Search Results - "LAWSON, Judy A"

Glutathione peroxidase–deficient mice are more susceptible to neutrophil‐mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress by Jaeschke, Hartmut, Ho, Ye‐Shih, Fisher, Michael A., Lawson, Judy A., Farhood, Anwar

“…Neutrophils contribute to hepatocellular injury in a number of acuteinflammatory reactions. However, the molecular mechanism of parenchymal cell injury remains…”
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Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo : Evidence for a postmitochondrial processing of caspase-8 by BAJT, Mary Lynn, LAWSON, Judy A, VONDERFECHT, Steven L, GUJRAL, Jasprect S, JAESCHKE, Hartmut

“…Lymphocytes can kill target cells including hepatocytes during various inflammatory diseases by Fas receptor-mediated apoptosis. Caspase-8 is activated at the…”
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Inhibition of Fas Receptor (CD95)-Induced Hepatic Caspase Activation and Apoptosis by Acetaminophen in Mice by Lawson, Judy A., Fisher, Michael A., Simmons, Carol A., Farhood, Anwar, Jaeschke, Hartmut

“…The mechanism of liver cell injury induced by an overdose of the analgesic acetaminophen (AAP) remains controversial. Recently, it was hypothesized that a…”
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Pathophysiologic Importance of E- and L-Selectin for Neutrophil-Induced Liver Injury During Endotoxemia in Mice by Lawson, Judy A., Burns, Alan R., Farhood, Anwar, Lynn Bajt, Mary, Collins, Robert G., Wayne Smith, C., Jaeschke, Hartmut

“…Neutrophils can cause parenchymal cell injury in the liver during ischemia-reperfusion and endotoxemia. Neutrophils relevant for the injury accumulate in…”
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Dopamine receptor agonists differ in their actions on cardiac ion channels by Hurst, Raymond S., Higdon, Nicole R., Lawson, Judy A., Clark, Michael A., Rutherford-Root, Karen L., McDonald, William G., Haas, Joseph V., McGrath, James P., Meglasson, Martin D.

“…Four dopamine receptor agonists used for the treatment of Parkinson's disease (apomorphine, pergolide, ropinirole and sumanirole) were evaluated for the…”
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Differential effect of 2-aminoethyl-isothiourea, an inhibitor of the inducible nitric oxide synthase, on microvascular blood flow and organ injury in models of hepatic ischemia-reperfusion and endotoxemia by Wang, Y, Lawson, J A, Jaeschke, H

“…The vasodilator nitric oxide (NO) is involved in the regulation of systemic blood pressure and local organ blood flow. Inhibitors of the constitutively…”
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A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization by Hurst, Raymond S., Hajós, Mihaly, Raggenbass, Mario, Wall, Theron M., Higdon, Nicole R., Lawson, Judy A., Rutherford-Root, Karen L., Berkenpas, Mitchell B., Hoffmann, W. E., Piotrowski, David W., Groppi, Vincent E., Allaman, Geraldine, Ogier, Roch, Bertrand, Sonia, Bertrand, Daniel, Arneric, Stephen P.

“…Several lines of evidence suggest a link between the α7 neuronal nicotinic acetylcholine receptor (nAChR) and brain disorders including schizophrenia,…”
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A Novel Positive Allosteric Modulator of the alpha 7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization by Hurst, Raymond S, Hajos, Mihaly, Raggenbass, Mario, Wall, Theron M, Higdon, Nicole R, Lawson, Judy A, Rutherford-Root, Karen L, Berkenpas, Mitchell B, Hoffmann, W E, Piotrowski, David W, Groppi, Vincent E, Allaman, Geraldine, Ogier, Roch, Bertrand, Sonia, Bertrand, Daniel, Arneric, Stephen P

“…Several lines of evidence suggest a link between the alpha 7 neuronal nicotinic acetylcholine receptor (nAChR) and brain disorders including schizophrenia,…”
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The Hepatic Inflammatory Response after Acetaminophen Overdose: Role of Neutrophils by Lawson, Judy A., Farhood, Anwar, Hopper, Robert D., Bajt, Mary Lynn, Jaeschke, Hartmut

“…Acetaminophen overdose induces severe liver injury and hepatic failure. There is evidence that inflammatory cells may be involved in the pathophysiology. Thus,…”
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Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model by Jaeschke, H, Fisher, M A, Lawson, J A, Simmons, C A, Farhood, A, Jones, D A

“…Endotoxin (ET)-induced liver failure is characterized by parenchymal cell apoptosis and inflammation leading to liver cell necrosis. Members of the caspase…”
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Potent renin inhibitory peptides containing hydrophilic end groups by Bundy, Gordon L, Pals, Donald T, Lawson, Judy A, Couch, Sally J, Lipton, Michael F, Mauragis, Michael A

“…A previously reported renin inhibitor, Boc-Pro-Phe-N(Me)His-Leu psi [CHOHCH2]Val-Ile-Amp (U-71038), was altered by the incorporation of polar, hydrophilic…”
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Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin-infused rat model and in conscious sodium-depleted monkeys by Thaisrivongs, Suvit, Pals, Donald T, DuCharme, Donald W, Turner, Steve R, DeGraaf, Garry L, Lawson, Judy A, Couch, Sally J, Williams, Mark V

“…We previously reported that Boc-Pro-Phe-N-MeHis-Leu psi [CHOHCH2]-Ile-Amp (1) is a potent and specific inhibitor of human renin in vitro. It was shown to…”
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Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and fas‐antibody–induced liver injury by Lawson, Judy A., Fisher, Michael A., Simmons, Carol A., Farhood, Anwar, Jaeschke, Hartmut

“…Endotoxin (ET) induces neutrophil sequestration in hepatic sinusoids, the activation of proinflammatory transcription factors (nuclear factor κB [NF‐κB]) with…”
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Synthesis and renin inhibitory activity of angiotensinogen analogs having dehydrostatine, Lue.psi.[CH2S]Val, or Lue.psi.[CH2SO] Val at the Pt, P1' cleavage site by Smith, Clark W, Saneii, Hossain H, Sawyer, Tomi K, Pals, Donald T, Scahill, Terrence A, Kamdar, Bharat V, Lawson, Judy A

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alpha.-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model by Thaisrivongs, Suvit, Pals, Donald T, Lawson, Judy A, Turner, Steve R, Harris, Douglas W

“…A structure-activity analysis of peptides containing backbone C alpha-methyl modification at the P4 site of the angiotensinogen sequence led to the discovery…”
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A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization by Hurst, Raymond S, Hajós, Mihaly, Raggenbass, Mario, Wall, Theron M, Higdon, Nicole R, Lawson, Judy A, Rutherford-Root, Karen L, Berkenpas, Mitchell B, Hoffmann, W E, Piotrowski, David W, Groppi, Vincent E, Allaman, Geraldine, Ogier, Roch, Bertrand, Sonia, Bertrand, Daniel, Arneric, Stephen P

“…Several lines of evidence suggest a link between the alpha7 neuronal nicotinic acetylcholine receptor (nAChR) and brain disorders including schizophrenia,…”
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Glyburide attenuates calmodulin antagonist-stimulated renin release from isolated mouse juxtaglomerular cells by Linseman, D A, Lawson, J A, Jones, D A, Ludens, J H

“…Previous reports have shown that K+ channel openers elevate plasma renin activity in vivo and stimulate renin release (RR) from juxtaglomerular (JG) cells in…”
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Appraisal of a glycopeptide cloaking strategy for a therapeutic oligopeptide: glycopeptide analogs of the renin inhibitor ditekiren by Harrison, A W, Fisher, J F, Guido, D M, Couch, S J, Lawson, J A, Sutter, D M, Williams, M V, DeGraaf, G L, Rogers, J E, Pals, D T

“…Among the limitations to the practical therapeutic oligopeptide are low oral availability, indifferent aqueous solubility, and an astonishing efficient…”
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An Orally Active Inhibitor of Renin by PALS, DONALD T, THAISRIVONGS, Suvrr, LAWSON, JUDY A, KATI, WARREN M, TURNER, STEVE R, DEGRAAF, GARRY L, HARRIS, DOUGLAS W, JOHNSON, GARLAND A

“…A potent renin inhibitor, U-71038 (BK-Pro-Phe-JV-MeHis-Leuψ[CHOHCH]Val-Ile-Amp), was tested for oral effectiveness. Enzyme kinetic studies indicated that…”
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A Novel Positive Allosteric Modulator of the {alpha}7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization by Hurst, Raymond S, Hajos, Mihaly, Raggenbass, Mario, Wall, Theron M, Higdon, Nicole R, Lawson, Judy A, Rutherford-Root, Karen L, Berkenpas, Mitchell B, Hoffmann, W. E, Piotrowski, David W, Groppi, Vincent E, Allaman, Geraldine, Ogier, Roch, Bertrand, Sonia, Bertrand, Daniel, Arneric, Stephen P

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