydroxy-MNAN (HO-MNAN) were provisionally identified as…”
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The failure of chronically administered saccharin to stimulate bladder epithelial DNA synthesis in F0 rats by Lawson, T A, Hertzog, P J

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Induction of hyperplastic liver nodules in Wistar and MRC-Wistar rats by phenobarbital and the liver carcinogens acetoxime, 1-nitroso-5,6-dihydrouracil and 3-nitroso-2-oxazolidinone by Mirvish, S S, Markin, R S, Lawson, T A, Nickols, J G

“…We tested the ability of phenobarbital and two liver carcinogens, acetoxime and 1-nitroso-5,6-dihydrouracil (NDHU), to induce hyperplastic liver nodules (HLN)…”
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Persistence of DNA single-strand breaks and other tests as indicators of the liver carcinogenicity of 1-nitroso-5,6-dihydrouracil and the noncarcinogenicity of 1-nitroso-5,6-dihydrothymine by Lawson, T A, Mirvish, S S, Pour, P, Williams, G

“…The cyclic nitrosourea 1-nitroso-5,6-dihydrothymine [(NDHT) 1-nitrosodihydrothymine] was not significantly carcinogenic when it was administered for 1 year in…”
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The involvement of DNA synthesis in the removal of bound ethyl carbamate from liver DNA by Lawson, T A

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The interaction of carbon-14-labelled alkyl carbamates, labelled in the alkyl and carbonyl positions, with DNA in vivo by Lawson, T A, Pound, A W

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